Thisen lama harsatna i nei bawk em? CMML (Chronic Myelomonocytic Leukemia) chungchang hi han sawi ila!

Natna `CMML` emaw Chronic Myelomonocytic Leukemia emaw tih i hre tawh em ? A ni lo mai thei. A chhan chu thisen cancer chi khat hmuh tur awm lo tak a nih vang a ni. Mahse hei hi kan hriat chian a pawimawh hle. A chhan chu kan taksain thisen a siam dan a nghawng vang a ni. Hemi chungchang hi awlsam takin, i hriatthiam theih dan tur angin sawi ila.

CMML chu eng nge ni? A awlsam zawngin i hrethiam ang u!

A awlsam zawngin, i ruhro – i ruh chhunga spongy part – hi thisen siamtu a ni. CMML vei chuan thisen var chi khat monocytes an tih chu a siam chhuah tam lutuk a . Heng monocyte pangngai lote hian kan mamawh thisen sen hrisel , platelet , leh thisen var hrisel dangte chu a tichhe vek a ni. Huana hnim hring, thing hrisel tak takte hnawhchhuah ang maiin han ngaihtuah teh.

Doctor-te chuan he natna hi Myeloproliferative neoplasm/Myelodysplastic syndrome (MPN/ MDS ) tiin an dah a. Hei hi thumal inzawmkhawm buaithlak tak angin a lang thei a, a nihna takah chuan:

• Myeloproliferative neoplasm (MPN): Hei hi i ruhroin thisen cell chi khat a siam tam lutuk hi a ni. A chi khat chauh a tam lutuk chuan thisen balance a tibuai a, thisen chu a thawk tha lo.
• Myelodysplastic syndrome (MDS): Hei hi i ruhro atanga thisen cell siam chu a pangngai lo va, a pianzia a dik lo . A bik takin thisen cell hrisel, puitling ai chuan blast cell an tih cell puitling lo zawk an siam chhuak thin.

CMML hi a chang chuan a thang zawi thei hle. Mahse a chang chuan tlem a rang zawkin a na zawk thei bawk. I doctor chuan a thanna thunun thei tur enkawlna chungchang a hrilhfiah ang che.

CMML natna lanchhuahna chu engte nge ni? Nang pawhin hengte hi i nei em?

CMML symptoms hi a langsar reng reng lo. A chang chuan thisen test hi clue hmasa ber a ni. Symptoms a lo lang tak tak pawhin a lo lang zauh zauh tlangpui. Heng symptoms te hi i hriat lar angin a lang em tih en rawh:

• Chau leh chak lo anga inhriatna: Hei hi thisen sen (red blood cells) tlahniam vang a ni a, chu chu thisen tlakchhamna (anemia) a ni.
• Natna leh hri kai tam lutuk: 1.1.Hei hi thisen var (white blood cells) tlahniam vang a ni a, chu chu neutropenia an ti a ni.
• Hnar thisen chhuak fo, hliam tenau nei pawhin blue a lo chang: Hei hi platelet tlahniam vang a ni a, chu chu thrombocytopenia an ti.
• Splenomegaly : Splenomegaly : I pum veilam sir chunglam a awm, i rilru a lo lian tihna a ni.
• Hepatomegaly : Thin lian tham.
• Sawifiah loha taksa rihna tlahniam.
• Zan a thawk hah.
• Ruh natna.
• Khawsik.

Heng symptoms nei zawng zawng hian CMML an nei vek lo tih hre reng ang che. Mahse heng symptoms te hi a awm reng chuan doctor pan a tha ber.

CMML hi a chhan bik a awm em?

Researcher-te chuan CMML hi eng nge a thlen tih chiang takin an la hre lo . Mahse, he natna nena inzawm gene mutations engemaw zat an hmuchhuak a ni. CMML i vei tih hmuhchhuah i nih chuan gene mutation pakhat aia tam i nei ngei ang. Gene mutations awm tam ber thenkhat chu:

• `TET2` tih a ni
• `SRSF2` tih a ni
• `ASXL1` tih a ni
• `RAS` (hei hi a tam ber) .

I doctor chuan he gene chungchang hi a hrilh belh ang che.

Tute nge CMML vei theihna sang zawk?

CMML lo awm dan tur tichhe thei risk factor engemaw zat a awm a:

• Kum: Kum upat deuh deuh hian he natna vei theihna hi a sang chho zel a. Diagnosis kum zat chu kum 73 leh 75 inkar a ni. Chumi awmzia chu he natna vei hmuhchhuah zinga a chanve chu chu aia naupang zawk an ni a, a chanve dang chu an upa zawk tihna a ni.
• Gender: CMML hi hmeichhia aiin mipaah ​​a tam zawk.
• Cancer enkawl hmasak tawh: CMML vei mi sawm zinga pakhat vel chu a hmain cancer natna avanga chemotherapy emaw radiation emaw an lo dawng tawh a ni. Mahse doctor-te chuan heng enkawlnate hi an pe thin a, chu enkawlna hlawkna chuan nakin lawka cancer vei theihna a tluk phah tih a chiang a nih chuan.

Hetiang dinhmunah hian eng harsatna dang nge awm thei?

CMML vei mi sawm zinga pahnih vel chuan thisen cancer na tak dang acute myeloid leukemia (AML) an nei leh ang. I diagnosis leh risk factors a zirin AML vei theihna tur i doctor nen sawiho rawh.

Doctor-te hian engtin nge CMML hi an hriat theih?

I doctor chuan i symptoms te a zawt ang a, i medical history a la ang. Tichuan i thisen cell te enfiah nan test eng emaw zat an ti ang. Heng test-ah hian:

• Complete blood count (CBC): Monocyte tam lutuk (monocytosis) chuan CMML chhinchhiahna a ni thei.
• Peripheral blood smear: Microscope hmanga en chuan monocyte te hi a mumal lo emaw, a puitling lo emaw (blast cells) anga lang a nih chuan hei hi CMML chhinchhiahna a ni thei bawk.
• Bone marrow biopsy: A chang chuan doctor chuan bone marrow sample tlemte a lak a ngai thei a, lab-ah monocyte pangngai lo a awm leh awm loh enfiah a ngai mai thei.
• Genetic testing: Doctor-te chuan thisen cancer dang nena inzawm gene mutations an zawng bawk. Hei hian natna dang, symptom leh thisen test result inang nei te chu an paih chhuak thei a ni.

CMML hi eng stage nge ni?

Doctor-te chuan CMML hi eng chen nge a darh tawh tih, a nih loh leh a nasat dan (cancer staging) chu i thisen leh ruhroa blast cell awm zat a zirin an rel thin. Heng stage pahnih hi:

• CMML-1: I thisena cell 100 zinga 4 aia tlem chu blast cell an ni. I ruhroa cell 100 zinga 9 aia tlem chu blast cell an ni.
• CMML-2: I thisena cell 100 zinga 5 leh 19 inkar chu blast cell an ni. I ruhro chhunga cell 100 zinga 10 leh 19 inkar chu blast cell an ni.

Hetiang dinhmunah hian i doctor chuan eng enkawlna nge i tana tha ber leh tangkai ber tih a rel ang.

CMML enkawl dan tur chu engte nge ni?

Pakhatnaah chuan thisen cell hrisel i neih tlem theih nan enkawlna i mamawh mai thei. Hei hian i thisen cell count tihpunna tur damdawi emaw, thisen pek fo emaw a huam thei a ni. Hei hi symptoms control nan palliative care-ah pawh a tel thei bawk.

CMML direct-a target-a enkawlna dangte chu:

• Allogeneic stem cell transplant: Hei hi CMML tidam kim thei tur enkawlna awmchhun a ni. Mahse, mi zawng zawng tan a inhmeh lo. Graft-versus-host disease ang chi nunna atana hlauhawm tak tak a thlen thei bawk.
• Chemotherapy: Chemotherapy damdawi hian monocytes te chu control loh taka lo thanglian zel chu a titawp thin. Hei hian symptoms a tiziaawm thei a ni. Hei hian damdawi Hydroxyurea leh Hypomethylating agents (HMA) te a hmang a.
• Clinical trial hrang hrangah:Enkawlna dangin a puih loh chuan i doctor chuan clinical trial-ah tel turin a rawt thei che a ni. Tunah hian clinical trial-ah CMML enkawlna thar (e.g., targeted therapy, immunotherapy) hman tangkai dan an zirchiang mek a ni.

Engtikah nge Doctor ka hmuh ang?

Doctor i hmuh fo a ngai ang (a tlangpuiin thla khatah vawi khat atanga thla ruk danah vawi khat). Heng appointment te hi i zawm a pawimawh hle. Heng appointment neih chhung hian i doctor chuan i natna lan chhuah dan a zawt ang a, thisen test a ti ang a, i enkawlna a thawh that dan a enfiah ang a, a tul angin siamthatna a siam ang.

Chutih lai chuan, i enkawlna avanga beisei loh, nghawng na tak i neih chuan i doctor nen inbia nghal rawh . I doctor chuan eng symptom nge i fimkhur tur tih a hrilh ang che, chu chu i enkawlna a zirin a ni.

Hetiang dinhmun nen hian eng nge i beisei theih ang?

CMML vei nia hriat mi pakhat dam rei zawng chu kum khat atanga kum thum vel a ni. Hetah pawh hian "median" hi middle value a ni. Chumi awmzia chu mipui zinga a chanve chuan dam rei zawk an nei thei a, a chanve pawh an dam rei zawk thei tihna a ni. Mahse, i prognosis tichiangtu thil tam tak a awm . Chung zingah chuan:

• Thisen test result: I thisen cell count hian i prognosis chungchangah clues a pe thei a ni. I monocyte, blast cell leh platelet count te hi value pawimawh tak a ni. I hemoglobin level pawh hi value pawimawh tak a ni a, i doctor chuan a enfiah fo ang.
• Genetic mutations: Genetic mutations thenkhat, entirnan `ASXL1` gene-a mutation awm hi prognosis chhe zawk nen a inzawm a ni.
• Thisen pek tam dan: I thisen cell siam that leh nan thisen pek fo i mamawh loh chuan i result chu a tha tlangpui.

I prognosis pawh hi i dinhmun chu `AML` (acute myeloid leukemia) a nih leh nih lohah a innghat bawk. Hei hi `CMML-2` i neih chuan a thleng tam zawk.

Dam leh chak taka awm reng turin eng nge ka tih theih ang?

CMML i neih chuan i tih theih tha ber pakhat chu kawng engkimah i hriselna mawhphurhna lak hi a ni . Hetih lai hian chaw tha tak tak ei leh mut that a pawimawh hle. Active taka awm leh chawlh hahdam tawk neih inkara inthlauhna pawh a pawimawh hle. Cancer natna vei midangte nena inzawmna siam hi mahni chauhna rilru put hmang dona kawng tha tak a ni. Cancer vei te nena thawhhona lama tawnhriat nei therapist nen inbiakna neihpui rawh.

Cancer hian mi chu tanpui theih lohvin a inhriat tir thei a, mahse hre reng ang che, i nun i la thunun reng a ni.Tin, i tanpui thei tur enkawlna pawh a awm bawk.

CMML nena khawsak hi thil awlsam a ni lo. I result chu i tana thil danglam bik tam takah a innghat a ni. I doctor hnenah heng thilte hi eng nge an nih leh i prognosis a nghawng dan sawifiah turin hrilh rawh. I enkawlna tur i thlan chuan i thil tum a tlin ngei ang tih i rin theih nan i enkawlna kawng hrang hrangte hrethiam rawh.

In lama hruai tur thuchah pawimawh ber

CMML hi natna khirh tak a ni. Mahse, i hriat chian a, i doctor nena thawhhona tha tak i neih a, in enkawl dan tur dik tak i neih a, nunphung tha tak i tihdanglam chuan he natna hi i hman that theih nan i bei thei a ni. Beiseina chu bansan ngai suh. I chhungte, i thiante leh doctor te chu tanpui turin an awm reng a ni. Nangmah chauh i ni lo. Zawhna emaw, harsatna emaw i neih chuan i doctor zawh hreh suh. I dikna a ni.

` CMML, Chronic Myelomonocytic Leukemia, Thisen Cancer, Ruhro, Monocytes, A lan chhuah dan, Enkawl dan