Nsɛmfua ntumi nkyerɛ awerɛhow ne mmoa a yentumi nyɛ ho hwee a yɛte nka bere a yɛn dɔfo, ebia ɛna, agya, anaa yɛn adamfo, nya Alzheimer yare a ɛma yɛkae ade no. Nnuruyɛfo ne nyansahufo a wɔwɔ wiase nyinaa reyɛ adwumaden de anya yare yi ano aduru. Esiane mmɔdenbɔ a ɛte saa nti, wiase no fii ase kaa aduru Aducanumab , a ɛba wɔ edin Aduhelm ase no ho asɛm. Nanso ɛwom sɛ na anidaso kɛse wɔ aduru yi ho de, nanso akyinnyegye kɛse nso sii. Seesei wɔagyae aduru yi a wɔyɛ no. Enti ɛnnɛ, momma yɛnka nea Aduhelm yi yɛ, sɛnea ɛyɛɛ adwuma, ne nea enti a enni hɔ bio.
Sɛ yɛbɛka no tiawa a, dɛn ne Aduhelm (Aducanumab) yi?
Aduhelm yɛ aduru a wɔde ma ayarefo a wɔwɔ Alzheimer yare no mfiase, kyerɛ sɛ, wɔn a wɔn adwene mu yɛ wɔn naa kakra . Ɛka nnuru soronko bi a wɔfrɛ no monoclonal antibodies ho .
Fa no sɛ, sɛ Alzheimer yare no ba a, protein bi a wɔfrɛ no amyloid boaboa ano wɔ yɛn amemene mu ntini mu nkwammoaa no ntam, na ɛde ne ho gu te sɛ nwura. Yɛfrɛ eyi amyloid plaques . Saa mprɛte yi sɛe amemene mu nkwammoaa na ɛma wowuwu. Aduhelm aduru no adwuma titiriw ne sɛ ɛbɛkyerɛ amyloid plaques a ɛboaboa ano wɔ amemene no mu na aboa nipadua no ma ayi afi hɔ.
U.S. FDA penee aduru no so wɔ ɔkwan a ɛyɛ soronko bi so, na wobuu wɔn ani guu adwumakuw no ankasa afotufo bagua no nyansahyɛ ahorow so. Ne saa nti, aduruyɛ ho abenfo binom gyee hia a ehia sɛ wɔyɛ nhwehwɛmu pii wɔ aduru no ahobammɔ ne sɛnea etu mpɔn no ho kyim.
Nanso, adwumakuw a wɔyɛɛ saa aduru yi gyaee ne yɛ koraa wɔ afe 2024. Yɛbɛhu nea enti a akyiri yi.
Ɔkwan bɛn so na saa aduru yi yɛ adwuma wɔ nipadua no mu?
Eyi yɛ aduru a wɔde ma pɛnkoro ɔsram biara denam IV a wɔde ma so . Sɛnea yɛadi kan aka no, Alzheimer yare no ho sɛnkyerɛnne atitiriw no mu biako ne protein bi a wɔfrɛ no amyloid-beta a ɛboaboa ano wɔ amemene no mu, na ɛyɛ mprɛte. Eyi ma amemene mu nkwammoaa wuwu, na ɛno ne ade titiriw a ɛde nkae ne nneyɛe mu nsakrae ba.
Aduhelm nnubɔne no yɛ adwuma te sɛ ɔsraani titiriw bi. Ɛkɔ amemene no mu na ɛkyerɛ baabi pɔtee a saa amyloid plaques no wɔ. Ehu wɔn na ɛbata wɔn ho. Afei ɛde sɛnkyerɛnne bi kɔ yɛn nipadua no ankasa nipadua mu ahoɔden a ɛko tia nyarewa no nkyɛn, na ɛka sɛ, "Biribi a ɛsɛ sɛ woyi fi hɔ ni." Afei nipadua no mu nkwammoaa a ɛko tia nyarewa no ba mu na ɛsɛe saa nsensanee no.
Nyansahufo susuwii sɛ sɛ woyi akisikuru fi hɔ wɔ saa kwan yi so a, amemene mu nkwammoaa begyae owu na wɔadi nkae ne nsusuwii ho nimdeɛ a ɛbɛsɛe bio no so.
So aduru yi tu mpɔn ankasa? Dɛn nti na wogye akyinnye saa wɔ ho?
Eyi ne asɛmmisa a nnipa pii wɔ. Wɔyɛɛ nhwehwɛmu atitiriw abien de hwehwɛɛ sɛnea Aduhelm aduru no yɛ adwuma yiye no mu.
1. Nhwehwɛmu a edi kan: Eyi kyerɛe sɛ aduru Aduhelm brɛɛ amyloid plaques a ɛwɔ amemene no mu no ase. Ɛmaa wɔn a wɔnom aduru no dodow a ɛkɔ soro no nkae ne sɛnea wotumi yɛ da biara da nnwuma nso brɛɛ ase kakra . Nanso aduru no antumi ansiw yare no ano anaasɛ antumi ansan ankɔ.
2. Nhwehwɛmu a ɛto so abien: Nhwehwɛmu yi ankyerɛ mfaso biara amma ayarefo. Enti, wogyaee adesua yi mfinimfini.
Nea efii saa nhwehwɛmu biako no mu bae nkutoo nnɔɔso sɛ ɛbɛma FDA afotufo bagua no ani agye. Nanso FDA sii gyinae sɛ wɔbɛpene aduru no so. Nanso bere koro no ara mu no, ɛmaa Biogen, adwumakuw a ɛyɛ aduru no, mfe akron sɛ wɔnyɛ nhwehwɛmu foforo mfa nkyerɛ sɛ aduru no yɛ adwuma yiye. Saa pene a wɔpenee so mpofirim yi de akyinnyegye pii bae, na ayaresabea nhyehyɛe akɛse bi sii gyinae sɛ wɔremfa mma wɔn ayarefo kosi sɛ wobenya aduru no ho nsɛm pii.
Nsonsonoe a ɛda Aducanumab ne Lecanemab ntam
Aduru foforo bi wɔ hɔ a wɔfrɛ no Lecanemab (Leqembi) a ɛte sɛ Aducanumab (Aduhelm). Ɛyɛ monoclonal antibody nso. Eyinom abien nyinaa yɛ adwuma denam amyloid protein ahorow a ɛwɔ amemene no mu a wɔde wɔn ani si so no so. Nanso, nsonsonoe kakra wɔ ɔkwan a wɔfa so yɛ adwuma no mu. Ɛne sɛ, nnuru abien yi yɛ adwuma wɔ akwan horow abien so wɔ amyloid plaque a ɛba no mu. Lecanemab nyaa FDA pene wɔ afe 2023. Nhwehwɛmu ada no adi sɛ ɛbɛtumi ama yareɛ no akɔ so brɛoo bɛyɛ 20%-30%.
Dɛn ne Aducanumab ho nsunsuanso bɔne?
Te sɛ aduru biara no, Aducanumab betumi de ɔhaw ahorow aba . Eyinom bi betumi ayɛ aniberesɛm, enti ɛho hia sɛ wohu.
| Nkɛntɛnso a Ɛfa Ho | Nkyerɛkyerɛmu a ɛnyɛ den |
|---|---|
| Amemene a ɛho ahonhon bere tiaa bi | Eyi ne ɔhaw a wɔtaa bɔ ho amanneɛ. Mpɛn pii no, enni sɛnkyerɛnne biara na wɔnam scan so hu. |
| Amemene mu mogya nketenkete | Eyinom taa yɛ mogya a ɛba a ɛnyɛ anifere a wobetumi ahu denam scan nkutoo so. |
| Ti a ɛyɛ yaw | Nsunsuanso bɔne a ɛtaa ba. |
| Ahwease | Wɔabɔ amanneɛ sɛ obi ahwe ase efisɛ nipadua no kari pɛ betumi aka. |
| Ayamtuo | Nsunsuanso bɔne a ɛfa aduan a wɔyam no ho betumi aba. |
| Kesereneeyɛ | Ebia adwene a emu da hɔ no bɛka bere tiaa bi. |
Nea ɛho hia sen biara ne sɛ, sɛ obi a ɔnom aduru yi hu sɛnkyerɛnne biara a ɛyɛ soronko a, ɛsɛ sɛ ɔbɔ ne duruyɛfo amanneɛ ntɛm ara.
Enti dɛn nti na wogyaee saa aduru yi?
Wɔ Ɔpɛpɔn 2024 mu no, Biogen de too gua sɛ wɔbɛgyae Aducanumab a wɔyɛ ne ne tɔn koraa. Nnipa pii susuwii sɛ ahobammɔ ho haw anaasɛ nea entumi nyɛ adwuma yiye na ɛde eyi bae. Nanso ɛnyɛ ɛno ne nea enti ankasa.
Adwumakuw no kyerɛkyerɛɛ mu sɛ wɔyɛɛ saa adeyɛ yi efisɛ wosii gyinae sɛ wɔde wɔn nneɛma (sika, nhwehwɛmu akuw, ne nea ɛkeka ho) besi Alzheimer nnuru afoforo a wɔbɛyɛ na wɔahyɛ ho nkuran, titiriw nnuru te sɛ Lecanemab. Ɛne sɛ, na eyi yɛ adwumayɛ ne nneɛma a wɔde di dwuma ho gyinaesi, na ɛnyɛ gyinaesi a wosii esiane sɛnea na aduru no ahobammɔ anaa sɛnea ɛyɛ adwuma yiye ho dadwen nti.
Wɔ saa gyinaesi yi mu no, wɔ November 1, 2024 akyi no, ayarefo a wɔanya saa aduru yi wɔ aduruyɛ mu mpo rentumi nnya bio.
Nkrasɛm a Wɔde Kɔ Fie
- Aduhelm (Aducanumab) yɛ aduru bi a wɔde bae sɛ wɔde bɛsa Alzheimer yare a edi kan, nanso mprempren wɔagyae .
- Ná ne kwan titiriw ne sɛ ɛbɛboa nipadua no ma ayi amyloid ntini a ɛboaboa ano wɔ amemene no mu no afi hɔ.
- Wɔagye akyinnye kɛse wɔ nnuruyɛfo mu wɔ sɛnea aduru yi yɛ adwuma yiye no ho. Bere a nhwehwɛmu ahorow bi ada no adi sɛ mfaso kakra wɔ so no, afoforo nso nnya mmae.
- Wɔannyi eyi amfi nneɛma a wɔyɛ mu esiane ahobammɔ ho asɛm bi nti, na mmom esiane sɛ adwumakuw a wɔyɛ no sii gyinae sɛ wɔde wɔn nneɛma besi nnuru afoforo so nti.
- Sɛ wo anaa wo dɔfo bi wɔ Alzheimer yare no ho dadwen anaa nsɛmmisa bi a, ade a eye sen biara a ɛsɛ sɛ woyɛ ne sɛ wo ne w’abusua oduruyɛfo anaa oduruyɛfo titiriw bi bɛkasa. Kwati sɛ wubegyina nsɛm a wubehu wɔ Intanɛt so nkutoo so asi gyinae.
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