He ihu paʻa kou? Ua nalowale anei kou ʻala a me kou ʻono? Ke kahe mau nei anei kou ihu? ʻAʻole kēia he anu wale nō, akā he maʻi i kapa ʻia ʻo Chronic Rhinosinusitis me Nasal Polyps (CRSwNP) . ʻOiai he nui ka poʻe e loaʻa pinepine ana i ka hōʻoluʻolu mai nā ʻūpī ihu a i ʻole nā lāʻau lapaʻau waha, ʻike kekahi poʻe he paʻakikī loa ka kaohi ʻana i ko lākou mau hōʻailona me kēia mau lāʻau lapaʻau. Akā, mai hopohopo, me ka holomua o ka ʻepekema lapaʻau, aia nā ala hou a maikaʻi e mālama ai i ia mau maʻi. I kēia lā e kamaʻilio mākou e pili ana i kekahi o ia ʻano lāʻau lapaʻau kūikawā, ʻo Dupixent.
Pehea e hana ai ka lāʻau ʻo Dupixent no CRSwNP?
I ka ʻōlelo maʻalahi, he mau ulu liʻiliʻi nā polyp nasal e kū mai ana ma nā membrane mucous o nā ʻeke ea (sinuses) i loko a puni paha o ko kākou ihu. ʻO ke kumu nui o kēia, ʻo ia ka sinusitis mau loa . ʻO ia ka wā e pehu ai a hoʻomāhuʻi ʻia ai nā lua ihu a me nā sinus no nā mahina ʻekolu a ʻoi. ʻO kēia pehu mau ke kumu o ka hana ʻana o nā polyp.
ʻO ka hapa nui o ka manawa, ʻaʻole kēia mau polyp e hōʻike i kekahi mau hōʻailona. Akā i ko lākou ulu ʻana, hiki iā lākou ke hoʻomaka e ālai i ka hana maʻamau o ka ihu a me nā lua sinus. E noʻonoʻo iā ia e like me ka paipu wai e pau ke kahe ʻana ke paʻa kekahi mea i loko.
Hiki i kēia ke hana i nā hōʻailona e like me ka ihu paʻa, ka ihu kahe pinepine, ka ʻūhā ʻana, a me ka nalowale ʻana o ke ʻala a me ka ʻono . Eia kekahi, ke hiki ʻole i ka mucus (phlegm) ke kahe pono mai nā lua sinus, hiki iā ia ke hōʻiliʻili, e hōʻeha ai a me ka maʻi.
ʻO ka pahuhopu nui o ka mālama ʻana ma ʻaneʻi, ʻo ia ka hoʻēmi ʻana i ka mumū i loko o ka ihu a me nā lua sinus, ka mea e hoʻēmi i ka mucus a hāʻawi i ka hōʻoluʻolu nui mai nā hōʻailona.
ʻO ka mea hana nui i loko o Dupixent ʻo dupilumab . Hana ia ma ke kāohi ʻana i ʻelua mau protein (`interleukin-4` a me `interleukin-13`) e hoʻouna ana i nā hōʻailona e hoʻoulu ai i ka ʻōnaehana pale o ko mākou kino e pane nui a hoʻoulu i ka mumū. Ke ālai ʻia kēia mau protein, e emi nui ana ka pehu a me ka ʻoluʻolu ʻole i ka ihu a me nā sinuses.
Hiki i kekahi me kēia kūlana ke hoʻohana iā Dupixent?
ʻO ka hapa nui o ka poʻe me CRSwNP e mālama mua ʻia me ka ʻaila ʻūlū ihu. He ʻano lāʻau lapaʻau kēia i kapa ʻia he corticosteroid. Inā ua hoʻohana ʻoe i kēia ʻaila no kekahi mau mahina a ʻaʻole i kāohi ʻia kāu mau hōʻailona, hiki paha ka manawa e noʻonoʻo ai i kāu kauka.Hiki i ke kauka ke kuhikuhi i kahi pila corticosteroid pōkole. Pono paha kekahi poʻe i ke ʻoki ʻana e wehe i ka puʻupuʻu.
He koho maikaʻi ʻo Dupixent no ka poʻe i hoʻāʻo i kēia mau mea āpau, me nā ʻōpala ihu, nā pila, a me ke ʻoki kino paha, akā loaʻa mau nā hōʻailona koʻikoʻi. ʻO ia hoʻi, hoʻohana pinepine ʻia ia ma ke ʻano he lāʻau lapaʻau laina lua a ʻekolu paha.
Nā Haʻawina e pili ana i ka pono o Dupixent (LIBERTY Studies)
Ua mālama ʻia ʻelua mau hoʻokolohua lapaʻau nui, i kapa ʻia ʻo LIBERTY, e hoʻoholo ai i ka palekana a me ka pono o kēia lāʻau. Ua hoʻohana nā mea komo a pau i kēia mau hoʻokolohua i ka pīpī ihu i kēlā me kēia lā akā ua ʻeha mau lākou i nā hōʻailona. Eia kekahi, ua nalowale loa a hapa paha ko lākou ʻala ʻana i ka 76% o lākou.
Ma kēia mau haʻawina, ua hoʻohālikelike ʻia ʻo Dupixent me kahi placebo, kahi lāʻau lapaʻau i like me ka lāʻau lapaʻau akā ʻaʻohe mea hana maoli. Ua ana ʻia nā hopena ma hope o 6 mau mahina.
| Nā pono i hōʻike ʻia e ka noiʻi | Wehewehena |
|---|---|
| Ka nui o ka septum nasal | ʻO ka poʻe i lawe iā Dupixent no 6 mau mahina, ua emi iki ko lākou mau ʻiole a me nā ʻiole liʻiliʻi ma mua o ka poʻe i lawe i kahi placebo. Ua like nā hopena i hoʻokahi makahiki ma hope. |
| Nā hōʻailona o ka ʻūpā ihu | ʻO ka poʻe i lawe iā Dupixent, ua emi iki ko lākou mau hōʻailona o ka ihu paʻa a me ka ihu wai ma mua o ka poʻe i lawe i ka placebo. Ua mau nō hoʻi kēia no hoʻokahi makahiki. |
| ʻO ke ʻala | I waena o ka poʻe me ka ʻala ʻino, ʻo ka poʻe i lawe iā Dupixent ua hoʻomaikaʻi nui ʻia ko lākou ʻala i hoʻohālikelike ʻia me ka poʻe i lawe i ka placebo. |
Pehea e hoʻohana ʻia ai ʻo Dupixent?
He injection wai ʻo Dupixent i hoʻokomo ʻia ma lalo o ka ʻili i kēlā me kēia ʻelua pule , maʻamau ma ka ʻūhā, ka ʻōpū, a i ʻole ka lima o luna.
Hele mai kēia i loko o kahi mea like me ka peni i hoʻopiha mua ʻia hiki iā ʻoe ke hoʻokomo iā ʻoe iho ma ka home. No laila, ʻaʻohe pono e hopohopo e pili ana i nā nila a i ʻole nā syringe. Akā e hoʻomanaʻo, e hōʻike pololei kāu kauka a kahu maʻi paha iā ʻoe pehea e hoʻokomo mua ai. He mea nui loa ia e hahai pololei i kēlā mau kuhikuhi.
Pehea ka lōʻihi e ʻike ai i nā hopena mai Dupixent?
Inā hana kēia lāʻau lapaʻau iā ʻoe, e ʻike paha ʻoe i kahi hoʻomaikaʻi iki i kou ʻala i loko o ka pule mua. Hiki ke hala kekahi mau pule a i ʻole hoʻokahi a ʻelua paha mahina no nā hōʻailona ʻē aʻe, e like me ka ihu paʻa, e emi ai.
He mea nui loa: Mai ho'ōki i ka lawe ʻana iā Dupixent a i ʻole kekahi lāʻau lapaʻau ʻē aʻe no kēia maʻi me ka ʻole o ke kamaʻilio ʻana me kāu kauka, ʻoiai inā ua hoʻomaikaʻi nui ʻia kāu mau hōʻailona. ʻO ka hana ʻana pēlā e hoʻi hou mai ai kāu mau hōʻailona.
Nā hopena ʻaoʻao a me nā pilikia me nā lāʻau lapaʻau ʻē aʻe
ʻO ka hopena ʻaoʻao maʻamau o Dupixent ka hopena ʻili ma kahi i hoʻokomo ʻia ai . Hiki i kēia ke komo pū me ka ʻulaʻula, ka ʻeha, ka pehu ʻana, a i ʻole ka palapū ma kahi i hāʻawi ʻia ai ka inikini. ʻO ke ala maikaʻi loa e pale aku ai i kēia, ʻo ia ke hoʻololi i nā wahi inikini. Eia kekahi, e pale i ka inikini ʻana i loko o ka ʻili i haki, palapū, a i ʻole i ʻeha.
ʻAʻole kēia nā hopena ʻaoʻao āpau. Inā loaʻa iā ʻoe kekahi mau hōʻailona e hoʻopilikia nei iā ʻoe, e kamaʻilio me kāu kauka e pili ana iā lākou.
Nā lāʻau lapaʻau a me nā lāʻau pale ʻē aʻe
- Nā lāʻau lapaʻau ʻē aʻe: Ma mua o kou hoʻomaka ʻana iā Dupixent, he mea nui loa ia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei (ʻoi aku ka lāʻau lapaʻau hānō), nā huaora, a me nā lāʻau lapaʻau lāʻau.
- Nā lāʻau pale: ʻAʻole pono e hāʻawi ʻia kekahi mau "lāʻau pale ola" i ka wā e lawe ana iā Dupixent. No laila, inā e loaʻa koke ana iā ʻoe kekahi mau lāʻau pale, e haʻi i kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau.
Aia kekahi mau noʻonoʻo kūikawā i ka wā e lawe ai iā Dupixent?
ʻAʻole ʻo Dupixent kahi lāʻau lapaʻau hiki ke loaʻa maʻalahi ma kahi hale kūʻai lāʻau maʻamau. Ua hoʻokaʻawale ʻia ʻo ia he "lāʻau lapaʻau kūikawā." ʻO ke ʻano kēia, hiki ke loaʻa wale mai kekahi mau haukapila nui a i ʻole nā hale kūʻai lāʻau lapaʻau kūikawā.
Hiki ke pipiʻi loa kēia lāʻau lapaʻau. No laila, he mea nui loa e kamaʻilio me kāu kauka e pili ana i kēia ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a e hoʻomaopopo pono ʻia e pili ana i ke kumukūʻai a me nā ʻano o ka loaʻa ʻana ma ko mākou ʻāina.
Leka Lawe-Home
- He lāʻau lapaʻau hou ʻo Dupixent no ka rhinosinusitis mau loa a me ka sinusitis (CRSwNP). Hoʻohana pinepine ʻia ia no ka poʻe me nā hōʻailona koʻikoʻi i kāohi ʻole ʻia e nā lāʻau lapaʻau ʻē aʻe (nā pīpī ihu, nā pila, ke ʻoki kino).
- Hana kēia ma ke kāohi ʻana i nā hōʻailona o ka ʻōnaehana pale e hoʻoulu ai i ka mumū, e hōʻemi ana i ka pehu ʻana i ka ihu a me nā sinuses.
- He inikini kēia i hoʻokomo ʻia ma lalo o ka ʻili i kēlā me kēia ʻelua pule. He mea nui e aʻo mua pehea e inikini pololei ai mai ke kauka a kahu maʻi paha.
- Mai hoʻōki i ka mālama ʻana no kekahi kumu me ka ʻole o ke aʻo ʻana a kāu kauka. ʻO ka hana ʻana pēlā e hoʻi hou mai ai nā hōʻailona.
- He mea nui loa e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, nā wikamina, a me nā lāʻau pale āu e lawe nei.
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