Koj tsis zoo siab? Koj puas nkees ntawm txhua yam? Peb hu qhov mob no ua kev nyuaj siab. Yog li, muaj ntau hom tshuaj uas tau muab los kho qhov mob hlwb no hu ua kev nyuaj siab. Hnub no peb yuav tham txog ib pawg tshuaj uas laus me ntsis thiab koj yuav tsum ceev faj heev thaum siv. Cov no hu ua MAOIs, uas sawv cev rau Monoamine Oxidase Inhibitors. Txawm hais tias lub npe no yuav zoo li nyuaj me ntsis, cia peb tham txog nws yooj yim.
Cov MAOIs no yog dab tsi tiag?
Hais yooj yim xwb, MAOIs yog ib hom tshuaj uas pab tswj cov tsos mob ntawm kev nyuaj siab. Cov no yog thawj cov tshuaj antidepressants uas tau pom hauv ntiaj teb . Txawm li cas los xij, cov kws kho mob tsis yooj yim sau cov tshuaj no rau hnub no. Qhov laj thawj rau qhov no yog tias koj yuav tsum ceev faj heev txog yam koj noj thiab haus thaum noj cov tshuaj no, thiab koj kuj yuav tsum tau ua tib zoo saib xyuas qee yam kev phiv thiab kev nyab xeeb.
Feem ntau, cov kws kho mob tsuas yog sau ntawv rau MAOIs ua qhov chaw kawg thaum lwm cov tshuaj antidepressants tshiab (xws li SSRIs) tsis tau txhim kho cov tsos mob.
Cov tshuaj twg koom nrog pawg no?
Nov yog qee hom MAOIs siv hauv ntiaj teb:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Selegiline (Emsam®)
- Tranylcypromine (Parnate®)
Cov npe no tej zaum koj yuav tsis paub, vim tias lawv tsis tshua siv hauv peb lub tebchaws. Tab sis nws yog ib qho zoo uas paub.
Cov mob twg kho tau nrog MAOIs?
Cov tshuaj no tau txais kev pom zoo rau ntau yam kab mob.
| Hom tshuaj | Feem ntau siv rau cov mob nkeeg |
|---|---|
| Isocarboxazid thiab Tranylcypromine | Kev Nyuaj Siab Loj |
| Phenelzine | Kev nyuaj siab uas tsis kam kho, kev ntshai ntshai, thiab kev ntxhov siab hauv zej zog |
| Selegiline | Ua ib qho kev kho mob ntxiv rau kev nyuaj siab loj thiab tus kab mob Parkinson. |
Kev siv "tsis yog daim ntawv lo" yog dab tsi?
Qee zaum, cov kws kho mob siv tshuaj rau ib yam mob uas tsis tau txais kev pom zoo los ntawm nom tswv. Qhov no hu ua kev siv "tsis suav nrog daim ntawv lo". Tsuas yog ua tau yog tias tus kws kho mob txoj kev paub thiab kev paub qhia tias nws yuav pab tau tus neeg mob. Piv txwv li, Selegiline qee zaum raug sau rau ADHD, thiab Tranylcypromine qee zaum raug sau rau kev ntxhov siab hauv zej zog.
Cov tshuaj no ua haujlwm li cas?
Qhov no yooj yim to taub heev. Xav txog tias muaj cov tub txib me me hauv peb lub hlwb. Peb hu lawv ua cov neurotransmitters . Serotonin, Norepinephrine, thiab Dopamine yog cov tub txib tseem ceeb uas tswj cov yam xws li kev zoo siab, kev pw tsaug zog, thiab kev nco qab hauv peb lub siab.
Tam sim no, muaj lwm yam enzyme hauv peb lub hlwb hu ua monoamine oxidase . Lub luag haujlwm ntawm cov enzyme no yog "ntxuav" cov neeg xa xov ntawd. Uas yog, rhuav tshem lawv thiab txo lawv cov theem.
Qhov uas MAOI ua yog nws ua rau cov enzyme uas ntxuav (Monoamine Oxidase) tsis ua haujlwm. Tom qab ntawd yuav ua li cas? Cov neeg xa xov zoo siab (xws li serotonin thiab dopamine) sib sau ua ke hauv lub hlwb es tsis raug rhuav tshem. Lawv cov theem nce ntxiv. Tom qab ntawd peb lub siab zoo dua thiab cov tsos mob ntawm kev nyuaj siab txo qis.
Lub sijhawm no, kuj muaj ib yam tshuaj hu ua Tyramine . Nws pab tswj cov ntshav siab hauv peb lub cev. Cov tshuaj MAOI kuj tseem tiv thaiv kev tawg ntawm Tyramine no. Qhov no yog qhov kev pheej hmoo loj tshaj plaws uas los nrog cov tshuaj no . Peb yuav tham txog nws tom qab.
Cov kev mob tshwm sim thiab kev pheej hmoo ntawm MAOIs yog dab tsi?
Muaj ntau yam kev phiv thiab kev pheej hmoo loj uas cuam tshuam nrog kev siv cov tshuaj no. Yog li ntawd, nws yog qhov txaus ntshai heev rau kev siv lawv yam tsis tau kev qhia los ntawm kws kho mob .
Cov kev mob tshwm sim feem ntau
- Kiv taub hau los yog lub taub hau me me (vim yog ntshav siab qis)
- Qhov ncauj qhuav (xerostomia)
- Xeev siab
- Kev o lossis cem quav
- Kev tsaug zog tsis taus
- Tsis tsaug zog
Kev pheej hmoo loj thiab teeb meem
1. Kab mob Serotonin
Qhov no yog qhov mob hnyav tshaj plaws thiab muaj peev xwm ua rau tuag taus. Nws tshwm sim thaum cov serotonin hauv lub cev siab dhau. Qhov kev pheej hmoo no yuav loj dua yog tias koj noj MAOIs nrog lwm yam tshuaj uas ua rau cov serotonin ntau ntxiv (piv txwv li, SSRIs, qee cov tshuaj tua kab mob). Yog vim li cas nws thiaj li tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj noj, txawm tias cov vitamins.
| Cov tsos mob ntawm serotonin syndrome | |
|---|---|
| Cov yam ntxwv dav dav | Tsis nyob twj ywm, xeev siab, ntuav, mob plab, qhov muag ntswj , tawm hws , tshee hnyo, cov leeg nqaij ntswj. |
| Cov tsos mob hnyav (yuav tsum tau mus pw hauv tsev kho mob tam sim ntawd) | Kev tsis meej pem, tachycardia, ntshav siab, kub taub hau, qaug dab peg, tsis nco qab. |
Yog koj muaj cov tsos mob hnyav no, mus rau chav kho mob ceev (ETU) ze tshaj plaws tam sim ntawd . Kev ncua kev kho mob tuaj yeem ua rau tuag taus.
2. Teeb meem nrog zaub mov (kev sib cuam tshuam ntawm Tyramine)
Qhov no yog qhov teeb meem loj tshaj plaws nrog MAOIs. Raws li peb tau hais ua ntej, MAOIs tiv thaiv kev tawg ntawm cov tshuaj hu ua tyramine, uas pom muaj nyob rau hauv qee yam khoom noj.
Yog koj noj cov khoom noj uas muaj tyramine ntau thaum noj MAOI, qib tyramine hauv koj cov ntshav yuav nce siab heev. Qhov no tuaj yeem ua rau ntshav siab nce sai thiab hnyav . Qhov no hu ua "Tyramine Pressor Response." Hauv qee kis tsawg, qhov ntshav siab no tuaj yeem ua rau ntshav hauv lub hlwb (cerebral hemorrhage) thiab txawm tias tuag.
Koj yuav tsum tsis txhob noj cov khoom noj dab tsi thaum noj MAOIs?
Hauv qab no yog cov npe ntawm cov khoom noj uas ib tus neeg noj cov tshuaj no yuav tsum tsis txhob noj, vim lawv muaj cov tyramine ntau.
| Hom zaub mov | Kev piav qhia thiab piv txwv |
|---|---|
| Cov Cheese Laus | Cov cheese xws li Cheddar, Swiss, thiab Parmesan (cov cheese tshiab xws li Cottage cheese thiab Mozzarella tsis tshua muaj kev pheej hmoo). |
| Kua txob | Tag nrho cov khoom ua los ntawm taum pauv. |
| Nqaij/ntses uas tau fermented los yog khaws cia | Cov hnyuv ntxwm, salami, ntses qhuav, thiab lwm yam khoom. |
| Siab | Txawm hais tias daim siab tshiab tsis muaj tyramine, cov theem tyramine yuav nce ntxiv vim nws lwj sai. |
| Txiv hmab txiv ntoo siav heev | Thaum cov txiv hmab txiv ntoo xws li txiv tsawb, txiv avocados, thiab txiv figs siav tag. |
| Cawv fermented | Tshwj xeeb tshaj yog npias kais. |
Qhov tseem ceeb tshaj plaws: Thaum cov khoom noj laus zuj zus, nws cov tyramine nce ntxiv. Yog li ntawd, ib tus neeg uas noj cov tshuaj no yuav tsum tsis txhob noj cov khoom seem thiab noj cov khoom noj uas nyuam qhuav ua tiav .
3. Kev Tsis Siv Tshuaj Tiv Thaiv Kev Nyuaj Siab
Qhov mob no yuav tshwm sim tau yog tias koj tsum tsis txhob noj cov tshuaj no tam sim ntawd tom qab noj nws ntau tshaj 6 lub lis piam. Cov tsos mob xws li kub taub hau, mob lub cev, mob taub hau, kiv taub hau, pw tsis tsaug zog, thiab tsis so. Yog li ntawd, tsis txhob tsum tsis txhob noj cov tshuaj no yam tsis tau sab laj nrog koj tus kws kho mob . Yog tias koj tsum tsis txhob noj cov tshuaj, koj yuav tsum ua li ntawd maj mam li ob peb lub lis piam thiab tsuas yog nyob rau hauv kev saib xyuas ntawm koj tus kws kho mob.
4. Kev xav tua tus kheej
Muaj kev pheej hmoo me me ntawm kev xav tua tus kheej thaum cov tub ntxhais hluas hnub nyoog qis dua 25 xyoo pib noj cov tshuaj no. Yog tias koj lossis koj tus menyuam muaj cov kev xav no, tham nrog tus kws kho mob uas tau sau tshuaj rau lawv tam sim ntawd.
Thaum twg koj yuav tsum mus ntsib kws kho mob?
Yog koj noj tshuaj MAOI, koj yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom paub seb cov tshuaj puas ua haujlwm thiab puas muaj teeb meem dab tsi. Tsis tas li ntawd, nrog koj tus kws kho mob tham txog tej yam no thiab.
- Yog tias koj ntsib cov kev mob tshwm sim uas koj tsis tuaj yeem zam tau.
- Yog tias koj cov tsos mob tsis zoo dua, lossis yog tias lawv hnyav zuj zus.
- Yog koj xav tias koj yuav tsum tsis txhob noj tshuaj ntxiv lawm.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- MAOIs yog ib pawg tshuaj antidepressants uas muaj zog heev thiab txaus ntshai uas tsis tshua siv niaj hnub no.
- Yog koj noj cov tshuaj no, yuav tsum tau tswj kev noj zaub mov kom zoo . Yuav tsum tsis txhob noj cov khoom noj uas muaj tyramine ntau.
- Nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog lwm yam tshuaj uas koj noj, txwv tsis pub koj yuav muaj tus kab mob serotonin syndrome txaus ntshai.
- Tsis txhob pib lossis tsum noj cov tshuaj no yam tsis tau kev qhia los ntawm kws kho mob rau txhua qhov laj thawj.
- Yog tias koj muaj cov tsos mob hnyav ntawm serotonin syndrome lossis xav tua tus kheej, mus rau chav kho mob ceev hauv tsev kho mob (ETU) tam sim ntawd.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus