Amaphilisi e-Mifepristone e-Cushing's syndrome? Ake sixoxe ngalokhu!

Ingabe une -Cushing Syndrome ? Noma ingabe othile omaziyo unalesi simo? Okwenzekayo kulesi simo ukuthi umzimba wethu ukhiqiza i- cortisol eningi kakhulu kunokudingekile, okubangela ukuba izinga likashukela egazini, okungukuthi, i-glucose, likhuphuke. Ngakho-ke, omunye wemithi odokotela abayincomayo ngezikhathi ezinjengalena yi-Mifepristone. Namuhla, sizoxoxa kabanzi ngala maphilisi e-Mifepristone.

Uhlobo luni lomuthi iMifepristone?

Kalula nje, amaphilisi e-Mifepristone asetshenziswa kakhulu ukulawula amazinga kashukela egazini ku- Cushing's Syndrome , isimo esenzeka lapho i-hormone i-cortisol emzimbeni wakho ikhuphuka kakhulu.

Uyazi ukuthi le hormone ebizwa ngokuthi i-cortisol ibalulekile emzimbeni wethu? Uma sicindezelekile, umzimba wethu uzilungiselela ukubhekana nayo ngale hormone. Isibonelo, lapho umzimba udinga amandla engeziwe ngokushesha, le cortisol iyasiza ekukhipheni ushukela owengeziwe egazini. Kodwa-ke, uma lokhu kwanda ngokungalawuleki, kuvela izinkinga ezahlukahlukene. Amaphilisi e-Mifepristone anciphisa umphumela we-hormone ye-cortisol, ngaleyo ndlela anciphise izinga likashukela egazini.

Lo muthi ngezinye izikhathi unganikezwa odokotela ngenxa yezinye izimo. Ngakho-ke, uma ungaqiniseki ukuthi unikezwe ini ngempela, kungcono ukubuza udokotela wakho noma usokhemisi ekhemisi ukuthi uwuthathaphi umuthi wakho. Lo muthi waziwa emakethe ngegama lomkhiqizo iKorlym .

Yiziphi izinto okudingeka ngizitshele udokotela ngaphambi kokuthatha lo muthi?

Ngaphambi kokuthi uqale ukusebenzisa amaphilisi e-Mifepristone, kunezinto ezibalulekile okufanele uzitshele udokotela wakho. Ngoba, abantu abanezimo ezithile zezokwelapha noma labo abathatha eminye imithi kufanele baqaphele kakhulu lapho benikeza i-Mifepristone. Bheka ukuthi lokhu okulandelayo kuyasebenza yini kuwe:

• Ingabe unesifo sokopha ?
• Ingabe unomdlavuza njengamanje noma uyalashwa?
• Ingabe unesifo sengqondo esifana nokucindezeleka ?
• Ingabe unolunye uhlobo lwesifo sikashukela olungahlobene nesifo sikaCushing?
• Isifo senhliziyoUnesifo senhliziyo?
• Ingabe unaso isifo somfutho wegazi ophakeme ?
• Ingabe unesifo sesibindi?
• Ingabe odokotela bakutshelile ukuthi izinga lakho le-potassium egazini liphansi?
• Wake wafakelwa isitho somzimba?
• Ingabe okwamanje usebenzisa ama-steroid njenge-dexamethasone noma i-prednisone?
• Ingabe unesifo sokuphuma kwegazi esithweni sangasese sowesifazane esingachazeki?
• Wake waba nokusabela kokungezwani komzimba ne-mifepristone, noma yimuphi omunye umuthi, ukudla, udayi wokudla, noma izithasiselo?
• Ingabe okwamanje uzama ukukhulelwa? Noma usuvele ukhulelwe?
• Ingabe ungumama oncelisayo? (Uyancelisa)

Uma unesifo esifana nalesi, kungcono ukutshela udokotela wakho ngaso ngaphandle kokufihla lutho .

Ngingawusebenzisa kanjani lo muthi?

La maphilisi e-Mifepristone kufanele athathwe ngamanzi. Kubaluleke kakhulu ukuthatha lo muthi ngesikhathi esifanayo nsuku zonke , njengoba kuqondiswe kwilebula kadokotela. Ungawaphuli , uwachoboze, noma uwahlafune la maphilisi. Gwinya lonke iphilisi ngamanzi.

Enye into ebalulekile ukuthi lo muthi kufanele uthathwe kanye nokudla. Futhi, ungawuthathi lo muthi kanye nojusi we-grapefruit nganoma yisiphi isizathu. Kufanele uqhubeke nokusebenzisa lo muthi njengoba kuyalelwe kuze kube yilapho udokotela wakho ekutshela ukuthi uyeke.

Uma unikezwa lo muthi yikhemisi, uzonikezwa incwajana enemiyalelo ekhethekile ngalo muthi, ebizwa ngokuthi i-MedGuide . Kubaluleke kakhulu ukufunda nokuqonda leli pheshana le-MedGuide ngokucophelela isikhathi ngasinye lapho uthatha umuthi, nalapho uthola ukugcwalisa kabusha.

Uma unikeza izingane ezincane lo muthi, qiniseka ukuthi ukhuluma nodokotela wakho ngawo, ngoba ungadinga ukubhekwa okukhethekile kwezokwelapha kanye nokunakekelwa.

Yini okufanele uyenze uma uphuza ngokweqile?

Uma ucabanga ukuthi usuthathe lo muthi omningi kakhulu, shayela ngokushesha isikhungo sokulawula ubuthi esiseduze noma igumbi lezimo eziphuthumayo lesibhedlela sikahulumeni ukuze uthole iseluleko.

Khumbula futhi: Lo muthi unikezwe wena kuphela. Ungawuniki umngane noma ilungu lomndeni nganoma yisiphi isizathu, noma ngabe banezimpawu ezifanayo nezakho.

Yini okufanele uyenze uma uphuthelwa umthamo wemithi?

Uma ukhohlwa ukuphuza iphilisi le-Mifepristone ngolunye usuku, lithathe ngokushesha nje lapho ukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo wakho olandelayo lapho ukhumbula, yeqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esihleliwe. Ungalokothi uthathe imithamo ephindwe kabili noma eyengeziwe, okungukuthi, thatha kokubili umthamo ophuthelwe kanye nalowo obekufanele uwuthathe ngesikhathi esisodwa. Ukwenza kanjalo kwandisa ingozi yemiphumela emibi.

Yimiphi eminye imithi okungafanele ithathwe nalo muthi?

Uma okwamanje uthatha noma yimiphi imithi elandelayo, ungalokothi uyithathe kanye ne-Mifepristone. Lokhu kungabangela ukuhlangana okungathi sína nokuyingozi okungaba yingozi empilweni:

• Eminye imithi esetshenziswa ukwelapha izifo zesikhunta, isibonelo, i-fluconazole, i-ketoconazole, kanye ne-posaconazole.
• Eminye imithi inikezwa ukwehlisa amazinga e-cholesterol egazini, isibonelo i-lovastatin ne-simvastatin.
• I-Cisapride
• I-Cyclosporine
• I-Dronedarone
• Ama-alkaloid e-Ergot, isibonelo, i-dihydroergotamine kanye ne-ergotamine.
• I-Fentanyl
• I-Pimozide
• I-Quinidine
• I-Sirolimus
• I-Tacrolimus
• I-Thioridazine

Lolu hlu aluphelele, ngakho-ke kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi oyithathayo, ngisho namavithamini.

Eminye imithi nezinto ezingase zihlangane

Kuneminye imithi nezinto ezingasebenzisana ne-Mifepristone, ngakho-ke kuwumqondo omuhle ukuqaphela nalokhu:

• Ezinye izinhlobo zama-antibiotic, isibonelo i-clarithromycin, i-erythromycin, i-telithromycin.
• Eminye imithi yokulwa namagciwane inikezwa ukutheleleka nge-HIV noma izifo zesibindi ezifana ne-hepatitis.
• Imithi esetshenziselwa ukwelapha izimo zesimiso sezinzwa ezifana nokuquleka, isibonelo i-carbamazepine, i-phenytoin, kanye ne-phenobarbital.
• Eminye imithi evimbela ukujiya kwegazi, isibonelo i-warfarin.
• I-Conivaptan
• Ijusi le-Grapefruit – Njengoba kushiwo ngaphambili, lokhu kuyinto engalungile ukuyiphuza ngenkathi uthatha i-Mifepristone.
• Amaphilisi okuvimbela inzalo, imijovo, ama-patches kanye namadivayisi aqukethe ama-hormone.
• I-Itraconazole
• Imithi yokwelapha izimo zengqondo ezifana nokucindezeleka noma ukukhathazeka okukhulu.
• Eminye imithi yezidakamizwa inikezwa njengezinhlungu zobuhlungu.
• Eminye imithi engabangela ukushaya kwenhliziyo okungajwayelekile, njengaleyo enweba isikhathi se-QT.
• I-Repaglinide
• I-Rifabutin, i-Rifampin, i-Rifapentine.
• I-St. John's wort iyisengezo semifino.
• Imithi ye-steroid, njenge-prednisone noma i-cortisone.
• Ama-hormone e-thyroid.
• I-Voriconazole.

Lolu hlu lungase lungahlanganisi konke. Ngakho-ke, qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi, amakhambi, imithi engekho ngaphansi kukadokotela, kanye nezithasiselo zokudla ozithathayo . Futhi, tshela udokotela wakho uma ubhema, uphuza utshwala, noma usebenzisa izidakamizwa ezingekho emthethweni. Lokhu kungathintana ne-Mifepristone oyithathayo.

Yiziphi izinto okufanele uziqaphele lapho uthatha lo muthi?

Ngesikhathi uthatha i-Mifepristone, kuzodingeka ubone udokotela wakho ukuze ahlolwe njalo ukuze aqaphe impilo yakho. Udokotela wakho angase futhi akuncome ukuthi wenze umsebenzi wegazi.

Lo muthi ungathinta amazinga kashukela egazini. Uma unesifo sikashukela, qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokwenza noma yiziphi izinguquko ekudleni kwakho noma kumthamo wemithi yakho yesifo sikashukela.

Gcina incwajana yemiyalelo ekhethekile yalo muthi, ebizwa ngokuthi i-MedGuide, ngokucophelela. Uma udinga usizo oluphuthumayo lwezokwelapha, bonisa ithimba lezokwelapha incwajana ethi i-MedGuide. Batshele nokuthi uthatha i-Mifepristone.

Izinto okufanele uziqaphele kakhulu kwabesifazane:

• Kufanele uhlole ukukhulelwa ukuze uqinisekise ukuthi ukhulelwe yini ngaphambi kokuqala lo muthi we-Mifepristone. Ungakhulelwa ngenkathi uthatha lo muthi noma inyanga eyodwa ngemva kokuyeka umuthi.
• Uma uhlela ukukhulelwa noma ucabanga ukuthi kungenzeka ukuthi ukhulelwe, tshela udokotela wakho ngokushesha. Lo muthi ungabangela imiphumela emibi kakhulu enganeni engakazalwa. Cela udokotela wakho ukuthola ulwazi olwengeziwe.
• Kumelwe usebenzise izithibelo zokubeletha ezisebenzayo ngenkathi uthatha i-Mifepristone. Izithibelo zokubeletha ezingezona eze-hormone zingcono kakhulu ngenkathi uthatha lo muthi futhi inyanga eyodwa ngemva kokuyeka umuthi. Khuluma nodokotela wakho ngendlela engcono kakhulu yokuvimbela ukukhulelwa. Uma usola ukuthi ukhulelwe, tshela udokotela wakho ngokushesha.

Kwabomama abancelisayo: Ungamncelisi umntwana wakho ngenkathi uthatha lo muthi we-Mifepristone.

Yimiphi imiphumela emibi engaba khona yalo muthi?

Njengayo yonke imithi, i-Mifepristone ingabangela imiphumela emibi. Kuneminye imiphumela emibi okufanele uyitshele udokotela wakho ngokushesha uma ivela. Yile:

• Ukusabela kokungezwani komzimba: Ukuqubuka kwesikhumba, ukulunywa, ukuqubuka, ukuvuvukala kobuso, izindebe, ulimi, noma umphimbo. Lokhu kungaba yingozi.
• Ukushintsha kwesigqi senhliziyo: ukushaya kwenhliziyo okusheshayo noma ukushaya kwenhliziyo okungajwayelekile, isiyezi, ukuzizwa ubuthakathaka noma ubuthakathaka, ubuhlungu besifuba, ukuphefumula okunzima.
• Kwabesifazane: Imijikelezo yokuya esikhathini engajwayelekile noma ukuphuma kwegazi okungavamile (ukuvela kwamabala) ngesikhathi sokuya esikhathini.
• Izimpawu zokungasebenzi kahle kwe-adrenal gland: isicanucanu, ukuhlanza, ukulahlekelwa yisifiso sokudla, ubuthakathaka noma ukukhathala okungavamile, isiyezi.
• Izimpawu zamazinga aphansi e-potassium egazini: ubuhlungu bemisipha noma ukuqaqamba, ukuzizwa ubuthakathaka noma ukhathele ngendlela engajwayelekile, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ukuqunjelwa.

Imiphumela emibi ebhalwe ngezansi ngokuvamile ayibi mibi kakhulu, kodwa uma iqhubeka noma ikukhathaza, tshela udokotela wakho:

• Isiyezi
• Ukukhathala
• Ikhanda elibuhlungu
• Ubuhlungu bamalunga
• Ukulahlekelwa yisifiso sokudla
• Isicanucanu
• Ukuvuvukala kwamaqakala, izandla, noma izinyawo.

Lolu hlu alufaki yonke imiphumela emibi engaba khona ye-Mifepristone. Uma uhlangabezana nanoma yiziphi izimpawu ezingavamile, tshela udokotela wakho. Ungabika futhi imiphumela emibi kwi-US Food and Drug Administration (FDA) ku-1-800-FDA-1088.

Ngingayigcina kanjani imithi yami?

Gcina lo muthi we-Mifepristone endaweni ephephile kude nezingane ezincane nezilwane ezifuywayo . Ugcine ekamelweni lokushisa, phakathi kwama-degree Celsius angu-20 no-25 (ama-degree Fahrenheit angu-68 no-77). Hlola usuku lokuphelelwa yisikhathi emuthini futhi ungalokothi usebenzise noma yimuphi umuthi ophelelwe yisikhathi. Ulahle ngendlela efanele.

Uyilahla kanjani imithi engasadingeki noma esephelelwe yisikhathi ngaphandle kokulimaza imvelo?

• Amanye amakhemisi noma izibhedlela zinezinhlelo zokuthatha imithi. Uma kungenzeka, thatha imithi yakho uye kwenye yalezi zindawo. Ungathola okwengeziwe ngalokhu ekhemisi lakho noma ehhovisi lezempilo lomphakathi lendawo.
• Uma kungekho ndlela yokuyibuyisela, hlola iphakethe lemithi noma imiyalelo engaphakathi ukuze ubone ukuthi kufanele yini ilahlwe kudoti noma ihlanzwe endlini yangasese. Uma ungaqiniseki, buza udokotela wakho noma usokhemisi.
• Uma ungawalahla emgqonyeni kadoti, khipha amaphilisi ebhodleleni noma ephaketheni, uwaxube kahle nemfucumfucu yekati esetshenzisiwe, inhlabathi ethile, ikhofi eligayiwe, noma ezinye izinto ezifanayo ezingafuneki. Bese ubeka le ngxube esikhwameni se-polythene esivaleka kabusha noma esitsheni sepulasitiki, uyivale kahle, bese uyiphonsa emgqonyeni kadoti.

Okokugcina, izinto okufanele uzikhumbule

Kulungile, manje usuyaqonda ukuthi i-Mifepristone iwumuthi obalulekile ongasiza ekulawuleni amazinga kashukela egazini kumuntu onjengawe one-Cushing Syndrome. Kodwa futhi uyabona ukuthi kunezinto eziningi okufanele uziqaphele kakhulu uma uyisebenzisa.

Ikakhulukazi, kubaluleke kakhulu ukutshela udokotela wakho ngokucacile ngeminye imithi oyithathayo kanye nezinye izifo onazo, ukuthatha umuthi njengoba nje udokotela esho, ngesikhathi nangenani elibekiwe, ukuqaphela imiphumela emibi engaba khona, nokuqaphela ikakhulukazi ngokukhulelwa kanye nokuvimbela inzalo.

Uma unemibuzo noma ukungabaza ngalo muthi, ungalokothi unqikaze ukucela udokotela wakho noma usokhemisi ekhemisi ukuthi akuxazulule. Khumbula, impilo yakho ibaluleke kakhulu kuwe!

I- Mifepristone, i-Cushing's syndrome, i-cortisol, ushukela wegazi, i-adrenal gland, ukusebenzisana kwezidakamizwa, imiphumela emibi