No ke aha i kapa ʻia ai ka maʻi akepaʻa ʻo PBC i ʻoi aku ka maʻamau i nā wahine? (Primary Biliary Cholangitis - PBC)

Ua lohe paha ʻoe iā PBC, he maʻi akepaʻa? ʻAʻole paha ʻoe i kamaʻāina i ka inoa. Akā, ua ʻike anei ʻoe he ʻeiwa o kēlā me kēia ʻumi kānaka e loaʻa ana i kēia maʻi he wahine? He mea kupanaha maoli kēlā, ʻeā? No laila, no ke aha e like ai kēia maʻi me he mea lā e pili ana i nā wahine? He aha ke kumu o kēia? I kēia lā, e kamaʻilio maʻalahi mākou e pili ana iā ia, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.

E nānā mua kākou, he aha ka PBC?

ʻAe, he ʻano inoa ʻepekema kēia, akā he mea maʻalahi loa ka mea e hana ʻia. ʻO PBC, ʻo ia hoʻi ke kū nei no Primary Biliary Cholangitis, he maʻi ia e hele hewa ai ka ʻōnaehana pale o ko mākou kino a hoʻouka i ko mākou ake. Kāhea mākou i kēlā mau maʻi he mau maʻi autoimmune. E noʻonoʻo, ua like ka ʻōnaehana pale o ko mākou kino me kahi pūʻali koa e pale ana i kahi ʻāina. ʻO ke kuleana o kēia pūʻali koa ke kaua aku i nā germs a me nā virus e hele mai ana mai waho a hoʻopakele iā mākou mai nā maʻi. Akā i kekahi manawa hana hewa kēia pūʻali koa a hoʻomaka e hoʻouka i nā poʻe hala ʻole ma kona ʻāina ponoʻī. Hana ʻia kekahi mea like ma PBC. Hoʻouka kā mākou ʻōnaehana pale ponoʻī i nā ʻauwai bile liʻiliʻi i loko o ko mākou ake. ʻO kēia mau ʻauwai bile kahi ʻōnaehana koʻikoʻi loa o nā paipu e lawe ana i ka bile i hana ʻia e ke ake i nā ʻōpū. Ke hōʻino ʻia kēia mau ʻauwai, ʻaʻole kahe pono ka bile a hōʻiliʻili i loko o ke ake, e hōʻino mālie ana i ke ake.

No ke aha i hoʻopilikia nui ai kēia i nā wahine?

I kēia manawa, e nānā kākou i ka pane i ka nīnau nui loa a nā kānaka a pau. ʻAʻole i loaʻa i nā kānaka noiʻi kekahi kumu paʻa no kēia. Eia naʻe, manaʻoʻiʻo lākou he ʻekolu mau kumu nui e kōkua ana i ia mea.

1. Ka mana o nā hormones

ʻIke ʻoe, ʻokoʻa loa ke kino o nā wāhine mai ke kino o nā kāne. ʻO ke kumu nui o ia mea, ʻo ia nā hormones. ʻO ka mea nui, he kuleana koʻikoʻi ko ka hormone estrogen i kēlā me kēia pae o ke ola o ka wahine. E noʻonoʻo e pili ana i ia mea, me ke kaʻina hana menstrual o kēlā me kēia mahina, a ʻoi aku hoʻi me ka menopause, kahi e hana ʻia ma waena o nā makahiki 40-60, aia nā loli nui i nā pae o kēia hormone estrogen. Hoʻopilikia pololei kēia mau loli hormonal i ke ʻano o ka hana ʻana o nā cell o kā mākou ʻōnaehana pale. Hiki i ka hormone estrogen ke hoʻoulu nui i ka ʻōnaehana pale. ʻO ia hoʻi, hoʻāla i ka "pūʻali koa" a mākou i kamaʻilio ai ma mua. Ke hana ʻia kēia, piʻi ka pilikia o ka hoʻouka ʻana i kāna mau cell ponoʻī. Hiki iā mākou ke noʻonoʻo i kēia pilina ʻoiai ʻo PBC ka mea maʻamau i waena o nā wahine o kēia hui makahiki.

2. Nā bacteria i loko o nā ʻōpū

He mea hou paha kēia iā ʻoe. Noho nā triliona o nā bacteria maikaʻi a maikaʻi ʻole i loko o ko kākou ʻōpū. He mea nui loa kēia kaiāulu o nā bacteria no ko kākou olakino. Ua ʻike ʻia e ka noiʻi ʻana he ʻokoʻa nā ʻano bacteria o ka poʻe i loaʻa i kahi predisposition genetic i ka hoʻomohala ʻana i ka PBC i loko o ko lākou ʻōpū ma mua o nā mea ʻē aʻe. Loaʻa iā lākou nā pae kiʻekiʻe o kahi ʻano bacteria e pili pinepine ʻia me nā maʻi urinary tract (UTIs). No laila, hōʻike kēia e hiki i kekahi mau maʻi bacteria a me nā kaulike ʻole i loko o nā bacteria ʻōpū ke kōkua i ka hoʻomohala ʻana o PBC ma ka hoʻopilikia ʻana i ka ʻōnaehana pale.

3. Ka mana o nā genes a me ka hoʻoilina

"He maʻi hoʻoilina anei kēia?" e noʻonoʻo paha ʻoe. ʻAe, i kekahi ʻano, he kuleana ko nā genes.

• Ma waena o 1% a me 9% o ka poʻe me PBC he lālā ʻē aʻe ko lākou me ka maʻi.
• Inā loaʻa i kekahi o nā māhoe like ʻelua ka PBC, aia he 63% ka manawa e loaʻa pū kekahi i kekahi.

ʻOi aku ka mea nui ma mua o kēia mau mea a pau, ʻo ia ke komo ʻana o ka chromosome X. I ka ʻōlelo maʻalahi, loaʻa i nā wahine ʻelua chromosome X (XX), aʻo nā kāne hoʻokahi chromosome X a hoʻokahi chromosome Y (XY). Ua hōʻike ʻia e ka noiʻi ʻana ua nalowale kekahi chromosome X i nā wahine me PBC a i ʻole he mau loli i loko o ka chromosome X i loko o kekahi mau cell o ko lākou kino. Hiki i kēia mau loli ke hoʻopilikia i ka hana o nā genes i komo i loko o ka ʻōnaehana pale, e hoʻonui ana i ka pilikia o ka loaʻa ʻana o kēia maʻi autoimmune.

Hiki paha ke ola maikaʻi me PBC?

ʻAe loa! He maʻi ka PBC hiki ke hoʻomalu maikaʻi ʻia me ka mālama pono ʻana i nā lāʻau lapaʻau a me nā hoʻololi ʻana i ke ʻano o ka nohona. ʻO ka ʻike mua ʻia ʻana o ka maʻi, ʻo ka maʻalahi ka hoʻomalu ʻana i ka hōʻino ʻana i ke akepaʻa. ʻO ka mea nui loa i ka wā e noho ai me kēia maʻi, ʻo ia ka mālama ʻana i ka pilina mau me kāu kauka . He mea nui e lawe i ka lāʻau lapaʻau āna i kuhikuhi ai i ka manawa kūpono, e hele i nā keʻena lapaʻau i ka manawa kūpono. Eia kekahi, ma ka ʻai ʻana i ka meaʻai kaulike, ka pale loa ʻana i ka waiʻona, a me ke komo ʻana i ka hoʻoikaika kino kūpono e like me ka ʻōlelo a kāu kauka, hiki iā ʻoe ke ola i kahi ola olakino. I kēia manawa, aia nā lāʻau lapaʻau maikaʻi loa e hoʻomalu i nā hōʻailona o ka maʻi, e like me ka luhi nui a me ka ʻili ʻāʻī. No laila e kamaʻilio ākea me kāu kauka e pili ana i ia mea. PBC, Primary Biliary Cholangitis, Nā Maʻi Ake, Ola Kino Wahine, Nā Maʻi Autoimmune, Estrogen, Hormones, Genes, Maʻi Ake i nā Wahine Sinhala, akmawe leda