Koj cov qe ntshav dawb puas qis txaus ntshai? Puas yog qhov ntawd agranulocytosis? Cia peb tham txog nws!

Koj puas mob txhua lub sijhawm? Koj puas xav tias koj lub cev tsis muaj zog thiab nkees txawm tias me ntsis xwb los xij? Qee zaum qhov no yuav yog vim koj lub cev tiv thaiv kab mob tsis zoo, uas yog cov qe ntshav dawb hu ua neutrophils . Niaj hnub no peb tab tom tham txog ib qho mob loj tab sis kho tau hu ua agranulocytosis . Tsis txhob txhawj, nws yog ib qho tseem ceeb uas yuav tsum paub txog qhov no.

Agranulocytosis yog dab tsi tiag?

Hais yooj yim xwb, Agranulocytosis yog ib yam mob uas ua rau tuag taus uas cov qe ntshav dawb hu ua neutrophils hauv peb lub cev poob qis heev. Koj puas paub tias cov qe ntshav dawb zoo li cov tub rog hauv peb lub cev tiv thaiv kab mob? Lawv yog cov uas tiv thaiv peb ntawm cov kab mob ua rau muaj kab mob. Thaum cov neutrophils no txo ​​qis, peb lub cev yuav yooj yim rau cov kab mob. Txawm tias cov kab mob uas feem ntau tsis ua rau peb raug mob ntau kuj tuaj yeem ua rau peb mob. Xav txog, yog tias ib pab tub rog tshwj xeeb hauv peb lub teb chaws cov tub rog ploj mus tam sim ntawd, txawm tias tus yeeb ncuab me me puas yuav tsis yog teeb meem loj? Qhov no zoo ib yam. Lub npe "agranulocytosis" los ntawm lo lus granulocytes . Granulocytes kuj yog ib hom qe ntshav dawb. Lawv muaj cov enzymes uas rhuav tshem cov kab mob. Muaj peb hom granulocytes: Neutrophils , Eosinophils, thiab Basophils . Neutrophils yog cov qe ntshav dawb ntau tshaj plaws hauv peb lub cev. Yog vim li cas cov kws kho mob thiaj li kuaj cov qib neutrophil los kuaj mob agranulocytosis. Qhov no qee zaum hu ua granulocytopenia .

Qhov txawv ntawm Neutropenia thiab Agranulocytosis yog dab tsi?

Ob qho tib si puav leej cuam tshuam nrog kev txo qis ntawm cov neutrophils. Txawm li cas los xij, agranulocytosis yog hom neutropenia hnyav tshaj plaws.

• Neutropenia yog ib qho mob uas tus lej ntawm neutrophils hauv cov ntshav qis dua li qub. Cov neeg uas muaj tsawg dua 1,500 neutrophils ib microliter (mL) ntawm cov ntshav raug hais tias muaj neutropenia.
• Agranulocytosis yog theem kawg, qhov txaus ntshai tshaj plaws, thaum cov lej neutrophil poob qis dua 100 ib microliter ntawm cov ntshav. Koj puas tau hnov? Qhov no yog hom neutropenia hnyav tshaj plaws.

Puas muaj hom agranulocytosis?

Yog, qhov no tuaj yeem los ua ob txoj hauv kev tseem ceeb: 1. Agranulocytosis uas tau txais los ntawm noob caj noob ces:Qhov no yog tshwm sim los ntawm kev mob caj ces. Uas yog, muaj teeb meem nrog cov noob caj ces uas pab peb lub cev tsim cov neutrophils. Qhov mob no cuam tshuam rau cov menyuam mos thiab cov menyuam yaus tshaj plaws. 2. Tau txais agranulocytosis: Qhov no tuaj yeem muaj ntau yam ua rau. Txawm li cas los xij, feem ntau ntawm lub sijhawm (kwv yees li 70% ntawm lub sijhawm!) nws yog tshwm sim los ntawm kev phiv ntawm qee cov tshuaj uas peb noj. Hom no feem ntau tshwm sim rau cov neeg laus.

Tus mob no feem ntau tshwm sim li cas?

Qhov no yeej yog ib qho mob uas tsis tshua muaj. Qhov nruab nrab, muaj li xya tus neeg ntawm txhua ib puas txhiab tus neeg muaj tus mob no txhua xyoo. Yog li ntawd, tsis txhob ntshai tsis tsim nyog, tab sis nws yog ib qho tseem ceeb uas yuav tsum paub txog.

Cov tsos mob ntawm Agranulocytosis yog dab tsi?

Hauv qhov no, cov tsos mob tseem ceeb yog muaj feem cuam tshuam nrog kev kis kab mob. Cov no tuaj yeem pib sai sai, lossis lawv tuaj yeem nce zuj zus mus raws sijhawm. Saib seb cov tsos mob no puas zoo li koj paub:

• Kub taub hau, txias thiab tshee hnyo.
• Lub plawv dhia thiab ua pa nrawm dua.
• Kev xav tias tsis muaj sia nyob thiab qaug zog heev.
• Mob caj pas (pharyngitis), gingival recession, cov pos hniav los ntshav .
• Mob hauv qhov ncauj thiab caj pas, ua rau nws nyuaj rau nqos zaub mov thiab haus dej.
• Ntshav siab qis tam sim ntawd (hypotension), kiv taub hau, tsaus muag, thiab tej zaum yuav tsis nco qab.

Yog tias koj muaj cov tsos mob zoo li no, tshwj xeeb tshaj yog tias lawv tshwm sim ntau zaus, koj yuav tsum nrhiav kev pab kho mob.

Vim li cas thiaj muaj agranulocytosis? Dab tsi yog cov ua rau muaj?

Qhov laj thawj tseem ceeb rau qhov no yog qhov txo qis ntawm cov qe ntshav dawb hu ua neutrophils hauv peb lub cev. Muaj ob qho laj thawj rau qhov no:

• Los yog peb lub cev tsis tsim cov neutrophils txaus kom ua haujlwm tau zoo.
• Txwv tsis pub, cov neutrophils hauv lub cev raug rhuav tshem, lossis lawv tuag ua ntej lub sijhawm.

Tam sim no cia peb saib seb yog vim li cas thiaj ua li no.

Cov kab mob agranulocytosis uas tau txais los ntawm noob caj noob ces

Hauv qhov no, muaj teeb meem nrog ib tug gene uas pab ua neutrophils. Qhov no yog ib qho mob uas muaj thaum yug los (congenital). Piv txwv li, yog tias peb coj Kostmann syndrome , lossis congenital agranulocytosis , ib qho mob tsis tshua muaj, cov menyuam mos feem ntau muaj kev kis kab mob, kub taub hau, o, thiab teeb meem pob txha.

Tau txais agranulocytosis

Tej zaum yuav muaj ntau yam ua rau qhov no. Cia peb saib seb lawv yog dab tsi:

• Qee cov tshuaj: Qhov no yog qhov ua rau feem ntau . Qee cov tshuaj tua kab mob , cov tshuaj tiv thaiv kev puas siab puas ntsws , thiab cov tshuaj thyroid tuaj yeem ua rau muaj qhov mob no.
• Cov kab mob autoimmune : Cov no yog cov kab mob uas lub cev tiv thaiv kab mob tawm tsam lub cev cov hlwb. Piv txwv li suav nrog lupus thiab rheumatoid arthritis .
• Cov kab mob pob txha thiab cov teeb meem pob txha tsis ua haujlwm: Piv txwv li , aplastic anemia . Cov pob txha yog qhov chaw uas peb cov qe ntshav raug tsim.
• Mob qog noj ntshav: Mob qog noj ntshav uas cuam tshuam rau cov pob txha, tshwj xeeb yog mob leukemia .
• Kev Kho Mob Cancer (Chemotherapy): Cov kev kho mob no tuaj yeem rhuav tshem cov hlwb noj qab haus huv thiab cov neutrophils.
• Kev raug tshuaj lom lossis tshuaj lom neeg: Kev raug tshuaj lom xws li txhuas lossis mercury mus sij hawm ntev.
• Cov kab mob: Cov kab mob hnyav xws li mob malaria , mob ntsws , thiab mob Rocky Mountain spotted fever .
• Kev Tsis Txaus ntawm Cov Khoom Noj Khoom Haus: Tsis txaus cov as-ham tseem ceeb xws li Vitamin B12 thiab Folate.

Leej twg muaj feem yuav mob no tshaj?

Cov poj niam muaj feem yuav mob no ntau dua li cov txiv neej. Tsis tas li ntawd, agranulocytosis tuaj yeem cuam tshuam rau txhua tus neeg txawm tias muaj hnub nyoog li cas los xij. Txawm li cas los xij, cov neeg hauv qab no muaj feem yuav mob:

• Cov neeg uas tab tom kho mob qog noj ntshav los ntawm kev siv tshuaj chemotherapy .
• Cov neeg uas muaj cov kab mob autoimmune xws li lupus thiab rheumatoid arthritis .
• Cov neeg noj qee yam tshuaj, xws li Clozapine (Clozaril®) , ib yam tshuaj tiv thaiv kev puas siab puas ntsws , Trimethoprim/sulfamethoxazole (Bactrim™) , thiab Methimazole (Tapazole®), ib yam tshuaj kho mob thyroid.

Cov teeb meem dab tsi uas tuaj yeem tshwm sim vim yog agranulocytosis?

Tus mob no tuaj yeem ua rau muaj kev kis kab mob ntau zaus lossis ntev mus (kev kis kab mob ntev).

Yog tias agranulocytosis tseem muaj ntau tshaj peb mus rau plaub lub lis piam, ces muaj 100% txoj hmoo ntawm kev kis tus kab mob.

Yog tias tsis kho, sepsis tuaj yeem ua rau muaj kev tiv thaiv kab mob hnyav, uas ua rau tuag taus hu ua sepsis. Sepsis yog ib qho kab mob hnyav uas kis thoob plaws lub cev. Cov neeg hnub nyoog tshaj 65 xyoo lossis cov neeg uas muaj teeb meem kev noj qab haus huv, xws li kab mob plawv, kab mob raum, lossis kab mob ntsws, muaj feem yuav muaj cov teeb meem no ntau dua.

Koj kuaj qhov no li cas?

Tus kws kho mob kuaj mob agranulocytosis li cas? Feem ntau lawv ua raws li cov kauj ruam no:

• Kev suav cov ntshav tag nrho (CBC) thiab qhov sib txawv: Qhov kev kuaj no saib cov hom hlwb sib txawv hauv koj cov ntshav, tshwj xeeb tshaj yog cov lej ntawm cov neutrophils. Cov lej neutrophil tag nrho (ANC) tsawg dua 100 ib microliter ntawm cov ntshav suav tias yog agranulocytosis. (Tus nqi ib txwm rau ib tus neeg noj qab haus huv yog ntau dua 1,500.)
• Kev kuaj mob pob txha thiab kev nqus cov ntshav: Qee zaum, qhov kev kuaj no yuav ua tau los saib seb koj cov pob txha tsim cov neutrophils li cas.
• Cov tsos mob thiab keeb kwm kho mob: Tus kws kho mob yuav nug koj txog koj cov tsos mob, cov tshuaj uas koj noj, cov kab mob tsis ntev los no, thiab txhua yam kev raug tshuaj lom neeg.
• Kev kuaj mob caj ces: Yog tias xav tias muaj mob caj ces, kev kuaj mob caj ces yuav ua tau los xyuas kom meej. Qhov no yuav suav nrog kev kuaj daim tawv nqaij lossis kev kuaj ntshav.

Cov kev kho mob rau qhov no yog dab tsi?

Qhov xov xwm zoo yog tias muaj kev kho rau qhov mob no, agranulocytosis. Kev kho mob nyob ntawm seb ua rau muaj li cas.

• Tsum Tsis Txhob Noj Tshuaj Uas Ua Rau Koj Mob: Yog tias muaj tshuaj uas ua rau koj mob, thawj qhov uas yuav tsum ua yog tsum tsis txhob noj tshuaj raws li koj tus kws kho mob hais. Tsis txhob tsum tsis txhob noj tshuaj yam tsis tau sab laj nrog kws kho mob.
• Tshuaj tua kab mob: Yog tias koj muaj kev kis kab mob, koj tus kws kho mob yuav sau ntawv kom siv tshuaj tua kab mob thiab lwm yam tshuaj kom txo cov tsos mob.
• Granulocyte colony-stimulating factor (G-CSF): Hom kev txhaj tshuaj no tuaj yeem muab tau los pab lub cev tsim cov neutrophils sai dua. Piv txwv li suav nrog cov tshuaj xws li Filgrastim (Neupogen®) , Pegfilgrastim (Neulasta®) , thiab Lenograstim (Granocyte®) .
• Cov Tshuaj Tiv Thaiv Kab Mob: Yog tias qhov mob yog los ntawm kev puas tsuaj ntawm lub cev tiv thaiv kab mob, cov tshuaj uas tiv thaiv lub cev tiv thaiv kab mob, xws li Prednisone, yuav raug sau tseg.
• Kev hloov pob txha: Yog tias lwm yam kev kho mob tsis ua tiav, koj yuav tsum tau hloov pob txha. Hauv qhov no, koj yuav tau txais pob txha los ntawm tus neeg pub dawb uas noj qab nyob zoo. Qhov no yuav pab koj lub cev tsim cov neutrophils noj qab nyob zoo dua.
• Tiv thaiv kev kis kab mob: Qhov no tseem ceeb heev. Cov neeg uas muaj tus mob no yuav tsum ceev faj heev kom tsis txhob kis kab mob.
• Ntxuav koj txhais tes kom huv si nrog xab npum.
• Tsis txhob mus rau qhov chaw uas muaj neeg coob coob li ntau tau.
• Hnav lub npog ntsej muag/lub npog ntsej muag thaum tawm mus sab nraud.
• Tham nrog koj tus kws kho mob txog lwm yam uas koj ua tau kom tsis txhob muaj mob.

Kuv yuav zoo sai npaum li cas tom qab kho tas?

Lub sijhawm rov zoo nyob ntawm seb ua rau koj cov neutrophil tsawg npaum li cas thiab qhov mob hnyav npaum li cas. Yog tias nws yog ib qho kev phiv los ntawm kev siv tshuaj, feem ntau nws yuav siv sijhawm ib lub lis piam mus rau peb lub lis piam rau koj cov neutrophil kom rov qab mus rau qhov qub tom qab koj tsum tsis noj tshuaj lawm.

Qhov no puas tiv thaiv tau?

Qee zaum, agranulocytosis tsis tuaj yeem tiv thaiv tau tag nrho. Txawm li cas los xij, yog tias koj noj tshuaj uas tuaj yeem txo koj cov neutrophils (piv txwv li, chemotherapy, qee cov tshuaj kho mob puas siab puas ntsws), nws yog ib qho tseem ceeb uas yuav tsum tham nrog koj tus kws kho mob thiab kuaj xyuas koj cov neutrophil tsis tu ncua. Yog tias koj tau txais chemotherapy rau mob qog noj ntshav, koj tus kws kho mob yuav pom zoo kom txhaj tshuaj G-CSF los pab ua kom cov neutrophil ntau ntxiv.

Yuav ua li cas rau ib tus neeg uas muaj agranulocytosis?

Txawm hais tias qhov no yog ib qho mob uas kho tau los xij, cov txiaj ntsig yuav txawv ntawm ib tus neeg mus rau ib tus neeg. Yog tias kho kom zoo, lossis yog tias tsis noj tshuaj uas txo cov neutrophils lawm, feem ntau qhov mob yuav zoo.

Txawm li cas los xij, yog tias tsis kho, kev kis kab mob hnyav thiab txawm tias tuag tau. Qhov ntev ntawm cov neutrophil suav tseem nyob rau theem txaus ntshai, qhov ntau dua ntawm kev pheej hmoo ntawm kev kis kab mob thiab teeb meem. Qhov no yog qhov tseeb tshwj xeeb rau cov neeg hnub nyoog tshaj 65 xyoo thiab cov neeg uas muaj mob nkeeg (xws li kab mob raum, kab mob plawv, lossis kab mob ntsws).

Thaum twg koj yuav tsum mus ntsib kws kho mob?

Agranulocytosis yog ib yam mob uas ua rau tuag taus. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau kuaj mob thiab kho tam sim ntawd. Mus ntsib kws kho mob tam sim ntawd yog tias koj muaj ib qho ntawm cov tsos mob no:

• Yog koj kis tau tus kab mob ntau zaus.
• Yog tias qhov kev kis kab mob siv sijhawm ntev los kho.
• Yog koj muaj cov tsos mob ntawm kev kis kab mob xws li kub taub hau, mob khaub thuas, lossis mob caj pas.

Yog tias koj muaj tus kab mob autoimmune lossis noj tshuaj uas ua rau koj cov neutrophils qis dua, tsis txhob hla koj qhov kev kuaj mob. Kev kuaj mob tsis tu ncua nrog koj tus kws kho mob tuaj yeem pab koj saib xyuas koj cov neutrophils thiab pab tiv thaiv kev kis kab mob.

Tej yam tseem ceeb tshaj plaws uas peb yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Zoo, yog li cia peb rov hais dua qee cov ntsiab lus tseem ceeb tshaj plaws los ntawm qhov peb tau tham txog:

• Agranulocytosis yog ib qho mob hnyav tab sis kho tau uas muaj cov qe ntshav dawb hu ua neutrophils txo qis heev.
• Yog koj muaj cov tsos mob xws li mob ntau zaus, kub taub hau, lossis mob caj pas, mus ntsib kws kho mob tam sim ntawd.
• Qhov no tuaj yeem tshwm sim los ntawm qee cov tshuaj, cov kab mob autoimmune, thiab kev kho mob qog noj ntshav.
• Kev kho mob yuav suav nrog kev tsum tsis txhob siv tshuaj uas ua rau mob, tshuaj tua kab mob, kev txhaj tshuaj G-CSF, thiab tej zaum yuav hloov pob txha.
• Kev tiv thaiv koj tus kheej kom tsis txhob muaj kab mob yog ib qho tseem ceeb heev. Koj tuaj yeem tiv thaiv koj tus kheej los ntawm kev ua tej yam yooj yim xws li ntxuav koj txhais tes ntau zaus thiab hnav lub npog ntsej muag thaum nyob rau pej xeem.
• Yog tias koj muaj kev pheej hmoo rau qhov no (piv txwv li, yog tias koj noj qee yam tshuaj), tsis txhob hla qhov kev teem caij mus ntsib kws kho mob.

Vam tias cov ntaub ntawv no yuav pab tau koj. Nyob zoo!