Yu kin taya bak fɔ di wan ol de we yu gɛt maygren? Di pen we de fil lɛk se yu ed de split, yu nɔ ebul fɔ luk di layt, yu de fil nɔs... Tin dɛn lɛk dis de mek ɔl di tin dɛn we yu de du ɛvride at, nɔto so? Fɔ sɔm pipul dɛn, dis kin apin wan ɔ tu tɛm insay di mɔnt, fɔ ɔda pipul dɛn, i kin kam bɔku tɛm insay di wik ɛn mek dɛn layf nɔ fayn. So, fɔ di wan dɛn we de sɔfa wit maygren lɛk dis bɔku tɛm, naw wan nyu we de fɔ trit pipul dɛn we rili wok. Tide wi de tɔk bɔt wan spɛshal klas fɔ drɔgs we dɛn kɔl CGRP Inhibitors.
Fɔ tɔk am simpul wan, wetin na dɛn CGRP Inhibitors ya?
Dis na mɛrɛsin dɛn we dɔktɔ kin gi pɔsin. Dɛn kin yuz dɛn mɔ fɔ mɛn maygren ed we de at. If yu gɛt maygren we nɔ de dɔn ɔ maygren we de apin ɔltɛm, dis mɛrɛsin kin fayn fɔ yu.
Fɔ tɔk am simpul wan, dɛn tin ya na wan patikyula kayn mɛrɛsin we dɛn mek fɔ kɔntrol maygren. Nɔ lɛk di ol mɛrɛsin dɛm, dɛn wan ya kin wok bay we dɛn kin tɔch di prɔses we kin mek pɔsin gɛt maygren dairekt wan.
Aw dis mɛrɛsin de wok insay wi bɔdi?
Fɔ ɔndastand dis, wi fɔs nid fɔ no wetin na CGRP.
CGRP na shɔt fɔ Calcitonin Gene-Related Peptide . Na prɔtin we de insay wi bɔdi bay wilful. nכmal wan, dis CGRP protin de du sכmtin fכ wi. Fɔ ɛgzampul, i de ɛp fɔ kɔntrol blɔd prɛshɔn bay we i de mek wi blɔd vesel dɛn big (vasodilation).
Bɔt pipul dɛn we gɛt maygren kin mek mɔ pan dis CGRP protin pas aw i nid. dis CGRP we pasmak de mek di pen nεv dεm na di bren, we de mek di pen signal dεm wכs. Dis kin mek bak de pen kin te.
wetin CGRP inhibito dεm de du na fכ stכp da prכsεs de bifo i apin. Di wɔd ‘inhibit’ min ‘stɔp’ ɔ ‘inhibit’. Dat min se dɛn mɛrɛsin ya kin stɔp di tin we kin mek pɔsin fil pen na maygren.
Tu men kayn CGRP inhibito dεm de:
Dɛn kin sheb dɛn mɛrɛsin ya to tu men kayn dɛn bay aw dɛn de wok. Yu dɔktɔ go ɛksplen dɛn tin ya to yu mɔ.
| Tayp fɔ mɛrɛsin | Aw i de wok & Ɛgzampul dɛn |
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| 1. CGRP Mɔnoklɔnal Antibɔdi dɛn (moAbs) . | Dɛn tin ya tan lɛk spɛshal ‘difɛns rɔbɔt’ dɛn we dɛn mek na lɛbɔtri. jכs lεk aw wi imyun sistεm de fכt di jεm dεm, dεn ‘rכbכt' dεm ya de luk fכ di CGRP protin dεm we pasmak na di bכdi, kech dεm, εn pwεl dεm. Aw fɔ gi:
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| 2. CGRP Risεptor Antagonist (Gepants) . | I tan lɛk gem we dɛn kin ple wit myuzik chia dɛn. bifo di CGRP protin kin sidon pan di risεptor dεm na di nεv dεm, dis dכg de go εn grap dεn chia dεm de. Bikɔs di chia dɛn ful-ɔp, ples nɔ de fɔ di CGRP fɔ sidɔm. So dɛn nɔ de mek ɛni sayn fɔ mek pɔsin fil pen. Aw fɔ gi:
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Uswan pan dɛn tu kayn tin ya bɛtɛ fɔ mi?
Dat na yu dɔktɔ fɔ disayd. I go gi yu di mɛrɛsin we bɛtɛ fɔ yu bay aw yu gɛt maygren, aw i izi fɔ yu (pill ɔ injɛkshɔn ɛvride ɔ ɛvri mɔnt), ɛn yu ɔl wɛlbɔdi.
Wetin na di men bɛnifit dɛn we dis mɛrɛsin de gi?
CGRP inhibitors na di fɔs klas ɔf drɔgs we dɛn mek spɛshal fɔ kɔntrol maygren, ɛn di rizɔlt dɛn dɔn rili saksesful.
- Di frɛkuɛns we maygren kin gɛt kin go dɔŋ.
- Ivin if maygren apin, di kayn pen ɛn ɔda sayn dɛm go shɔt.
- Di tɛm we maygren kin tek kin shɔt.
- Sɔm maygren atak dɛn kin avɔyd ɔltogɛda .
Dis kin mek yu gɛt bɔku fridɔm fɔ du yu wok dɛn we yu de du ɛvride, wok, ɛn lan buk ɛn nɔ gɛt ɛnitin fɔ ambɔg yu.
Ɛni bad bad tin dɛn de we kin apin to am?
Jɔs lɛk ɛni ɔda mɛrɛsin, sɔm sayd ɛfɛkt dɛn kin apin, bɔt bɔku tɛm dɛn tin ya kin apin smɔl smɔl.
| Kɔmɔn smɔl smɔl sayd ɛfɛkt dɛn | Rare bɔt kɔndishɔn dɛn fɔ wach fɔ |
|---|---|
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Di tin we impɔtant pas ɔl: If yu gɛt ɛni wan pan dɛn sayd ɛfɛkt ya ɔ yu gɛt sɔm kayn sayn dɛn we nɔ kɔmɔn, tɛl yu dɔktɔ wantɛm wantɛm. | |
Aw kwik a go ebul fɔ ɛkspɛkt fɔ gɛt rizɔlt?
Dis nɔto sɔntin we go chenj wan nɛt. Bɔku tɛm yu go bigin fɔ notis fayn chenj afta wan ɔ tu mɔnt . Di spid we di rizɔlt dɛn kin gɛt kin dipen pan sɔm tin dɛn:
- Di kayn CGRP inhibitor mɛrɛsin we dɛn gi yu.
- Aw ɔltɛm yu kin gɛt maygren?
- Di kayn we aw yu maygren de tranga.
- Yu ɔl wɛlbɔdi biznɛs.
Nɔ wɔri. Yu dɔktɔ go ɛksplen dis to yu. Di impɔtant tin na fɔ peshɛnt ɛn kɔntinyu fɔ gɛt di tritmɛnt.
Maygren nɔto kol we kin go insay wan ɔ tu dez. Na sɔntin we de afɛkt yu wan ol layf. So wit wan mɔdan tritmɛnt lɛk dis, yu kin tek kɔntrol pan yu layf bak.
Mɛsej we dɛn kin kɛr go na os
- CGRP Inhibitors na wan mכdan εn hεli ifektiv tכp mεdikeshכn we dεn dεvεlכp spεshal fכ kכntrכl maygrεn.
- dis de blכk di akshכn fכ wan protin we dεn kכl CGRP, we de rispansabl fכ maygrεn pen.
- Dis tritmɛnt de difrɛn we dɛn, lɛk injɛkshɔn, pils, ɛn sprɛy na yu nos.
- Dis kin rili ridyus di frɛkuɛns ɛn di kayn we aw yu kin gɛt maygren, ɛn ɛp yu fɔ liv fayn layf.
- Bifo yu bigin ɛni tritmɛnt, tɔk to yu dɔktɔ bɔt di bɛnifit ɛn di bad tin dɛn we go apin to yu. Nɔ ɛva bigin ɔ stɔp fɔ tek ɛni mɛrɛsin we yu nɔ gɛt dɔktɔ advays.
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