Aw i kin sɔri fɔ si yu mama, papa, ɔ pɔsin we rili lɛk yu de fɔgɛt ɔltin smɔl smɔl? Alzaima sik, wae kin bigin wit fɔgɛt nem ɛn ples, ɛn nɔr kin mɛmba ivin smɔl smɔl tin dɛm, kin wɔs smɔl smɔl as tɛm de go. Naw, no mɛrɛsin nɔ de fɔ dis sik. Bɔt naw, wan nyu mɛrɛsin de we dɛn kɔl Leqembi (lecanemab) we kin mek di sik nɔ bɔku we i bigin. Lɛ wi tɔk bɔt dis simpul ɛn fayn tide.
Wetin dis drɔg we dɛn kɔl Leqembi kin rili du to di bren?
Fɔ tɔk am simpul wan, Leqembi kin ɛp pipul dɛm wae de bigin fɔ gɛt Alzaima fɔ du dɛn yone tin ɛn liv fɔ dɛnsɛf fɔ smɔl tɛm.
Tink bɔt di nɛv sɛl dɛn we de na wi bren lɛk se dɛn tan lɛk di strit dɛn na siti. Infɔmeshɔn ɛn mɛmori dɛn kin travul na dɛn strit dɛn ya. Insay Alzaima sik, wan kayn prɔtin we dɛn kɔl ‘amyloid beta’ kin gɛda ɛn kin kam lɛk bɔku bɔku dɔti na dɛn strit ya. Wi kin kɔl dis `amiloid beta pleks.' Dis bɔku bɔku dɔti de mek di infɔmeshɔn nɔ flɔ bitwin di nɛv sɛl dɛn. Na dat mek tin dɛn lɛk we pɔsin nɔ ebul fɔ mɛmba, we i nɔ ebul fɔ tink, ɛn we pɔsin kin kɔnfyus kin apin smɔl smɔl.
Leqembi in drɔg de du ɛksaktɔli dis bay we i de klin di bren bay we i de pul dɛn "amyloid beta plaques ." Dis kin ridyus di disrɔpshɔn fɔ di kɔmyunikeshɔn bitwin di bren sɛl dɛm, we kin mek di sik slo.
Di tin we impɔtant pas ɔl na dat dis mɛrɛsin nɔ go ebul fɔ mek pɔsin mɛmba bak we i dɔn lɔs. Bɔt i kin mek di sik slo ɛn mek di pɔsin liv fayn fɔ smɔl tɛm.
Aw fɔ gɛt dis tritmɛnt?
Dis nɔto pil we yu kin tek na os. Leqembi na likwid mεdisin we dεn kin gi insay wan vein (intravenous - IV infusion) . Dɛn kin gi dis tritmɛnt na ɔspitul ɔ klinik, ɔnda dɔktɔ in sɔpɔtishɔn.
- Di tɛm fɔ tritmɛnt: Dɛn kin gi dis mɛrɛsin ɛvri tu wik.
- Taym: Ɛni sɛshɔn kin tek lɛk wan awa so. Bɔt di wan ol apɔntinmɛnt kin tek lɔng tɛm bikɔs dɛn go de wach yu bifo ɛn afta dɛn gi yu di mɛrɛsin.
- Tɛst: Bifo yu bigin dis tritmɛnt, yu dɔktɔ go du MRI (Magnetic Resonance Imaging) skan fɔ chɛk fɔ si if amyloid beta plek dɛn de na yu bren. We dɛn de du di tritmɛnt, dɛn kin du MRI skan bak fɔ si if di mɛrɛsin de wok ɛn if i de afɛkt yu bren.
I rili impɔtant fɔ atɛnd di tritmɛnt sɛshɔn dɛn jɔs lɛk aw yu dɔktɔ dɔn sɛtul am. If yu skip dɛn, dat kin mek di mɛrɛsin nɔ wok fayn.
Udat dis mɛrɛsin bɛtɛ fɔ? Udat i nɔ fayn fɔ?
Leqembi nɔto drɔg we dɛn kin gi ɔl di wan dɛn we gɛt Alzaima. I kin spɛshal fɔ di wan dɛn we de na di fɔs stej fɔ di sik. Lɛ wi ɛksplen dis mɔ na di tebul we de dɔŋ ya.
| Pozishɔn | Tɔk bɔt |
|---|---|
| Di wan dɛn we fit fɔ di mɛrɛsin |
|
| Di wan dɛn we nɔ fayn fɔ di mɛrɛsin |
Di tin dɛn we kin mek pɔsin gɛt jenɛtik risk
sכm pipul dεn kin gεt wan jεnεtik risk fכktכ we dεn kכl di `homozygous apolipoprotein E gene.` Pipul dεm we gεt dis jin kin gεt inkrεs risk fכ gεt ARIA (dεn dεskrεb dεn dכn), we na wan siriכs sayd ifekt fכ di dכg. So, yu dɔktɔ kin disayd fɔ du jenɛtik tɛst bifo yu bigin fɔ trit yu, if nid de.
Yu tink se wi fɔ no bak bɔt di bad tin dɛn we kin apin to wi?
Lɛk ɛni mɛrɛsin, Leqembi kin gɛt sayd ɛfɛkt. Pan ɔl we sɔm pan dɛn tin ya na smɔl smɔl tin dɛn, sɔm de we wi fɔ no mɔ bɔt.
| Sayd ɛfɛkt we pɔsin kin gɛt | Diskripshɔn ɛn wetin fɔ pe atɛnshɔn to |
|---|---|
| Riakshɔn dɛn we gɛt fɔ du wit infushɔn | I kin apin we dɛn gi di mɛrɛsin insay di bɛlɛ ɔ jɔs afta dat. Sɔm kayn sik lɛk fiva, kol, bɔdi we de at, chenj na di at rit, ɛn i nɔ kin izi fɔ blo. Di mɛdikal tim de wach dis ɔltɛm. |
| ARIA (Amyloid-Rɛlayt Imej Abnɔmaliti) . | Dis na wan sayd ɛfɛkt we yu fɔ tek tɛm mɔ bɔt . Dis kin mek smɔl smɔl swel ɔ smɔl blɔd kɔmɔt na di bren. Bɔrku pipul kin gɛt ARIA wae nɔr gɛt ɛni sayn ɛn i kin sɔlv fɔ insɛf. Bɔt sɔntɛnde, i kin rili siriɔs. If yu gɛt sɔm sayn dɛn lɛk fɔ kɔnfyus bad bad wan wantɛm wantɛm, yu ed de tɔn, ɔ yu ed de at bad bad wan , yu fɔ tɛl yu dɔktɔ wantɛm wantɛm. Dɔktɔ dɛn kin chɛk dis sik ɔltɛm wit MRI skan. |
| Ɔda kɔmɔn sayd ɛfɛkt dɛn | Ɛd we kin at kin apin ɔltɛm. Tɔk to yu dɔktɔ bɔt ɛni sayn we de mɔna yu. |
I kin miks wit ɔda mɛrɛsin dɛn?
Yɛs, dat na kwɛstyɔn we rili impɔtant.
If yu de tek tin dɛn we de mek yu blɔd tan lɛk aspirin, wɔfarin, ɔ apixaban (Eliquis) , yu fɔ rili tɛl yu dɔktɔ bɔt dis. If yu tek dɛn mɛrɛsin ya wit Leqembi, i kin mek yu gɛt mɔ blɔd na yu bren (na ARIA kin mek yu gɛt am).
Apat frɔm dat, mek shɔ se yu tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin, vaytamɛn, ɛbul mɛrɛsin, ɛn sɔpɔtmɛnt we yu de tek so dat i go no if dis tritmɛnt sef fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- Leqembi nɔto mɛrɛsin fɔ Alzaima sik. Na tritmɛnt wae de slo di rεt wae de sik de wɔs.
- Dis tritmɛnt kin bɛtɛ fɔ di wan dɛn we de na di fɔs stej fɔ di sik, wit smɔl smɔl sayn dɛm.
- di dכg de wok bay we i de pul `amyloid beta plaques` we de kכmכt na di bren.
- We dɛn de trit am, di dɔktɔ kin du MRI skan ɔltɛm fɔ wach fɔ di sayd ɛfɛkt dɛn lɛk ARIA.
- I impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek, mɔ di wan dɛn we de mek yu blɔd tan.
- I rili impɔtant fɔ disayd afta yu dɔn tek tɛm tɔk wit yu dɔktɔ if dis tritmɛnt fayn fɔ yu ɛn wetin na di bɛnifit ɛn bad tin dɛn we i gɛt.
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