COX-2 Inhibitors an tih painkiller chungchanga i hriat tur

I ruh natna , hnungzang na , emaw, thlasik laiin natna nasa tak i tuar fo em? Tichuan rang takin painkiller kan ei ta a . Mahse, heng natna tidamtu hi chi hrang hrang a awm tih i hria em? Vawiin hian an zinga hmun bik luahtu, leh a hnathawh dan pawh a danglam deuh deuha natna tidamtu chi khat kan sawi dawn a ni. Chu chu COX-2 inhibitor te an ni .

A awlsam zawngin, heng COX-2 Inhibitor te hi engte nge ni?

COX-2 inhibitor hi a takah chuan natna tidamtu leh inflammation tihziaawmna (anti-inflammatory) damdawi pawl a ni. He pawl damdawi lam hming chu NSAIDs a ni a, Nonsteroidal Anti-inflammatory Drugs tihna a ni. Ibuprofen , Naproxen , leh Diclofenac ang damdawi i hriat fo thin te pawh hi he NSAIDs an tih pawlah hian an tel ve a ni .

Mahse, he chi bik, COX-2 inhibitor tia koh hian taksaah hian kan hriat vek NSAID hmanlai aiin a danglam deuh hlek a ni. Chu danglamna chu eng nge ni tih i han thlir teh ang.

He damdawi hian taksa chhungah engtin nge hna a thawh? Mechanism mak tak a ni!

Hei hi hrethiam tur chuan kan taksaa enzyme chi hnih kan hriatthiam hmasak a ngai a ni. Hengte hi COX-1 leh COX-2 enzyme te an ni . Heng enzyme pahnih hian kan taksaah chemical prostaglandins an siam chhuak a . Heng prostaglandins te hi natna, hring (inflammation), leh khawsik kan neih chhan ber a ni.

Hei hi han ngaihtuah teh: Kan taksa an tih factory chhungah hian hnathawk pahnih an awm a.

• COX-1 (first worker): Hemi hi hnathawk tha tak a ni. Prostaglandins a siam a, chu chuan natna leh hliam a thlen thin. Mahse chu bâkah chuan thil pawimawh tak pahnih a ti . Pakhat chu kan pum leh kan intestines lining te chu stomach acid atanga venhim a ni. A dang chu thisen zam chhuahna kawnga puih a ni.
• COX-2 (Hnathawktu 2): Hei hi buaina tak tak chu a ni. A hna ber chu natna leh inflammation thlentu prostaglandins siam a ni.

Tunah chuan en teh, Ibuprofen leh Diclofenac ang chi painkiller (Non-selective NSAIDs) kan ei hian damdawi chuan chu hnathawk pahnih chu a titawp vek a ni . Tichuan, COX-2 tihtawp a nih avangin a na leh a hring chu a reh ta a ni. Mahse, hnathawk tha, chu chu COX-1 chu tihtawp a nih avangin, pum chhunga invenna a bo , gastritis, pum natna, leh ulcer awm thei te pawh a pung ta a ni.

COX-2 inhibitor hi eng condition atan nge hman?

Damdawi lam harsatna hrang hrang avanga natna leh hliam na lo leh hliam na tak te control nan he damdawi chi hi doctor-te chuan an rawt a ni.

Tin, i doctor chuan gout leh migraine ang chi natna tan pawh he damdawi hi a pe thei bawk.

COX-2 Inhibitors hman hian eng hlauhawmna leh side effect nge a neih?

Gastrointestinal side effects tlahniam mahse COX-2 inhibitor hi damdawi risk-free tak tak a ni lo. Risk engemaw zat a awm thei a , a bik takin dose sang tak leh hun rei tak hman a nih chuan .

Risk lian ber berte

• Heart attack leh stroke: COX-2 inhibitors hian heart attack leh stroke vei theihna a tisang deuh tih hmuhchhuah a ni. He risk hi thinlung natna emaw, a risk factors emaw nei tawhte tan chuan a nasa zawk a ni. Hemi avang hian COX-2 inhibitor thenkhat, `Rofecoxib (Vioxx®)` leh `Valdecoxib (Bextra®)` te chu market atangin an paih chhuak ta a ni.
• Pum leh intestinal lama harsatna: Pum chhiatna hi a tlem hle nachungin a bo vek lo. Mi thenkhat chuan thisen chhuah leh ulcer an nei thei bawk .

Side effect awm fo thin

Tute nge COX-2 Inhibitors ei loh tur?

I doctor chuan i health history kimchang chu a enfiah ang a, he damdawi hi i tan a tha em tih a hriat theih nan. A hnuaia natna te hi i neih chuan he damdawi hi i ei loh tur a ni:

• Stroke i lo vei tawh a nih chuan.
• Tun hnaia coronary artery bypass surgery i neih emaw tih tur emaw i nih chuan .
• Kidney natna na tak emaw liver natna emaw i neih chuan .
• Tun hmaa asthma attack emaw, NSAID dang, aspirin emaw, sulfa antibiotic emaw avanga allergy na tak i neih tawh chuan.
• Naupai thla thum hnuhnung ber i nih chuan .
• Nu hnute petu i nih chuan (hemi chungchang hi i doctor nen sawiho rawh).

Engtikah nge Doctor i hmuh nghal tur?

He damdawi i ei lai hian a hnuaia symptoms te hi i neih chuan tihkhawtlai suh la, i doctor hmu nghal la , damdawi in hnai ber Emergency Department (ETU) ah kal nghal rawh.

• Liver problem chhinchhiahna: zun dum, hah lutuk, vun emaw mit emaw a sen, bawlhhlawh rawng hring, pum na.
• Thisen chhuah chhinchhiahna: thisen chhuak emaw, coffee ground ang maia luak emaw, ek chhunga thisen kal (black or dark red stools), zun atanga thisen kal, ham thisen chhuak, vun natna danglam tak tak.
• Kidney problem symptoms: zun theih lohna, zun chhuah zat inthlak danglam, rang taka taksa rihna sang.
• Allergy na tak chhinchhiahna: vun rawng emaw, hive emaw, hnim hring, thawk harsa, hmai, hmui emaw lei emaw a hring.
• Heart attack chhinchhiahna: rilru na, thawk hah, jaw emaw shoulder emaw thlenga radiate na.
• Stroke symptoms: taksa sir khatah a bengchheng, tawng harsa, hmai a tlakbuak.