Ðe kuxiwo le viwòa ƒe ŋkuwo, towo, kple ƒunukpeƒewo ŋu le ɣeyiɣi ɖeka mea? Esia ate ŋu anye Stickler Syndrome!

Ɣeaɖewoɣi la, mía vi suewo dzea dɔ ɖe wo nɔewo yome, alo? Gake kasia ɖevi aɖewo ate ŋu adze kuxi geɖe siwo dze abe ɖe womedo ƒome kplii o ene, abe ŋku ƒe kuxiwo , tosese ƒe kuxiwo, kple ƒunukpeƒeveame ene. Ðe nuteƒekpɔkpɔ sia tɔgbe dzɔ ɖe dziwòa? Ekema nya sia ku ɖe domenyiŋusẽfianu ƒe nɔnɔme aɖe si woyɔna be Stickler Syndrome, si ate ŋu ahe nɔnɔme sia tɔgbe vɛ ŋu. Togbɔ be esia adze nu sesẽ vie hã la, mina míaƒo nu tso eŋu bɔbɔe.

Nukae nye Stickler ƒe Dɔléle? Ne míagblɔe tututu la...

Kpuie ko la, Stickler ƒe dɔlélea nye domenyiŋusẽfianu ƒe dɔléle . Míaƒe domenyiŋusẽfianu ƒe tɔtrɔ gbɔe wòtsona. Míaƒe ŋutilã ƒe kadodoŋusẽwo koŋue wògblẽa nu le. Kadodoŋusẽ sia nye lãmenugbagbevi tɔxɛ aɖe si doa ka kple míaƒe ŋutilã ƒe akpa bubuwo abe ŋutinuwo kple lãkusiwo ene, léa wo ɖe te, eye wònaa nɔnɔme wo. Bu eŋu abe siminti kple ka zazã atsɔ alé míaƒe aƒea ƒe gliwo kple xɔa tame ɖekae ene. Kadodoŋusẽ sia le vevie na míaƒe ŋutilã hã.

Eyata le Stickler ƒe dɔléle sia me la, kadodoŋusẽ siwo le teƒewo abe mo, to, ŋku, kple ƒunukpeƒewo ene ye wògblẽa nu le wu. Le esia ta la, ɖevi aɖewo ƒe mo ate ŋu atrɔ, abe aɖu ƒe ʋuʋu ene. Kuxiwo ate ŋu anɔ nukpɔkpɔ , nusese, kple ʋuʋu hã ŋu. Woyɔa esia ɣeaɖewoɣi be Stickler dysplasia.

Aleke gbegbee nɔnɔme sia bɔe? Amekae ate ŋu atue ɖo wu?

Wobu akɔnta be Stickler ƒe dɔlélea dzea vidzĩ yeye 7,500 va ɖo 10,000 ɖesiaɖe dometɔ ɖeka va ɖo etɔ̃ dzi. Gake esi wònye be zi geɖe la, womekpɔa dɔlélea dzea sii nyuie o ta la, esesẽna be woagblɔ ame agbɔsɔsɔme si tututu dɔlélea le fu ɖem na ŋutɔŋutɔ.

Le amesi axɔe gome la, amesiame ate ŋu axɔ Stickler ƒe dɔlélea. Gake ne dɔlélea le ame aɖe ŋu le ƒomea me, si nye vidada, vifofo, alo nɔvia, la, afɔku si li be ame bubuwo naxɔe la lolo wu. Gake ɣeaɖewoɣi la, ƒome ŋutinya aɖeke manɔmee la, dɔléle sia ate ŋu adzɔ hã le domenyiŋusẽfianu ƒe tɔtrɔ le vome ta (` domenyiŋusẽfianu ƒe tɔtrɔ`) . Eyae nye be, mehiã be wòanye nane si ƒe dome wonyi o.

Aleke Stickler Syndrome kpɔa ŋusẽ ɖe ŋutilã dzii?

Abe alesi míeƒo nu tso eŋu va yi ene la, nɔnɔme sia gblẽa nu le kadodoŋusẽ ŋu. Dɔ vevi siwo kadodoŋusẽ si le míaƒe ŋutilã me wɔna dometɔ ɖekae nye be wòakpɔ lãmenugbagbevi kple ŋutinu bubuwo ta ahado alɔ wo. Eyata ne domenyiŋusẽfianu aɖe si wɔa kadodoŋusẽ sia ƒe tɔtrɔ, alo nusi gblẽ le eŋu la, domenyiŋusẽfianu ma mekpɔa mɔfiame nyuitɔ ku ɖe alesi woawɔ kadodoŋusẽ sia kple alesi wòle be wòawɔ dɔe ŋu o.

Esia tae, le amesi ŋu Stickler ƒe dɔlélea le gome la, .Egblẽa nu le nukpɔkpɔ, nusese, kple ƒunukpeƒewo ƒe ʋuʋu ŋu. Ŋku, to, kple ƒunukpeƒewo koŋue wògblẽa nu le. Zi geɖe la , amesiwo ŋu Stickler ƒe dɔlélea le la xɔa ƒunukpeƒetetedɔ le woƒe ɖevime . Gake ne woda dɔ nyuie la, woate ŋu aɖu dzesiawo dzi eye amesiwo ŋu dɔléle sia le ate ŋu anɔ agbe si sɔ, si me wowɔa dɔ le .

Nukae nye esia ƒe dzesiwo? Aleke woawɔ ade dzesii?

Stickler ƒe dɔlélea ƒe dzesiwo ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ . Menye amesiamee akpɔ dzesiawo katã o. Emae na wòle etɔxɛ alea gbegbe. Le kpɔɖeŋu me, ŋkudɔ ate ŋu anɔ ɖevi ɖeka ŋu geɖe wu, evɔ ƒunukpeƒetetedɔ ate ŋu anɔ ɖevi bubu ŋu wu.

Dzesi vevi geɖewo li siwo woate ŋu akpɔ:

Ƒu kple ƒunukpeƒewo ƒe kuxiwo:

• Le gɔmedzedzea me la , ƒunukpeƒeawo ate ŋu atrɔ akpa , gake le ɣeyiɣi aɖe megbe la , woate ŋu adze sesẽ gɔme .
• Akɔta ƒe ƒoƒo, alo scoliosis, ate ŋu adzɔ.
• Ƒunukpeƒetetedɔ ate ŋu adze ame dzi le eƒe ɖevime. Bu eŋu kpɔ ne ɖevi aɖe, si mexɔ ƒe ewo gɔ̃ hã o, fɔ le ŋdi me heto nyatoƒoe le vevesese le woƒe ƒunukpeƒewo ŋu la, ele be nàtsi dzi.

Tosese kple to ƒe kuxiwo:

• Tosese ate ŋu adzɔ le agbɔsɔsɔ vovovowo me. Ame aɖewo ƒe to me gblẽ vie ko, evɔ ame bubuwo ya ate ŋu ase tokunɔ keŋkeŋ.

Ŋku ƒe kuxiwo:

• Nukpɔkpɔ kpui (alo nukpɔkpɔ kpuie) vevie fia be nusiwo te ɖe wo nɔewo ŋu koe woate ŋu akpɔ nyuie, evɔ nusiwo le didiƒe ya ya mekɔna o.
• Retina si ɖe eɖokui ɖa. Esia ate ŋu adzɔ kpata eye abia be woawɔ atike nɛ enumake.
• Ŋku ƒe ʋuʋu .
• Nyaƒoɖeamenu si dzina ɖe edzi le ŋkua me, si woyɔna be ŋkudɔ.

Nu tɔxɛ siwo dzena le mo dzi:

Zi geɖe la, ate ŋu akpɔ ŋusẽ ɖe ɖevi siwo ŋu dɔléle sia le ƒe mo ƒe nɔnɔme hã dzi le woƒe tsitsi me.

• Cleft palate : Esia fia be dometsotso aɖe le nu ƒe xɔta.
• Aɖu si le sue eye wòge ɖe eme le mɔ si mesɔ o nu (`micrognathia`) : Woyɔa esia ɣeaɖewoɣi be `Pierre Robin ƒe ɖoɖo`. Esia ate ŋu ana be gbɔgbɔ kple nu mimi nasesẽ na ɖevi aɖewo.
• Moa va nɔa gbadzaa eye ŋɔti hã va nɔa sue.

Dzesi bubuwo:

Tsɔ kpe ɖe esia ŋu la, woate ŋu akpɔ dzesi bubuwo:

• Yagbɔgbɔ sesẽ (vevietɔ le ɖevi siwo ŋu micrognathia le gome).
• Nuɖuɖu nana vidzĩ siwo wodzi yeyee ƒe kuxiwo.
• Nusɔsrɔ̃ ƒe kuxiwo le nukpɔkpɔ kple tosese ƒe kuxiwo ta.

Vevietɔ: Menye amesiamee akpɔ dzesi siawo katã o. Mègatsi dzi ne dzesi siawo dometɔ ɖeka alo eve le viwòa ŋu o, gake ne èkpɔ wo dometɔ geɖe ɖekae la, anyo wu be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo.

Ðe Stickler Syndrome ƒomevi vovovowo lia?

Ẽ, wokpɔ Stickler ƒe dɔlélea ƒomevi vevi ade. Dzesiawo ƒe sesẽme kple woƒe nɔnɔme toa vovo le ƒomevi siawo nu.

• Ƒomevi I: Esiae nye ƒomevi si bɔ wu . Tosese fafɛ kple nukpɔkpɔ kpuie nye dzesi vevitɔwo.
• Ƒomevi II: Tosese ƒe kuxi kple nukpɔkpɔ kpuie gblẽa nu le esia ŋu vevie wu.
• Ƒomevi III: Tosese kple ƒunukpeƒewo ƒe kuxiwoe nye dzesi vevitɔwo. Zi geɖe la , nukpɔkpɔ ƒe dzesiwo menɔa anyi o .
• Ƒomevi IV, V, kple VI: Ƒomevi siawo mebɔ kura o . Woate ŋu akpɔ nu kple tosese ƒe kuxi sesẽwo. Dzesi siwo sesẽ wu hã ate ŋu anɔ wo ŋu, abe ƒu didiawo ƒe nugbɔ siwo lolo (spondyloepiphyseal dysplasia) kple ƒunukpeƒetetedɔ ene.

Ðɔktawo nɔa te ɖe dɔlélea ƒe dzesiwo kple dodokpɔ siwo wowɔ dzi dea dzesi ame ƒomevi si me wòle.

Nuka gbɔe esia tso? Nukae nye domenyiŋusẽfianu ƒe ŋusẽkpɔɖeamedzi?

Nu vevitɔ si gbɔ Stickler ƒe dɔlélea tsoe nye domenyiŋusẽfianu ƒe tɔtrɔ . Dzɔdzɔmeŋusẽ ƒe tɔtrɔ sia ate ŋu adzɔ le domenyiŋusẽfianu ade siwo fiaa mɔ míaƒe ŋutilã be wòawɔ protein tɔxɛ aɖe si woyɔna be collagen la dometɔ ɖesiaɖe me . Collagen ye nye nu vevitɔ si naa míaƒe kadodoŋusẽwo te ŋu trɔna ɖe nɔnɔmewo ŋu eye ŋusẽ nɔa wo ŋu. Bu eŋu abe rababa ene, si naa wo te ŋu nɔa te sesĩe eye ŋusẽ nɔa wo ŋu.

Eyata ne nu gblẽ le domenyiŋusẽfianu siawo ŋu la, womewɔa collagen protein la nyuie o. Esia gblẽa nu le kolagen si wɔa míaƒe ƒunukpeƒe kple nusi le abe jelly ene si le míaƒe ŋkuwo me ŋu koŋ. Le domenyiŋusẽfianu siawo dome la, domenyiŋusẽfianuwo abe `(COL2A1)`, `(COL11A1)`, `(COL11A2)` ye nye vevitɔwo.

Ne ɖevi nyi domenyiŋusẽfianu siawo siwo trɔ la dometɔ ɖeka ƒe dome la, woate ŋu aɖe Stickler ƒe dɔlélea ƒe dzesiwo afia.

Aleke wonyi domenyiŋusẽfianu siawo ƒe domee?

Mɔ vevi eve li siwo dzi woato anyi esia ƒe dome:

• Autosomal ƒe nɔnɔme si xɔ aƒe ɖe eme:Esiae nye ƒomevi si bɔ wu (vevietɔ ƒomevi I, II, kple III). Nusi dzɔna le afisia enye be ne domenyiŋusẽfianu ƒe tɔtrɔ le dzila ɖeka ŋu gɔ̃ hã la , mɔnukpɔkpɔ 50% li be ɖevia anyi eƒe dome.
• Autosomal recessive: Esia mebɔ vie o (woate ŋu akpɔe le ƒomevi IV, V, kple VI me). Le afisia la, ele be dzila evea siaa nanye ʋukula siwo le lãmesẽ me . Eyae nye be dzesi aɖeke mele wo ŋu o, gake domenyiŋusẽfianu si trɔ le wo si. Ne nenemae la, ke mɔnukpɔkpɔ 25% li be ɖevia anyi nɔnɔmea ƒe dome.

Ɣeaɖewoɣi la, domenyiŋusẽfianu ƒe tɔtrɔ yeye (`de novo mutation`) ate ŋu adzɔ le vome , ƒome ŋutinya aɖeke manɔmee. Esesẽna be woagblɔ nusiawo ɖi do ŋgɔ.

Aleke ɖɔktawo dea dzesi esiae?

Ðɔkta wɔa afɔɖeɖe geɖe tsɔ dia Stickler ƒe dɔlélea.

• Ƒomea ƒe atikewɔwɔ ŋutinya kple ŋutilãmedɔdada tsitotsito: Gbã la, woabia wò kple viwòa tso wò dzesiwo kple nenye be dɔléle sia tɔgbe nɔ wò ƒomea me dometɔ aɖe ŋu hã. Emegbe, woado viwòa kpɔ be nɔnɔme tɔxɛ aɖewo le mo, to, ŋku, kple ƒunukpeƒewo hã.
• Nukpɔkpɔ kple tosese dodokpɔwo: Ðɔkta bibiwoe wɔa dodokpɔ siawo tsɔ daa ŋku kple nusese ƒe sesẽme kpɔ.
• Nɔnɔmetatawo dodokpɔ: Ɣeaɖewoɣi la, woate ŋu awɔ dodokpɔwo abe X-ray ene atsɔ akpɔe ɖa be ƒuwo kple ƒunukpeƒewo mesɔ o hã.
• Domenyiŋusẽfianu dodokpɔ: Esiae nye dodokpɔ vevitɔ si kpena ɖe ame ŋu wòkpɔa dɔlélea nyuie. Woɖea ʋu alo lãkusi aɖe hedoa domenyiŋusẽfianu ƒe tɔtrɔ siwo hea Stickler ƒe dɔlélea vɛ hã kpɔna.

Ðe woate ŋu ade dzesi esia hafi woadzi via?

Ẽ, ɣeaɖewoɣi la, domenyiŋusẽfianu dodokpɔ do ŋgɔ na vidzidzi ate ŋu ade dzesi nusiwo mesɔ o alo tɔtrɔ ɖesiaɖe si le vidzĩ ƒe domenyiŋusẽfianu me. Gake zi geɖe la, wokpɔa dɔlélea nyuie le vidzĩa dzidzi vɔ megbe, ne wowɔ ŋutilãmedɔ bliboe kple dodokpɔ bubu siwo hiã be woatsɔ aɖo kpe dzesiawo dzi vɔ.

Nukawoe nye atike siwo wozãna na Stickler Syndrome?

Esia nye kuxi si le ame geɖe ŋu. Fifia womekpɔ atike aɖeke na Stickler ƒe dɔlélea o. Gake mègatsi dzi o. Atikewɔwɔ nyui geɖe li woatsɔ aɖu dzesiawo dzi eye woaɖe woƒe ŋusẽkpɔɖeamedzi dzi akpɔtɔ . Dɔlélea didi kaba kple edadae nye nu vevitɔ kekeake. Vevietɔ le ŋku ƒe ŋkume ƒe ʋuʋu alo ƒunukpeƒe ƒe kuxiwo gome la, atikewɔwɔ kaba ate ŋu axe mɔ ɖe nusiwo gblẽ vevie nu.

Atikewɔwɔ ƒe mɔnuwo toa vovo le dzesiawo nu. Atikewɔwɔ vevi aɖewoe nye esi:

• Na ŋku ƒe nukpɔkpɔ nanyo ɖe edziŊkuɖodzinu alo ŋkumeɖonu nana.
• Tomemɔ̃wo nana be woana nusese nanyo ɖe edzi.
• Atike nana be wòaɖe ƒunukpeƒeveame dzi akpɔtɔ.
• Ne aɖuawo le ƒoƒom alo mesɔ o la, woate ŋu awɔ aɖuɖɔɖɔɖɔdɔ atsɔ aɖɔ wo ɖo.
• Lãmesẽfefewɔwɔ ( abe kamedede tɔxɛwo ene) be woado ŋusẽ ƒunukpeƒewo eye woana woƒe ʋuʋu nanyo ɖe edzi.
• Amekoko:
• Retina si ɖe eɖokui ɖa ƒe gbugbɔgaƒoƒo (amekoko si wowɔna tsɔ gbugbɔa ŋkume ƒe ŋkume ƒe ŋkume kpena ɖe eŋu).
• Cleft aɖuɖɔɖɔɖɔ.
• Ne gbɔgbɔ sesẽ la, woate ŋu ade mɔ̃ sue aɖe kɔa me be gbɔgbɔ nanɔ bɔbɔe (ɖewohĩ woaɖe yaƒoƒo).
• Dzra ƒunukpeƒe siwo gblẽ ɖo alo nàɖɔlii.

To atikewɔwɔ sia dzi la, ɖeviwo kple ame tsitsi siwo ŋu Stickler ƒe dɔlélea le la xɔa kpekpeɖeŋu gã aɖe le agbenɔnɔ si sɔ, si me blibo, kple esi me wowɔa dɔ le me .

Ðe woate ŋu axe mɔ ɖe nɔnɔme sia nua?

Stickler ƒe dɔlélea nye domenyiŋusẽfianu ƒe dɔléle, eyata womate ŋu axe mɔ ɖe enu o . Gake ne dɔlélea le wò ƒomea me tɔ aɖe ŋu eye nèle ɖoɖo wɔm be yeadzi vi la, domenyiŋusẽfianu ŋuti aɖaŋuɖoɖo kple domenyiŋusẽfianu dodokpɔ ate ŋu akpe ɖe ŋuwò nàse afɔku si le viwòa ƒe domenyinyi me gɔme.

Nukae nàte ŋu akpɔ mɔ na ne èle agbe kple Stickler Syndrome?

Togbɔ be womekpɔ atike aɖeke na dɔléle sia o hã la, mekpɔa ŋusẽ ɖe ame ƒe agbenɔƒe dzi o . Eyae nye be amesiwo ŋu dɔléle sia le nɔa agbe si sɔ abe ame bubu ɖesiaɖe ene. Ne woléa ŋku ɖe ame geɖe ŋu edziedzi le atikewɔwɔ me, wowɔa atike na wo si hiã, eye wodoa alɔ wo la, wonɔa agbe dovevienu ŋutɔ eye woƒe dzi dzea eme.

Nu vevitɔe nye be woakpɔ dɔlélea le vidzĩme alo ɖevimenɔɣi . Emegbe woate ŋu akpɔ dzesiawo gbɔ kaba eye woaxe mɔ ɖe kuxi siwo ate ŋu ado mo ɖa le etsɔme nu.

Ɣeaɖewoɣi la, dzesiawo ate ŋu agadze le atikewɔwɔ vɔ megbe gɔ̃ hã. Le kpɔɖeŋu me, ne wowɔ dɔ na wò be woaɖe ŋku ƒe ŋkumeʋuʋu si ɖe ɖa gɔ̃ hã la, nɔnɔmea ate ŋu agava. Eyata ele vevie ŋutɔ be nàyi atikewɔlawo ƒe dodokpɔ edziedzi eye nàlé ŋku ɖe wò dzesiwo ŋu .

Ðe ŋusẽ aɖe le gbesiagbedɔwo ŋua?

Esia toa vovo tso ame ɖeka gbɔ yi bubu gbɔ, le dzesiawo ƒe nɔnɔme nu. Ðewohĩ ame aɖewo makpɔ ŋusẽ boo aɖeke ɖe amewo dzi o, evɔ ahiã be ame bubuwo nanɔ agbe kple seɖoƒe aɖewo. Vevietɔ ɖɔktawo ɖo aɖaŋu be woaƒo asa na kamedefefe siwo me wodoa ka kple ame bubuwo le , abe rugby kple bɔlƒoƒo ene, elabena afɔku si le ŋku ƒe ŋkume ƒe ʋuʋu me lolo wu le kamedefefe mawo me.

Ɣekaɣie wòle be nàkpɔ ɖɔkta?

Ne dzesi aɖewo le ŋuwò alo viwòa ŋu siwo nèsusu be ate ŋu atso Stickler ƒe dɔlélea gbɔ eye wole ŋusẽ kpɔm ɖe wò gbesiagbedɔwo dzi ale gbegbe be màte ŋu awɔ dɔ o la, kpɔ egbɔ be yeyi ɖɔkta gbɔ.

• Ne ƒunukpeƒewo le veve sem vevie la .
• Ne wò nukpɔkpɔ trɔ kpata (le kpɔɖeŋu me, nukpɔkpɔ si me kɔ o, akaɖi siwo le keklẽm le wò ŋkume kpɔkpɔ, teƒe yibɔwo alo ɖɔ siwo le tsia dzi le wò ŋkume kpɔkpɔ, alo nèse le ɖokuiwò me abe vɔvɔli ene le wò ŋku ƒe akpa aɖe me - esiawo ate ŋu anye ŋku ƒe ŋkume ƒe dzesi siwo ɖe eɖokui ɖa).
• Ne nuɖuɖu alo nunono mimi sesẽ na wò.
• Ne ʋu le dodom le teƒe si wowɔ dɔa le, evuvu, alo tsi ɣi aɖe le dodom (esia ate ŋu afia be dɔlékui aɖe le eŋu).

Vevietɔ ŋutɔ: Ne gbɔgbɔ sesẽ na wò alo viwòa , ke enye nusi dzɔ kpata. Yi kɔdzi si te ɖe ŋuwò enumake, alo nàƒo ka na 1990.

Nya vevi kawoe wòle be míabia ɖɔktaa?

Ne ènya nya be Stickler ƒe dɔlélea le ye alo viwò ŋu ko la, àte ŋu abia nya siawo abe esiawo ene ɖɔktaa:

• Aleke gbegbee nɔnɔme sia si woyɔna be Stickler Syndrome nu sẽe?
• Nuka tae wòle alea ɖo?
• Aleke esia akpɔ ŋusẽ ɖe vinyea ƒe gbesiagbegbenɔnɔ dzii?
• Kuxi kawo ŋue wòle be matsi dzi ɖo etɔxɛe? Nukawoe nye woƒe dzesiwo?

Tsɔ kpe ɖe biabia siawo ŋu la, ƒo nu tso nusianu si ŋu bum nèle, vɔvɔ̃, alo ɖikeke ɖesiaɖe si le mewò ŋu na wò ɖɔkta.

Mlɔeba la, nya vevitɔwo (Take-Home Message) .

Stickler ƒe dɔlélea ate ŋu ado vɔvɔ̃ na ame vie be woase. Gake nusiawo nenɔ susu me na wò:

• Esia nye domenyiŋusẽfianu ƒe nɔnɔme , ke menye nane si tso wò ɖekematsɔleme gbɔ o.
• Esi wònye be egblẽa nu le kadodoŋusẽ ŋu koŋ ta la, ate ŋu ana ŋku, to, ƒunukpeƒewo, kple mo natrɔ.
• Dzesiawo ate ŋu ato vovo ŋutɔ tso ame ɖeka gbɔ yi bubu gbɔ .
• Togbɔ be womate ŋu adae bliboe o hã la, atikewɔmɔnu geɖe li siwo akpe ɖe ame ŋu wòaɖu dzesiawo dzi ahanɔ agbe nyuie wu .
• Dɔlélea didi kaba kple edada gɔmedzedze nye mɔ nyuitɔ siwo dzi woato akpɔ dzidzedze.
• Ne dɔléle sia le wò ƒomea me la, ele vevie be nàdi domenyiŋusẽfianu ŋuti aɖaŋuɖoɖo .

Ne amesi ŋu Stickler ƒe dɔlélea mele vɔvɔ̃ ɖo o eye wòwɔ ɖe atikewɔlawo ƒe aɖaŋuɖoɖo nyuiwo dzi la, ate ŋu aɖo agbe nyui nɔnɔ abe ame bubu ɖesiaɖe ene. Ne nya bubu aɖewo gale asiwò la, mègahe ɖe megbe le nuƒoƒo kple ɖɔkta me o.

` Stickler syndrome, domenyiŋusẽfianu ƒe dɔlélewo, kadodoŋusẽ, collagen, ŋku ƒe dɔmawɔmawɔ nyuie, tosese ƒe kuxi, ƒunukpeƒetetedɔ, ɖeviwo ƒe lãmesẽ