Ingabe unesifo sikashukela sohlobo lwesibili? Udokotela wakho kungenzeka ukuthi ukunike iphilisi elibizwa ngokuthi i-Jardiance. Ungase ube nesifiso sokwazi okwengeziwe ngalo muthi. Uhlobo luni lomuthi, kwenzekani emzimbeni wakho, nokuthi yiziphi izinyathelo zokuphepha okufanele uzithathe. Ngakho-ke namuhla, ake sixoxe kafushane nge-Jardiance, ukuthi isebenza kanjani, izinzuzo zayo, nokuthi yini okufanele uyiqaphele.
Iyini i-Jardiance? Isebenza kanjani emzimbeni?
I-Jardiance umuthi osetshenziselwa ukwelapha abantu abadala nezingane abanesifo sikashukela sohlobo lwesibili. Isebenza ngokulawula amazinga kashukela egazini. Iphinde isize ekunciphiseni ingozi yokuhlaselwa yinhliziyo kanye nesifo sohlangothi kubantu abadala abanesifo sikashukela. Kodwa-ke, ayivunyelwe isifo sikashukela sohlobo 1. Ngezinye izikhathi isetshenziswa nakubantu abangenaso isifo sikashukela kodwa abanesifo senhliziyo noma sezinso.
Kulungile, manje ake sibone ukuthi lokhu kusebenza kanjani. Kalula nje, lokho izinso zethu ezivame ukukwenza ukuhlunga ushukela (i-glucose) egazini bese ziwumunca emzimbeni. Aziwukhiphi emchameni.
Kukhona iphrotheni ekhethekile esiza izinso ngalo msebenzi, ebizwa ngokuthi i-SGLT2 (i-Sodium-glucose cotransporter-2) .
Iphilisi i-Jardiance livimba okwesikhashana ukusebenza kweprotheyini ye-SGLT2. Lokhu kuvumela ushukela owengeziwe umzimba ongakwazi ukuwumunca ukuthi udlule emchameni. Lokhu kwehlisa amazinga kashukela egazini. Le nqubo ingakusiza futhi ukuthi wehlise isisindo futhi ulawule umfutho wegazi lakho .
Izinzuzo zalo muthi ziye zafakazelwa ngezinga elingakanani?
Kwenziwe izifundo eziningi ezinkulu zezokwelapha ukuze kutholakale ukuthi i-Jardiance iphephile futhi isebenza kahle kangakanani. Lezi zifundo zibheke kakhulu ukuthi umuthi uphumelela kangakanani ekunciphiseni i-HbA1c (ukuhlolwa okubonisa amazinga kashukela egazini ajwayelekile ezinyangeni ezi-3 ezedlule).
Izifundo zazihlanganisa abantu abadala abanesifo sikashukela sohlobo 2, izingane ezineminyaka eyi-10-17, abantu abanesifo sezinso, kanye nabantu abanesifo senhliziyo. Imiphumela yalesi sidakamizwa yaqhathaniswa neminye imithi yesifo sikashukela (isib. i-insulin, i-metformin, i-glimepiride).
Kulungile, manje ake sibone ukuthi imiphumela yalezi zifundo ithole ini. Khumbula, lena imiphumela emaphakathi. Imiphumela yakho ingahluka kuye ngomzimba wakho.
| Imiphumela yabantu abadala (Abantu abadala abanesifo sikashukela sohlobo 2) | ||
|---|---|---|
| Isilinganiso | Ukwehla koshukela egazini lokuzila ukudla (mg/dL) | Ukwehla kwe-HbA1c |
| I-Jardiance 10 mg (ngaphandle kweminye imithi) | Cishe ngo-19 mg/dL | Cishe ngo-0.7% |
| I-Jardiance 25 mg (ngaphandle kweminye imithi) | Cishe ngo-25 mg/dL | Cishe ngo-0.8% |
| I-Jardiance (neminye imithi) | Cishe ngo-10 - 22 mg/dL | Phakathi kuka-0.2% - 2.1% |
| Imiphumela Kubantu Abadala Abanesifo Senhliziyo | |
|---|---|
| Ukwelashwa | Amaphesenti okufa ngenxa yokuhlaselwa yinhliziyo, unhlangothi, noma isifo senhliziyo |
| I-Jardiance 10 mg noma 25 mg | 10.5% |
| I-Placebo | 12.1% |
Imiphumela yezingane kanye neziguli zezinso
I-Jardiance iboniswe ukuthi yehlisa kakhulu amazinga e-HbA1c kanye namazinga kashukela egazini okuzila ukudla ezinganeni ezineminyaka eyi-10-17. Iphinde yasiza ekunciphiseni amazinga e-HbA1c kubantu abadala abanesifo sikashukela kanye nesifo sezinso.
Ingabe eminye imithi ingasebenzisana ne-Jardiance?
Yebo, kubaluleke kakhulu ukunakekela lokhu.
- Ushukela ophansi egazini: Uma uthatha eminye imithi yesifo sikashukela, ikakhulukazi i-insulin noma i-sulfonylureas (njenge-glimepiride), ungase ube noshukela ophansi egazini (hypoglycemia) uma uqala i-Jardiance. Ngakho-ke, udokotela wakho anganciphisa umthamo weminye imithi yakho.
- Ukuphelelwa amanzi emzimbeni: Uma uthatha imithi yokukhipha amanzi emzimbeni, ukuyithatha kanye ne-Jardiance kungabangela ukuphelelwa amanzi emzimbeni. Ngakho-ke, kubalulekile ukuphuza uketshezi oluningi.
- I-Lithium: Uma uthatha i-lithium ngenxa yesimo sengqondo, imiphumela yayo ingashintsha uma uqala i-Jardiance. Khuluma nodokotela wakho ngalokhu bese uthola ukuhlolwa kwegazi uma kudingeka.
Ungayigwema kanjani imiphumela emibi eyingozi?
Le ngxenye ibaluleke kakhulu. Nakuba i-Jardiance iyisidakamizwa esiwusizo kakhulu, kunemiphumela emibi ethile okufanele siyiqaphele.
1. I-Diabetic Ketoacidosis (DKA):
- Lesi isimo esiyingozi kancane. Uma umzimba ungakwazi ukusebenzisa ushukela, usebenzisa enye indlela yokuthola amandla. Lokhu kudala amakhemikhali abizwa ngokuthi ama-ketone . Uma lawa eqoqana egazini, angaba yingozi kakhulu.
- Izimpawu: isicanucanu, ukuhlanza, ubuhlungu besisu, ukukhathala okukhulu, ubunzima bokuphefumula.
- > Uma uhlangabezana nalezi zimpawu, yeka ukuthatha i-Jardiance ngokushesha bese ubona udokotela noma uye egumbini lezimo eziphuthumayo esibhedlela (ETU). Lesi yisimo esiphuthumayo.
2. Izifo:
- Lo muthi wandisa inani likashukela emchameni, okwandisa ingozi yokutheleleka ngamagciwane kanye nemvubelo. Ukutheleleka kungavela emgudwini womchamo, esinyeni, kanye nasezindaweni zobulili.
- I-Fournier's Gangrene: Ukutheleleka okungajwayelekile kakhulu, kodwa okuyingozi kakhulu okungase kwenzeke endaweni yangasese. Funa usizo lwezokwelapha ngokushesha uma unobuhlungu, ukubomvu, noma ukuvuvukala endaweni kanye nomkhuhlane kanye nobuthakathaka.
3. Izinkinga zemilenze nezinyawo:
- Ezinye izifundo zibonise ukwanda okuncane kokunqunywa kwamalungu omzimba, ikakhulukazi kubantu abanesifo semithambo yegazi engaphandle.
- Ngakho hlola izinyawo zakho ngokucophelela nsuku zonke.Uma unezilonda, izilonda, imifantu, noma izimpawu zokutheleleka, tshela udokotela wakho ngokushesha.
4. Imiphumela ezinso:
- Ukuphelelwa amanzi emzimbeni kungathinta ukusebenza kwezinso. Ngakho-ke, kubalulekile ukuphuza amanzi amaningi. Udokotela wakho angase akucele ukuthi uhlolwe igazi ukuze kuhlolwe ukusebenza kwezinso zakho.
5. Ukusabela Kokungezwani Nomzimba:
- Uma uhlangabezana nokusabela okukhulu kokungezwani komzimba njengokuvuvukala kwezindebe, ubuso, noma ulimi, ubunzima bokuphefumula, noma ukuqubuka kwesikhumba, yeka ukuthatha umuthi ngokushesha bese ucela iseluleko sezokwelapha.
Ungayisebenzisa kanjani imithi ngendlela efanele?
I-Jardiance iyiphilisi oliphuza kanye ngosuku. Thatha umthamo (10mg noma 25mg) onqunywe udokotela wakho.
- Kungcono ukuyithatha ekuseni: Odokotela abaningi batusa ukuyithatha ekuseni. Isizathu ukuthi yandisa ukuchama kaningi, ukuze kwenzeke emini ngaphandle kokuphazamisa ubuthongo ebusuku.
- Wazi kanjani ukuthi umuthi uyasebenza?: Ungabona ngokwehla kwezinga likashukela egazini lakho kanye ne-HbA1c. Kodwa kuthatha cishe izinyanga ezintathu ukuthi i-HbA1c yakho ishintshe. Uma wenza ukuhlolwa komchamo ngenkathi uthatha i-Jardiance, kuzobonisa ukuthi kukhona ushukela emchameni wakho. Lokhu kuvamile, ungakhathazeki ngakho. Kusho ukuthi umuthi uyasebenza.
Umlayezo Wokuya Nawe Ekhaya
- I-Jardiance umuthi wesifo sikashukela sohlobo lwesibili owehlisa ushukela egazini ngokukhipha ushukela emchameni.
- Njalo thatha umthamo obekwe udokotela wakho kuphela, ngesikhathi esibekiwe (kungcono ekuseni).
- Phuza amanzi amaningi usuku lonke ukuze ugweme ukuphelelwa amanzi emzimbeni.
- Qaphela izimpawu zoshukela ophansi egazini (i-hypoglycemia) kanye nezimpawu eziyingozi ze-diabetesic ketoacidosis (DKA) (ukuhlanza, ubuhlungu besisu, ubunzima bokuphefumula). Funa usizo lwezokwelapha ngokushesha uma unezimpawu ze-DKA.
- Hlola izinyawo zakho nsuku zonke ukuze ubone amanxeba, izilonda, noma izimpawu zokutheleleka.
- Khuluma nodokotela wakho nganoma yimiphi imiphumela emibi noma izinkinga obhekana nazo. Ungalokothi uyeke ukuthatha imithi yakho noma ushintshe umthamo ngaphandle kweseluleko sikadokotela.
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