Ingabe unesifo sikashukela sohlobo lwesibili? Noma unesifo senhliziyo noma semithambo yegazi? Uma kunjalo, udokotela wakho kungenzeka ukuthi ukunike umuthi obizwa ngokuthi i-Empagliflozin, owaziwa nangokuthi i-Jardiance. Lo muthi unikezwa nabantu abangenaso isifo sikashukela kodwa abanezinkinga ezithile zokwehluleka kwenhliziyo. Ngakho-ke, njengoba lo umuthi unikezwa abantu abaningi manje, ake sixoxe ngawo ngemininingwane ethe xaxa namuhla, njengokungathi sikhuluma nomngane.
Lo muthi i-Empagliflozin (Jardiance) usebenza kanjani?
Lokhu kungase kuzwakale kungokwesayensi kancane, kodwa kulula kakhulu. Lo muthi ungowesigaba semithi ebizwa ngokuthi i-SGLT2 inhibitors. Igama eliphelele yi-Sodium-glucose co-transporter 2 inhibitor.
Kulungile, manje ngamagama alula, nakhu okwenzekayo:
Izinso zethu zineprotheni ebizwa ngokuthi i-SGLT2. Umsebenzi wayo ukumunca ushukela (i-glucose) egazini ubuyele emzimbeni. I-Empagliflozin ivimba le phrotheni ebizwa ngokuthi i-SGLT2. Ngemuva kwalokho , izinso azimunci ushukela omningi osegazini ubuyele emzimbeni, kodwa kunalokho ziwudlulisela emchameni. Kufana nesihlungi esisusa izinto ezingafuneki. Ngale ndlela, izinga likashukela omningi emzimbeni liyalawulwa.
Lomuthi unciphisa nokumuncwa kabusha kwe-sodium (usawoti) ezinso ungene emzimbeni. Lokhu kunciphisa umthwalo womsebenzi enhliziyweni. Yingakho lo muthi uwusizo kakhulu nakubantu abanesifo senhliziyo.
Yini okufanele uyilindele uma usebenzisa lo muthi?
I-Empagliflozin iyiphilisi oliphuza kanye ngosuku. Kungcono ukunamathela esikhathini esifanayo nsuku zonke. Odokotela bavame ukukutshela ukuthi ulithathe ekuseni. Ungayithatha nokudla noma ngaphandle kokudla.
Lomuthi uza ngamandla amabili: amamililitha ayi-10 (10 mg) kanye namamililitha angama-25 (25 mg). Udokotela wakho angase akunike umthamo ophansi bese ewukhuphula uma kudingeka.
Yini okufanele uyenze uma ukhohlwa? Uma ukhohlwa ukuphuza iphilisi, liphuze ngokushesha nje lapho ukhumbula. Kodwa uma sekuyisikhathi sephilisi lakho elilandelayo, ungaliphuzi iphilisi eliphuthelwe kanye nelilandelayo ngesikhathi esisodwa. Yeqa iphilisi eliphuthelwe bese uphuza iphilisi elilandelayo ngesikhathi esihleliwe.
Ngezinye izikhathi udokotela wakho uzokunika lo muthi uhlanganiswe nomunye umuthi wesifo sikashukela. Isibonelo, ungawuthola uhlanganiswe ne-metformin (ebizwa ngokuthi i-Synjardy) noma ne-linagliptin (ebizwa ngokuthi i-Glyxambi) njengephilisi elilodwa.
Ukuze uthole okuningi ngalo muthi, kubalulekile ukudla ukudla okunempilo nokuzivocavoca njalo , njengoba kunconywe udokotela wakho. Futhi ungakhohlwa ukuphuza amanzi amaningi usuku lonke.
Ngesikhathi uthatha lo muthi, udokotela wakho uzokwenza ukuhlolwa kwegazi ngezikhathi ezithile ukuze ahlole ukuthi izinso zakho zisebenza kahle kangakanani. Uzokutshela nokuthi uhlole amazinga kashukela egazini lakho njalo. Kungathatha izinyanga ezifika kweziyisithupha ukuthi uzwakale umphumela ophelele walo muthi.
Iyini imiphumela emibi yalokhu?
Njenganoma yimuphi umuthi, lo ungaba nemiphumela emibi emincane. Kodwa ungakhathazeki, eminingi yayo ayibi kakhulu. Ake sibheke ukuthi iyini le miphumela emibi.
| Umphumela ongemuhle | Incazelo nokuthi yini okufanele uyenze |
|---|---|
| Imiphumela Emibi Evamile | |
| Ukutheleleka Kwemvubelo Endaweni Yangasese | Kuvame kakhulu kwabesifazane, kodwa kungavela nakwabesilisa. Izimpawu zifaka phakathi ukulunywa, ubuhlungu, ukuvuvukala, ukubomvu, kanye nokuphuma koketshezi emzimbeni. Kunezindlela zokwelapha lezi zimpawu, ngakho-ke bonana nodokotela uma unalezi zimpawu. |
| Ukutheleleka komgudu womchamo (UTIs) | Izimpawu ezifana nokusha, ubuhlungu, ukuchama njalo, umchamo onamafu, noma igazi zingase zivele. Ubuhlungu besisu bungase buvele. Tshela udokotela wakho ngalokhu ngoba nakho kudinga ukwelashwa. |
| Eminye imiphumela emibi emincane | Ungase ubhekane nezinto ezifana nokoma okukhulu, ukuchama njalo, isicanucanu, ubuhlungu bamalunga, kanye nokutheleleka komphimbo. Lokhu kuvame ukuphela ngokuhamba kwesikhathi njengoba umzimba wakho ujwayela imithi. Uma kuqhubeka, tshela udokotela wakho. |
| Imiphumela Emibi Engathi sína Edinga Ukunakwa Ngokushesha | |
| Ukutheleleka okukhulu komgudu womchamo | Umkhuhlane, ukubanda, ubuhlungu obukhulu esiswini noma emhlane. Lokhu kungaba izimpawu zokutheleleka okuthinta izinso. Funa iseluleko sikadokotela ngokushesha. |
| Umfutho Wegazi Ophansi | Isiyezi, ikhanda elikhanyayo, ikakhulukazi uma umile. |
| Ushukela wegazi ophansi | Izimpawu ezinjengokujuluka, ukuthuthumela, ukushaya kwenhliziyo okwandayo, indlala, nokudideka zingase zivele, ikakhulukazi uma zithathwa neminye imithi yesifo sikashukela. |
| I-gangrene kaFournier | Lokhu kuyisifo esingavamile kakhulu nesibucayi endaweni yesitho sangasese. Izimpawu zifaka phakathi ubuhlungu obukhulu endaweni, ukuvuvukala, umkhuhlane, kanye nokukhathala okukhulu. Lesi yisimo esiphuthumayo, hamba ngokushesha eMnyangweni Wezimo Eziphuthumayo wesibhedlela (ETU). |
| I-ketoacidosis yesifo sikashukela | Isimo esibi kakhulu esibangelwa ushukela ophezulu egazini. Izimpawu zifaka phakathi ukoma ngokweqile, ukuchama njalo, ubuhlungu besisu, isicanucanu, ukuzizwa ubuthakathaka, kanye nephunga elimnandi lomoya. Lokhu nakho kuyisimo esiphuthumayo, iya ku-ETU ngokushesha. |
| Ukusabela Kokungezwani Nomzimba | Ukuqubuka kwesikhumba, ukuvuvukala kobuso, izindebe, noma umphimbo, ubunzima bokugwinya noma ukuphefumula. Lokhu nakho kuyisimo esiphuthumayo, funa usizo lwezokwelapha ngokushesha. |
Izixwayiso nezinyathelo zokuphepha okufanele uziqaphele ngaphambi kokusebenzisa
Ngaphambi kokuqala lo muthi, kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi oyithathayo (kufaka phakathi imithi yezinye izimo, amavithamini, izithasiselo, kanye nemithi yendabuko). I-Empagliflozin ingasebenzisana nemithi elandelayo ikakhulukazi:
- Eminye imithi yesifo sikashukela
- Imithi yokucindezela kwegazi efana ne-ACE inhibitors kanye ne-Angiotensin receptor blockers (ARBs)
- Ama-diuretics noma "amaphilisi amanzi"
- Izibulala-zinhlungu ezifana ne-aspirin, i-ibuprofen, ne-naproxen
Udokotela wakho kungadingeka ashintshe umthamo weminye imithi oyithathayo noma aqaphele kakhudlwana ngemiphumela emibi.
Uma unezimpawu ze-ketoacidosis, udokotela wakho angase akucele ukuthi uhlole igazi lakho ukuze uthole ama-ketone. Kunemishini ekhethekile noma imichilo yokuhlola umchamo yalokhu.
Ungakhohlwa ukuphuza amanzi amaningi , ngoba lo muthi ungabangela ukuphelelwa amanzi emzimbeni.
Tshela udokotela wakho uma uphuza utshwala, futhi uma uvame ukuba nezifo zemvubelo noma izifo zomgudu womchamo.
Ubani okungafanele athathe lo muthi?
I-Empagliflozin ayifanele wonke umuntu. Kunezimo ezithile lapho lo muthi kungafanele uthathwe khona:
- Uma uhlinzwa i-dialgia yezinso.
- Uma ungumama oncelisayo (umuthi ungadluliselwa enganeni ngobisi lwebele).
- Uma ukhulelwe noma uhlela ukukhulelwa (njengoba kungase kulimaze ingane, khuluma nodokotela wakho ngalokhu).
- Uma une-allergy ku-empagliflozin noma kunoma yiziphi izithako zayo.
Futhi, lo muthi awuvunyelwe kubantu abanesifo sikashukela sohlobo 1, njengoba ungandisa ingozi yabo ye-Ketoacidosis.
Isebenza kangakanani i-Empagliflozin (Jardiance)?
Ukusebenza kahle kwalo muthi kuye kwabhalwa kahle ezivivinyweni zemitholampilo. Ocwaningweni lwezinyanga eziyi-6 kubantu abadala abanesifo sikashukela sohlobo lwesibili, i-Empagliflozin:
- Amazinga kashukela egazini okuzila ukudla ngokuvamile ehle cishe ngo-19-25.
- Inani le-A1c, elibonisa amazinga kashukela egazini ajwayelekile ezinyangeni ezi-2-3 ezedlule, lehle ngo-0.7% - 0.8%.
Ngaphezu kwalokho, abanye abantu nabo baye behlisa isisindo . Labo abathathe umthamo we-10mg ngosuku balahlekelwe cishe ngu-2.5% wesisindo somzimba wabo (isibonelo, cishe u-2.25 kg kumuntu onesisindo esingu-90 kg). Labo abathathe umthamo we-25mg balahlekelwe ngu-2.8% wesisindo somzimba wabo (isibonelo, cishe u-2.5 kg kumuntu onesisindo esingu-90 kg).
Kuye kwaba nokwehla okuncane komfutho wegazi we-systolic kulabo abathathe lo muthi.
Umlayezo Wokuya Nawe Ekhaya
- I-Empagliflozin (Jardiance) umuthi osetshenziselwa ukwelapha isifo sikashukela kanye nezimo ezithile zenhliziyo. Isebenza ngokusiza izinso ukususa ushukela omningi emzimbeni ngomchamo.
- Thatha lo muthi njengoba nje udokotela wakho ekuyalele, ngesikhathi esifanayo nsuku zonke. Uma uphuthelwa umthamo, ungaphuzi imithamo emibili ngesikhathi esifanayo ngesikhathi esilandelayo.
- Ukutheleleka komgudu womchamo kanye nokutheleleka kwemvubelo yesitho sangasese sowesifazane kuvamile kulo muthi. Tshela udokotela wakho uma uhlangabezana nanoma yiziphi zalezi zimpawu.
- Phuza amanzi amaningi usuku lonke ngoba lo muthi ungabangela ukuphelelwa amanzi emzimbeni.
- Kubalulekile ukwazisa udokotela wakho ngayo yonke eminye imithi oyithathayo.
- Uma uba nezimpawu ezinkulu ezifana nokusabela okukhulu kokungezwani komzimba, ubunzima bokuphefumula, i-Fournier's gangrene, noma i-ketoacidosis , hamba ngokushesha esibhedlela.
- Ungalokothi uyeke ukuthatha lo muthi ngaphandle kweseluleko sikadokotela.
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