Yu na pɔsin we kin gɛt alɛji bɔku tɛm? Yu kin bigin fɔ it afta yu blo wit dɔti, yu kin gɛt rash afta yu it it, ɔ yu kin jɔs skrach yu bɔdi sɔntɛnde? Tide wi de tɔk bɔt wan smɔl bɔt rili impɔtant sojaman we de biɛn ɔl dɛn tin ya. Yu kin dɔn si di wɔd ‘Basophils’ na wan pan yu blɔd ripɔt, dat na, na ‘Full Blood Count’. So, wetin na dɛn basofil ya ? Wetin mek wi bɔdi nid dɛn? Lɛ wi tɔk bɔt dis insay wan simpul we we izi fɔ ɔndastand.
Wetin rili na basophil?
Fɔ tɔk am simpul wan, basofil na wan kayn wayt blɔd sɛl (`White Blood Cell` - WBC) we de na wi blɔd. Imajin se wi bɔdi tan lɛk kɔntri. Dɔn wayt blɔd sɛl dɛn na di difɛns fɔs fɔ dis kɔntri. Difrɛn pawa dɛn de insay dis pawa. So, fayv kayn wayt blɔd sɛl dɛn de. Basofil na di wan dɛn we nɔ bɔku pan di fayv kayn dɛn, we min se dɛn na fɔs we nɔ bɔku.
insay dεn basofil sεl dεm ya, sכm sכm sכm granul dεm de. Dɛn granul ya ful-ɔp wit wan rili impɔtant kemikal we dɛn kɔl histamin. Dis histamin de mek yu yay it, rɛd, ɛn yu nos we de rɔn we yu gɛt alɛji. Basofil dɛn kin ɛp bak fɔ protɛkt wi bɔdi frɔm parasayt dɛn ɛn fɔ mɛn wund dɛn .
Nature ɛn prɔpati dɛm fɔ basophils
Dɛn prɔpati ya we basofil gɛt rili impɔtant fɔ dɔktɔ dɛn fɔ no sɔm sik dɛn. Lɛ wi tek tɛm luk sɔm tin dɛn bɔt dis smɔl sojaman.
| Kwaliti | Tɔk bɔt |
|---|---|
| Sayz | dis dεm rili sכm, lεk 5-10 maykromita (μm) in saiz. |
| Di we aw i tan ɛn di kɔlɔ we i gɛt | We dɛn put spɛshal day (Wright-Giemsa stain), di granul dɛn we ful-ɔp wit histamin insay dɛn sɛl dɛn ya kin tan lɛk dak pepul. I izi fɔ no dɛn tin ya ɔnda maykroskɔp. |
| Sɛl sɛnta (Nyukliɔs) . | di sεntrכm fכ di sεl kin shep lεk di lεta 'S'. |
| Layfspan ɛn di bɔn we dɛn bɔn am | di basofil dεm de kכmכt na di bon mכro insay wi bon dεm. We dɛn dɔn mek dɛn de, dɛn kin jɔs liv fɔ lɛk 60 awa so afta dɛn dɔn go insay di blɔd. |
| Mak dɛn we de mek di wɔl | sכm spεshal protin dεm we de na di sεl dεm (lεk `CD-123`, `CD-193`) de εp dכkta fכ no sik dεm lεk sכm bכdi kεnsar (`Lukemia`). |
Us savis basofil dɛn de gi wi bɔdi?
di men wok we basofil dεm de du na fכ rilis di histamin we wi bin tכk bכt bifo. Bɔt apat frɔm dat, dɛn smɔl smɔl sɛl dɛn ya de du big wok fɔ wi bɔdi.
- Protekshɔn frɔm Alɛrjens : We tin dɛn lɛk dɔst ɛn pɔlin go insay di bɔdi, i de fɛt dɛn.
- Fεt parasayt dεm: Dis dεm de aktibכt di tεm we parasayt infεksh כ n dεm lεk pinwכm .
- Wound healing : I de ɛp fɔ mek wund dɛn wɛl.
- Fɔ mek blɔd nɔ klɔt: Dɛn sɛl dɛn ya kin pul wan kemikal bak we dɛn kɔl ɛparin, we kin ɛp fɔ sɔlv di blɔd we dɛn nɔ want.
Di rilayshɔn bitwin alɛji ɛn basofil
Imajin se mɔskito de bit yu an. Afta sɔm tɛm, di say kin rɛd, i kin swel, ɛn i kin it bɔku, nɔto so? Na dat histamin we de kɔmɔt frɔm basofil dɛn kin du.
Wetin histamin de du na fɔ mek di blɔd flɔ to di eria. dis kin dכn bכn mכr bכdi na di εria, "wash" am kכmכt, εp fכ flush di alerjen. Dis swel ɛn inflamɛns na rili pat pan di hiling prɔses.
We alɛrjen go insay pɔsin we gɛt alɛji in bɔdi, di imyun sistɛm de mek wan kayn antibodi we dɛn kɔl Immunoglobulin E (IgE). Dis IgE de go ɛn atak di alɛrjen. afta dat di basofil dεm de kam εn atak dis IgE-allergen kכmpleks, we de rilis כl di histamin we dεn gεt insay. Na da tɛm de yu kin gɛt di sayn dɛm fɔ alɛji.
- Nɔs we de rɔn, we de sniz
- Rɛd, yay dɛn we de it
- Trot we de it
- Skin rash, i de it
- I nɔ kin izi fɔ blo pan pipul dɛn we gɛt asma
Aw yu kin chɛk di basophil lɛvɛl na yu blɔd?
If yu dɔktɔ ɔda yu fɔ mek yu du `Kɔmplit Blɔd Kɔnt (CBC)` tɛst, ɔ as wi kɔl am, `ful blɔd kɔnt,` di basofil kɔnt go de bak pan da ripɔt de. Dis kin de insay di ripɔt tu we dɛn.
1. As pasεnshכn (%): Us pasεnshכn pan di tכtal wayt bכdi sεl dεm na basofil? כltεm dis na rili sכm valyu, arawnd 0.5% - 1%.
2. Absolute Count: Na di aktual nכmba fכ di basofil dεm pan wan mililita bכdi.
Di tin we impɔtant pas ɔl na fɔ kɔmpia yu valyu dɛn wit di ‘Nɔmal Rɛnj’ ɔ ‘Rɛfrɛns Rɛnj’ kɔlɔm na yu lab ripɔt, bikɔs dɛn nɔmal valyu ya kin difrɛn smɔl dipen pan di mashin we dɛn yuz na ɛni lab.
| Lɛvul | Minin |
|---|---|
| Nɔmal Kɔnt | bitwin 0.5% - 2% pan di wayt bכdi sεl dεm. Di absɔlɔb valyu kin ɔltɛm kɔmɔt frɔm 0.01 x 109/L to 0.08 x 109/L. |
| Di lɛvɛl we dɔn go ɔp (Basophilia) . | di basophil lεvεl dεm hכy pas nכmal. |
| Lɔw lɛvɛl (Basopenia) . | di basophil lεvεl dεm de fכl dכn nכmal. |
Yu tink se we di basofil (basophilia) bɔku, i denja?
di inkris na di basophil lεvεl dεm dεn kכl am mεdikal wan as ``Basophilia.'' sεvεra rizin dεm kin de fכ dis.
- Alɛji: Alɛji to tin dɛm lɛk it, mɛrɛsin, dɔst, ɛn ɔda tin dɛm.
- Infεkshכn: Sɔm infεkshכn dεm lεk chikinpoks εn influenza.
- Tayroyd prɔblɛm: di tayroyd ɔmon we de dɔŋ (`Hypothyroidism`).
- Skin sik: Na di skin we tan lɛk ɛkzema lɛk atopik dɛmatitis.
- Blɔd sik: Kɔndishɔn lɛk polycythemia vera.
- Sɔm kansa sik dɛm: Blɔd kansa lɛk kronik maylɔyd lukimiya (CML).
Nɔ mek yu fred wit dis list. Bɔku tɛm, we di basophil kɔnt we go ɔp smɔl kin bi bikɔs ɔf sɔntin we simpul lɛk kɔmɔn alɛji. Bɔt yu fɔ lɛf am to yu dɔktɔ fɔ no di rayt tin we mek i apin. I go du ɔda tɛst dɛn if nid de fɔ kɔnfirm di tin we mek i apin.
Wetin na basopenia?
we di basophil lεvεl dεn dכn dכn dεn kכl am ``Basopenia.`` Dis kin sכmtεm sכmtεm pas ``Basophilia.`` Dis kin kכz bak fכ sεvεra rizin dεm.
- Sɔm infɛkshɔn dɛn.
- fכ prodyuz di tayroyd כmon pasmak (`Hyperthyroidism`).
- Wan siriɔs, kwik alɛji riakshɔn (`Anaphylaxis`).
- sכm imyun sistεm sik dεm, fכ egzampl `Systemic Lupus Erythematosus (SLE)`.
we di basofil dεm dכn dכn kin gεt impak bak pan di we aw wi bכdi de hεl di wund dεm.
Ustɛm fɔ go to dɔktɔ wantɛm wantɛm
Pan ɔl we nɔmal alɛji nɔ denja, sɔntɛnde di imyun sistɛm kin riak pasmak. Dɛn kɔl dis `Anaphylaxis`.
Anafylaksis na wan mɛrɛsin we kin mek pɔsin in layf de pan denja. If yu ɔ ɔda pɔsin gɛt ɛni wan pan dɛn sik ya, go na di ɔspitul imejensi dipatmɛnt (ETU) we de nia yu wantɛm wantɛm.
- Di lip, tɔng, ɔ fes we de swel
- I nɔ kin izi fɔ yu fɔ blo
- I nɔ izi fɔ swɛla
- Rash ɔ rɛdnɛs na di skin ɔlsay na di bɔdi
- Bɛlɛ de at, vɔmit, ɔ dayarɛa
- Chɛst tayt ɔ sawnd we de mek pɔsin wispa
- Fɔ fil se yu ed de tɔn ɔ yu de fil fɔdɔm
Sɔmtɛm lɛk dis, i rili impɔtant fɔ mek yu nɔ fred ɛn go to dɔktɔ wantɛm wantɛm.
Mɛsej we dɛn kin kɛr go na os
- Basofil na impɔtant kayn wayt blɔd sɛl na wi imyun sistɛm we de fɛt alɛji ɛn parasayt infɛkshɔn.
- Histamin, we dɛn kin pul, na in kin mek bɔku pan di sayn dɛm fɔ alɛji, lɛk fɔ it ɛn swel.
- If yu basophil lɛvɛl na yu blɔd ripɔt de ausayd di nɔmal rɛnj, nɔ panik ɛn tɔk to yu dɔktɔ. Bɔku tɛm, di tin we kin mek i apin kin bi sɔntin we simpul.
- If yu gɛt siriɔs alɛji simptom lɛk fɔ blo ɛn yu fes de swel, na imejensi. Go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
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