Ingabe unesimila esingavamile ohlelweni lwakho lwezinzwa? (Isimila Esibuhlungu Sezinzwa Ezingalapheki - MPNST) Ake sifunde ngaso.

Wake wezwa iqhubu endaweni ethile emzimbeni wakho, mhlawumbe engalweni noma emlenzeni, elikhula kancane kancane? La maqhubu, ngezinye izikhathi angaqala amancane njengephizi futhi akhule abe makhulu njengewolintshi, yilokho esizokhuluma ngakho namuhla. Lesi yisimo esibi kakhulu, kodwa esingavamile kakhulu. Sibizwa ngokuthi i-malignant peripheral nerve sheath tumor, noma i-MPNST ngamafuphi.

Iyini i-malignant peripheral nerve sheath tumor (MPNST)?

Kalula nje, i-MPNST (i-Malignant Peripheral Nerve Sheath Tumor) iyisimila esingavamile kakhulu esinomdlavuza esikhula ezimbozweni ezivikelayo (izimbobo zezinzwa) ezizungeze imizwa emzimbeni wakho. Lokhu kungokwezinhlobo ze -sarcoma yezicubu ezithambile . Zivela ohlelweni lwakho lwezinzwa olungaphandle . Cabanga ngakho, ungathola lezi zimila ezingalweni nasemilenzeni yakho. Akukhona lokho kuphela, ngezinye izikhathi zingakhula nasesinqeni, esiswini, ekhanda nasentanyeni. Lezi zimila zingelapheka ngokuzisusa ngokuhlinzwa. Kodwa-ke, kumelwe sikhumbule nokuthi ngezinye izikhathi lezi zimila zingaphinde zivele .

I-MPNST ingavamile kangakanani?

Lesi yisimo esingavamile kakhulu. Cishe umuntu oyedwa kwabayi-100,000 utholakala enalesi sifo esibuhlungu se-peripheral nerve sheath (MPNST) minyaka yonke. Ngokuvamile sithinta abantu abaneminyaka ephakathi kuka-30 no-50 .

Ngaphezu kwalokho, abantu abanesimo sofuzo esibizwa ngokuthi i-Neurofibromatosis uhlobo 1 (NF1) banamathuba amaningi okuthola i-MPNST. Kutholakale ukuthi phakathi kuka-25% no-50% wabantu abane-MPNST nabo bane-NF1 .

Ngokuvamile, i-MPNST ingakhula kusenesikhathi kubantu abane-NF1 kunakubantu abangenayo i-NF1. Futhi, abesilisa abane-NF1 banamathuba amancane okukhula ne-MPNST kunalabo abangenayo i-NF1.

Ziyini izimpawu ze-MPNST?

Ama-MPNST angakhula noma kuphi eduze kwezinzwa zakho zangaphandle, kodwa avame ukuthinta izindawo ezifana nezingalo nemilenze yakho. Ngezinye izikhathi angakhula nasezindaweni ezifana ne-pelvis yakho, isifuba, isisu, noma ikhanda nentamo. Izimpawu ze-MPNST zifaka:

• Isigaxa esikhula kancane ngaphansi kwesikhumba. Lezi zigaxa zingaba zincane njenge-pea (cishe amasentimitha amabili) noma zibe zinkulu njenge-orange (cishe amasentimitha ayi-10).
• Ukuzwa ubuhlungu (ikakhulukazi uma une-NF1).
• Ukungabi namizwa (i-Paresthesia).
• Ukuzizwa ubuthakathaka ezingalweni nasemilenzeni.

Yini ebangela i-MPNST?

Izifundo zibonise ukuthi ama-50% ezimila ze-peripheral nerve sheath eziyingozi zibangelwa yi -neurofibromatosis uhlobo 1 (NF1).Lesi simo sibizwa ngokuthi. Ezinye izizathu zingaba:

• Ukwelashwa ngemisebe: Cishe abantu abayi-10% abane-MPNST bathole ukwelashwa ngemisebe kwezinye izifo.
• Ukuguquka kwezakhi zofuzo: Abacwaningi bathole ukuthi kunezinhlobo eziningana zokuguquka kwezakhi zofuzo ezibangela ukuba amangqamuzana avamile e-nerve sheath abe amangqamuzana angajwayelekile, aphindaphindeke, futhi akhe amathumba.
• Ezinye izinhlobo ze-neurofibroma: Abantu abane -plexiform neurofibroma basengozini enkulu yokuthola i-MPNST.

Itholakala kanjani i-MPNST?

Uma ubona udokotela, uzoqala ngokukwenza ukuhlolwa komzimba bese ebuza ngempilo yakho iyonke. Lokhu kuzofaka phakathi ukubuza ngomlando wakho wezokwelapha, umlando wezokwelapha womndeni, kanye nanoma yiziphi izimpawu ongase ube nazo. Ngaphezu kwalokho, bangenza okulandelayo:

• Ukuhlolwa kwezithombe: Odokotela bangenza ukuhlolwa okufana ne-MRI (Magnetic Resonance Imaging) kanye ne-PET (Positron Emission Tomography) .
• Ukuhlolwa kwezicubu: Udokotela angenza i-biopsy, athathe isampula yezicubu bese ehlolwa ngaphansi kwe-microscope ngudokotela wezifo .
• Ukuhlolwa kofuzo: Uma unesimila esibuhlungu esitholakala emithanjeni, udokotela wakho angase ancome ukuhlolwa kofuzo ukuze abone ukuthi wena noma ilungu lomndeni eliseduze ninesifo se-neurofibromatosis uhlobo 1 (NF1) noma olunye uhlobo lwesimila esitholakala emithanjeni , i-neurofibromatosis uhlobo 2 (Schwannomatosis) .

Yiziphi izindlela zokwelapha i-MPNST?

Odokotela bavame ukwenza ukuhlinzwa ukuze kususwe isimila esiyingozi se-peripheral nerve sheath. Kodwa-ke, kunezinye izimo lapho ukuhlinzwa kungenzeki khona. Isibonelo:

• Amantongomane amakhulu (amantongomane angama-5 cm noma ngaphezulu).
• Izimila ezisakazekile.
• Amathumba aseduze kakhulu nenethiwekhi yezinzwa eziyinkimbinkimbi angonakala ngesikhathi sokuhlinzwa.

Kulezi zimo, odokotela bangase baphathe i-MPNST ngokuhlanganiswa kokuhlinzwa, i-chemotherapy , noma ukwelashwa ngemisebe . Ukwelashwa ngemisebe kunganikezwa ngaphambi noma ngemva kokuhlinzwa.

Abacwaningi manje babheka ukuthi ngabe ukwelashwa nge-immunotherapy noma ukwelashwa okuqondiwe kungasetshenziswa yini njengokwelashwa okusha. Uma unesimila esibuhlungu se-peripheral nerve sheath, ungase ufanelekele ukuhlolwa kwezokwelapha okuvivinya ukwelashwa okusha.Kungaba ngumqondo omuhle ukukhuluma nodokotela wakho mayelana nokubamba iqhaza.

Yiziphi izinkinga noma imiphumela emibi engaba khona yokwelashwa?

Izinkinga ezingase zenzeke ngesikhathi sokuhlinzwa zifaka:

• Izimpendulo ku-anesthesia ejwayelekile.
• Ukopha kakhulu (ukopha kakhulu).
• Ubuhlungu.
• Izibazi zokuhlinzwa.
• Ukutheleleka kwenxeba ngokuhlinzwa.

Ukwelashwa okufana ne-chemotherapy noma ukwelashwa ngemisebe kungabangela imiphumela emibi efana nalokhu:

• Uhudo.
• Ukukhathala.
• Isicanucanu nokuhlanza.

Kuyini ukubikezela kokugula komuntu one-MPNST?

Ukubikezela yilokho ithimba lakho lezokwelapha elicabanga ukuthi uzoba yikho ngemuva kokuqeda ukwelashwa. Endabeni ye-MPNST, lesi sibikezelo sinqunywa yizici eziningana:

• Isimo se-NF1: Uma lezi zimila zikhula kubantu abane-NF1, isibikezelo sokululama singase sibe ngaphansi kancane kunabantu abangenayo i-NF1.
• Izinga lesimila: Odokotela bezifo babheka amangqamuzana ngaphansi kwe-microscope bese behlukanisa izimila njengezinga eliphezulu noma eliphansi . Izimila ezisezingeni eliphezulu zinethuba eliphezulu lokuba namangqamuzana omdlavuza ahlukana ngokushesha futhi asakazeke.
• Usayizi wesimila: Izimila ze-MPNST zingaba zinkulu ngamasentimitha ayi-10. Izimila ezinkulu ngokuvamile kunzima ukuzisusa ngokuhlinzwa.
• Ukusabalala kwezicubu: Uma isimila sesisabalale kwezinye izindawo kusukela lapho saqala khona, kungase kube nzima ukuselapha.

Njengoba ubona, kunezici eziningi ezingathinta amathuba akho okululama, futhi akuzona zonke lezi zinto ezingasebenza kuwe. Ngakho-ke, kungcono ukucela udokotela wakho imininingwane eqondile yesimo sakho. Njengoba esazi isimo sakho, angakunikeza ulwazi oludingayo.

Zingakanani amazinga okusinda kwe-MPNST?

Amazinga okusinda ayizilinganiso ezisekelwe kokuhlangenwe nakho kwabanye abaye baba nezimila ze-peripheral nerve sheath eziyingozi. Ngenxa yokuthi lezi zimila azivamile, kunzima kochwepheshe ukunikeza amazinga aqondile. Ngokusho kweNational Cancer Institute (US), phakathi kuka-23% no-69% wabantu abane-MPNST baphila iminyaka emihlanu ngemva kokuxilongwa. Lokho kuluhlu olukhulu, akunjalo? Ngakho-ke kungcono ukubuza udokotela wakho ngesimo sakho.

Ngizinakekela kanjani?

Uma unesimila esibuhlungu se-peripheral nerve sheath, ubhekene nomdlavuza ongavamile ongabuya ngemva kokwelashwa. Kunezinhlelo eziningana ezingakusiza kulesi simo:

• Ukunakekelwa kobuhlungu:Ekunakekelweni kokwelapha ubuhlungu, uzosebenzisana nethimba lodokotela abaqeqeshwe ngokukhethekile abangakusiza ukuphatha izimpawu ze-MPNST kanye nemiphumela emibi yokwelashwa. Ngaphezu kwalokho, bazokunikeza nokusekelwa kwengqondo.
• Izinhlelo zokusinda kumdlavuza: Umdlavuza ufana nohambo. Izinhlelo zokusinda kumdlavuza zikuqondisa kusukela ngosuku oxilongwa ngalo, ngokwelashwa kwakho, nokuthi yini okufanele uyenze uma umdlavuza ubuya.

Uma uqala ukubona, isimila esibuhlungu se-peripheral nerve sheath (MPNST) engalweni noma emlenzeni wakho singase sibonakale njengesigaxa ongasilimala kalula noma usilimaze. Ukuthola ukuthi lesi sigaxa siwuhlobo lomdlavuza olungavamile nokuthi sidinga ukuhlinzwa kungaba yinto eshaqisayo. Kungaba nzima ukukwamukela. Uma unemibuzo ngesimo sakho noma ukuthi yini ongayilindela, ithimba lakho lezokwelapha liyaqonda. Bazokujabulela ukuzinika isikhathi sokuphendula imibuzo yakho futhi babhekane nanoma yikuphi ukukhathazeka ongase ube nakho.

Umyalezo okufanele uwuthathe ekhaya ovela kulesi sihloko

Kulungile, ngakho-ke ngithemba ukuthi uyaqonda ngalesi simo somdlavuza esingavamile esibizwa ngokuthi i-MPNST esikhulume ngaso namuhla. Khumbula, lesi yisimo esingavamile kakhulu. Uma unamaqhubu angavamile, ubuhlungu, ukungazweli, njll. emzimbeni wakho aqhubeka, qiniseka ukuthi ubona udokotela futhi uthole iseluleko. Uma sitholakala kusenesikhathi, kuba lula ukwelapha.

Into ebaluleke kakhulu ukuthi awuwedwa. Ithimba lakho lezokwelapha, umndeni, nabangani bakho bonke bakhona ukukusiza. Into ebaluleke kakhulu ukuhlala uqinile futhi ulandele iseluleko sikadokotela wakho.

Isimila esibuhlungu se-peripheral nerve sheath, i-MPNST, umdlavuza we-nerve, isimila, umdlavuza, i-neurofibromatosis, i-NF1, ukuhlinzwa, ukwelashwa ngemisebe, i-chemotherapy