Cancer i vei tih i hriat chuan hlauhna leh lungkhamna nasa tak i nei thin. Mahse damdawi lam thiamna a lo thang chho zel a, tunlai hian cancer dona kawngah hian enkawlna kawng hmasawn tak tak a awm ta a ni. Vawiin hian kan sawi dawn a, enkawlna kawng thar leh chak tak, cancer chi hrang hrang , a bik takin thisena lo awm thinte enkawlna kawngah hlawhtling tak a ni.
CAR T-Cell Therapy hi eng nge ni?
A awlsam zawngin sawi ila, CAR T-Cell Therapy hi thisen cancer chi hrang hrang enkawlna atana hman thin immunotherapy a ni . Keimahni immune cells te hi kan taksaa sipai ang mai an ni. He enkawlna hian a tih chu i taksa chhunga heng sipai thenkhat, T cells ( T cells or T lymphocytes ) tia koh te hi la la, cancer cell tichhe thei super fighter ah a chantir a ni.
I T cell-te chu lab-ah hruaiin, chutah chuan gene thar dahin, cancer cell-te hriat theihna “special lens” i pe ang tih han ngaihtuah teh. Heng modified T cells te hi CAR T-cells kan ti a. `CAR` tih hi `Chimeric Antigen Receptor` tihna a ni. Tichuan, heng super-fighter cell maktaduai tam tak hi siamin i taksaah dah leh a ni. Chumi hnuah chuan heng cell te hian i taksa pum puiah an kal kual a, cancer cell te chu an zawng chhuak a, an tichhia a ni. A châng chuan, he enkawlna hian thisen cancer pawh a tidam vek thei a ni.
He damdawi hi eng cancer chi hrang hrangah nge hman a nih?
Tunah hian CAR T-Cell Therapy hi thisen cancer chi hrang hrang, enkawlna dang hlawhchhamna emaw, cancer lo awm lehna emaw tan chauh hman a ni. A hnuaia table-ah hian heng cancer chi hrang hrang thenkhat tarlan a ni.
| Cancer chi hrang hrang | Thuhmahruai tawi te |
|---|---|
| B-cell acute lymphoblastic leukemia (ALL) avanga natna hrik awm thei (ALL) . | B-cells atanga lo chhuak acute lymphoblastic leukemia. |
| B-cell lymphoma lian tak (diffuse) a awm | Lymphoma chi khat, a lo thang chak hle. |
| Follicular lymphoma natna a awm | Lymphoma chi khat, zawi zawiin a lo thang lian thin. |
| Mantle cell lymphoma natna a ni | A tlangpuiin a awm lo, mahse a nasat em em lymphoma chi khat. |
| Multiple myeloma a awm thei | Plasma cell-a lo awm bone marrow cancer a ni. |
| A rilru a buai em em a, a rilru a hah em em bawk a. Primary mediastinal large B-cell lymphoma | Lymphoma chi khat, rilru chhungril lam a awm. |
Awle, tunah chuan hei hi engtin nge a thawh tih i en ang u.
Hei hi hrethiam tur chuan kan immune system-a T cells chungchang tlem tal i zir hmasa phawt ang u. Kan taksaa cell tin hian a chung lamah antigen an tih protein an nei vek a. Chungte chu cell tin hian ID card an neih ang mai a ni. Cancer cell-te hian ID card danglam, pangngai lo an nei a.
Kan T cell te hian receptor an nei a . Heng receptor te hi cancer cell ang chi ID card (antigens) danglam tak nei invader te hretu an ni. Mahse a chang chuan cancer cell te hi an fing hle. Heng T cells atang hian an inthup thin.
Hei hi CAR T-cells puihna kan mamawhna hmun a ni. Hengte hi nangmah ngeiin i T cells te an ni a , lab ah a bik takin training i nei a , cancer cells a antigen bik hriat theihna turin siam danglam a ni .
He enkawlna hian heng cell te hian cancer cell te chu a that mai bakah taksa chhungah a inthen darh a, a pung thei bawk. Hei hian cancer do thei cells hun rei tak chhunga supply i hmu tihna a ni. Hei vang hian doctor-te chuan he enkawlna hi “damdawi nung” an ti a ni.
Engtin nge enkawlna kalphung hi a thawh?
Hetiang kalphung zawng zawng hi stage engemaw zatah a thleng vek a ni.
Enkawl hmain
Pakhatnaah chuan i taksa atanga thisen var, a bik takin T cells te i khawlkhawm a ngai a ni. Hei hi leukapheresis an ti a.Hei hi thisen pek dan ang chiah a ni. Machine hian i thisen thenkhat a la a, thisen var chauh a then a, chutah chuan thisen dang chu i taksaah a rawn thawn kir leh thin.
Heng T cells lakkhawmte hi CAR T-cells-a chantir turin specialized laboratory-ah thawn a ni. Hetiang hian kar 3 atanga kar 6 vel a awh thei. Hemi chhung hian cancer control nan chemotherapy ang chi enkawlna dang pek i ni thei bawk.
CAR T-cells dawng tura i inpeih hunah chuan i taksain cell thar a hnawl loh nan lymphodepleting chemotherapy tih damdawi pek i ni ang.
Enkawl lai hian
Enkawlna tak tak chu a awlsam hle. Saline pek ang bawkin heng CAR T-cells siam tharte hi i taksaah vein (IV line) hmangin minute 5 atanga 30 chhungin an infuse thin. Hemi chhung hian damdawi inah i awm a ngai dawn a ni.
Enkawl hnuah
Hei hi enkawlna chak tak a nih avangin a chang chuan side effect na tak tak a awm thei bawk. Chuvang chuan enkawl a nih hnuah ni 7-10 vel damdawi inah i awm a ngai mai thei. Thla khatna chhung chu damdawi in atanga i chhuah hnuah pawh i enkawlna hmun atanga awlsam taka thlen theihna hmuna awm a pawimawh hle. Pawh,
- Side effect i neih chuan nitin darkar 24 chhung mi tu emaw a awmpui tur che a ni .
- Enkawl hnu thla hnih chhung chu lirthei khalh loh tur . Chutiang ti tur chuan midang i mamawh a ni.
He enkawlna hian eng side effect nge a neih?
He enkawlna hmang hian side effect chi hnih a awm a, a tam ber leh ngaihven hlawh ber a ni. Side effect dang tlanglawn tak tak pawh a awm thei bawk.
| Side effect chi hrang hrang | Hmuh theih thil chi hrang hrang |
|---|---|
| Cytokine tihchhuahna Syndrome a awm | Khawsik, thawk harsa (dyspnea), thisen sang hniam. (Hei hi thil pawi tak a ni thei) |
| Neurological Issues chungchang a ni | Buaina, tawng harsa (aphasia), ziak harsatna (dysgraphia), lu na, seizure, khur. |
| Thildang | Enkawl lai hian allergy, hah, thisen chhuah, natna kai theihna a sang a, potassium (hypokalemia) leh sodium (hyponatremia) level hniam a awm bawk. |
He enkawlna hian eng hlawkna leh hlawhtlinna nge a neih?
CAR T-Cell Therapy thatna lian ber chu enkawlna dang hlawhchham tawh damlote tan beiseina thar a pe a ni. A chang chuan cancer (remission) chu a tidam vek thei. Chutiang a nih loh chuan he enkawlna hian damlo dam chhung a ti rei thei a ni.
Entirnan, kum 2020-a zirchianna pakhatah chuan acute lymphoblastic leukemia (ALL) vanga he enkawlna dawngtu naupang 85% aia tam chu enkawl hnuah an dam kim vek tih hmuhchhuah a ni. Tin, kum khat hnuah pawh 60% chu cancer nei lo an la ni bawk. Mahse hei hi mi zawng zawng tan 100% hlawhtling, mi zawng zawng tan damdawi a ni lo tih hriat reng a pawimawh. Mahse, hei hi cancer enkawlna kawngah hmasawnna lian tak a ni.
Engtikah nge Doctor i hmuh ang?
Hei hi a pawimawh hle. CAR T-Cell Therapy hian a nghawng tha lo thenkhat, a bik takin Cytokine Release Syndrome leh nervous system lama harsatna te hi nunna atana hlauhawm tak a ni thei
Chuvangin damdawi in i chhuahsan hmain i doctor hnenah eng symptom nge i ngaihtuah bik tur tih zawt hmasa phawt ang che. Khawsik, khawsik, lu na , leh rilru hahna ang chi symptoms a awm reng chuan doctor ko nghal la, a nih loh leh damdawi in Emergency Department (ETU)-ah kal rawh.
He enkawlna hi field thar a la ni reng a, a la hmasawn zel a ni. Chuvangin thisen cancer i vei a nih chuan he damdawi hi i tan a tha em tih i doctor nen inbia ang che.
Take-Home Thuchah a ni
- CAR T-Cell Therapy hi thisen cancer chi hrang hrang tan hman thin immunotherapy treatment chak tak leh personalized tak a ni .
- Hei hian lab-a i T-cells te chu i siam danglam a, chu chu i taksaah dah lehin cancer cells te chu tihlum a ngai a ni.
- He enkawlna hian “damdawi nung” angin hna a thawk a, taksaa cancer hun rei tak chhung chu a do thei a ni.
- Enkawl hnuah serious tak a niSide effect a awm theih avangin damdawi lam enkawlna hnai tak neih a pawimawh hle. A lan chhuah dan rinhlelh awm chuan doctor hnenah hriattir nghal tur a ni.
- Hei hian enkawlna dang hlawhchham tawh damlote tan beiseina thar a siam laiin, i tan a tha em tih chu i doctor chauhvin a rel thei a ni.
CAR T-Cell Therapy, cancer enkawlna, thisen cancer, immunotherapy, immune therapy, T cells, Sri Lanka
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