Ingabe ubhekene nezigaxa eduze kwamalunga akho? Ake sixoxe nge-Tumoral Calcinosis!

Ingabe ngezinye izikhathi uzizwa sengathi uneqhubu noma indawo eqinile ngaphansi kwesikhumba eduze kwelunga njengendololwane, ihlombe, noma idolo? Kungase kungabi buhlungu uma ulicindezela, kodwa kungaba likhulu kancane. Kuvamile ukuzizwa wesaba kancane uma ubona into efana nale. Kodwa akuzona zonke lezi ziqhubu eziyimidlavuza eyingozi. Namuhla sizokhuluma ngesimo esibonisa lezi zimpawu, kodwa esingesona umdlavuza, futhi esingavamile kodwa esibalulekile ukwazi ngaso. Leso yi -'Tumoral Calcinosis' .

Kuyini i-Tumoral Calcinosis?

Kalula nje, i-tumor calcinosis yisimo sofuzo . Lokhu kwenzeka lapho amazinga akho egazi lekhemikhali ebizwa ngokuthi i-phosphate ephezulu kakhulu. I-Phosphate iyinhlayiya kagesi, noma i-ion, equkethe i-phosphorus yamaminerali. Ngakho-ke, kumuntu one-tumor calcinosis, i-phosphorus ne-calcium kuqongelela emzimbeni, okubangela ukuba kwakheke amaqhubu ngaphansi kwesikhumba, ikakhulukazi eduze kwamalunga.

Kokubili i-phosphorus ne-calcium kubalulekile emizimbeni yethu ukuze sakhe amazinyo namathambo anempilo futhi aqinile. Kodwa uma ephakama kakhulu, ukukhula okungenawo umdlavuza (okungekuhle), okungeyona ingozi kodwa okufana nezimila, kuqala ukwakheka ezicutshini. Yilokhu esikubiza ngokuthi i-tumoral calcinosis.

Ingabe likhona elinye igama lalokhu?

Yebo, igama eliphelele lezokwelapha lalesi simo yi -'Hyperphosphatemic Familyal Tumoral Calcinosis' (HFTC) . Igama elide kancane, akunjalo? Abanye odokotela basibiza nangokuthi 'isifo sikaTeutschlaender'. Lokho kukhumbula u-Otto Teutschlaender, udokotela waseJalimane owafunda ngalesi sifo kusukela ngawo-1930 kuya ngawo-1950.

Lisho ukuthini leli gama elide lezokwelapha?

Ingabe kufanele sihlukanise leli gama libe izingxenye futhi siliqonde? Lokho kungaba lula.

• I-Hyperphosphatemic: Lokhu kusho ukuthi izinga le-phosphate egazini liphezulu.
• Umndeni: Lokhu kusho ukuthi lesi yisimo esiqhubeka emindenini futhi esidluliselwa ngofuzo.
• Umdlavuza: Leli gama lisetshenziswa ngoba lezi zimila ezifana nomdlavuza zibukeka njengezimila ezinomdlavuza.
• I-Calcinosis: Lokhu kusho ukuthi i-calcium ifakwa ezicutshini zemisipha yakho kanye nesistimu yemisipha.

Usuyaqonda incazelo yalelo gama elide manje?

I-Tumoral Calcinosis ithinta kanjani umzimba?

Lezi ziqhubu, ezibizwa ngokuthi i-tumoral calcinosis , zivame ukwakheka ngaphansi kwesikhumba, eduze kwamalunga . Zingakheka emalungeni angaphezu kwelilodwa, kodwa zingakheka futhi emalungeni amaningi. Izindawo ezivame kakhulu yilezi:

• Amalunga enqulu
• Izindololwane
• Amahlombe
• Ngaphansi
• Amalunga esihlakaleni
• Okuhlobene nentambo yomgogodla
• Indawo yomhlathi

Sivame kangakanani lesi simo?

Ochwepheshe bezokwelapha abaqiniseki ukuthi bangaki abantu abanalesi sifo se-calcinosis. Ngenxa yokuthi kuyisimo esingavamile kakhulu , sivame kakhulu kubantu bomdabu base-Afrika naseMpumalanga Ephakathi. Singathinta kokubili abesilisa nabesifazane.

Yiziphi izinhlobo eziyinhloko ze-Tumoral Calcinosis?

Uhlobo oluvame kakhulu lwalokhu yi-Hyperphosphatemic Familyal Tumoral Calcinosis, esixoxe ngayo ekuqaleni. Ngaphezu kwalokho, kunezinye izinhlobo ezingavamile:

• I-Hyperphosphatemia-hyperostosis syndrome (HHS): Lesi yisimo esibangela ukukhula kwamathambo ngokweqile kanye nokukhula kwezilonda zamathambo ezingezona umdlavuza.
• I-Normophosphatemic tumoral calcinosis: Lolu hlobo luvame ukubonakala kubantu abanenkinga yezinso. Lungabangela isimo esibizwa ngokuthi i-hyperparathyroidism, okuyi-parathyroid gland esebenza ngokweqile.

Yini ebangela i-Tumoral Calcinosis?

I-tumor calcinosis iyisifo se-metabolic esizuzwa njengefa . Cishe ingxenye yesithathu yabantu abanalesi simo banoshintsho, noma ukuguquka, ku-gene yabo ye-FGF23. I-gene ye-FGF23 isiza amangqamuzana ethu amathambo ukuthi enze iphrotheni ebizwa ngokuthi i-fibroblast growth factor (FGF) 23. Abanye abantu banalesi simo ngenxa yoshintsho ku-gene ye-GALNT3 ne-KL. Lawa ma-gene alawula ukukhiqizwa kwe-FGF23. Abantu abane-nomophosphatemic tumor calcinosis banokuguquka ku-gene ye-SAMD9.

Ngokuvamile, iphrotheni ethi `FGF23` itshela izinso zethu ukuthi ingakanani i-phosphate okufanele imuncwe egazini. Kodwa uma kukhona ukuguquka kwezakhi zofuzo, le nqubo iyaphambuka. Khona-ke izinso zimunca i-phosphate eningi kunalokho okufanele. Ngokuvamile, izinso zikhipha i-phosphate eningi emchameni. Kodwa ku-calcinosis ye-tumor, le phosphate ibopha i-calcium bese yakha izimila ezicutshini ezithambile.

Ubani osengozini yokuthola lesi simo?

I-tumorous calcinosis yisifo esibangelwa yi-autosomal recessive . Lokhu kunzima ukukuqonda, kodwa kalula nje, ukuze ube nalesi sifo, kufanele uthole i-gene mutation kubazali bakho bobabili. Abazali bakho bangaba ngabathwali be-mutation, kodwa kungenzeka ukuthi abanaso lesi sifo.

Uma bobabili abazali benalesi sifo, ingane ngayinye inale mathuba alandelayo:

• Kukhona ithuba elilodwa kwamane lokungabi nalesi sakhi sofuzo esiguquliwe (akukho bungozi bokuthola lesi sifo).
• Kukhona ithuba elilodwa kwamane lokuthola i-calcinosis yesimila.
• Kukhona ithuba elilodwa kwababili lokuba ngumthwali walesi sifo kodwa angasitholi.

Ziyini izimpawu ze-Tumoral Calcinosis?

Lesi simo sibangela ukuthi kwakheke amaqhubu anobukhulu obuhlukahlukene eduze kwelungu elilodwa noma ngaphezulu. La maqhubu avame ukuvela ebuntwaneni noma ebusheni . Kodwa-ke, angakhula nasezinsaneni nakubantu abadala. Ngezinye izikhathi, amaqhubu ambalwa kuphela akhula empilweni yonke. Noma, amaqhubu amaningi angakhula ngesikhathi esisodwa.

Ungase ube nezimpawu ezifana nalezi:

• Ubunzima bokunyakaza noma ukugoba ilunga elithintekile kahle.
• Amaqhubu aqinile, angenabuhlungu (amaqhubu athile angase abe buhlungu kancane uma uwathinta).
• Ubuhlungu bemisipha.

Itholakala kanjani i-Tumoral Calcinosis?

Udokotela wamathambo udokotela ogxile ezinkingeni zamathambo namalunga. Uzokuhlola futhi akubuze ngezimpawu zakho. Angase enze i-X-ray eyodwa noma ngaphezulu kwalawa alandelayo ukuze abheke lezi zimila nezinye izinkinga zamathambo:

• Ukuhlolwa kwe-X-ray `(X-ray)`
• Ukuskena kwe-CT
• Ukuskena kwe-MRI `(MRI)`

Yiziphi ezinye izimo ezibonisa izimpawu ezifana ne-Tumoral Calcinosis?

Lokhu kubaluleke kakhulu. Ngoba kubalulekile ukuthola ukuxilongwa okufanele . Isizathu ukuthi kunezinye izimo ezibonisa izimpawu ezifanayo, kodwa ezingathi sína kakhulu. Ezinye zalezi zimo yilezi:

• Izimila zezicubu ezithambile ezingembi kanye nezimila zezicubu ezithambile ezinobungozi
• I-Calcific myonecrosis (isimila esinokufakwa kwe-calcium emisipheni yemilenze)
• I-Calcific tendonitis (i-calcium deposits ene-tendonitis)
• I-Calcinosis circumscripta (i-calcium deposits esikhumbeni nasezicutshini zezandla nezinyawo)
• I-Calcinosis yokwehluleka kwezinso okungapheli (izinso) (ukufakwa kwe-calcium kubantu abasebenzisa i-dialysis)
• I-Calcinosis universalis (ukufakwa kukasawoti we-calcium esikhumbeni, ezicutshini, emisipha, nasemisipheni)
• Izifo zezicubu ezixhumene
• I-Gout
• I-Myositis ossificans (imisipha ephenduka ithambo)
• I-Osteosarcoma kanye ne-sarcoma (umdlavuza wamathambo)
• I-Synovial chondromatosis (amaqhubu e-cartilage emalungeni)

Uyabona? Ngisho noma izimpawu zifana, imbangela ingahluka kakhulu. Yingakho kubalulekile ukuthola ukuthi kwenzekani ngempela.

Yiziphi izindlela zokwelapha ezingadingi ukuhlinzwa?

Udokotela wakho angase anciphise inani le-phosphate egazini lakho.Imithi yokubopha i-phosphate inganikezwa. Uma le mithi yokubopha i-phosphate ihlanganiswa nomuthi obizwa ngokuthi i-acetazolamide (ovame ukusetshenziswa ekwelapheni isifo sokuwa kanye ne-glaucoma), ingavimba ikhono lomzimba lokumunca i-phosphorus. Kungase kudingeke futhi ukuthi udle ukudla okungenayo i-phosphorus eningi .

Kuyini ukudla okune-phosphorus ephansi?

Uma une-calcinosis yokuvuvukala, udokotela wakho angase akuncome ukudla okune-phosphorus eningi. I-phosphorus itholakala ngokwemvelo enyameni, enhlanzini, nasemikhiqizweni yobisi. I-phosphorus nayo yengezwa kokunye ukudla njengesivikelo noma isinongo.

Zama ukunciphisa ukudla neziphuzo ezine-phosphorus eningi, njenge:

• Ubhiya, ama-cola, itiye elibandayo kanye neziphuzo zetshokolethi.
• Izinhlobo ze-chocolate ne-caramel.
• Ukudla kobisi (ubisi, ushizi, i-ayisikhilimu, ama-yogurt angewona amaGreki, amasobho anokhilimu).
• Ukudla kwasolwandle okufana nama-oyster nama-sardine, kanye nezitho zangaphakathi njengesibindi senkomo nenkukhu.
• Inyama ecutshunguliwe (ama-hot dog, inyama yasemini, ubhekeni, amasoseji).
• Imikhiqizo eyenziwe nge-oat bran.

Kungcono ukukhuluma nodokotela wakho noma isazi sokudla okunempilo ngalokhu ukuze uthole ulwazi olwengeziwe.

Yiziphi izindlela zokwelapha ngokuhlinzwa?

Kungase kudingeke uhlinzwe ukuze kususwe izimila ezinkulu kakhulu ukuba zingasebenzi kahle. Kodwa-ke, lezi zimila zinamathuba amaningi okukhula futhi . Udokotela wakho angase futhi athathe isampula yezicubu ezisusiwe bese enza i-biopsy ukuqinisekisa ukuxilongwa.

Yiziphi izinkinga ezingaba khona ze-Tumoral Calcinosis?

Akuvamile kakhulu, lesi simo singathinta imithambo yegazi noma ubuchopho bakho, okwandisa ingozi yakho yezinkinga ezinkulu zempilo njengokuhlaselwa yinhliziyo kanye nesifo sohlangothi.

Ngaphezu kwalokho, lesi simo singadala okulandelayo:

• Ukwakheka kwe-corneal calcifications noma imivimbo ye-angioid (imivimbo ebomvu) ku-cornea yamehlo.
• Izinkinga zamazinyo.
• Ukukhula kwamathambo ngokweqile (hyperostosis).
• Ukuvuvukala kwamathambo amade (i-diaphysis) emilenzeni noma ezingalweni zakho.

Ingabe i-Tumoral Calcinosis ingavinjelwa?

Uma wena nomlingani wakho nobabili ninokuguquka kwezakhi zofuzo okubangela i-calcinosis yesimila, ningakhuluma nomeluleki wezakhi zofuzo ngezindlela zokunciphisa ingozi yokuthi izingane zenu zizuze ukuguquka kwezakhi zofuzo. Abanye abantu bakhetha inqubo ebizwa ngokuthi i-Preimplantation Genetic Diagnosis (PGD) . Lokhu kuhilela ukuhlonza imibungu engenalo ukuguqulwa kwezakhi zofuzo. Udokotela wakho ube esesebenzisa inqubo ebizwa ngokuthi i-In Vitro Fertilization (IVF) ukudlulisela imibungu enempilo ohlelweni lokuzala lowesifazane. Ngale nqubo, ingane yakho ngeke izuze ukuguqulwa kwezakhi zofuzo okubangela lesi sifo.

Uyini umbono womuntu one-Tumoral Calcinosis?

Iningi labantu abane-tumor calcinosis baphila impilo egcwele futhi esebenzayo . Lesi simo asivamile ukubangela izinkinga ezinkulu zempilo. Kodwa-ke, kuzodingeka ubone udokotela wakho njalo ukuze ahlole ukuthi ukuphindaphinda kwaso kuphinde kwenzeke yini.

Kufanele ngimbone nini udokotela?

Bona udokotela uma unalezi zimpawu:

• Ukwehla kwebanga lokunyakaza esilungwini.
• Ubuhlungu bamalunga, ubuhlungu bamathambo, noma ubuhlungu bemisipha.
• Ukuvela kwesimila noma iqhubu ngaphansi kwesikhumba.

Yini okufanele ngiyibuze udokotela wami?

Ungabuza udokotela imibuzo efana nale:

• Kungani ngathola i-calcinosis yesimila?
• Yikuphi ukwelashwa okungcono kakhulu kimi?
• Ingabe ngidinga ukuhlinzwa?
• Yiziphi izinhlobo zokudla okufanele ngizinciphise?
• Ingabe kufanele ngikhathazeke ngezinkinga?
• Ingabe umndeni wami wonke kufanele uhlolwe izakhi zofuzo?

Ingabe i-Tumoral Calcinosis ingaba umdlavuza?

Naphezu kwegama elithi "isimila" egameni, izimila ezikhula ngenxa ye-calcinosis yesimila empeleni azizona ezibangela umdlavuza . Akukho bungozi bokuthi lezi zimila zibe yingozi. Ngakho ungakhathazeki ngakho.

Kuyiqiniso ukuthi izimila ezingaphansi kwesikhumba ngenxa ye-calcinosis yesimila zingaba yinto engakhululekile futhi eyesabekayo. Kodwa kubantu abaningi, lezi zimila azibangeli izinkinga ezinkulu. Imithi inganciphisa izinga le-phosphorus egazini. Udokotela wakho angase futhi akuncome ukuthi ubonane nochwepheshe wezokudla ukuze akusize udle ukudla okune-phosphorus ephansi. Uma uzwa ubuhlungu emalungeni akho, emathanjeni, noma emisipheni ekuvimbela ukuhamba kwakho, tshela udokotela wakho. Ngisho noma izimila zingasuswa ngokuhlinzwa, khumbula ukuthi zingabuya.

Umyalezo Okufanele Uwuthathe Ekhaya (Izinto Okufanele Uzikhumbule)

Kulungile, ake siphinde sixoxe ngamaphuzu abaluleke kakhulu esixoxe ngawo namuhla mayelana ne-Tumoral Calcinosis:

• Lesi yisimo esingavamile, esizuzwa njengefa. Amazinga aphezulu e-phosphate egazini abangela ukuthi ahlangane ne-calcium ukuze akhe amaqhubu eduze kwamalunga.
• Lezi zimila aziwona umdlavuza .
• Lokhu kuvame ukungabi buhlungu, kodwa kungaphazamisa ukunyakaza kwamalunga.
• Ukwelashwa kuhlanganisa imithi yokwehlisa i-phosphate, ukudla okune-phosphorus ephansi, kanye nokuhlinzwa uma kudingeka.
• Uma ubona iqhubu elinjengaleli, ungesabi futhi ufune iseluleko sezokwelapha. Ukuxilongwa okufanele kubaluleke kakhulu.
• Abantu abaningi baphila impilo evamile nesebenzayo benalesi simo.

Ngakho-ke, uma wena noma othile omaziyo enalezi zimpawu, kungcono ukubona udokotela ukuze akunike iseluleko.

I- Calcinosis ye-Tumorous, ama-cyst amalunga, i-phosphate, i-calcium, izifo zofuzo, amaqhubu esikhumba, izifo zamathambo