Puas muaj teeb meem nrog koj cov qe ntshav dawb? Cia peb kawm txog Histiocytosis hauv cov lus yooj yim!

Koj puas paub tias qee zaum qee hom hlwb hauv peb lub cev pib ua txawv me ntsis? Ib qho mob tsis tshua muaj hu ua Histiocytosis. Qhov no yuav zoo li ntshai me ntsis rau koj, tab sis tsis txhob txhawj. Cia peb tham txog nws yooj yim thiab hauv txoj kev uas ua rau muaj kev nkag siab.

Histiocytosis yog dab tsi? Hauv cov lus yooj yim ...

Koj lub cev muaj ib hom qe ntshav dawb hu ua histiocytes. Ntawm cov qe ntshav dawb ntawd, muaj ib hom qe tshwj xeeb hu ua histiocytes . Cov no zoo li peb lub cev cov neeg saib xyuas kev ruaj ntseg. Lawv yog cov uas tawm tsam cov kab mob ua rau muaj kab mob hu ua pathogens - cov kab mob , cov kab mob me me , thiab cov pwm - thiab pab kom peb lub cev tiv thaiv kab mob noj qab haus huv.

Txawm li cas los xij, qee zaum cov hlwb histiocyte no pib loj hlob tsis zoo, uas yog, lawv dhau los ua " hloov pauv " . Tom qab ntawd, cov hlwb histiocyte tsis zoo no loj hlob ntau dhau thiab sib sau ua ke hauv ntau qhov chaw ntawm peb lub cev. Thaum lawv sib sau ua ke ntau dhau, peb lub cev tiv thaiv kab mob tuaj yeem muaj teeb meem. Qhov tseem ceeb yog tias o , uas yog, ib qho mob zoo li o, tshwm sim hauv cov nqaij ntawm lub cev. Qhov o no qee zaum tuaj yeem ua rau peb cov kabmob puas tsuaj.

Cov hlwb histiocyte uas tsis zoo no tuaj yeem sib sau ua ke hauv koj cov qog ntshav (tseem hu ua cov qog ntshav), daim tawv nqaij, pob txha, ntsws, siab, po, lossis lwm qhov chaw hauv koj lub cev. Qee zaum nws tsuas cuam tshuam rau ib feem ntawm koj lub cev xwb. Peb hu qhov no ua 'ib lub cev' . Lwm lub sijhawm nws tuaj yeem cuam tshuam rau ntau qhov ntawm koj lub cev. Peb hu qhov no ua 'multisystem' .

Qhov tseem ceeb yog tias histiocytosis tsis yog mob qog noj ntshav . Txawm li cas los xij, qee zaum nws tuaj yeem ua zoo li mob qog noj ntshav thiab qhia cov tsos mob zoo ib yam li mob qog noj ntshav. Yog vim li cas nws thiaj li yog ib qho mob uas xav tau kev saib xyuas tshwj xeeb me ntsis. Vim tias cov tsos mob ntawm qhov no txawv ntawm ib tus neeg mus rau ib tus neeg thiab qhov hnyav ntawm tus mob txawv, qee zaum nws tuaj yeem nyuaj rau kev kuaj mob histiocytosis sai.

Cov hom histiocytosis tseem ceeb yog dab tsi?

Tam sim no tej zaum koj yuav nkag siab txog histiocytosis yog dab tsi. Muaj ntau tshaj 100 hom ntawm nws. Tab sis muaj peb hom tseem ceeb uas peb pom thiab tham txog feem ntau. Cia peb los saib lawv.

1. Langerhans cell histiocytosis (LCH):

• Qhov no yog hom histiocytosis feem ntau .
• Feem ntau tus mob no cuam tshuam rau cov menyuam yaus . Nws cuam tshuam rau ntawm 5 thiab 9 ntawm txhua lab tus menyuam.
• Feem ntau, qhov no tsis yog qhov mob hnyav heev, thiab tej zaum yuav yooj yim li "tsis muaj tsos mob" . Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qee zaum, qhov no tuaj yeem ua rau mob hnyav thiab txawm tias ua rau tuag taus.

2. Kab mob Erdheim-Chester (ECD):

• Hom no feem ntau cuam tshuam rau cov neeg laus .
• Qhov no kuj yog ib qho xwm txheej tsis tshua muaj .
• Ib yam li LCH, ECD tuaj yeem muaj txij li me me mus rau hnyav thiab muaj kev phom sij rau lub neej.

3. Kab mob Rosai-Dorfman (RDD):

• Ib yam li LCH, RDD feem ntau tshwm sim rau cov menyuam yaus , tab sis nws kuj tuaj yeem tshwm sim rau cov neeg laus.
• Qhov no kuj tsis tshua muaj. Muaj li ntawm ib tug ntawm ob puas txhiab tus neeg uas kuaj pom tias muaj tus kab mob no.
• Hom mob no yog 'classical RDD' . Qhov no yog thaum koj cov qog ntshav (o) o tuaj.
• Lwm hom yog 'extranodal RDD' . Hauv qhov no, cov kabmob uas tsis yog cov qog ntshav hauv lub cev raug cuam tshuam. Qhov no txhais tau hais tias cov hlwb histiocyte ntau dhau tuaj yeem sib sau ua ke hauv daim tawv nqaij, pob txha, lossis lwm qhov chaw.

Tus kab mob no hu ua Histiocytosis tsawg npaum li cas?

Yog lawm, zoo li kuv tau hais ua ntej lawm, histiocytosis yog ib yam kab mob tsis tshua muaj . Qhov tseeb, cov mob qog nqaij hlav uas hnyav dua thiab hnyav dua muaj tsawg dua 1% ntawm tag nrho cov mob qog nqaij hlav uas kuaj pom hauv cov nqaij mos thiab cov qog ntshav. Yog li koj tuaj yeem xav txog qhov no tsis tshua muaj.

Cov tsos mob ntawm Histiocytosis yog dab tsi?

Tam sim no cia peb saib seb cov tsos mob twg qhia tau hauv tus mob histiocytosis no. Cov tsos mob no tuaj yeem sib txawv ntawm ib tus neeg mus rau lwm tus . Qhov laj thawj rau qhov no yog tias cov kabmob thiab cov nqaij uas cov hlwb histiocyte ntau dhau sib sau ua ke, raws li kuv tau hais, thiab qhov kev puas tsuaj rau cov nqaij ntawd, cuam tshuam rau qhov no.

Nov yog qee cov tsos mob uas koj yuav pom (thiab tej zaum yuav muaj ntau dua):

• Cov pob khaus ntawm daim tawv nqaij : Cov no tuaj yeem pom tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam plaub hau ntawm lub taub hau ntawm cov menyuam yaus (peb hu ua 'cradle cap' ) lossis nyob rau hauv thaj chaw nappy.
• Ua npaws .
• Qaug zog, qaug zog .
• Mob taub hau.
• Hnoos los yog ua tsis taus pa .
• Kev poob phaus yam tsis paub meej .
• Mob pob txha .
• Cov qog ntshav o (qhov no yog qhov o txhais tau tias).
• Kev pom kev hloov pauv los yog qhov muag loj .
• Tso zis ntau zaus thiab nqhis dej ntau dhau .
• Cov pob tawv nqaij (tuaj yeem tshwm sim ntawm qhov muag).
• Nyuaj siab rau kev tsom ntsoov lossis nco qab tej yam .
• Teeb meem nrog kev sib npaug thiab kev sib koom tes .

Cov tsos mob tshwm sim li cas? Nyob ntawm seb cov histiocytes sib sau ua ke qhov twg!

Cov tsos mob no nyob ntawm seb cov hlwb histiocyte sib sau ua ke qhov twg hauv lub cev. Cov chaw tseem ceeb uas sib sau ua ke sib txawv nyob ntawm hom histiocytosis.

Cov chaw uas yuav cuam tshuam rau Langerhans cell histiocytosis (LCH):

• Pob txha
• Tawv nqaij
• Cov qog ntshav (o)
• Siab
• Mob qog
• Qhov ncauj
• Lub ntsws
• Lub paj hlwb nruab nrab (uas yog, lub hlwb thiab tus txha caj qaum)

Cov cheeb tsam uas yuav cuam tshuam rau tus kab mob Erdheim-Chester (ECD):

• Cov pob txha ntev (tshwj xeeb tshaj yog nyob rau hauv ob txhais ceg)
• Qhov muag
• Lub paj hlwb nruab nrab
• Lub ntsws
• Lub plawv
• Cov hlab ntsha
• Cov raum
• Cov kabmob nyob tom qab ntawm lub plab (peb hu lawv ua 'retroperitoneum' )

Cov cheeb tsam uas yuav raug cuam tshuam los ntawm tus kab mob Rosai-Dorfman (RDD):

• Cov qog ntshav (tshwj xeeb tshaj yog nyob rau hauv lub caj dab, tab sis kuj tuaj yeem tshwm sim rau lwm qhov)
• Tawv nqaij
• Cov ntaub mos mos
• Txoj hlab pa sab saud
• Pob txha
• Retroperitoneum (cov kabmob nyob tom qab ntawm lub plab)
• Qhov muag

Dab tsi ua rau muaj Histiocytosis?

Cov kws tshawb fawb tseem tsis tau paub meej tias yog dab tsi ua rau muaj histiocytosis, tab sis lawv tau pom tias nws yuav muaj feem cuam tshuam nrog kev hloov pauv caj ces .

Hais yooj yim xwb, txhua lub cell hauv peb lub cev muaj cov khoom siv caj ces, lossis ib pawg lus qhia. Cov lus qhia no txiav txim siab seb cov cell ntawd yuav tsum ua li cas. Yog li, thaum muaj kev hloov pauv hauv cov lus qhia no, hu ua kev hloov pauv, tshwm sim, cov cell pib ua tsis zoo. Piv txwv li, kev hloov pauv caj ces tuaj yeem ua rau lub cell zoo li histiocyte theej nws tus kheej thiab pib kis mus rau lwm qhov tsis tuaj yeem tswj tau.

Kev txheeb xyuas cov kev hloov pauv caj ces no tau tso cai rau cov kws tshawb fawb los tsim cov kev kho mob tshiab rau histiocytosis. Cov kev kho mob no ua haujlwm los ntawm kev tiv thaiv cov kev hloov pauv cellular uas ua rau cov hlwb histiocyte loj hlob tawm ntawm kev tswj hwm.

Yuav kuaj mob histiocytosis li cas?

Yog koj xav tias koj muaj mob histiocytosis, koj tus kws kho mob yuav kuaj koj lub cev ua ntej thiab nug txog koj keeb kwm mob nkeeg. Tom qab ntawd, lawv yuav txiav txim siab seb yuav kuaj dab tsi raws li koj cov tsos mob thiab cov kab mob uas xav tias raug cuam tshuam los ntawm cov histiocytes ntau dhau.

Nov yog qee qhov kev ntsuam xyuas uas koj ua tau:

• Cov txheej txheem thaij duab :
• Koj tus kws kho mob yuav xaj kom ua ib qho kev ntsuas tshwj xeeb hu ua FDG PET/CT scan . Qhov no tuaj yeem nrhiav tau tej yam xws li qog nqaij hlav thoob plaws lub cev.
• Ntxiv rau , tej zaum yuav xav tau kev kuaj xws li CT scan, MRI scan, pob txha scan, ultrasound scan, X-ray, lossis echocardiogram (kev scan ntawm lub plawv).

• Kev kuaj hauv chaw kuaj mob :
• Koj tus kws kho mob yuav kuaj cov kua dej, xws li koj cov ntshav lossis zis, kom pom tias puas muaj cov cim qhia ntawm histiocytosis.
• Koj cov qe ntshav raug kuaj xyuas. Lawv kuj tseem nrhiav cov tshuaj hormones lossis cov protein tshwj xeeb uas qhia txog koj cov kab mob ua haujlwm li cas. Yog tias ib qho kab mob tsis ua haujlwm zoo, nws tuaj yeem qhia tau tias muaj ntau cov histiocytes hauv cov kab mob ntawd.

• Kev kuaj mob los ntawm kev siv koob txhaj tshuaj (Biopsy) :
• Qhov no ua yog tus kws kho mob coj cov qauv ntaub so ntswg thiab kuaj nws hauv qab lub tshuab microscope kom pom tias koj puas muaj histiocytosis.
• Nws kuj tseem nrhiav cov kev hloov pauv caj ces tshwj xeeb uas cuam tshuam nrog histiocytosis.
• Qee zaum, yog tias ua tsis tau qhov biopsy, cov khoom siv caj ces hauv koj cov ntshav tuaj yeem kuaj tau. Qhov no hu ua 'liquid biopsy' .

Cov kev kho mob rau Histiocytosis yog dab tsi?

Kev kho mob ntawm histiocytosis nyob ntawm ntau yam . Tshwj xeeb:

• Koj cov tsos mob hnyav npaum li cas .
• Txawm koj muaj ib qho mob lossis ntau qhov (cov no yog cov cheeb tsam ntawm cov nqaij tsis zoo).
• Cov 'qhov txhab' no nyob qhov twg ntawm lub cev ?
• Seb cov qog no puas yog mob qog noj ntshav los tsis yog .

Cov kws kho mob txiav txim siab txog kev kho mob raws li cov yam no. Nov yog qee txoj kev kho mob:

• Saib xyuas thiab tos : Yog tias koj cov histiocytosis tsis hnyav thiab koj tsis muaj cov tsos mob loj, koj tus kws kho mob yuav qhia koj kom saib xyuas koj tus mob.
• Kev phais mobYog tias cov hlwb histiocyte tsuas sib sau ua ke hauv ib feem ntawm lub cev xwb, ces yuav muaj kev phais kom tshem qhov ntawd tawm.
• Kev Kho Mob Hluav Taws Xob : Qhov no suav nrog kev siv lub tshuab los xa cov hluav taws xob muaj zog heev mus rau cov qhov txhab. Cov hluav taws xob no tua cov hlwb tsis zoo thiab qeeb qeeb kev loj hlob ntawm cov qog nqaij hlav. Qee zaum kev kho mob hluav taws xob kuj tseem tuaj yeem pab txo cov tsos mob.
• Kev kho mob qog nqaij hlav (tseem hu ua 'chemo') : Qhov no suav nrog kev xa cov tshuaj mus rau hauv koj cov ntshav kom rhuav tshem cov hlwb histiocyte uas tau kis thoob plaws koj lub cev. Cov kws kho mob tsuas yog pom zoo kom 'chemo' yog tias cov hlwb histiocyte tau kis thoob plaws koj lub cev.
• Cov tshuaj Corticosteroids : Cov tshuaj xws li prednisone poob rau hauv pawg no. Cov no tuaj yeem txo qhov o (o) uas nrog nrog histiocytosis. Cov tshuaj no tuaj yeem muab ib leeg lossis ua ke nrog lwm yam kev kho mob, xws li chemotherapy.
• Kev Kho Mob Tiv Thaiv Kab Mob : Qhov no ua haujlwm los ntawm kev txhawb nqa koj lub cev tiv thaiv kab mob, pab nws paub thiab rhuav tshem cov hlwb phem, xws li cov histiocytes tsis zoo.
• Kev kho mob rau lub hom phiaj : Qhov no yog kev kho mob tshwj xeeb. Kev kho mob no yog siv rau cov mob histiocytosis uas cuam tshuam nrog qee qhov kev hloov pauv caj ces.

Puas kho tau Histiocytosis kom zoo tag nrho?

Nws nyuaj rau hais tias 'yog' lossis 'tsis yog' rau qhov no, vim nws nyob ntawm qhov xwm txheej. Ntau tus neeg uas muaj histiocytosis mus rau qhov hu ua 'kev zam txim ntev.' Uas yog, lawv ploj mus yam tsis muaj tsos mob lossis cim ntawm tus kab mob.

Qee hom histiocytosis, tshwj xeeb tshaj yog thaum cov histiocytes tsuas nyob hauv ib qho chaw hauv lub cev, tuaj yeem kho tau tag nrho los ntawm kev phais . Koj tus kws kho mob yuav coj koj mus ntsib kws kho mob kom paub seb puas rov qab muaj dua.

Txawm li cas los xij, yog tias hom histiocytosis uas koj muaj tsis kho tau tag nrho, koj tus kws kho mob yuav pom zoo kom muaj txoj kev npaj kho mob uas tuaj yeem pab koj tswj hwm tus mob.

Qhov kev kwv yees rau tus mob no yog dab tsi?

Qhov kev kwv yees ntawm koj tus mob nyob ntawm ntau yam. Rau qee tus neeg, histiocytosis zoo dua ntawm nws tus kheej yam tsis muaj kev kho mob . Piv txwv li, kwv yees li 40% ntawm cov neeg uas muaj RDD zoo dua yam tsis muaj kev kho mob. Tsis tas li ntawd, thaum LCH tsuas cuam tshuam rau ib feem ntawm lub cev (peb hu nws 'localized LCH') , nws feem ntau zoo dua ntawm nws tus kheej.

Tab sis, hauv lwm qhov xwm txheej, histiocytosis xav tau kev kho mob hnyav thiab kev soj ntsuam zoo, ob qho tib si rau menyuam yaus thiab cov neeg laus.Hauv cov xwm txheej hnyav dua, histiocytosis tuaj yeem ua rau lub cev puas tsuaj thiab txawm tias muaj kev phom sij rau lub neej .

Yog li ntawd, nws yog qhov zoo tshaj plaws los nug koj tus kws kho mob txog qhov kev kwv yees tshwj xeeb rau koj qhov kev kuaj mob.

Puas tiv thaiv tau tus kab mob Histiocytosis? Yuav ua li cas thiaj txo tau qhov kev pheej hmoo?

Qhov tseeb, tsis muaj txoj hauv kev los tiv thaiv histiocytosis, tab sis kev kho mob tuaj yeem pab koj tswj koj cov tsos mob.

Tiam sis muaj ib qho. Kev tso tseg haus luam yeeb tuaj yeem txo koj txoj kev pheej hmoo ntawm kev mob LCH (Langerhans cell histiocytosis), uas yog mob qog nqaij hlav hauv lub ntsws. Kev tso tseg haus luam yeeb lossis tsis haus luam yeeb kuj tseem tuaj yeem txhim kho koj txoj kev teb rau kev kho mob. Yog tias koj xav tau kev pab tso tseg haus luam yeeb, nug koj tus kws kho mob txog cov kev pab cuam xa mus rau kev tso tseg haus luam yeeb.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Yog tias koj tau kuaj pom tias muaj histiocytosis, nws yog ib qho ib txwm muaj ntau cov lus nug hauv koj lub siab. Nws yog ib qho tseem ceeb uas yuav tsum tham nrog koj tus kws kho mob txog txhua yam no thiab nkag siab zoo txog koj tus mob. Nov yog qee cov lus nug uas koj tuaj yeem nug:

• Kuv muaj hom histiocytosis twg?
• Kuv puas yuav tsum tau kev kho mob?
• Koj pom zoo kom muaj kev kho mob twg?
• Tej yam tshwm sim sab nraud uas yuav tshwm sim thaum lub sijhawm kho mob?
• Tej zaum yuav muaj tej yam tshwm sim ntawm kev kho mob li cas?
• Puas kho tau kuv tus mob kom zoo tag nrho?

Cov Lus Xaus Kawg coj mus tsev

Hais yooj yim xwb, histiocytosis yog lub npe muab rau ib pawg ntawm cov kab mob ntshav tsis tshua muaj uas tshwm sim los ntawm kev tsim ntau dhau ntawm histiocytes, ib hom qe ntshav dawb, hauv cov nqaij. Qee qhov ntawm cov no tuaj yeem yooj yim heev, tsis ua rau muaj tsos mob, thaum lwm tus tuaj yeem hnyav txaus kom ua rau tuag taus .

Txhua tus neeg uas muaj histiocytosis muaj cov histiocytes ntau dhau hauv lawv cov nqaij, ua rau o (o). Txawm li cas los xij, cov tsos mob, kev kho mob, thiab qhov tshwm sim ntawm tus kab mob tuaj yeem sib txawv heev, txawm tias ntawm cov neeg uas muaj tib hom histiocytosis los xij .

Koj tus kws kho mob yog tus neeg zoo tshaj plaws los nkag siab txog koj qhov kev kuaj mob thiab cov xwm txheej tshwj xeeb uas nyob ib puag ncig nws. Yog li ntawd, kom nkag siab tag nrho koj qhov kev kuaj mob thiab txoj kev npaj kho mob, tsis txhob ntshai nug cov lus nug. Tham nrog koj tus kws kho mob txog txhua yam uas koj xav txog.

` Histiocytosis, Cov qe ntshav dawb, Histiocytes, Lub cev tiv thaiv kab mob, LCH, ECD, RDD, Cov tsos mob, Kev kho mob