Natna damdawi hian pum a ti na em? Tichuan heng COX-2 Inhibitors te hi i zir dawn teh ang!

I doctor-in ruh natna, hnungzang natna emaw, natna dang emaw atana a pek painkiller i ei hian pum na, pum chhunga kang emaw, gastritis emaw i nei bawk em? Hei hi a takah chuan mi tam tak tan chuan harsatna tlanglawn tak a ni. Natna tihziaawmna tur damdawi ei zawha harsatna dang neih leh chu a thinrim hle. Mahse, he pum natna tihziaawm thei leh natna thunun thei damdawi chi khat bik a awm tih i hria em? Chu damdawi chi chu COX-2 inhibitors an ti a. Vawiin hian chu chu kan sawi dawn a ni.

COX-2 Inhibitor te hi engte nge ni? A awlsam zawngin i hrethiam ang u.

COX-2 inhibitor hi a takah chuan NSAIDs (Nonsteroidal Anti-inflammatory Drugs) tia hriat natna tidamtu chhungkaw khata mi an ni. I hman fo thin damdawi, Ibuprofen , Diclofenac, leh Naproxen , te hi he NSAID pawlah hian an tel a ni. Heng damdawite hnathawh ber chu natna tihziaawmna, vun hring tihziaawmna leh khawsik tihziaawmna a ni.

Chuti a nih chuan heng COX-2 inhibitor te hi eng nge danglam bik? Chu chu hrethiam tur chuan kan taksa chhunga NSAID pangngai hnathawh dan kan en hmasak a ngai a ni.

Kan taksaa "hnathawk" pahnih: COX-1 leh COX-2 te

Kan taksa chhungah hian enzyme chi khat Cyclooxygenase ( COX ) tih hi a awm tih han ngaihtuah teh. Hengte hi kan taksaa hna hrang hrang thawktu hnathawk te te ang an ni. Heng COX hnathawkte hi chi hnih an ni ber.

1. COX-1: Hei hi hnathawk "tha" tak a ni. A hna ber chu kan pum leh kan chhungril lining venhim hi a ni. Kan ei leh in a digestive acids atanga kan pum venhimna tur protective layer siam nan a pui thin. Thisen zam (blood clotting process)-ah pawh a inrawlh bawk.

2. COX-2: Hei hi "buaina siamtu" a ni fo thin. Kan taksaah hliam, natna hrik, a nih loh leh chhiatna a awm chuan chutah chuan a kal a, prostaglandins tih chemicals a siam chhuak a ni. Heng prostaglandins te hi natna, hliam leh khawsik thlentu an ni. Hei hi taksaah hian a takah chuan venhimna ni mah se, arthritis ang chi natna khirh takah chuan he thil hian natna a thlen chhunzawm zel a ni.

Tunah chuan en teh, Ibuprofen ang chi NSAID hman tlanglawn tak kan ei hian chu damdawi chu taksaah a lut a, mi tha (COX-1) leh mi tha lo (COX-2) te chu a block vek a, chu chu an pahnih hian hna an thawk tawh lo tihna a ni. COX-2 hi a block avangin a na leh a hring a ti tlem a ni. A tha alawm. Mahse COX-1 a block avangin pum venhimna pawh a tawp a, pum na, gastritis, leh pum ulcer thlengin a awm theihna chance a sang hle.

Chuvangin, pum hi venhim a nih chhunzawm zel laiin, natna leh inflammation siamtu COX-2 enzyme chauh hi a inthiarfihlim a ni. A awlsam zawngin sawi ila, COX-2 inhibitor te thatna lian ber chu natna a control a, chutih rualin pum chhunga side effects te pawh a ti tlem thei hle.

COX-2 inhibitor hi eng condition atan nge hman ber?

Hetiang damdawi chi hi doctor-te chuan natna chi hrang hrang, natna leh inflammatory conditions tan chuan an rawt a ni. A hnuaia tarlan te hi a bulpui ber thenkhat an ni.

Tin, heng damdawi te hi natna dang, gout leh migraine te tan pawh hman theih a ni a, doctor duh dan angin.

Sri Lanka leh khawvela COX-2 Inhibitor hman thinte hi engte nge ni?

Khawvel leh Sri Lanka-a COX-2 inhibitor hman tam ber chu Celecoxib a ni. Brand name Celebrex® hmangin i hre tawh mai thei.

Hei bakah hian COX-2 inhibitor dang Etoricoxib (Arcoxia®) leh Parecoxib (Dynastat®) te pawh khawvel ram hrang hrangah hman a ni bawk.

Mahse hei hi i hriat ve tur a ni bawk. Kum engemaw zat kalta khan COX-2 inhibitor dang, Rofecoxib (Vioxx®) leh Valdecoxib (Bextra®) , te chu market-ah an lo awm tawh a. Mahse, a hnu lama zirchianna hrang hrangah chuan heng damdawi te hi hun rei tak hman a nih chuan heart attack leh stroke vei theihna a tipung hle tih hmuhchhuah a ni. Tin, mi thenkhatin vun natna khirh tak tak an neih tir bawk. Heng avang hian heng damdawi te hi market atanga lakchhuah a ni ta a ni.

Engtin nge he damdawi hi ka ei ang? Eng chen nge ka lak ang?

COX-2 inhibitor hi pill angin a awm tlangpui a, mahse oral solution angin a awm thei bawk.

He damdawi ei atanga darkar khat chhungin a natna hi a reh tan thin .Mahse, anti-inflammatory benefits kimchang, swelling tihziaawmna ang chi chu ni engemaw zat a la ngai thei.

He damdawi hi eng chen nge i ei a ngaih tih chu i damdawi lam dinhmun a zirin a ni.

• Hun rei lote chhunga natna (ni engemaw zat emaw kar hnih emaw ang chi): Hun rei lote chhung atan a effective dose hniam ber ei hi a tha fo thin .
• Arthritis ang chi hun rei tak chhunga awm tur tan: I doctor chuan i hriselna chanchin kimchang, damdawi dang i ei te, a tul chuan thisen test result pawh a enfiah ang a, he damdawi hi i ei chhunzawm zel chu i tan a him em tih a hriat theih nan.

A pawimawh ber chu i doctor-in a pek ang chiah, a tih ang chiah leh a pek hun chhung zawnga ei fo tur a ni. Thil ngaihtuah tur i neih chuan damdawi i tihtawp hmain emaw, i ei tur i thlak hmain i doctor nen inbiakna neih hmasak phawt ang che.

COX-2 inhibitor te hian eng nge a hlauhawmna leh a side effect te?

Kan sawi tawh ang khan heng damdawi te thatna ber chu pum leh ril ah nghawng a nei tlem zawk hi a ni. Mahse chu chuan risk-free an ni tihna erawh a ni lo. Side effect thenkhat chu a awm thei a, a bik takin a tam zawk leh rei tak ei a nih chuan.

Risk lian pahnih: 1.1.

1. Heart attack leh stroke vei theihna: NSAID zawng zawng, COX-2 inhibitor te pawhin heart attack leh stroke vei theihna hi eng emaw chen chu a tipung thei a ni. He risk hi thinlung natna vei tawh, thisen sang leh cholesterol sang te tan chuan a nasa zawk a ni.

2. Pum leh intestinal lama harsatna: NSAID pangngai aiin a tam lo hle nachungin COX-2 inhibitor hian mi thenkhatah chuan pum thisen leh ulcer a thlen thei a ni. Hetiang hlauhawmna hi tar leh pum natna thlen thei damdawi dang ei thinte tan a sang hle.

Side effect dang awm thei:

He list-a side effect tarlan zawng zawng hi mi zawng zawngin an hmu vek lo. Heng symptoms te hi i neih emaw, thil danglam tak i hriat emaw chuan doctor hnenah hrilh nghal rawh.

He damdawi hi tuin nge ei loh tur?

Damdawi lam harsatna thenkhat nei thenkhat chu COX-2 inhibitor hmang hian an tling lo. I doctor chuan damdawi a pek hmain heng zawng zawng hi a ngaihtuah hmasa ang.

COX-2 inhibitor ei loh tur mite chuan:

• A hmaa stroke i lo neih tawh chuan.
• Coronary artery bypass surgery neih tura inbuatsaih emaw, tun hnaia tih tawh emaw i nih chuan.
• Kal natna na tak emaw, thin (liver failure) i neih chuan.
• Aspirin emaw NSAID dang emaw i ei hnua asthma attack emaw allergy na tak i neih tawh chuan.
• Sulfonamide antibiotics allergy i neih chuan.

A bik taka fimkhur tur te:

• Pum ulcer emaw thisen chhuak emaw i neih tawh chuan.
• Naupai thla 3 hnuhnung ber i nih chuan.
• Nu hnute pe lai i nih chuan.

Heng zinga pakhat tal i neih chuan i doctor hnenah i hrilh ngei tur a ni.

Damdawi lam pan vat ngai vaukhânna chhinchhiahna!

COX-2 inhibitor i ei laiin a hnuaia symptoms te hi i neih chuan damdawi ei kha bansan la, doctor hmu nghal la, a nih loh leh hospital emergency department (ETU) hnai ber pan rawh.

• Liver harsatna lan chhuah dan: zun dum, hah lutuk, vun emaw mit emaw sen, bawlhhlawh rawng hring, pum na.
• Thisen chhuah chhinchhiahna: thisen chhuak, coffee ground ang maia luak, ek emaw black tarry stool emaw-a thisen, zun-a thisen, hmui thisen chhuak, leh hliam awlsam.
• Kidney lama harsatna lan chhuah dan: zun theih lohna, zun chhuah tlem, zun chhunga thisen awm, rang taka taksa rihna sang.
• Allergy na tak chhinchhiahna: vun rawng, vun hring, thawk harsa, thawk hah, hmai, hmui emaw lei emaw a hring.
• Heart attack chhinchhiahna: rilru natna hnim hring, kut veilam, hmui emaw hnungzang emaw thlenga natna darh, thawk harsa, thawk hah.
• Stroke chhinchhiahna: hmai, kut leh ke sir khata rilru hahna, tawng harsa, leh lu na tak, na tak.