Uyafuna ukwazi nge-Pelger-Huet Anomaly? Ake sixoxe ngayo!

Wake watshelwa udokotela ngoshintsho oluncane kumaseli akho amhlophe egazi lapho uhlolwa igazi? Kungaba yiPelger-Huet Anomaly. Igama lingase lizwakale njengento enkulu, kodwa ungakhathazeki , ngokuvamile alibi kangako. Ake sixoxe ngalokhu ngemininingwane ethe xaxa, ngendlela elula.

Iyini i-Pelger-Huet Anomaly?

Kalula nje, i-Pelger-Huet Anomaly (PHA) yisimo sofuzo esithinta ama-neutrophil, uhlobo lweseli elimhlophe legazi emzimbeni wethu. Ama-neutrophil afana namasosha amancane emzimbeni wethu asiza umzimba wethu ukulwa namagciwane.

Lesi simo sibangelwa ukushintshashintsha kwe-DNA yethu, ikakhulukazi ku-gene ebizwa ngokuthi i-Lamin B Receptor (i-LBR gene). Le gene ye-LBR yiyona esiza amaseli e-neutrophil ukuthi akhule futhi akhule kahle.

Manje bheka, yonke iseli le-neutrophil inesikhungo sokulawula, esisibiza ngokuthi i-nucleus . Le nucleus iqukethe lonke ulwazi lwe-DNA oludingwa yiseli ukuze lisebenze futhi likhule. Ngokuvamile, i-nucleus ye-neutrophil enempilo ihlukaniswe izingxenye ezintathu noma ngaphezulu. Kodwa-ke, i-nucleus ye-neutrophil kumuntu one-Pelger-Huette inezingxenye ezimbili. Ifana ne-dumbbell, enamafutha kuzo zombili izinhlangothi kanye nephakathi elincane. Akuvamile kakhulu, kwabanye abantu, le nucleus ye-neutrophil ingaba nesimo se-oval, okungukuthi, ibunjwe njengeqanda.

Kodwa into ebalulekile lapha ukuthi noma ngabe uzalwa une-Pelger-Huette anomaly, isikhathi esiningi amaseli akho e-neutrophil asebenza ngendlela evamile. Lokhu kusho ukuthi awaphazamiseki kakhulu ekukuvikeleni ezifweni. Ngakho-ke, ngokuvamile kubangela izinkinga ezimbalwa kakhulu zempilo.

Kukhona esinye isimo esibizwa ngokuthi i-Pseudo Pelger-Huet Anomaly (PPHA) . Lokhu kungenzeka kwabanye abantu kamuva ekuphileni. I-PPHA ingenzeka njengomphumela ongemuhle wemithi ethile noma njengophawu lwesinye isimo, njengokutheleleka.

Ziyini izimpawu ze-Pelger-Huette anomaly?

Lapha sidinga ukugxila ezinhlotsheni ezimbili esikhulume ngazo ngaphambili.

I-Hereditary Pelger-Huet Anomaly (HPA)

Uma une-Pelger-Huette anomaly (HPA), ezuzwe njengefa, ngokuvamile awunazo izimpawu. Ungase ungazi nokuthi unalesi simo. Ngokuvamile sitholakala ngengozi lapho kwenziwa ukuhlolwa kwegazi ngesinye isizathu.

I-Pseudo Pelger-Huet Anomaly (PPHA)

Kodwa-ke, uma une-pseudo-Pelger-Huette anomaly (PPHA), okusho ukuthi yavela kamuva, ungase ube nezimpawu ezihlobene nesimo esiyisisekelo esabangela lokho.Isibonelo, uma i-PPHA ibangelwa ukutheleleka, kungase kube nezimpawu ezifana nomkhuhlane kanye nobuhlungu bomzimba obuhlobene nalolo gciwane.

Yini ebangela i-Pelger-Huette anomaly?

Isizathu salokhu siyahlukahluka kuye ngezinhlobo ezimbili esixoxe ngazo ekuqaleni.

I-Hereditary Pelger-Huette anomaly (HPA)

Lokhu kubangelwa ukuguquka kwezakhi zofuzo ze-Lamin B Receptor (LBR), njengoba sishilo ngaphambili. Le zakhi zofuzo ze-LBR iyala umzimba wethu ukuthi wenze amaprotheni adingekayo ukuvikela amangqamuzana e-neutrophil futhi uwanike isimo esifanele. Ku-Pelger-Huytt anomaly, lokhu kuguquka kwezakhi zofuzo kuphazamisa leyo nqubo, okubangela ukuthi ama-nuclei ama-neutrophil athathe isimo se-dumbbell. Lesi yisimo esingazuzwa kubazali siye ezinganeni.

I-Pseudo Pelger-Huette anomaly (PPHA)

Lesi akusona isimo sofuzo. Kunezici eziningana ezingabangela lesi simo:

• Izifo zomnkantsha wamathambo: Izibonelo zifaka phakathi izimo ze-leukemia ezifana ne-myelodysplastic syndrome kanye ne-acute myeloid leukemia (AML).
• Ezinye izifo: ikakhulukazi izifo ezithwalwa yizimpukane.
• Ama-immunosuppressants: Le mithi, enikezwa izifo ezithile, ingaba yimbangela.
• Ukuchayeka emisebeni: Isibonelo, ngesikhathi sokwelashwa komdlavuza.

Uma udokotela ekutshela ukuthi une-'PHA' noma i-'PPHA', kubaluleke kakhulu ukwazisa udokotela ngayo yonke imithi oyiphuzayo, ngisho namavithamini.

Yiziphi izinto ezibangela lesi simo?

Isici esiyinhloko sengozi ye-Pelger-Huette anomaly (PHA) ukuba nomzali wemvelo onalesi simo. Lokhu kusho ukuthi uma umama noma ubaba wakho ene-PHA, unethuba elingama-50% lokuyithola njengefa. Kufana nokuphonsa uhlamvu lwemali, awukwazi ukusho ngokuqinisekile, kodwa kungenzeka.

Esimweni se-'PPHA`, ukuchayeka ezimweni zezokwelapha noma ekwelashweni okukhulunywe ngakho ngaphambilini kuyizinto eziyingozi.

Ingabe zikhona izinkinga ngalesi simo?

Ngokuvamile, i-Pelger-Huette anomaly (PHA) yefa ayibangeli izinkinga ezinkulu. Ngoba, nakuba ishintsha ukubukeka kwamaseli akho e-neutrophil, ayishintshi kakhulu indlela asebenza ngayo. Ayaqhubeka nokulwa namagciwane.

Kodwa-ke, uma une-pseudopelgar-huwat anomalous (PPHA), isimo sezokwelapha esibangele lokhu (njenge-leukemia) singabangela izinkinga. Ngakho-ke, kubalulekile ukukhuluma nodokotela wakho ngalokhu futhi wazi ukuthi yini ongayilindela.

Odokotela bakuthola kanjani uPelger-Huette anomaly?

Odokotela basebenzisa kakhulu ukuhlolwa kwegazi ukuthola lesi simo. Ngokukhethekile,Kwenziwa ukuhlolwa okubizwa ngokuthi i-peripheral blood smear. Lokhu kuhlolwa kuhilela ukuthatha ithonsi lesampula yakho yegazi, ulisakaze kancane ku-slide yengilazi, bese ulibheka ngaphansi kwe-microscope.

Lokhu kuhlolwa yi-pathologist noma i-hematologist.

Uma une-Pelger-Huette anomaly, lolu vivinyo luzobonisa ngokusobala ukuma okungavamile kwe-nuclei yamaseli akho e-neutrophil (njenge-dumbbell).

Ingabe ikhona indlela yokwelapha i-Pelger-Huette anomaly?

Nazi izindaba ezinhle! I-Hereditary Pelger-Huette anomaly (PHA) ngokuvamile ayibangeli zimpawu, ngakho ayidingi ukwelashwa okukhethekile. Ngisho noma unalesi simo, ungaphila impilo evamile.

Kodwa-ke, endabeni ye-'PPHA', kubalulekile ukwelapha isifo esiyisisekelo esibangele lesi sifo. Uma leso sifo sesilaphekile, isimo se-'PPHA' singase siphele.

Kufanele ngimbone nini udokotela?

Uma uthola ukuthi unesifo esingajwayelekile sikaPelger-Huette, qiniseka ukuthi utshela udokotela wakho uma uthola izimpawu ezintsha (njengomkhuhlane, ukukhathala okukhulu, ukutheleleka okuvamile). Udokotela wakho angabe esenquma ukuthi izimpawu zihlobene yini ne-'PHA`, `PPHA`, noma okunye.

Uma uya kudokotela, kuwumqondo omuhle futhi ukubuza le mibuzo:

• Ingabe ngine-Pelger-Huette anomaly ezuzwe njengefa `(HPA)` noma `pseudo `(PPHA)`?
• Kungenzeka yini ukuthi izingane zami zizuze lesi simo njengefa? (Uma i-HPA)
• Kufanele ngimbone kangaki udokotela?
• Yiziphi izimpawu okufanele ngizazi ngokukhethekile?

Yini okufanele ngiyilindele ngalesi simo?

I-Pelger-Huette anomaly (PHA) ngokwayo ayikubangeli ubuhlungu noma yenze umehluko omkhulu empilweni yakho. Ngokuvamile ayithinti imisebenzi yakho yansuku zonke.

Kodwa-ke, uma unalesi simo (ikakhulukazi uhlobo lwe-'PPHA'), kungaba uphawu lwesinye isimo sempilo esiyisisekelo. Yingakho odokotela bekhathazekile ngaso. Uma udokotela wakho esola ukuthi une-'PHA' noma i-'PPHA', uzokwenza izivivinyo ezidingekayo ukuze akuqinisekise, futhi athathe nezinyathelo zokususa ezinye izimo zezokwelapha.

Ungase ube ne-Pelger-Huette anomaly (PHA) kodwa ungazi ngoba awunazo izimpawu. Ungase ucabange, "Uma kungangikhathazi, kungani ngicabanga ngakho?" Kuyiqiniso ukuthi ungase ungazizwa ugula ngenxa yalolu shintsho oluthile lweseli. Kodwa kubalulekile ukwazisa udokotela wakho ngakho. Udokotela wakho ukhona ukukusiza uhlale uphilile. Futhi kuyasiza ukwazi ngalezi zinto ezincane emzimbeni wakho. Ukuthi nje une-Pelger-Huette anomaly kungenye into ekwenza "ube nguwe." Akuyona into okufanele ukhathazeke ngayo.

Isifinyezo (Umyalezo Wokuya Nawe Ekhaya)

Kulungile, ake siphinde sixoxe ngezinye zezinto esikhulume ngazo:

• I-Pelger-Huet Anomaly (PHA) yisimo sezakhi zofuzo esibangela isimo esingavamile se-nucleus yama-neutrophil, uhlobo lweseli elimhlophe legazi.
• Lokhu ngokuvamile akulona ingozi futhi akubanga izimpawu. Amaseli e-neutrophil asebenza kahle.
• Kunezinhlobo ezimbili zalokhu: `i-HPA`, ewufuzo, kanye ne-`PPHA`, ebangelwa kamuva ezinye izifo noma imithi.
• I-HPA ngokuvamile ayidingi ukwelashwa. Endabeni ye-PPHA, imbangela eyinhloko iyelashwa.
• Lesi simo sitholakala ngokuhlolwa kwegazi (i-peripheral blood smear).
• Uma uthola ukuthi unalesi simo, ungakhathazeki. Kodwa-ke, khuluma nodokotela wakho ngaso bese uthola iseluleko esidingekayo. Yazisa udokotela wakho uma kuvela izimpawu ezintsha.

Ngiyethemba ukuthi lesi sihloko siphendule imibuzo yakho eminingi mayelana ne-Pelger-Huette anomaly. Khumbula, nganoma iyiphi inkinga yezempilo, kungcono ukukhuluma ngokukhululekile nodokotela wakho.

I- Pelger-Huet Anomaly, Ama-Neutrophils, Amaseli Amhlophe Egazi, Izifo Zofuzo, Ukuhlolwa Kwegazi, i-PPHA, i-HPA