Yu gɛt bɔku bɔku pletlɛt dɛn na yu blɔd? Lɛ wi tɔk bɔt Essential Thrombocythemia!

Yu dɔn ɛva luk pan blɔd ripɔt ɛn notis se yu pletlɛt dɛn rili bɔku? Ɔ yu dɔn ɛkspiriɛns tin dɛn lɛk we blɔd kin klɔt na difrɛn say dɛn na yu bɔdi fɔ natin, ɔ jɔs blɔd? Sɔntɛm yu nɔ bin pe atɛnshɔn tumɔs pan dɛn tin ya. Bɔt i rili impɔtant fɔ no bɔt di rare kɔndishɔn we kin de biɛn dɛn tin ya, we wi go tɔk bɔt tide, we dɛn kɔl Essential Thrombocythemia.

Wetin na di Essential Thrombocythemia? Lɛ wi ɔndastand am simpul wan.

Fɔ tɔk am simpul wan, impɔtant trombosaytemia na wan sik we wi bon mɛro, we na di men faktri we de mek blɔd, de mek wan kayn blɔd sɛl we dɛn kɔl pletlɛt pas wetin dɛn nid. Naw yu kin de aks se, "Wetin na dɛn pletlɛt ya ?" Plɛtlɛt na di smɔl smɔl sɛl dɛn we de na wi blɔd. Dɛn tan lɛk smɔl sojaman dɛn. We wund de sɔmsay ɛn blɔd bigin fɔ kɔmɔt, na dɛn pletlɛt ya kin rɔsh go de, jɔyn togɛda, ɛn mek blɔd klɔt fɔ stɔp di blɔd. Imajin, wetin go apin if sɔntin nɔ rayt na di bon mɛro, di faktri we de mek pletlɛt, ɛn dɛn mek dɛn pletlɛt ya pasmak? Na da tɛm de di prɔblɛm bigin. Dis sik kin apin bikɔs sɔm pan di jin dɛn we de na wi bɔdi kin chenj, dat na di chenj dɛn we kin apin . Dis nɔto sɔntin we dɛn bɔn wit, bɔt na sɔntin we de divɛlɔp we pɔsin de liv. na dat mek dεn kכl am ``acquired genetic condition.'' כl di tεm, dεn kin fכnshכn di kכndyushכn insidεnt wan we dεn de du b כdi tεst f כ כda rizin. Sɔm pipul dɛn nɔ kin gɛt ɛni sayn atɔl. Dɔn bak, nɔto ɔlman go nid tritmɛnt wantɛm wantɛm. Pan ɔl we dɛn nɔ go ebul fɔ mɛn am ɔl, if dɛn gi am di rayt tritmɛnt, dat kin mek i nɔ gɛt siriɔs prɔblɛm dɛn bad bad wan.

Aw dis kin afɛkt mi bɔdi?

Naw yu ɔndastand wetin kin apin we di bon mɛro mek bɔku bɔku pletlɛt dɛn. Dɛn ɛkstra pletlɛt ya nɔ tan lɛk nɔmal pletlɛt dɛn, sɔm kin big pas di nɔmal wan ɛn dɛn gɛt difrɛn shep smɔl. I tan lɛk faktri we de mek wan batch fɔ guds we nɔ impɔtant. Dɛn abnɔmal, ɛkstra pletlɛt ya kin mek blɔd klɔt na di blɔd vesel dɛn. Dɛn blɔd klɔt ya kin mek blɔd nɔ de flɔ, lɛk we trafik jam na rod. Dɛn blɔd klɔt ya kin fɔm ɛnisay na di bɔdi. Bɔt dɛn kin si dɛn mɔ na di bren, an, ɛn leg.

Dis sik, mɔ fɔ mama dɛn we gɛt bɛlɛ , kin mek di blɔd klɔt mɔ ɛn mɔ .

Wan ɔda tin we kin mek wi sɔprayz na dat, sɔntɛnde dis sik kin mek pɔsin blɔd pasmak.Yu kin de tink se, "Blɔd klot na wetin kin apin, so aw di blɔd kin flɔ?" Di rizin na bikɔs we blɔd de klɔt tumɔs, ɔl di pletlɛt dɛn na di bɔdi kin yuz. Dɔn, nɔto inɔf pletlɛt dɛn de fɔ rili stɔp di blɔd if pɔsin wund. Si? Bikɔs ɔf dis, pipul dɛm wae gɛt impɔtant trombocythemia kin gɛt bɔrku risk fɔ gɛt siriɔs sik lɛk hat atak ɔr strok.

Na dis kansa? Yu tink se i gɛt fɔ du wit lukimiya?

Yɛs, impɔtant trombocythemia na wan kayn blɔd kansa. Dɔktɔ dɛn kɔl am mayloproliferative neoplasm. Fɔ tɔk am simpul wan, na tin we kin mek wan kayn blɔd sɛl (insay dis kes, di pletlɛt dɛn) de mek tumɔs. Bɔt i nɔto jɔs wan kayn blɔd kansa we dɛn kɔl lukimiya. Bɔt, na sɔm kayn tin wae nɔr kin bɔrku, dis sik kin kam to lukimiya pan sɔm pipul dɛm. Na dat mek dɔktɔ dɛn kin de wach am ɔltɛm.

Yu tink se impɔtant trombosaytemia ɛn trombosaytɔsis na di sem tin?

Dɛn tu nem ya fiba smɔl, so wi kin kɔnfyus. Bɔt difrɛns de bitwin dɛn tu.

• Essential Thrombocythemia: Na ya, di pletlet kכnt de inkrεs bikoz fכ prכblεm na di bon mכro insεf, nכto fכ eni כda sik.
• Riaktiv Thrombocytosis: Na ya, di pletlet kכnt de inkrεs as riakshɔn to כda mεdikal kכndyushכn (e.g., infεkshכn, ayron dεfisiεns , afta כpεrayshכn).

pan di tu, wan kכndyushכn we dεn kכl trombosaytosis de kכmכn pas di εsεnsial trombosaytεmia.

Udat kin gɛt dis sik?

Essential thrombocythemia na wan sik we nɔ kin apin so ɔltɛm. Statistikin na Amɛrika sho se i kin afɛkt lɛk tu pipul dɛn pan ɛvri 100,000 pipul dɛn. Uman dɛn kin gɛt am tu tɛm pas man dɛn. Dis sik kin afɛkt pipul dɛm wae ol bitwin 60 ɛn 80. Bɔt lɛk 20% pan di wan dɛm wae gɛt dis sik nɔr rich 40. I nɔr kin bɔrku fɔ mek pikin dɛn gɛt am. If dɛn du dat, i go mɔs bi se na frɔm dɛn mama ɛn papa dɛn gɛt am.

Wetin na di sayn dɛm fɔ dis? Aw yu no am?

Nɔto ɔlman gɛt di sem sayn dɛn. Sɔm pipul kin go fɔ lɔng lɔng tɛm ɛn nɔr kin gɛt ɛni sayn. Di sayn dɛn kin jɔs bigin fɔ sho we di pletlɛt dɛn de bɔku smɔl smɔl. Di men sayn dɛm na di wan dɛm wae kin kam wae blɔd kin rɔtin. Dɛn tin ya kin apin na say dɛn lɛk di bren, an, ɛn leg. Di sayn dɛm we kin apin bikɔs blɔd kin klɔt na:

• Ed we de at we nɔ de dɔn .
• Diziz we pɔsin kin gɛt .
• Fɔ fil fɔ bɔn ɔ fɔ de bit na di an ɛn di fut dɛn we de na di fut.
• An ɛn fut dɛn we nɔ gɛt bɛtɛ trɛnk ɔ we rɛd .
• Di chenj dɛn we de apin na di we aw dɛn de tɔk .
• Maygren we kin mek pɔsin gɛt .
• Di sik dɛn we kin mek pɔsin sik .
• Pen ɔ nɔ kin fil fayn na yu chɛst, yu an, yu bak, yu nɛk, yu jaw, ɔ yu bɛlɛ.
• Vɔmit .
• I nɔ izi fɔ blo (dyspnea).
• Chɛst pen .
• Wik .
• di splin we big - na כgan we de na di כp lεft say na di bכdi.
• Nɔs blɔd (epistaxis).
• Di blɔd we de kɔmɔt na di gɔm.
• Blɔd we de na di stɔl.
• Blɔd we de na di urine (hematuria).
• Brus izi wan.
• Uman dɛn kin gɛt ebi ebi mɔnt.

Aw dis kin afɛkt uman we gɛt bɛlɛ?

Risk de ɔltɛm fɔ mek blɔd klɔt na uman in bɔdi we i gɛt bɛlɛ. Dis risk kin ivin pasmak fɔ mama we gɛt bɛlɛ we gɛt impɔtant trombosaytemia. Dɔn bak, sɔm tritmɛnt fɔ dis sik nɔ fayn fɔ uman dɛn we gɛt bɛlɛ ɔ di wan dɛn we de plan fɔ gɛt bɛlɛ. So, if yu de sɔfa wit dis sik, i impɔtant fɔ tɔk bɔt dis wit yu dɔktɔ bifo yu tink bɔt fɔ bɔn pikin.

Nɔr fɔgɛt, dis sik kin mek yu gɛt at atak ɛn strok. If yu gɛt dis sik, yu fɔ kɔl 1990 wantɛm wantɛm if yu si sayn dɛm fɔ hat atak ɔr strok.

Wetin mek dis tin kin apin? Wetin na di rizin dɛn?

As wi bin dɔn tɔk, dis kin apin bay we di jin dɛn chenj (muteshɔn). dis nכto jin dεm we de de we dεn bכn am, bכt na jin dεm we de chenj we dεn de liv. spεshal wan, di mכtεshכn dεm na tri jin dεm we de afekt di stεm sεl dεm na wi bon mכro we de mek blכd sεl dεm na di men tin we de mek dεn kכz. Dɛn jin ya na:

• (JAK2) jin: Dis jin de kכd fכ wan protin we dεn kכl ``(JAK2)``. Dis protin de ɛp fɔ kɔntrol di we aw di blɔd sɛl dɛn de mek.
• (CALR) jin: dis jin de kכd fכ wan protin we dεn kכl ``calreticulin''. Risach pipul dɛn biliv se dis kin ɛp fɔ kɔntrol di sɛl dɛn we de gro, fɔ sheb, ɛn day.
• (MPL) Jin: dεn kכl dis jin bak ``כnkojin'', we na jin we de kכz kεnsar.

we dεn jin dεm ya chenj, di prכsεs fכ mek pletlet dεm na di bon mכro kin bi we dεn nכ kin kכntro εn i kin tu fast. I tan lɛk se aksilarayta nak yu! Na da tɛm de di bɔdi de mek bɔku pletlɛt dɛn pas aw i ebul fɔ bia.

Aw dɔktɔ dɛn kin no bɔt dis? (Diagnosis) .

If dɔktɔ tink se yu gɛt dis sik, dɛn go du fɔs fɔ chɛk yu bɔdi . Dɛn go aks bak bɔt yu sik ɛn if ɛnibɔdi na yu famili dɔn gɛt dis kayn prɔblɛm. Dɔn, dɛn kin du sɔm tɛst dɛn, lɛk:

• Kɔmplit Blɔd Kɔnt (CBC): Dis de chɛk di lɛvɛl we ɔl kayn sɛl dɛn de na yu blɔd, mɔ di nɔmba fɔ di pletlɛt dɛn.
• Peripheral Blood Smear: Dis na fɔ tek blɔd sɛmpul ɛn luk di pletlɛt dɛn ɔnda maykroskɔp fɔ si if dɛn nɔmal ɔ dɛn nɔmal in shep ɛn saiz. Di pletlɛt dɛn we nɔ de wok kin big ɛn dɛn kin gɛt difrɛn shep.
• Bon mכro tεst: sכmtεm dεn kin tek sכm sכm sכm bon mכro fכ tεst (Bכn Mכro Aspirashכn כ Bone Marrow Biopsy). Dis kin ɛp fɔ no di kayn we aw di bon mɛro de kɔrɛkt wan.
• jεnεtik tεst: dεn kin du dεn tεst ya fכ si if mכtεshכn de na di jin dεm we wi bin tכk bכt, lεk (JAK2), (CALR), εn (MPL).

Di rizɔlt fɔ dɛn tɛst ya go ɛp yu dɔktɔ fɔ no if yu gɛt prɔblɛm ɛn mek wan tritmɛnt plan. In jɛnɛral, di risk factor dɛm fɔ dis kɔndishɔn na:

• Bikɔs i dɔn pas 60 ia.
• Fɔ bi uman.
• Bikɔs i bin dɔn gɛt blɔd we bin dɔn klɔt bifo tɛm.
• di prεsεns fכ di jεnεtik mכtεshכn dεm we wi bin dכn tכk bכt na di bכdi.

Ɔlman nid mɛrɛsin fɔ dis? Wetin na di tritmɛnt dɛn?

Dis nɔto di sem tin fɔ ɔlman. Fɔ sɔm pipul dɛm, if dɛn nɔr gɛt ɛni sayn, dɔktɔ kin tɛl yu fɔ du wan tritmɛnt wae dɛn kɔl "watchful waiting." Dis min se yu fɔ wach fɔ di sayn ɛn sayn dɛm we de sho se yu de fil. Pipul wae gɛt sɔm kayn sik ɔr wae gɛt bɔrku risk fɔ gɛt blɔd klɔt go nid tritmɛnt. Di tritmɛnt na fɔ mek di blɔd nɔ klɔt ɛn/ɔ fɔ ridyus di pletlɛt lɛvɛl. Bɔku kayn mɛrɛsin dɛn de we dɛn kin yuz fɔ dis:

• Aspirin: Dis kin mek blɔd nɔ klɔt. Bɔt dɔktɔ dɛn kin tek tɛm fɔ gi aspirin to pipul dɛn we gɛt bɔku bɔku pletlɛt, bikɔs i kin mek pipul dɛn we gɛt wan sik we dɛn kɔl acquired Von Willebrand syndrome, blɔd bɔku.
• Hydroxyurea: Dis na mɛrɛsin fɔ kemotɛrapi. I de mek di pletlɛt lɛvɛl go dɔŋ. Dɛn kin gi am wit aspirin fɔ pipul dɛn we gɛt ay risk fɔ mek blɔd klɔt.
• Anagrelide: Lɛk haydroksiyuria, dis kin ɛp bak fɔ ridyus di pletlɛt lɛvɛl ɛn di risk fɔ gɛt at atak ɛn strok.
• Intɛrfɛrɔn alfa: .Dis na wan imyunotɛrapi. I de stɔp di abnɔmal pletlɛt dɛn fɔ sheb ɛn gro.
• Busulfan: Dis na mɛrɛsin bak we de mek pɔsin nɔ gɛt kansa. Dɛn kin gi am to pipul dɛm wae nɔr de ansa to haydroksiyuria ɔr wae nɔr kin ebul fɔ yuse am.
• Ruxolitinib: Dɛn kin yuse dis mɛrɛsin fɔ pipul dɛm wae nɔr dɔn tek ɔda mɛrɛsin ɛn wae gɛt sɔm sayn dɛm bak lɛk fɔ it, fil ful ivin afta dɛn it smɔl, ɛn taya pasmak.

Sɔntɛnde, if yu pletlɛt lɛvɛl go ɔp tumɔs wantɛm wantɛm, dɛn kin yuz wan tin we dɛn kɔl pletletfɛrɛsis . Insay dis, dɛn kin kɔnɛkt yu blɔd to wan spɛshal mashin, we kin pul sɔm pan di pletlɛt dɛn we pasmak.

Yu tink se we de fɔ mek dis nɔ apin?

Fɔ tru, nɔto so. Dis kin bi bikɔs ɔf di chenj dɛn we de apin na di jin, ɛn natin nɔ de we wi go du fɔ mek dɛn chenj dɛn de nɔ apin. Risach pipul dɛn stil nɔ dɔn no wetin mek dɛn jin ya kin chenj.

I pɔsibul fɔ liv nɔmal layf wit dis sik? Wetin na di layf we pɔsin kin liv?

Yu go mɔs ebul fɔ du am! Ivin if yu gɛt sɔm sayn dɛm, dɔktɔ kin trit yu fɔ mek yu nɔ gɛt siriɔs prɔblɛm lɛk at atak ɛn strok. So, i impɔtant fɔ mek yu nɔ fred ɛn tek tɛm fala wetin yu dɔktɔ tɛl yu fɔ du. We i kam pan di layf we pɔsin kin liv, dɛn kin se pipul dɛn we gɛt dis sik kin liv shɔt smɔl pas di wan dɛn we nɔ gɛt dis sik. Bɔt dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Bɔku tin dɛn lɛk aw yu de fil ɛn aw yu gɛt wɛlbɔdi, kin afɛkt dis. So, di bɛst we fɔ no bɔt dis na fɔ aks yu dɔktɔ.

Aw a kin kia fɔ misɛf? (Fɔ kia fɔ yusɛf) .

Pipul dɛm wae gɛt impɔtant trombocythemia kin gɛt bɔrku risk fɔ gɛt blɔd klot ɛn/ɔ abnɔmal blɔd. Bɔku tin dɛn de we yu kin du fɔ ridyus dis prɔblɛm:

• Nɔ smok kpatakpata: Pipul dɛn we de smok kin gɛt mɔ blɔd klɔt. If yu na pɔsin we de smok, aks fɔ ɛp fɔ lɛf fɔ smok.
• Mek yu gɛt wɛl bɔdi wet: Pipul dɛn we fat kin gɛt ay risk fɔ gɛt blɔd klɔt. Aks advays frɔm pɔsin we sabi bɔt it ɛn tek di we aw yu de it fayn.
• Ɛksesaiz ɔltɛm: We yu de du ɛksɛsayz, dat de mek yu nɔ gɛt bɔku blɔd.
• Kɔntrol ɔda sik dɛn we de mek yu gɛt mɔ blɔd klɔt: If yu gɛt tin dɛn lɛk dayabitis ɔ ay blɔd prɛshɔn, kɔntrol dɛn fayn fayn wan.
• Yu fɔ no bɔt yu ɔl yu wɛl bɔdi: Sɔmtɛm dis sik kin de wae yu nɔr gɛt ɛni sayn fɔ yu, so aks yu dɔktɔ us sayn dɛm fɔ luk fɔ.

Ustɛm a fɔ go to dɔktɔ? Ustɛm a fɔ go na di imejensi rum?

If yu gɛt dis sik, i rili impɔtant fɔ go fɔ chɛk-ap ɔltɛm. Dis go mek yu dɔktɔ ebul fɔ wach yu sik, chɛk yu pletlɛt lɛvɛl, ɛn mek ɛni chenj we nid fɔ chenj di tritmɛnt. Insay imejensi, dat min seIf yu si sayn dɛm fɔ hat atak ɔ strok, yu fɔ kɔl 911 wantɛm wantɛm ɛn go na ɔspitul. Di sayn dɛm fɔ hat atak kin bi:

• Chɛst de pen ɔ tayt (angina).
• I nɔ kin izi fɔ yu fɔ blo.
• Fɔ fil se yu de fil lɛk yu nɔs ɔ yu bɛlɛ de pwɛl.
• At bit kwik kwik wan (palpitations).
• Filin fɔ fil bad ɔ lɛk se sɔntin bad go apin.
• We pɔsin de swet.
• Diziz (vertigo), yu nɔ de si fayn, ɔ yu nɔ de no natin.

Uman dɛn kin gɛt difrɛn sayn dɛn:

• Taya pasmak ɛn nɔ ebul fɔ slip.
• I nɔ izi fɔ blo (dyspnea).
• Pen na di bak, sholda, nɛk, an, ɔ bɛlɛ.
• Fɔ vɔmit.

Di sayn dɛm fɔ strok kin bi:

• Wan say na di bɔdi (fes, an).
• I nɔ izi fɔ tɔk wantɛm wantɛm.
• I nɔ kin izi fɔ si na wan ɔ ɔl tu yay wantɛm wantɛm.
• Diziz bad bad wan, i nɔ kin izi fɔ waka, i nɔ kin balans igen.
• Wan bad bad ed we kin kam wantɛm wantɛm fɔ natin.

Us kwɛstyɔn dɛn yu fɔ aks di dɔktɔ?

Bikɔs essential thrombocythemia na sik wae nɔr kin bɔrku, yu kin gɛt bɔrku kwɛstyɔn bɔt am. We yu go to yu dɔktɔ, nɔ shem fɔ aks kwɛstyɔn dɛn lɛk dɛn wan ya:

• Wetin mek dis bin apin to mi?
• A nɔ gɛt ɛni simptom rayt naw. Ustɛm di sayn dɛn go sho?
• Wetin "watchful waiting" min?
• Us mɛrɛsin yu kin rɛkɔmɛnd fɔ mi?
• A go gɛt fɔ tek mɛrɛsin fɔ di res ɔf mi layf?

Mɛsej we dɛn kin kɛr go na os

Okay, so mek a tɛl yu dis fɔ ɛp yu fɔ mɛmba sɔm pan di impɔtant pɔynt dɛn frɔm wetin wi dɔn tɔk bɔt.

Essential Thrombocythemia na wan sik we nɔ kin apin so ɔltɛm, we kin mek di bon mɛro kin mek bɔku bɔku blɔd sɛl dɛn we dɛn kɔl pletlɛt. Dis kin mek di blɔd klɔt, at atak, ɛn strok.

Pan ɔl we dɛn nɔ go ebul fɔ mɛn am ɔl, if yu gɛt di rayt mɛrɛsin ɛn yu sɔpɔt yu, yu go ebul fɔ kɔntrol dis sik fayn fayn wan, nɔ gɛt bɔku prɔblɛm dɛn, ɛn liv nɔmal layf. So, if yu gɛt ɛni dawt bɔt dis, ɔ if yu gɛt sɔm kayn sayn dɛn we nɔ kɔmɔn, go to dɔktɔ wantɛm wantɛm. Nɔto yu wan de, ɛn dɔktɔ dɛn de fɔ ɛp yu pan dis waka. Essential Thrombocythemia, Plɛtlɛt, Blɔd Klɔt, Bɔn Mɛro, Blɔd Sik, Jɛnɛtik Muteshɔn, Kansa