Dɛn ne Serotonin Syndrome? Momma yɛnhwɛ eyi yiye!

So worenom nnuru a wɔde sa adwenemhaw, dadwen, anaa ayaresa tebea foforo bi? Afei asɛm yi ho hia wo paa. Ɛtɔ da bi a, aduru biako anaa nea ɛboro saa a yɛnom betumi ama yɛn nipadua no ayɛ nnuru bi a wɔfrɛ no serotonin dodo. Eyi ne nea nnuruyɛfo frɛ no serotonin syndrome . Bere a ebia edin no bɛyɛ te sɛ nea ɛyɛ den wɔ nea edi kan no mu no, ɛyɛ biribi a ɛsɛ sɛ yɛn nyinaa hu. Ma yɛnhwɛ nea ɛyɛ, nea enti a ɛyɛ hu, ne sɛnea yebetumi abɔ yɛn ho ban.

Nea edi kan koraa no, dɛn ne Serotonin?

Sɛ yɛbɛka no tiawa a, serotonin yɛ nnuru a yɛn nipadua yɛ wɔ yɛn mu. Sɛ yɛbɛka no pɛpɛɛpɛ a, ɛte sɛ ɔbɔfo ketewaa bi a ɔde nkrasɛm kɔ nkwammoaa a ɛwɔ yɛn ntini mu no ntam. Wɔ aduruyɛ mu no, yɛfrɛ eyi neurotransmitter.

Ɛyɛ nnwuma a ɛho hia pii wɔ yɛn nipadua mu. Nhwɛsoɔ:

• Ɛdi w'anigye ne w'adwene so .
• Ɛboa wo ma woda yiye anadwo .
• Ɛma sɛnea obi kae ade na osua ade tu mpɔn .
• Ɛhwɛ nipadua mu hyew so .
• Aduan kanyan akɔnnɔ .

Nnipa pii susuw sɛ amemene no mu nkutoo na wohu serotonin. Nanso nokwarem no, serotonin a ɛwɔ yɛn nipadua mu no 90% wɔ awotwaa mu. Bɛyɛ 10% pɛ na wɔyɛ wɔ amemene no mu. Nhwehwɛmufo gye di sɛ ade biako a ɛde tebea horow te sɛ adwenemhaw ba ne serotonin dodow a ɛso tew wɔ amemene no mu. Nanso, sɛ eyi kɔ soro dodo a, ebetumi akanyan ntini mu nkwammoaa dodo na ɛde sɛnkyerɛnne ahorow a ɛyɛ hu aba. Eyi ne nea yɛfrɛ no serotonin syndrome.

Dɛn ne serotonin yare no ho sɛnkyerɛnne?

Mpɛn pii no, saa sɛnkyerɛnne ahorow yi da adi wɔ nnɔnhwerew kakraa bi akyi bere a wɔafi aduru foforo a ɛka serotonin dodow ase, anaasɛ wɔama aduru bi a ɛwɔ hɔ dedaw dodow akɔ soro no.

Sɛ wuhu sɛnkyerɛnne ahorow a edidi so yi mu biara : atiridiinini a ano yɛ den yiye, akisikuru, koma a ɛbɔ a ɛnteɛ, anaasɛ w’adwene mu yɛ wo naa , ɛyɛ aduruyɛ mu asɛm a egye ntɛmpɛ. Kɔ ayaresabea bi Emergency Department (ETU) ntɛm ara anaa frɛ ambulance. Sɛ wɔansa eyi ntɛm a, ebetumi akum obi.

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Dɛn na ɛde tebea yi ba?

Mpɛn pii no, nnuru na ɛde eyi ba, titiriw bere a wɔde nnuru abien anaa nea ɛboro saa a ɛka serotonin dodow bom di dwuma no.

Wɔn a wodi fɔ titiriw: Nnuru a ekum adwenemhaw

• SSRIs (Selective Serotonin Reuptake Inhibitors): Eyinom ne nnuru a wɔtaa kyerɛw ma sɛ wɔde ko tia adwenemhaw. Wɔma serotonin dodow a ɛwɔ amemene no mu no yɛ kɛse. Nhwɛsoɔ: Citalopram, Escitalopram (Lexapro), Fluoxetine (Prozac), Sertraline (Zoloft).
• SNRIs (Serotonin ne Norepinephrine Reuptake Inhibitors): Eyi yɛ aduru foforo a ekum adwenemhaw. Nhwɛsoɔ: Duloxetine (Cymbalta), Venlafaxine (Effexor).
• MAOIs (Monoamine Oxidase Inhibitors): Eyinom yɛ aduru a akyɛ kakra, nanso ɛda so ara yɛ den a ekum adwenemhaw.

Nnuru afoforo, nnuru a wɔde ka aduan ho, ne nnuru a ɛma asiane no yɛ kɛse

• Nnuru a wɔde kum ɛyaw: Nnuru a ano yɛ den bi, titiriw opioid te sɛ Tramadol ne Fentanyl.
• Nnuru a wɔde sa atiridiinini (Triptans): Nhwɛso: Sumatriptan (Imitrex).
• Nnuru a wɔde sa ɔfe bi: Ɔfe aduru a Dextromethorphan wom.
• Nnuru a wɔde ko tia akisikuru: Nhwɛso: Metoclopramide (Reglan), Ondansetron (Zofran).
• Nnuru a wɔde ma: Asiane ahorow wɔ hɔ bere a wɔde nneɛma te sɛ St. John’s wort ne Ginseng ka nnuru a ekum adwenemhaw ho no.
• Nnuru a mmara mma ho kwan: Nnuru te sɛ Ecstasy (MDMA), LSD, Cocaine, ne Amphetamines a wɔde nnuru a ekum adwenemhaw di dwuma no yɛ asiane kɛse.

Ɔkwan bɛn so na oduruyɛfo hu eyi?

Sɔhwɛ biako biara nni hɔ a ebetumi ama woahu nea eyi yɛ no yiye. Wo duruyɛfo no behu saa tebea yi denam nsɛm a obebisa wo na wahwehwɛ wo mu no so.

Ɛho hia paa sɛ wobɛka nnuru biara, vitamin, nhabannuru a wɔde ma, ne nnuru a mmara mma ho kwan mpo a worenom ho asɛm kyerɛ wo duruyɛfo. Wo duruyɛfo wɔ hɔ sɛ ɔbɛboa wo, na ɛnyɛ sɛ obebu wo atɛn. Sɛnea wobehu yare no ne ayaresa a ɛteɛ no gyina nsɛm a wode bɛma no so.

Wo duruyɛfo betumi ahyɛ sɛ wɔnyɛ mogya mu nhwehwɛmu, wɔnyɛ wɔn nsu mu nhwehwɛmu, na ebia wɔnyɛ CT scan de hwɛ sɛ aduruyɛ mu tebea foforo biara nni hɔ (e.g., ɔyare mmoawa, ɔhyew a ɛma obi ho kyere no).

Ɔkwan bɛn so na wɔsa?

Ɔkwan a wɔfa so sa yare no gyina sɛnea wo sɛnkyerɛnne ahorow no mu yɛ den so.

Ade a edi kan na ɛho hia sen biara ne sɛ wubegyae nnuru a ɛde eyi bae no.

• Nsɛnkyerɛnne nketenkete: Nnipa dodow no ara te nka sɛ wɔn ho tɔ wɔn wɔ nnɔnhwerew 24 akyi bere a wɔagyae aduru a ɛde sɛnkyerɛnne no bae no. Ebia wo duruyɛfo de wo bɛto ayaresabea ma wɔahwɛ wo.
• Nsɛnkyerɛnne a ɛkɔ fam: Ebia ɛho behia sɛ wɔde obi bɛkɔ ayaresabea na anyɛ yiye koraa no wɔde nnɔnhwerew 24 ahwɛ no.
• Nsɛnkyerɛnne a emu yɛ den: Saa bere yi de, ebia ebehia sɛ wɔde wo kɔ ayaresabea a wɔhwɛ wɔn a wɔyare denneennen (ICU) kɔsa wo yare. Ɛha no, wɔhwɛ nneɛma te sɛ koma bɔ ne mogya mmoroso bere nyinaa.

Ebia ayaresa ahorow no bi ne:

• Nnuru a esiw serotonin a wɔyɛ no kwan: Sɛ nhwɛso no, nnuru te sɛ Cyproheptadine.
• Nnuru a ɛma ntini mu dwo ne nnuru a ɛko tia dadwen: Benzodiazepines, te sɛ Diazepam (Valium).
• Nnuru a ɛma koma bɔ ne mogya mmoroso.
• Oxygen ne saline (Intravenous - IV fluids): Sɛnea ɛbɛyɛ a wobedi nsu a ɛtɔ ne atiridiinini ano.

Yɛbɛyɛ dɛn atumi abɔ yɛn ho ban afi tebea yi ho?

Eyi yɛ biribi a mpɛn pii no wobetumi asiw ano. Nneɛma kakraa bi wɔ hɔ a ɛsɛ sɛ woyɛ.

• Ka kyerɛ wo duruyɛfo sɛ:Ka nnuru, vitamin, ne nhabannuru biara a wobɛnom ho asɛm kyerɛ wo duruyɛfo. Eyi ho hia titiriw sɛ worenom nnuru afi nnuruyɛfo pii hɔ a.
• Hu sɛnkyerɛnne ahorow no: Sɛ worenom nnuru bɛboro biako a ɛka serotonin a, hu serotonin syndrome ho sɛnkyerɛnne ahorow. Sɛ sɛnkyerɛnne bi da adi a, wubetumi ahu no ntɛm.
• Nnyae w’aduru no nom mpofirim: Nnyae nnuru biara a wobɛnom mpofirim anaasɛ nsakra dodow a wode ma no a wo ne wo duruyɛfo nkasa.
• Bisa sɛ wowɔ asɛm bi a: Sɛ wowɔ nsɛmmisa anaa adwenem naayɛ bi wɔ aduru bi ho a, bisa wo duruyɛfo.