We dɔktɔ dɛn kɔnfirm se yu ɔ pɔsin we de nia yu gɛt bɔdi kansa, i nɔ kin izi fɔ tɔk bɔt di fred ɛn wɔri we yu de fil. Na di sem tɛm, we dɔktɔ dɛn de tɔk bɔt difrɛn tɛst ɛn tritmɛnt dɛn , i kin at fɔ ɔndastand dɛn wɔd dɛn de. Wan tɛst we yu go yɛri bɔku tɛm na di IHC tɛst. Pan ɔl we di nem kin tan lɛk se i kɔmplikt smɔl, nɔ fred . Dis na wan impɔtant tɛst wae de ɛp yu dɔktɔ fɔ pik di bɛst tritmɛnt fɔ yu kansa. Tide, wi go tɔk bɔt dis insay wan rili simpul we, insay wan we we yu go ɔndastand.
Wetin na di IHC tɛst simpul wan?
Fɔ tɔk am simpul wan, IHC (Immunohistochemistry) na spɛshal tɛst we de sho di rayt we aw yu kansa sɛl dɛn tan. Nɔto ɔl di bɔdi kansa na di sem. Sɔm kansa dɛn kin yuz ɔmon dɛn na wi bɔdi fɔ gro. Ɔda wan dɛn de dipen pan ɔda prɔtin dɛn fɔ mek dɛn gro. So we yu dɔn no gud gud wan wetin de ɛp yu kansa fɔ gro, yu dɔktɔ kin tɔch dɛn tin dɛn de ɛn trit dɛn.
Di IHC tɛst men wan de luk fɔ tu tin dɛn:
1. di כmon rεsεpכta dεm : Wi bכdi de prodyuz כmon dεm we dεn kכl εstrojen εn prכjεstεron. sכm brεst kεnsar sεl dεm gεt spεshal ples dεm na dεn sεf we dεn kכl rεsεpכta dεm usay dεn כmon dεm ya kin atak. We dɛn ɔmon dɛn ya atak, di kansa sɛl dɛn kin gɛt sayn fɔ mek dɛn gro. if yu kansa sεl dεm gεt dεn כmon rεsεpכta dεm ya, dεn kכl am "hכmon rεsεpכta-positiv."
2. HER2 protin: `(HER2)` na כda protin we de εp fכ kכntro di sεl dεm we de gro. כltu, sכm brεst kεnsar sεl dεm de prodyuz tu mכch pan dis `HER2` protin. dis dεn kכl am "HER2-positiv". Dis na rizin bak we mek di kansa de gro kwik kwik wan.
Di men gol fɔ dis tɛst na fɔ no ustɛm di tin dɛn we de "fid" yu kansa, dat na wetin de mek i gro. Dɔn, wi kin gi yu mɛrɛsin we go stɔp da "fidin."
Aw dɛn kin du dis IHC tɛst?
Dis tɛst nid fɔ tek sampul pan yu kansa sɛl dɛn . Dɛn kin gɛt dis frɔm wan pat pan di tisu we dɛn tek we dɛn de du bayɔpsi fɔ kɔnfirm se kansa de ɔ we dɛn de du ɔpreshɔn fɔ pul di kansa.
Dɔn dɛn kin sɛn dis pat pan di tisu na di lɛbɔraytri, dat na, na di lɛb. Na de, sɔntin we rili intrestin kin apin:
- Di prɔfɛshɔnal dɛm na di lab go ad spɛshal kemikal to yu kansa sɛl sɛmpul. dis de yuz wan kayn protin we dεn mek spεshal wan na di lab. dεn kכl dεn tin ya ``antibodi''.
- dεn `(antibodi dεm)` dεm dεn mek dεn fכ כnli atak to `(Estrogen)`, `( Progesterone )` כ `(HER2)` rεsεpכta dεm. Jɔs lɛk kihol we fit ki.
- If yu kansa sel dεm gεt dεn rεsεpכta dεm ya, dεn antibodi dεm go go εn stik to dεm.
- Dɔn we dɛn ad ɔda kemikal to dis, di sɛl dɛn we gɛt antibodi dɛn we dɔn atak di bɔdi kin chenj di kɔlɔ .
- Patɔlɔjis , ɔ histɔlɔjis, kin luk di tisu ɔnda maykroskɔp ɛn kɔnt if ɛni sɛl de we dɔn chenj kɔlɔ ɛn ɔmɔs de.
dis na aw yu kin fכnכt εksakכt if yu kεnsar na `HER2-positiv`, `hכmon rεsεptכr-positiv`, כ `bכt-nεgεtiv`.
Aw yu ɔndastand wetin de na di tɛst ripɔt?
We yu gɛt yu IHC tɛst ripɔt, i kin mek yu fred smɔl fɔ si di nɔmba ɛn wɔd dɛn we de pan am. Bɔt di tin we impɔtant pas ɔl na fɔ sidɔm wit yu dɔktɔ ɛn tɔk klia wan bɔt ɔltin we de na di ripɔt . Na dis na aw dɛn kin ripɔt di rizɔlt dɛn:
HER2 rizulyt
`HER2` rizulyt dεn kin gi am as nכmba.
| Rizɔlt | Minin |
|---|---|
| 0 ɔ 1+ | Dis min se yu kansa na HER2-negative . dis min se di kεnsar sεl dεm nכ gεt HER2 rεsεpכta dεm כ dεn gεt rili lכw lεvεl dεm pan dεm. |
| 2+ | Dis na "borderline" ɔ indeterminate kɔndishɔn. i nכ posbul fכ se fכ sכri if di tכmכro na HER2-positiv כ nεgεtiv. If na so i bi, di dɔktɔ kin tɛl yu fɔ du tɛst we go mek yu no mɔ, we dɛn kɔl FISH tɛst (Fluorescence In Situ Hybridization). |
| 3+ | Dis min se yu kansa gɛt HER2-positiv . dis min se di kεnsar sεl dεm gεt tu mכch HER2 rεsεpכta dεm. |
Hכmon Risεptor (ER/PR) Rizult
Dɛn kin ripɔt dɛn rizɔlt ya difrɛn we dɛn:
- as pasεnshכn (0% - 100%): di pasεnshכn fכ 100 kεnsar sεl dεm we gεt כmon rεsεpכta dεm.
- wan nכmba frכm 0 to 3: 0 min se nכ rεsεpכta dεm nכ de. 1, 2, εn 3 de sho se lכw, mεdiכm, εn hכy rεsεpכta dεm, rispεktivli.
- wan "Allred score" (0-8): di hכy dis skכ, di nכmba fכ di rεsεpכta dεm εn dεn klia.
- "Pozitiv" ɔ "Nɛgitiv": "Pozitiv" min se rεsεpכta dεm de. ivin if na sכm 1% pan di rεsεpכta dεm, dεn stil kכnsida am as "Positiv." So, i impɔtant fɔ no di pasɛnt ɔ di mak.
Sɔntɛnde, di tin dɛn we kin apin kin rɔng. If yu gɛt ɛni dawt, nɔ ɛva shek fɔ aks yu dɔktɔ fɔ mek ɔda ``pathologist`` ɛgzamin di ripɔt bak ɔ fɔ ripit di tɛst.
Aw di IHC rizɔlt kin afɛkt yu tritmɛnt?
Dis na di pat we impɔtant pas ɔl. Yu ɔnkɔlɔjis go disayd di bɛst tritmɛnt plan fɔ yu bay di rizɔlt fɔ di IHC tɛst.
| Di kayn kansa (bays pan di IHC rizɔlt) . | Tritmɛnt dɛn we go gri wit am |
|---|---|
| HER2-pɔzitiv | tεrapi we dεn tכk bכt, we de tכk bכt di HER2 protin, de rili ifektiv fכ dis kayn. |
| HER2-nɛgitiv | Dis kayn kin gro sloslo pas HER2-positiv kansa. HER2-targeted drugs nɔ de wok fɔ dis kayn. So yu dɔktɔ kin pik ɔda tritmɛnt dɛn lɛk kemotɛrapi ɔ ɔmon tɛrapi. |
| Hכmon rεsεptכr-pכzitiv (ER+ εn/כ PR+) . | Ɔmon tritmɛnt kin rili ɛp fɔ dis kayn kansa. Dɛn drɔgs ya kin mek di lɛvɛl we di ɛstrojen de na di bɔdi go dɔŋ ɔ i kin mek di kansa sɛl dɛn nɔ gɛt ɛstrojen. |
| Hכmon rεsεptכr-nεgεtiv | Dɛn kansa ya kin gro kwik kwik wan. Ɔmon tritmɛnt nɔ kin afɛkt dis. So, dɛn nid ɔda tritmɛnt dɛn lɛk kemotɛrapi. |
| Tripul-pɔzitiv | Dis min se ɔl tri pan dɛn tin ya na pɔsitiv: `(Estrogen), `(Progesterone), ɛn `HER2.` Dɛn kin gi dɛn pipul ya ɔl tu di ɔmon tɛrapi ɛn HER2-targeted therapy. |
| Tripul-nɛgitiv | Dis min se ɔl di tri tin dɛn nɔ fayn. Bɔku tɛm, dɛn tin ya kin gro kwik kwik wan. Bikɔs ɔmon ɔ HER2-targeted therapies nɔ de wok fɔ dis, dɛn kin yuz tin dɛn lɛk ɔpreshɔn, kemotɛrapi, ɛn redyushɔn mɔ. |
Mɛsej we dɛn kin kɛr go na os
- Di IHC tɛst na wan tɛst we rili impɔtant we dɛn kin yuz fɔ plan fɔ trit brɔst kansa. Nɔ mek yu fred di nem.
- dis de mεntal fכ no if yu kεnsar de dipεnd pan כmon (ER/PR positifu) εn HER2 protin-dipεndεnt (HER2 positifu).
- Bay di rizɔlt fɔ dis tɛst, yu dɔktɔ go ebul fɔ pik di tritmɛnt we go wok fɔ yu, wit di smɔl sayd ɛfɛkt dɛn.
- We yu gɛt yu tɛst ripɔt, aks yu dɔktɔ fɔ ɛksplen ɔl di wɔd ɛn nɔmba dɛn we de insay so dat yu go ɔndastand am klia wan. Nɔ ɛva fred fɔ aks kwɛstyɔn.
- If yu nɔ shɔ bɔt di rizɔlt, tɔk to yu dɔktɔ bɔt fɔ gɛt sɛkɔn opinion ɔ fɔ ripit di tɛst. I impɔtant fɔ mek yu tek pat tranga wan fɔ disayd bɔt yu wɛlbɔdi biznɛs.
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