Yu fil se yu gɛt bɔku bɔku rɛd blɔd sɛl dɛn? Lɛ wi tɔk bɔt ɛrythrocytosis!

Sɔntɛnde, yu kin jɔs fil taya, yu ed kin at, ɔ yu kin fil wik? Bɔku tɛm, wi nɔ kin pe atɛnshɔn tumɔs pan dɛn smɔl smɔl tin ya, nɔto so? Bɔt if di nɔmba fɔ di rɛd blɔd sɛl dɛn na yu bɔdi go ɔp pas di lɛvɛl we dɛn se, we na wetin dɔktɔ dɛn kin kɔl erythrocytosis ɔ polycythemia , dɛn sayn ya kin apin. Dis na sɔntin we yu fɔ wɔri bɔt smɔl sɔntɛnde. So, tide wi go tɔk ditayli bɔt wetin na erythrocytosis, wetin mek i kin apin, ɛn wetin dɛn kin du bɔt am.

Wetin rili na ɛrythrocytosis?

Fɔ tɔk am simpul wan, Erythrocytosis na we yu blɔd gɛt ay pas di nɔmal kɔnsɛntreshɔn pan Rɛd Blɔd Sɛl (Erythrocytes). As yu no, wi blɔd gɛt tu pat. Wan pan dɛn na di sɔlid pat, we na di rɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn, ɛn di pletlɛt dɛn. Di ɔda pat na di wata pat, we wi kɔl plasma. insay εrythrocytosis, di nכmba fכ di rεd bכdi sεl dεm de inkrεs we yu kɔmpia am to di likwid pat we na di plasma.

If yu du blɔd tɛst, yu go si tu valyu dɛn na di ripɔt: Ɛmatokrit ɛn Ɛmoglobin .

• Hematocrit (HCT): Dis de tɛl yu us pasɛnt pan yu blɔd na rɛd blɔd sɛl.
• Ɛmoglobin (HB): Dis na wan rili impɔtant prɔtin we de insay di rɛd blɔd sɛl dɛn we de kɛr ɔksijɛn ɔlsay na wi bɔdi.

insay εrythrocytosis, wan כ tu pan dεn hεmatokrit εn εmoglobin valyu dεm kin hכy pas nכmal.

Aw dis bɔku bɔku rɛd blɔd sɛl dɛn kin afɛkt di bɔdi?

Rɛd blɔd sɛl dɛn impɔtant fɔ wi bɔdi. dεn kin kכri כksijεn frכm di lכng dεm to εvri sεl εn tisu dεm na di bכdi. Dis na di rizin we mek wi tisu dɛn gɛt tin fɔ it ɛn gɛt wɛlbɔdi.

Bɔt if dɛn rɛd blɔd sɛl ya bɔku pasmak, prɔblɛm kin apin. I dipen pan di rizin we mek di rɛd blɔd sɛl dɛn de bɔku. Sɔm ifɛkt dɛn kin rili smɔl. Yu kin jɔs fil tin dɛn lɛk ed we de at ɛn taya. Bɔt if di rɛd blɔd sɛl dɛn bɔku fɔ sɔm siriɔs rizin dɛn, di blɔd kin bigin fɔ tik. Dɔn, risk kin de fɔ gɛt tin dɛn we de mek yu gɛt prɔblɛm lɛk we blɔd kin klɔt, at atak ɔ strok .

Na dat mek, if yu gɛt dɛn kayn sik ya, i rili impɔtant fɔ go to dɔktɔ fɔ no di rayt tin we kin mek yu gɛt dis sik. Na da tɛm de nɔmɔ yu go gɛt di rayt tritmɛnt, ridyus di sayn dɛm, ɔr fɔ mek yu nɔr gɛt prɔblɛm wit denja.

Wetin na di men kayn εrythrocytosis?

di εrythrocytosis kin sheb to tu tכp dεm dipכnt pan di we aw dεn rεd sεl dεm ya de inkrεs:

1. Absolute Erythrocytosis: Dis na we di nכmba fכ di rεd bכdi sεl dεm we de prodyuz na yu bכdi rili hכy pas nכmal.

. Fɔ ɛgzampul, if yu vɔmit bɔku ɛn yu gɛt dayarɛa ɛn yu nɔ gɛt bɔku wata na yu bɔdi, di wata we de kɔmɔt na yu blɔd go go dɔŋ. Dis kכndyushכn kin apun lεk dεn tεm ya.

Absolut Erythrocytosis dεn divayd am bak to tu tכp dεm, dipכnt pan di kכz:

Praymari Ɛritrosaytɔsis

Di prɔblɛm de na wi bon mɛro. As yu no, di bon mכro na di men faktri na wi bכdi we de mek rεd bכdi sεl dεm. so, insay dis praymar εrythrocytosis, bikoz fכ wan jεnεtik difεkt na di stεm sεl dεm (projenitor sεl dεm) na di bon mכro, di prodakshכn fכ rεd bכdi sεl dεm de inkrεs we dεn nכ de kכntro. Dis jεnεtik difεkt kin kכmכt frכm am (as bכn difεkt), כ i kin apin bak we i de liv.

• Acquired Primary Erythrocytosis: Wan gud ɛgzampul fɔ dis na wan sik we dɛn kɔl Polycythemia Vera . Bɔrku pipul kin kɔnfyus Erythrocytosis ɛn Polycythemia Vera as di sem sik. Bɔt, dɛn nɔto di sem. Polycythemia Vera na wan spεsifi k εn rili siriכs kכndyushכn we de mek Erythrocytosis.
• Inherited Primary Erythrocytosis: sכmtεm, difεkt dεm na di jin dεm we dεn gεt frכm di mama εn papa kin mek di bon mכro prodyuz tu mכch rεd sεl dεm.

Sɛkɔndari Ɛritrosaytɔsis

di prכblεm ya nכ de na di bon mכro, bכt na כda tin we de ausayd di bon mכro. Bɔku tɛm, sɛkɔndari ɛrythrocytosis kin kam bikɔs wi bɔdi de mek tumɔs pan wan ɔmon we dɛn kɔl erythropoietin , ɔ EPO . `EPO` na kemikal mɛsenja. na wetin de tεl di bon mכro fכ "mek mכr rεd sεl dεm."

Imajin, yu gɛt lɔng sik ɔ at sik. Dɔn di ɔksijɛn we di bɔdi de gɛt nɔ kin bɔku. da tεm de, di bכdi de tray fכ mek mכr pan di כmon `EPO`, εn tru am, i de mek di bon mכro fכ mek mכr rεd sεl dεm. Na bikɔs rɛd sɛl dɛn kin kɛr ɔksijɛn. כltu, if di prodyushכn fכ rεd sεl dεm dis we de inkrεs tu mכch, i de mek sεkכnd εrythrocytosis. dis sεkכnd εrythrocytosis kin kכz bak fכ sכm jεnεtik kכndishכn dεm, bכt dεn jεnεtik dεfεkt dεm de nכto di wan dεm na di bon mכro.

Aw yu kin chɛk di blɔd valyu fɔ si if yu gɛt ɛrythrocytosis?

Infakt, di lɛvɛl we di rɛd blɔd sɛl dɛn we dɛn kin tek as nɔmal kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Bɔku tin dɛn kin afɛkt dis, lɛk yu ej, ilɛksɛf yu na man ɔ uman, ɛn di ayt we di eria usay yu de (ilɛksɛf yu de na di si ɔ yu de na say we gɛt mawnten dɛn).

di εrythrocytosis insay big pipul dεn kin no bay we di εmatokriyt (HCT) εn/כ εmoglobin (HB) de inkrεs. yu kin mכsu dεn valyu dεm ya wit bכdi tεst we dεn kכl ``Kכmplit Blכd Kכnt (CBC)``.

Fɔ man dɛn:

• Ɛmatokrit (HCT): If i pas 50% .
• Ɛmoglobin (HB): If i pas 17.5 g/dL

Fɔ uman dɛn we nɔ gɛt bɛlɛ:

• Ɛmatokrit (HCT): If i pas 45% .
• Ɛmoglobin (HB): If i pas 15.3 g/dL

Impɔtant: Dɛn valyu ya na jɔs wan jenɛral gayd. Yu dɔktɔ go no if yu gɛt ɛrythrocytosis afta i dɔn tink bɔt yu ɔl wɛlbɔdi.

Wetin na di tin dɛn we kin mek pɔsin gɛt Rilativ Ɛritrosaytɔsis?

dis kin bi we di wata we de na di bכdi de dכn, we de mek di bכdi we de fכm (plasma) dכn εn di kכnsantreshכn fכ di rεd bכdi sεl dεm de bכku. So, di men rizin fɔ dis na we yu nɔ gɛt wata na yu bɔdi .

• Fɔ vɔmit bad bad wan
• Rɔnbɛlɛ
• Sɔm mɛrɛsin dɛm, fɔ ɛgzampul, diuretics (mɛrɛsin dɛm we de pul wata na di bɔdi) (Dɛn kin gi dɛn tin ya fɔ mek yu blɔd prɛshɔn ɔ fɔ mek yu nɔ gɛt wata).

fכ dεn kayn rizin dεm ya, di כmכnt fכ wata na di bכdi kin dכn εn mek i gεt rilitiv εrythrocytosis.

Wetin na di tin dɛn we kin mek pɔsin gɛt Absolute Erythrocytosis?

Tu difrɛn tin dɛn de we kin mek dis apin: praymari ɛn sɛkɔndari.

Di tin dɛn we kin mek pɔsin gɛt praymari ɛrythrocytosis:

Bɔku tɛm dis kin apin bikɔs ɔf wan jenɛtik dɛfɛkt we kin afɛkt di bon mɛrɔ.

• Polycythemia Vera εn כda Myeloproliferative Neoplasm dεm: Dis na kכndyushכn dεm we di bon mכro de כva prodyuz rεd bכdi sεl dεm εn כda bכdi sεl dεm. Polycythemia Vera na di wan we kin bɔku pan dɛn tin ya.
• Bɔn pikin dɛn we nɔ fayn: Sɔm pipul dɛn kin bɔn wit wan tin we nɔ fayn na dɛn jɛnɛtiks we kin mek di bon mɛrɔ de mek bɔku bɔku rɛd blɔd sɛl dɛn.

Di tin dɛn we kin mek pɔsin gɛt sɛkɔndari ɛrythrocytosis:

dis kin kכz fכ di inkrεs pan di כmon `EPO`.

• di kכndishכn dεm we de ridyus כksijεn to di tisu dεm:
• Lכng sik (e.g. krεse brכnkitis, εmfysema) .
• At sik (e.g. di at pwɛl hat we dɛn bɔn wit) .
• Slip apnɛa fɔ slip
• εmoglobinopathy: Dis na tin dεm we di hεmoglobin protin we de insay di rεd bכdi sεl dεm nכ kin ebul fכ kכri כksijεn fayn fayn wan biכs fכ difεkt.
• Kidni sik ɛn transplant:
• di rεnal atεri stεnosis (di bכdi we de sכpכt di kidni dεm de sכmtεm sכmtεm) .
• Hydronephrosis (di kidni dɛn kin swel bikɔs ɔf di urine we kin gɛda) .
• Dis kכndyushכn kin apin sכmtεm ivin afta dεn transplant di kidni.
• Tumɔs: Sɔm tɔŋ dɛn we gɛt kansa ɛn we nɔ gɛt kansa kin mek di EPO ɔmon we pasmak.
• Kansa tכmכro dεm: Rεnal Sεl Karsinoma, Hεmangioblastoma, Epatosεlulyar Karsinoma, Paratayroyd Kansa.
• tכmכro dεm we nכ gεt kεnsar: Uterine Fibroids, Pheochromocytoma, Meningioma.
• Kabon monoksayd pɔyzin ɛn smok: If yu smok bɔku, dat kin mek yu gɛt kabon monoksayd pɔyzin, we kin mek di ɔksijɛn nɔ bɔku na di tisu dɛn.
• Sɔm mɛrɛsin ɛn mɛrɛsin dɛn:
• Anabolic Steroids (we atlet dɛn kin tek fɔ mek dɛn gɛt mɔ trɛnk) .
• Fɔ tek di ɔmon we dɛn kɔl tɛstostɛron.

Us sayn dɛm wae pɔrsin wae gɛt εrythrocytosis kin gɛt?

De sayn dɛm wae yu kin gɛt (ɛn aw dɛn kin tranga) kin dip pan de kɔz fɔ yu εrythrocytosis. Fɔ ɛgzampul, pɔrsin wae gɛt sɛkɔndari ɛrythrocytosis kin gɛt sɔm kayn sik lɛk:

• Ed de at
• Kɔnfyus, i nɔ kin izi fɔ yu fɔ pe atɛnshɔn
• I nɔ kin izi fɔ mek yu slip
• Fɔ fil wik, taya

Pɔsin we gɛt praymari ɛrythrocytosis (especially polycythemia vera) kin gɛt mɔ siriɔs sik dɛn:

• Ay Blɔd Prɛshɔn
• Fɔ swet pasmak na nɛt
• We yu de lɔs yu wet fɔ natin
• Bɔrku pen, swel, ɛn rɛd na di jɔyn dɛm (dɛn kin kɔl am bak gaut ) .
• Prɔblɛm fɔ blɔd (blɔd we de kɔmɔt na yu nos bɔku tɛm, blɔd ɔ brus frɔm ivin smɔl injury) .
• Skin we de it (it kin bɔku, mɔ afta yu dɔn was yu bɔdi ɔt) .
• Numbness in di limbs, wan filin lɛk ant de rɔn rawnd
• Rɛdnɛs wit inflamɛns na di fes, an, ɛn fut.

Aw dɔktɔ dɛn kin no if pɔsin gɛt ɛrythrocytosis?

Yu dɔktɔ go tray fɔs fɔ no wetin mek yu gɛt bɔku bɔku rɛd blɔd sɛl, ɛn i go yuz difrɛn tɛst ɛn we dɛn fɔ du tin.

Fɔs, dɛn go aks kwɛstyɔn bɔt yu mɛdikal istri, di mɛrɛsin dɛn we yu de tek, yu layf (e.g., yu de smok), ɛn yu simptom dɛm, ɛn chɛk fɔ rilitiv erythrocytosis (we kin kam bikɔs di plasma na di blɔd dɔn go dɔŋ). Dɛn go du wan ɛgzam bak fɔ dɛn bɔdi.

Di nɛks tin we yu fɔ chɛk na if yu gɛt praymari ɔ sɛkɔndari . Yu kin du sɔm ɔda tɛst dɛn bak wit di infɔmeshɔn we wi dɔn tɔk bɔt.

Us tɛst dɛn de du?

• Kɔmplit Blɔd Kɔnt (CBC): Dis kin chɛk yu rɛd blɔd sɛl, ɛmoglobin (HB), ɛn ɛmatokrit (HCT) lɛvɛl.
• Peripheral Blood Smear (PBS): Dis na fɔ tek wan drop pan blɔd ɛn luk di sɛl dɛn ɔnda maykroskɔp fɔ si if dɛn shep ɔ saiz nɔmal. If yu gɛt wan sik lɛk Polycythemia Vera, yu kin si abnɔmal sɛl dɛn.
• Kidni ɛn Liva Fɔnkshɔn Tɛst: Dis kin gi yu aidia fɔ no if kidni sik de ɔ tumor we de mek tumɔs EPO.
• Pulse Oximetry: Na smɔl sɛns we dɛn put na di finga de mɛzhɔ di ɔksijɛn lɛvɛl na di blɔd. Dis kin ɛp fɔ no if de sik kin kam wit tin dɛm lɛk at sik ɔr lɔng sik.
• fכ chεk di lεvεl fכ εrythropoietin (EPO): if di lεvεl fכ `EPO` lכw, i kin bi praymar εrythrocytosis, if di lεvεl fכ `EPO` hכy, i kin bi sεkכnd εrythrocytosis.
• Urinalysis: Dɛn kin tek urine sample fɔ chɛk fɔ si if i nɔ fayn. If rεd sεl dεm de na di urine, i kin bi fכ di kidni sik.

If di dɔktɔ tink se wan patikyula sik lɛk polycythemia vera, i kin du ɔda tɛst dɛn bak, lɛk fɔ tek bon mɛro bayɔpsi .

Aw dɛn kin trit ɛrythrocytosis?

Bɔrku tɛm, dɛn nɔ kin ebul fɔ wɛl di tin we kin mek pɔsin gɛt ɛrythrocytosis ɔltogɛda. Bɔt, tritmɛnt kin kɔntrol ɛn ridyus di sayn dɛm. If yu gɛt ɛrythrocytosis we gɛt siriɔs kɔz, dɛn kin yuz tritmɛnt bak fɔ mek yu nɔ gɛt prɔblɛm dɛn lɛk we blɔd nɔ de klɔt.

• Flebotomi ɔ Venesekshɔn: .

Dis na di tritmɛnt we dɛn kin yuz mɔ fɔ polycythemia vera. I tan lɛk fɔ gi blɔd, bɔt i min fɔ tek smɔl blɔd na wan vein ɛn ridyus di nɔmba fɔ di rɛd blɔd sɛl dɛn ɛn di blɔd volyum we tu bɔku. Bɔku tɛm, sɛkɔndari ɛrythrocytosis nɔ kin nid dis tritmɛnt.

• Di mɛrɛsin dɛn we dɛn kin yuz:
• Fɔ pipul dɛn we gɛt bɔku risk fɔ mek blɔd klɔt, dɔktɔ kin se dɛn fɔ tek aspirin we nɔ bɔku ɛvride.
• Mɛrɛsin dɛn de bak we de mek di rɛd blɔd sɛl nɔ bɔku:
• Haydroksikarbamid `(Haydroksikarbamid)`
• Haydroksiyuria `(Haydroksiyuria)`
• Busulfan we de na di wɔl
• Intεrfεron alfa `(Intεrfεron alfa)`
• Ruksolitinib we dɛn kin yuz

Yu dɔktɔ go gi yu mɛrɛsin dɛn we fit fɔ yu sik. Dɛn go gi yu tritmɛnt bak fɔ di ɔndalayn kɔndishɔn, i go dipen pan di ɔndalayn kɔz fɔ yu ɛrythrocytosis.

If a gɛt dis sik, wetin a fɔ ɛkspɛkt?

Di ɛkspiriɛns we yu go gɛt go dipen pan wetin mek yu gɛt di sik we de mek yu gɛt di sik ɛn aw i rili bad. fכ egzampl, sכm kכndyushכn dεm we dεn kin gεt we dεn kin gεt praymar εrythrocytosis kin kכz כnli sכm sכm sכmtεm dεm εn dεn nכ de mek yu layf de pan denja. Bɔt, mɔ siriɔs sik dɛn lɛk polycythemia vera, kin nid fɔ gɛt tritmɛnt fɔ ɔl dɛn layf.

Aw a kin kia fɔ misɛf?

Di tin we impɔtant pas ɔl na fɔ fala yu dɔktɔ in instrɔkshɔn dɛn di rayt we. Insay dis tɛm, sɔm chenj dɛn de we yu go chenj yu layf we go ɛp yu:

• If yu de smok, stɔp am.
• Mek yu gɛt wɛlbɔdi bɔdi wet.
• If yu gɛt ay blɔd prɛshɔn, kɔntrol am.
• Nɔ travul frɔm di si lɛvɛl to ples dɛn we rili ay (mawnt eria dɛn) as yu ebul.

Ustɛm a fɔ go na ɔspitul kwik kwik wan (ETU) ?

If yu gɛt wan sik we gɛt fɔ du wit ɛrythrocytosis we de put yu pan denja fɔ mek yu blɔd klɔt, i impɔtant fɔ no di sayn dɛn we de sho se yu blɔd dɔn klɔt. If yu gɛt ɛni wan pan dɛn sik ya, go to dɔktɔ wantɛm wantɛm:

• Dip Vein Thrombosis (DVT): Wan leg kin swel, pen, ɛn rɛd.
• Blɔd we de klɔt na di lכng (Pulmonary Embolism - PE): Chɛst de pen, i nɔ izi fɔ blo, i de fil diziz.
• Strɔk: Wantɛm we yu nɔ de balans, yu nɔ de wok togɛda, yu mɔsul dɛn de wik ɔ yu nɔ de fil fayn na wan say na di bɔdi.
• At Atak: Chɛst de pen, yu nɔ de blo fayn, yu de fil lɛk yu ed de tɔn, yu de swet.

If yu gɛt ɛni wan pan dɛn sayn ya, duya go to dɔktɔ wantɛm wantɛm ɛn nɔ de te.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Erythrocytosis na we di nɔmba fɔ di rɛd blɔd sɛl dɛn we de na yu blɔd go bɔku. Dis kin bi smɔl sik, ɔr sɔmtɛm kin bi sayn fɔ siriɔs sik.

• If yu gɛt ɛni ɔda sayn we nɔ kɔmɔn (espɛshali we yu taya ɔltɛm, ed we de at, yu skin de rɔsh, i nɔ izi fɔ blo), go to dɔktɔ.
• Di dɔktɔ go no di rayt tin we mek yu gɛt bɔku bɔku rɛd blɔd sɛl dɛn.
• Sɔmtɛm, simpul chenj na yu layf (e.g., fɔ ridyus di mɛrɛsin we yu de tek, fɔ trit di wata we yu nɔ gɛt wata) kin sɔlv dis prɔblɛm.
• If na wan sik we rili siriɔs, yu dɔktɔ go de wach yu ɔltɛm ɛn gi yu di tritmɛnt we yu nid.

Fɔ kia fɔ yu wɛlbɔdi rili impɔtant, so if yu gɛt ɛnitin fɔ wɔri bɔt, nɔ fred fɔ tɔk to dɔktɔ.

` Erythrocytosis, polycythemia, rεd bכdi sεl dεm, εmoglobin, εmatokrit, bכdi kכlכt, bon mכro