Ðe gayibɔ yɔ wò ŋutilã fũ akpaa? Mina míasrɔ̃ nu tso ʋumenugbagbeviɣidɔ ŋu.

Ðe ɖeɖi tea ŋuwò zi geɖe eye ƒunukpeƒewo le veve sem na wòa? Ɣeaɖewoɣi la, míesusuna be nusiawo sɔ eye míeŋea aɖaba ƒua wo dzi. Gake nu siawo ate ŋu anye iron si sɔ gbɔ ɖe míaƒe ŋutilã me ƒe dzesiwo hã. Egbea míele nu ƒom tso nɔnɔme mawo dometɔ ɖeka ŋu, "Hemochromatosis". Togbɔ be ŋkɔ sia nye ŋkɔ si míenya vie o hã la, ele vevie ŋutɔ be nànya nu tso eŋu.

Kpuie ko la, nukae nye ʋumenugbagbeviɣidɔ?

Hemochromatosis nye nɔnɔme si me wò ŋutilã ƒoa iron nu ƒu akpa. Ame aɖewo hã yɔnɛ be "gayibɔ ƒe agba si gbɔ eme." Zi geɖe la, iron agbɔsɔsɔme si míaƒe ŋutilã hiã tso nuɖuɖu siwo míeɖuna me koe míaƒe dɔgbowo xɔna. Gake le amesiwo ŋu ʋumenugbagbeviɣidɔ le gome la, ŋutilãa xɔa iron geɖe wu alesi wòhiã. Kuxiae nye be mɔ aɖeke meli si dzi woato aɖe gayibɔ sia si sɔ gbɔ la ɖa o. Eyata ŋutilãa dzraa iron si sɔ gbɔ sia ɖo ɖe wò ƒunukpeƒewo kple ŋutinu veviwo abe aklã, dzi, kple dɔgbo ene me.

Nɔnɔme sia ƒomevi vevi evee li.

Woate ŋu ama nɔnɔme sia ɖe hatsotso vevi eve me. 1. Primary Hemochromatosis: Esia nye domenyiŋusẽfianu ƒe dɔléle. Eyae nye be wotoa ƒomea me tɔwo dzi toa domenyiŋusẽfianuwo dzi. Ne míagblɔe tututu la, hafi dɔléle sia nadze ŋuwò la, ele be nàxɔ domenyiŋusẽfianu si gblẽ la tso dawò kple fofowò siaa gbɔ. 2. Secondary Hemochromatosis: Esia dzɔna le susu bubuwo ta. Le kpɔɖeŋu me, nɔnɔme sia ate ŋu ado mo ɖa le amesiwo ŋu atikewɔwɔ me dɔléle aɖe le si hiã be woado ʋu enuenu (e.g., thalassemia) alo amesiwo ŋu aklãdɔ bubuwo le.

Nukawoe hea ʋumenugbagbeviɣidɔ vɛ?

Nusiwo gbɔ domenyiŋusẽfianu tsona

HFE domenyiŋusẽfianu lae kpɔa iron agbɔsɔsɔme si míaƒe ŋutilã xɔna tso nuɖuɖu me dzi. Dzɔdzɔmenugbagbevi eve siwo le HFE domenyiŋusẽfianu me, siwo nye C282Y kple H63D, gbɔe domenyiŋusẽfianu ƒe ʋumenugbagbeviɣidɔ ƒe akpa gãtɔ tso. Domenyiŋusẽfianu bubuwo hã ateŋu ahe dɔléle ʋɛ aɖewo vɛ (anɔ abe 10%-15%). Woyɔa esiawo be non-HFE hemochromatosis. Ne domenyiŋusẽfianuwo abe HJV alo HAMP ene ƒe tɔtrɔwo la, zi geɖe la, dzesiawo dzena le woƒe ɖevime. Ɣeaɖewoɣi la, aklã ƒe gbegblẽ kple aklã ƒe ʋuʋu ate ŋu adzɔ le ɖevi sue me ke.Anɔ eme be nɔnɔmea ado mo ɖa.

Nu bubu siwo gbɔ wòtsona le gota (Secondary Causes) .

Zi geɖe la, esia ƒomevi dzɔna ne dɔléle aɖe abe ʋusɔgbɔdɔ sesẽ ene le ame ŋu eye wòhiã be woado ʋu nɛ enuenu. Esia le alea elabena iron sɔ gbɔ ɖe ʋumenugbagbevi dzĩ siwo wonana wo tso egodo la me. Esi mɔ aɖeke meli si dzi ŋutilãa ato aɖe gayibɔ sia ɖa o ta la, edzea ƒoƒo ƒu gɔme. Iron ƒe ƒuƒoƒo ate ŋu adzi ɖe edzi hã ne dɔlélewo abe aklãdɔ alo aklãdɔléle si nɔa anyi didi B alo C gblẽ nu le aklãa ŋu.

Amekae le afɔku me wu le esia ta?

Ne nusiwo gbɔna le ŋuwò la, ke afɔku le eme be ʋumenugbagbeviɣidɔ nadze dziwò. Mina míalé ŋku ɖe kplɔ̃ aɖe ŋu be míase esia gɔme nyuie.

Nukae nye ʋumenugbagbeviɣidɔ ƒe dzesiwo?

Ame siwo ŋu ʋumenugbagbeviɣidɔ le la dometɔ siwo ade afã mekpɔa dzesi aɖeke o. Le ŋutsuwo gome la, zi geɖe la, dzesiawo dzea egɔme tso ƒe 30 va ɖo ƒe 50. Le nyɔnuwo gome la, zi geɖe la, dzesiawo dzena le ƒe 50 xɔxɔ megbe, alo le dzinukpɔkpɔ megbe. Dzesi vevi aɖewoe nye esi:

• Joint pain , vevietɔ le ƒunukpeƒewo kple klowo me.
• Ðeɖiteameŋu atraɖii le susu aɖeke manɔmee.
• Lolo dzi ɖeɖe kpɔtɔ susu aɖeke manɔmee.
• Ŋutilã si trɔna zua akɔbli alo ɣie .
• Ƒodo ƒe vevesese .
• Gbɔdɔdɔ ƒe dzodzro dzi ɖe kpɔtɔ .
• Ŋutilã me fuwo ƒe ŋeŋe.
• Dzi ƒe tsotso ƒe tɔtrɔ (Heart flutter).
• Ŋkuɖodzinya si me afu le la senɛ le eɖokui me be yetɔtɔ vie, abe ahɔhɔ̃ si me afu le ene.

Ɣeaɖewoɣi la, dɔlélea meɖea dzesi siawo fiana o, ke boŋ edzena abe kuxi bubuwo ene. Le kpɔɖeŋu me:

• Aklã me kuxiwo, vevietɔ aklãdɔ
• Suklidɔ
• Dzi ƒe tsotso ƒe masɔmasɔ
• Ƒunukpeƒetetedɔ
• Tsitretsitsi ƒe dɔmawɔmawɔ nyuie

Aleke nèwɔ kpɔ esia, Ðɔkta?

Esi wònye be woate ŋu akpɔ dzesi siawo le dɔléle bubuwo me ta la, ɣeaɖewoɣi la, dɔlélea didi ate ŋu asesẽ vie. Gake ne dɔlélea ƒe dzesiwo le ŋuwò, nusiwo ate ŋu agblẽ nu le ŋuwò, alo dɔlélea le ƒomea me tɔ aɖe ŋu la, wò ɖɔkta alé ŋku ɖe eŋu. Mɔ vevi siwo dzi woato anya dɔlélea dometɔ aɖewoe nye esi:

• Biabia tso wò kple wò ƒomea ƒe atikewɔwɔ ŋutinya ŋu: Ðɔktaa abia nenye be dɔléle sia, aklãdɔ, alo ƒunukpeƒetetedɔ le wò ƒomea me.
• Ŋutilãmedodokpɔ: Woado wò ŋutilã kpɔ.
• Ʋudodokpɔ: Wowɔa dodokpɔ vevi eve.

1. Transferrin saturation: Esia ɖea alesi gbegbe iron bla ɖe transferrin, si nye protein si tsɔa iron yia ʋu me la fiana. 2. 2. .Serum ferritin: Esia dzidzea ferritin, si nye protein si dzraa iron ɖo ɖe ŋutilã me ƒe agbɔsɔsɔ. Ne dodokpɔ siawo ɖee fia be iron sɔ gbɔ ɖe lãme na wò la, wò ɖɔkta ate ŋu aɖo wò ɖe domenyiŋusẽfianu ƒe dodokpɔ be woakpɔe ɖa be domenyiŋusẽfianu si hea ʋumenugbagbeviɣidɔ vɛ la le asiwò hã.

• Aklã ƒe lãmenugbagbeviwo ɖeɖe: Woɖea aklãa ƒe akpa sue aɖe ŋutɔ hedoa eŋu le nusuekpɔmɔ̃ me be woakpɔe ɖa be nu gblẽ le aklãa ŋu hã.
• MRI scan: Ezãa magnet kple radio ƒutsotsoewo tsɔ naa wò ŋutinuwo ƒe nɔnɔmetata siwo me kɔ.

Nukawoe nye atikewɔmɔnuawo?

Ne domenyiŋusẽfianu ƒe ʋumenugbagbeviɣidɔ le ŋuwò la, atikewɔwɔ vevitɔe nye ʋuka me ʋu ƒe sisi . Kpuie ko la, esiae nye ʋu ɖeɖe le wò ŋutilã me le ɣeyiɣi aɖewo me . Eɖi ale si míedoa ʋu le Sri Lanka. Ðɔkta alo dɔnɔdzikpɔla si xɔ hehe dea aŋe ɖe ʋuka aɖe me le wò alɔnu eye wòɖea ʋu agbɔsɔsɔme aɖe ɖa. Esia ƒe taɖodzinu vevitɔe nye be nàna iron ƒe agbɔsɔsɔ si le wò ʋu me natrɔ ava nɔ abe tsã ene. Esia dzɔna le akpa eve me:

• Atikewɔwɔ gbãtɔ: Ahiã be nàyi kɔdzi alo atikewɔƒe zi ɖeka alo zi eve le kwasiɖa me be woaɖe ʋu vaseɖe esime wò iron ƒe agbɔsɔsɔ atrɔ ava nɔ abe tsã ene. Esia ate ŋu axɔ ƒe ɖeka alo esi wu nenema.
• Dɔdamɔnu si woatsɔ alé be na ame: Ne iron ƒe agbɔsɔsɔ gaɖo nɔnɔme si sɔ me ko la, ʋudodo zi gbɔ zi geɖe dzi ɖena kpɔtɔna. Zi geɖe la, wowɔa esia zi eve va ɖo zi ene le ƒea me.

Ne ʋumenugbagbeviɣidɔ evelia le ŋuwò, alo ne wò ʋukawo mesẽ ale gbegbe be woate ŋu aɖe ʋua ɖa o la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàzã atike si woyɔna be chelation therapy . Esia bia be woana atike siwo akpe ɖe wò ŋutilã ŋu wòaɖe iron si sɔ gbɔ ɖe wò aɖuɖɔ kple aɖuɖɔ me ɖa.

Tɔtrɔ kawoe nàte ŋu awɔ le aƒeme kple wò agbenɔnɔ me?

Ne wole ʋukawo ɖeɖem na wò la, zi geɖe la, mehiã be nàwɔ ɖe nuɖuɖu sesẽ aɖe dzi o elabena ekpena ɖe ŋuwò nèɖua iron ƒe agbɔsɔsɔ dzi. Gake àte ŋu awɔ nu siwo gbɔna be nàɖe kuxi siwo ate ŋu ado mo ɖa dzi akpɔtɔ:

• Ƒo asa na ahanono keŋkeŋ. Ahanono ate ŋu ana aklã ƒe gbegblẽ nadzi ɖe edzi.
• Ƒo asa na tɔmelã ƒuƒu alo ƒumelã ƒuƒu ɖuɖu. Ðewohĩ dɔlékui siwo ate ŋu ahe dɔlékuiwo vɛ na amesiwo me iron sɔ gbɔ ɖo la le wo me.
• Ƒo asa na vitamin C ƒe kpeɖeŋutɔ nono. Gake kuxi aɖeke mele dzɔdzɔmenuɖuɖu siwo me vitamin C le (e.g. oranges, tangerines) ɖuɖu me o.
• Ƒo asa na iron kpeɖeŋutɔ alo vitamin geɖe siwo me iron le nono.
• Ƒo asa na ŋdi nuɖuɖu siwo me wotsɔ gayibɔ de eme (siwo ŋu wodo ŋusẽe).
• Ðe nuɖuɖu siwo me iron sɔ gbɔ ɖo (e.g., oysters, dadilã, aŋanyi) ɖuɖu dzi kpɔtɔ. Bia wò ɖɔkta tso esia ŋu.Se to eye nànya nu geɖe tso eŋu.

Gbedasi si Wotsɔ Yi Aƒeme

• Hemochromatosis nye nɔnɔme si me iron sɔ gbɔ ɖo ƒoa ƒu ɖe ŋutilãa me. Domenyiŋusẽfianu ƒe nɔnɔme si wotsɔna tsoa dzidzimewo me koŋue wònye.
• Dzesiawo ate ŋu anye ɖeɖiteameŋu, ƒunukpeƒeveame, kple ŋutigbalẽ ƒe amadede ƒe tɔtrɔ. Ðewohĩ dzesi aɖeke manɔ ame aɖewo ŋu kura o.
• Ne dzesiwo le ŋuwò alo wò ƒomea me tɔ aɖe le dɔléle sia ŋu la, yi ɖɔkta gbɔ enumake hena aɖaŋuɖoɖo.
• Ne wokpɔ dɔlélea kaba hedae (Phlebotomy) ate ŋu akpɔ iron ƒe agbɔsɔsɔ le ŋutilã me dzi eye wòaxe mɔ ɖe ŋutinuwo ƒe gbegblẽ nu.
• Esia menye nɔnɔme si ŋu wòle be woavɔ̃ ɖo o. Ne wowɔ atike na wò nyuie heɖo aɖaŋu na wò la, àte ŋu anɔ agbe si sɔ, si me lãmesẽ le.

Hemochromatosis, Iron ƒe agbɔsɔsɔ fũ, Aklãdɔ, Ƒunukpeƒeveame, Phlebotomy