Ingabe umzimba wakho awusabeli kahle ku-Parathyroid Hormone? Ake sixoxe ngalesi simo esingajwayelekile (i-Pseudohypoparathyroidism)!

Ingabe ngezinye izikhathi uzizwa sengathi kukhona into engasebenzi kahle emzimbeni wakho? Kunezifo ezithile ezingajwayelekile, amagama azo angaba ayesabeka kancane. Esinye sezifo ezinjalo esingavamile ukuzwakala ngaso, kodwa okubalulekile ukwazi ngaso, yi-Pseudohypoparathyroidism (PHP). Nakuba igama lingase libonakale lide kancane, masiligcine lilula.

Kuyini i-pseudohypoparathyroidism?

Kalula nje, lesi yisimo esingavamile sofuzo . Sinezindlala ezincane emizimbeni yethu ezibizwa ngokuthi ama-parathyroid glands. Lezi zikhiqiza i-hormone ebizwa ngokuthi i-Parathyroid Hormone (PTH). Le hormone ye-PTH ibaluleke kakhulu emizimbeni yethu. Ngoba, le hormone isiza ukugcina amazinga afanele e-Calcium, i-Phosphorus, ne-Vitamin D egazini lethu.

Manje, uyazi ukuthi kwenzekani kumuntu one-pseudohypoparathyroidism (PHP)? Ngisho noma izindlala zakhe ze-parathyroid zikhiqiza i-PTH hormone ngokuvamile, amangqamuzana emzimbeni wawo awasabeli kahle kuyo, okusho ukuthi awakwazi "ukuyibona". Kufana nomuntu okhuluma nawe kodwa awukwazi ukumuzwa. Lokhu sikubiza ngokuthi yi -Parathyroid Hormone Resistance .

Kwenzekani ngenxa yalokho? Amazinga e-calcium egazini ayancipha, kuyilapho amazinga e-phosphorus ekhuphuka. Lokhu kungalingani kungabangela ukudikiza kwemisipha, ukungazweli, ukuxhuzula, kanye nezinkinga zamazinyo.

Okubalulekile, lesi simo esibizwa nge-PHP sihlukile esimweni esibizwa nge-Hypoparathyroidism. Abantu abane-hypoparathyroidism abakhiqizi i-PTH hormone eyanele ekuqaleni. Kodwa-ke, ku-PHP, i-hormone iyakhiqizwa, kodwa umzimba awusebenzisi.

Yiziphi izinhlobo eziyinhloko ze-PHP?

Kunezinhlobo eziningana eziyinhloko zesimo se-PHP. Ake sibone ukuthi ziyini.

Uhlobo lwe-PHP-1

Lolu uhlobo oluvame kakhulu lwe-PHP . Ngaphezu kokumelana ne-hormone ye-PTH okukhulunywe ngayo ngaphambili, ezinye izinguquko zesistimu yamathambo zingabonakala. Isibonelo:

• Ubuso obuyindilinga
• Ukuphakama okunciphile (ubufushane bomzimba)
• Ubuhlungu bentamo
• Ukuphuka kwezandla nezinyawo

Odokotela babiza lokhu ngokuthi inhlanganisela yezimpawu ngokuthi i-Albright Hereditary Osteodystrophy (AHO) . Abantu abane-PHP-1 banalesi simo ngenxa yohlobo oluthile lwezakhi zofuzo olubizwa ngokuthi i-'GNAS' abaluzuza njengefa komunye wabazali babo.

I-PPHP (Pseudopseudohypoparathyroidism)

Lolu uhlobo olulinganiselwe lwe-PHP-1. Abantu abane-PPHP (Pseudopseudohypoparathyroidism) bangase babe nezici zomzimba ezibonakala ku-AHO (njengobuso obuyindilinga kanye nobude obufushane), kodwa abanakho ukumelana nama-hormone e-PTH . Lokhu kusho ukuthi amazinga abo e-calcium ne-phosphorus ajwayelekile.

Uhlobo lwe-PHP-2

Abantu abane-PHP-2 banokumelana nama-hormone e-PTH, okusho ukuthi bane-calcium ephansi kanye ne-phosphorus ephezulu. Kodwa abanazo izici zomzimba (njengobuso obuyindilinga kanye nobude obufushane) ezibonakala ku-AHO. Abacwaningi abakatholi ukuthi yikuphi ukukhubazeka kwezakhi zofuzo okubangela lolu hlobo lwe-PHP-2.

Ziyini izimpawu ze-PHP?

Izimpawu ze-PHP zingahluka kumuntu nomuntu . Lokhu kusho ukuthi akuwona wonke umuntu ozoba nezimpawu ezifanayo. Ezinye izimpawu ezivamile zifaka:

• Ukuqaqamba kwemisipha
• Ukuqaqamba kwemisipha okuvamile : Ukuzwa sengathi umlenze uyadonswa.
• Ukuba ndikindiki noma ukuqaqamba emilenzeni
• Ukuquleka
• Ukuhluma kwamazinyo okubambezelekile
• Ubuthakathaka be-enamel yamazinyo
• Umfutho wegazi ophansi
• Izinwele nezinzipho ezithambile
• Ukukhathazeka
• Ukucindezeleka

Abantu abane-PHP-1 bangase babe nezimpawu ezengeziwe ezihambisana nesimo se -Albright hereditary osteodystrophy (AHO) esishiwo ngaphambilini. Abanye abantu abane-PHP bangase babe nalezi zimpawu:

• Ubuso obuyindilinga
• Ubufushane (ubufushane besiqu)
• Ubuhlungu bentamo
• Amathambo ezandleni nasezinyaweni : Ama-knuckle, ikakhulukazi lawo eminwe yesine neyesihlanu, angase abonakale sengathi abheke ngaphakathi.
• Ukukhuluphala ngokweqile : Kusho ukukhuluphala ngokweqile.
• Ukukhubazeka kokubona : izinto ezifana ne-cataracts, ukubona okufiphele, kanye nokuzwela ukukhanya.
• Amaqhubu amathambo ngaphansi kwesikhumba sakho
• Ukulibaziseka kokukhula : Ezinye izingane zingase zibe nokulibaziseka kokukhula.

Ziyini izimbangela ze-PHP?

Imbangela eyinhloko yalesi sifo ukushintshashintsha kwezakhi zofuzo zethu, ikakhulukazi ku-gene ebizwa ngokuthi 'i-GNAS' . Abanye abantu bayizuza njengefa kubazali babo . Lokho kusho ukuthi iwufuzo. Kodwa ngezinye izikhathi lesi simo singavela ngaphandle komlando womndeni futhi akukho sizathu esingatholakala.

I-PHP ivame ukutholakala isencane noma isencane , kodwa ngezinye izikhathi ingabonakala lapho isikhulile.

Yiziphi izinkinga ezingaba khona ze-PHP?

Uma une-PHP, kungenzeka kakhulu ukuthi ube nezinye izinkinga zesistimu ye-endocrine . Lezi zinkinga ezihlobene nama-hormone zingabangela izimpawu ezifana namandla aphansi kanye nomdlandla ophansi wocansi.

Abanye abantu abane-PHP basengozini enkulu yokuba nezimo ezifana nalezi:

• I-Parkinsonism: Ukubonisa izimpawu ezifana nesifo sikaParkinson.
• Ubunzima ngamakhono okunyakaza kahle : Lokhu kusho ubunzima ngemisebenzi emihle njengokufaka izinkinobho noma ukubhala.
• I-Carpal Tunnel Syndrome : Ikakhulukazi kulabo abane-PHP-1. Lesi yisimo lapho inzwa esihlakaleni icindezelwa khona, okubangela ukungazweli nobuhlungu esandleni.
• I-stenosis yomgogodla
• Ukuphefumula komoya : Ikakhulukazi ezinganeni.

Odokotela bayixilonga kanjani i-PHP?

Uma usola ukuthi une-PHP, udokotela wakho uzoqala ngokukuhlola ngokomzimba . Uzobuza nangomlando womndeni wakho. Angase enze ezinye izivivinyo eziningana ukuqinisekisa ukuxilongwa. Lokhu kufaka phakathi:

• Ukuhlolwa kwegazi : Kala amazinga ama-hormone, ikakhulukazi i-calcium, i-phosphorus, kanye namazinga e-PTH.
• Ukuhlolwa komchamo : Hlola amazinga e-calcium ne-phosphorus emchameni.
• Ukuhlolwa kwezakhi zofuzo : Hlola izinguquko ku-gene ethi `GNAS`.
• I-Electrocardiogram (EKG) : Ihlola ukungasebenzi kahle kwenhliziyo.
• Ama-X-ray esandla : Hlola amathambo aphukile nezinye izinguquko.
• I-CT Scan (CT - I-Computed Tomography scan) : Ukubona ukuthi kukhona yini izinguquko ebuchosheni.

Kusekelwe olwazini olutholwe kulezi zivivinyo ukuthi udokotela angaqinisekisa ngokunembile isimo se-PHP.

Iphathwa kanjani i-PHP?

Akukho ukwelashwa kwalesi simo okwamanje . Kodwa ungakhathazeki. Ngokwelashwa nokuphathwa okufanele, ungalawula izimpawu zakho futhi uphile impilo evamile.

Umgomo oyinhloko wokwelashwa ukugcina amazinga afanele e-calcium ne-phosphorus egazini lakho . Ukugcina la mazinga kunganciphisa kakhulu izimpawu. Lokhu kuyindlela yokwelapha impilo yonke .

Izinketho zokwelapha zingafaka:

• Izithasiselo ze-calcium ne-vitamin D : zisefomini noma ngesimo soketshezi.
• Ama-capsule e-Calcitriol : Lona umuthi owandisa inani le-calcium emzimbeni.
• Umjovo weCalcitriol
• Ukwelashwa kokushintsha i-hormone yokukhula noma i-thyroid hormone : uma kudingeka.
• Ukudla okune-calcium ephezulu, i-phosphorus ephansi : Njengoba kwelulekwa yisazi sokudla okunempilo.

Into ebaluleke kakhulu ukulandela iseluleko sezokwelapha ngokucophelela futhi uhlolwe ngesikhathi.

Kufanele ngimbone nini udokotela?

Uma une-PHP, kubalulekile ukubona udokotela wakho njalo ukuze kuhlolwe amazinga akho e-calcium ne-phosphorus . Lokhu kuqapha njalo kuzosiza ukugcina konke kulawulwa.

Uma uhlangabezana nezimpawu ezinzima njengobunzima bokuphefumula ngokuzumayo, ukudikiza kwemisipha okukhulu, noma ukuxhuzula , iya ekamelweni lezimo eziphuthumayo esibhedlela esiseduze ngokushesha noma ushayele u-1990.

Yini ongayilindela uma uphila nesimo se-PHP?

Uma une-PHP, kufanele uqhubeke nokusebenzisana nodokotela wakho wokunakekelwa okuyinhloko . Ngenxa yokuthi i-PHP ingathinta izingxenye eziningi zomzimba, kungadingeka ukuthi ubonane nochwepheshe abaningana ukuze baphathe izimpawu zakho ezithile. Ithimba lakho lezokwelapha lingafaka:

• Ochwepheshe be-Endocrinologists : Ochwepheshe bama-hormone.
• Odokotela abahlinza amathambo : Ngezinkinga ezihlobene namathambo.
• Odokotela bezingane : Uma kungumntwana.
• Odokotela bezinzwa : Ngezinkinga ezihlobene nesimiso sezinzwa.
• Abelaphi bomzimba
• Abelaphi bomsebenzi
• Ochwepheshe bezokudla
• Odokotela bamazinyo
• Izazi zezakhi zofuzo
• Ochwepheshe bokuphatha ubuhlungu

Cishe kuzodingeka uthathe lezo zithako impilo yakho yonke .

Amakhono okukhula nawokucabanga angahluka kakhulu kuye ngohlobo kanye nobunzima besifo. Kodwa-ke , ezimweni eziningi, abantu abane-PHP baphila isikhathi esijwayelekile uma kuqhathaniswa nabantu abangenayo i-PHP . Udokotela wakho angakutshela ukuthi yini ongayilindela ngokusekelwe esimweni sakho.

Ngenxa yokuthi i-PHP iyisimo esingavamile, kungaba nzima ukuthola abanye abanesimo esifana nesakho . Kungazizwa futhi unesizungu ngezinye izikhathi. Uma wena noma ingane yakho nitholakala nine-PHP, khuluma nodokotela wakho mayelana namaqembu okusekela kanye nezinsiza zemfundo . Lokhu kungakusiza ukuthola izindlela zokuthuthukisa izimpawu zakho kanye nekhwalithi yokuphila iyonke.

Umlayezo Wokuya Nawe Ekhaya

Kulungile, ake sibheke ezinye izinto okufanele sizikhumbule nge-pseudohypoparathyroidism (PHP) ebesikhuluma ngayo.

• I-PHP yisimo esingavamile sofuzo lapho umzimba ungasabeli kahle ku-hormone ye-parathyroid (PTH).
• Lokhu kubangela ukuthi i-calcium egazini yehle futhi i-phosphorus yande.
• Kunezinhlobo eziningana eziyinhloko : i-PHP-1, i-PHP-2, kanye ne-PHP-3.Yebo. I-PHP-1 ingabangela izinguquko emathanjeni ezibizwa ngokuthi i-AHO.
• Izimpawu ezahlukahlukene zingavela, njengokuqhaqhazela kwemisipha, ukungazweli, ukuxhuzula, izinkinga zamazinyo, ubude obufushane, kanye nobuso obuyindilinga .
• Imbangela eyinhloko ukuguquka kwezakhi zofuzo ze-`GNAS` .
• Nakuba kungekho ikhambi eliphelele, izimpawu zingalawulwa ngokwelashwa impilo yonke (i-calcium, i-vitamin D, ukudla okukhethekile).
• Ukuhlolwa njalo kwezokwelapha kanye nokusekelwa odokotela abangochwepheshe kubalulekile.
• Iningi labantu lingaphila impilo evamile .
• Usizo oluvela emaqenjini okusekelana lubaluleke kakhulu ukuze uhlale uqinile engqondweni.

Ungakhohlwa, awuwedwa. Nakuba lesi kuyisimo esingavamile, singaphathwa kahle ngeseluleko nokusekelwa okufanele kwezokwelapha. Khumbula ukuthi odokotela, umndeni, nabangani bakhona lapho udinga amandla.

I- Pseudohypoparathyroidism, i-PHP, i-parathyroid hormone, i-calcium, i-phosphorus, izifo zofuzo, i-AHO