I thisen var (white blood cells) ah hian harsatna a awm em? Histiocytosis chungchang hi a awlsam zawngin i zir dawn teh ang!

A châng chuan kan taksaa cell chi hrang hrangte chu tlem a danglam deuhin an awm ṭan tih i hria em? Chutiang dinhmun hmuh tur awm lo pakhat chu Histiocytosis an ti a. Hei hi i tan chuan hlauhawm deuhin a lang thei a, mahse lungngai suh. A awlsam zawng leh awmze nei taka sawi ila.

Histiocytosis chu eng nge ni? A awlsam zawngin...

I taksa hian thisen var chi khat histiocytes an tih a nei a. Chu thisen var cell zingah chuan cell chi khat bik histiocytes . Hengte hi kan taksa venhimtu ang mai an ni. Natna thlentu hrik, pathogens - virus , bacteria , leh fungi - te dotu an ni a, kan immune system hrisel taka awmtirtu an ni .

Mahse, a chang chuan heng histiocyte cell te hi a pangngai lo takin an thang tan a, chu chu `` mutant '' an lo ni ta tihna a ni . Tichuan, heng histiocyte cell pangngai lo te hi an thang tam lutuk a, kan taksa hmun hrang hrangah an pung khawm thin. An tam lutuk chuan kan taksa hriselna (immune system) hian harsatna a nei thei a ni. A pawimawh ber chu inflammation , chu chu swelling-like condition , taksa tissue-ah a awm a ni. He inflammation hian a chang chuan kan taksa peng hrang hrang a tichhe thei a ni.

Heng histiocyte cell pangngai lo te hi i lymph nodes (lymph nodes an ti bawk), vun, ruh, lung, liver, spleen emaw i taksa hmun dangah emaw an lo pungkhawm thei a ni. A chang chuan i taksa peng pakhat chauh a nghawng thin. Hei hi ‘single system’ condition kan ti a. Hun dangah chuan i taksa peng tam tak a nghawng thei bawk. Hei hi ‘multisystem’ condition kan ti a.

A pawimawh ber chu histiocytosis hi cancer a ni lo . Mahse, a chang chuan cancer ang maiin a awm thei a, cancer ang chi symptoms a lantir thei bawk. Chuvang chuan ngaihven bik tlemte mamawh condition a ni. Hemi chhinchhiahna hi mi hrang hrangah a inang lo va, natna nasat dan pawh a inang lo va, a chang chuan histiocytosis hi rang taka hriatchhuah a harsa thei bawk.

Histiocytosis chi hrang hrangte chu engte nge ni?

Tunah chuan histiocytosis tih hi i hrethiam tawh mai thei. A nihna takah chuan chi 100 chuang a awm. Mahse kan hmuh leh kan sawi tam ber chi thum a awm. Anni hi han thlir ila.

1. Langerhans cell histiocytosis (LCH) atanga lo chhuak a ni.

• Hei hi histiocytosis chi khat a ni ber .
• Hetiang dinhmun hian naupang tê tête a nghawng tam ber . Naupang maktaduai khat zinga 5 leh 9 inkar a nghawng a ni.
• A tam zawkah chuan hei hi chutiang chuan a pawi lo va, ``asymptomatic'' ang maia awlsam pawh a ni thei. Mahse, a then phei chuan hei hi a na thei a, nunna atana hlauhawm hial a ni thei tih hriat reng a pawimawh.

2. Erdheim-Chester natna (ECD): 1. A rilru a hah lutuk chuan a rilru a buai em em a.

• Hetiang chi hian puitling a nghawng ber a ni .
• Hei pawh hi thil awm lo tak a ni.
• LCH ang bawkin ECD pawh hi a na lo atanga na tak thlengin a awm thei a, nunna atana hlauhawm tak a ni.

3. Rosai-Dorfman natna (RDD): .

• LCH ang bawkin RDD hi naupangah a awm tam ber , mahse puitlingah pawh a awm thei bawk.
• Hei pawh hi a tlem hle. Mi sang hnih zinga pakhat velin he natna hi an vei tih hmuhchhuah a ni.
• Hei hi a chipui ber chu ‘classical RDD’ a ni. Hei hi i lymph node (glands) te a lo hring chhuak thin a ni.
• A chi dang chu ‘extranodal RDD’ a ni. Hemiah hian lymph node ni lo organ dangte a nghawng a ni. Chumi awmzia chu histiocyte cell tam lutuk chu vun, ruh emaw hmun dangah emaw a awm khawm thei tihna a ni.

He natna hi Histiocytosis an tih hi engtiang chiahin nge a tlem?

Ni e, ka sawi tawh ang khan, histiocytosis hi natna hmuh tur awm lo tak a ni . Dik tak chuan, a aggressive zawk, cancer chi hrang hrang hi soft tissue leh lymph node-a cancer hmuhchhuah zawng zawng zinga 1% aia tlem lo a ni. Chuvangin hei hi a tlem zia chu i ngaihtuah thei ang.

Histiocytosis natna lan chhuah dan chu engte nge ni?

Tunah chuan he histiocytosis condition-ah hian eng symptoms nge a lan tih kan en ang. Heng symptoms te hi mi pakhatah a inang lo thei . A chhan chu ka sawi tawh ang khan histiocyte cell tam lutuk awmna organ leh tissue te hian hei hi a nghawng a ni.

I hmuh theih (a dang pawh a awm thei) symptom thenkhat chu hetiang hi a ni:

• Skin rashes : Hengte hi a bik takin naute naupang lu ( ‘cradle cap’ kan ti thin) emaw, nappy area-ah emaw hmuh theih a ni.
• Khawsik .
• Chauhna, hahna .
• Lu na.
• Khuh emaw thawk hah emaw .
• Sawifiah loh takin taksa rihna tihtlem .
• Ruh natna .
• Lymph nodes a hring (hei hi a hring tihna a ni).
• Vision a inthlak emaw mit bulging emaw .
• Zun tam leh tuihal lutuk .
• Skin bumps (mitmengah pawh a lang thei).
• Thil ngaihtuah emaw hriat reng emaw harsatna .
• Balance leh coordination lama harsatna awmte .

Engtin nge symptoms te hi a lo awm thin? Histiocytes awmna hmun a zirin!

Heng symptoms te hi taksa chhunga khawiah nge histiocyte cells te hi an awm khawmna ah a innghat a ni. A khawlkhawmna hmunpui ber chu histiocytosis chi hrang hrang a zirin a inang lo.

Langerhans cell histiocytosis (LCH) natna vei theihna hmunte:

• Ruh
• Vun
• Lymph nodes (a hring) 1.1.
• Thin
• Spleen (Spleen) a ni
• Ka
• Chuap
• Central nervous system (chu chu thluak leh ruhro) .

Erdheim-Chester natna (ECD) vei theihna hmunte:

• Ruh sei tak (a bik takin keah) .
• Mit
• Central nervous system a ni
• Chuap
• Thinlung
• Thisen kalna kawng
• Kidney a ni
• Pum hnung lama taksa peng hrang hrangte ( ‘retroperitoneum’ kan ti a ) .

Rosai-Dorfman natna (RDD) vei theihna hmunte:

• Lymph nodes (a bik takin kawr chhungah, mahse hmun dangah pawh a awm thei) .
• Vun
• Tissue nem tak a ni
• Upper thawkna kawng
• Ruh
• Retroperitoneum (a pum hnung lama taksa peng hrang hrang) .
• Mit

Eng thilin nge Histiocytosis hi a thlen?

Scientist-te chuan histiocytosis thlentu hi eng nge ni tih chiang takin an la hre lo a , mahse, chu chu genetic mutations nen a inzawm thei tih an hmuchhuak a ni .

A awlsam zawngin, kan taksaa cell tin hian genetic material, a nih loh leh instruction set khat an nei vek a ni. Heng thupekte hian chu cell-te chu engtin nge an awm ang tih a hril a ni. Chuvângin, heng thupêk, mutations tia koh, inthlâk danglamna a awm chuan, cell-te chu a danglamin an awm ṭan a ni. Entirnan, genetic mutation hian histiocyte ang cell chu a copy a, thunun theih lohvin a darh tan thei a ni.

Heng genetic mutations te hi hriatchhuah a nih avangin zirchiangtute chuan histiocytosis enkawlna thar an siam thei ta a ni. Heng enkawlnate hian histiocyte cells te chu thunun theih loha an lo thanglian theihna tur cellular change tha lo tak takte venna hmangin hna an thawk a ni.

Engtin nge histiocytosis hi i hriat theih ang?

Histiocytosis i vei nia i rinhlelh chuan i doctor chuan taksa enfiahna a nei hmasa ang a, i medical history a zawt hmasa ang. Tichuan, i natna lan chhuah dan leh histiocyte tam lutuk hian a nghawng nia ngaih taksa peng hrang hrangte a zirin eng test nge tih tur tih an rel ang.

Test i tih theih thenkhat chu hetiang hi a ni:

• Imaging tih dan tur : 1.1.
• I doctor chuan special scan a order thei a, chu chu FDG PET/CT scan tih a ni. Hei hian taksa pum puiah tumor ang chi thil a hmuchhuak thei a ni.
• Chu bâkah , CT scan, MRI scan, ruh scan, ultrasound scan, X-ray, emaw echocardiogram (thinlung scan) ang chi test a ngai thei bawk.

• Laboratory-a test neih thin te : 1.1.
• I doctor chuan i thisen emaw zun emaw ang chi fluid sample te chu histiocytosis chhinchhiahna a awm leh awm loh a enfiah ang.
• I thisen cell zat an enfiah thin. I taksa peng hrang hrangte hnathawh dan tilangtu hormone emaw protein emaw bik an zawng bawk. Organ pakhatin hna a thawk tha lo a nih chuan chu organ chhungah chuan histiocytes a tam lutuk tih a tilang thei a ni.

• Biopsy test `(Biopsy)` tih hi a ni : 1.1.
• Hei hian a tih theih chu doctor chuan tissue sample a la a, microscope hmangin histiocytosis i nei em tih a enfiah thin.
• Histiocytosis nena inzawm genetic mutations bik a zawng bawk.
• A châng chuan biopsy tih theih a nih loh chuan i thisena genetic material awmte chu test theih a ni. Hei hi ‘liquid biopsy’ an ti a.

Histiocytosis enkawlna tur engte nge ni?

Histiocytosis enkawl dan hi thil tam takah a innghat a ni . A bik takin:

• I symptoms te hi a nasat zia .
• Lesion pakhat emaw, tam emaw i neih pawhin (hengte hi tissue pangngai lo awmna hmun a ni).
• Taksa chungah khawiah nge heng `lesion` te hi an awm ?
• Heng lumps te hi cancer an nih leh nih loh .

Doctor-te chuan heng thilte a\angin enkawl dan tur an rel \hin. Enkawl dan tur thenkhat chu hetiang hi a ni:

• En reng la, nghak rawh : I histiocytosis a na lo a, symptom lian tham i neih loh chuan i doctor chuan i dinhmun en turin a ti mai thei che a ni.
• Inzai: Taksa peng pakhatah chauh histiocyte cells a awm khawm a nih chuan chu hmun chu paih chhuah nan operation tih theih a ni.
• Radiation therapy : Hei hi machine hmanga high-energy beams of radiation beams te chu lesions ah direct a ni. Heng rays te hian cell pangngai lo te chu a that a, tumor te chu a tizau bawk. A châng chuan radiation therapy hian natna lan chhuahna a tihziaawm thei bawk.
• Chemotherapy (‘chemo’ tia koh bawk) : Hei hian i thisenah chemical thawnin i taksa chhunga histiocyte cell tam lutuk, a darh tawhte chu a tichhe vek a ni. Doctor-te chuan histiocyte cells te chu i taksa pum puiah a darh tawh chuan ‘chemo’ tih chauh an rawt a ni.
• Corticosteroids : Damdawi prednisone ang chi hi he category-ah hian a tel a. Hengte hian histiocytosis nena inzawm inflammation (swelling) a tiziaawm thei a ni. Heng damdawi te hi a ringawt emaw, enkawlna dang, chemotherapy ang chi te nen pawh pek theih a ni.
• Immunotherapy : Hei hian nangmah ngeiin i immune system a tichak a, cell tha lo, histiocytes pangngai lo ang chi te hriatchhuah leh tihchhiat kawngah a pui a ni.
• Targeted therapy : Hei hi enkawlna bik a ni. He enkawlna hi histiocytosis condition, genetic mutations thenkhat nena inzawm tan hman a ni.

Histiocytosis hi a dam kim thei em?

Hemi chungchangah hian ‘ni’ emaw, ‘ni lo’ emaw tih a har a , a chhan chu thil awmdan a zirin a ni. Histiocytosis vei tam tak chu ‘durable remission’ an tih hmunah an lut thin. Chu chu natna lanchhuahna leh chhinchhiahna awm lovin an kal bo tihna a ni.

Histiocytosis chi thenkhat, a bik takin histiocyte te chu taksa hmun khatah chauh an awm chuan operation hmangin a tidam vek thei a ni . I doctor chuan a lo lang leh tawh em tih enfiah turin follow-up visit a pe ang che.

Mahse, histiocytosis i neih chi chu tihdam theih a nih loh chuan i doctor chuan i natna enkawl dan tur ruahmanna a rawn rawt ang che.

Hetiang dinhmun hi eng prognosis nge ni?

I dinhmun tur prognosis hi thil tam takah a innghat a ni. Mi thenkhat tan chuan histiocytosis hi enkawlna engmah awm lovin a mah chauhin a tha chho thin . Entirnan, RDD vei zinga 40% vel chu enkawl lohvin an dam leh thin. Tin, LCH hian taksa peng pakhat chauh a nghawng hian ( ‘localized LCH’ kan ti) , a mah chauhin a tha chho fo thin.

Mahse, thil dang dangah chuan histiocytosis hi enkawlna nasa tak leh uluk taka enfiah a ngai a, naupang leh puitlingah pawh.A nasat zawkah chuan histiocytosis hian taksa peng hrang hrang a tichhia thei a, nunna pawh a tichhe thei bawk .

Chuvangin, i doctor hnenah i diagnosis atana prognosis bik zawt la a tha ber.

Histiocytosis hi a veng thei ang em? Engtin nge a hlauhawmna chu tihziaawm theih ang?

Dik tak chuan histiocytosis hi ven theih a ni lo a , mahse enkawlna hian i symptoms te chu a enkawl thei che a ni.

Mahse thil pakhat a awm. Meizial zuk bânsan hian lung cancer LCH (Langerhans cell histiocytosis) vei theihna a ti tlem thei a ni. Meizial zu bânsan emaw, meizuk lohna emaw hian enkawlna i dawngsawng ṭha thei bawk. Meizial zuk bânsan tura ṭanpuina i mamawh chuan, i doctor hnenah meizuk bânsan referral program chungchang zawt rawh.

Doctor hnenah eng zawhna nge ka zawh ang?

Histiocytosis i vei tih hmuhchhuah i nih chuan i rilruah zawhna tam tak awm hi thil pangngai tak a ni. Heng zawng zawng hi doctor nen inbiakna neih a pawimawh a, i dinhmun hriatthiamna tha tak neih a pawimawh bawk. Zawhna i zawh theih ṭhenkhat chu hetiang hi a ni:

• Eng ang histiocytosis nge ka neih?
• Enkawlna ka mamawh dawn em?
• Eng enkawlna tur nge i rawt?
• Enkawl chhung hian eng side effect nge beisei theih ang?
• Enkawlna avanga rah chhuah theihte chu engte nge ni?
• Ka dinhmun hi tihdam theih vek a ni em?

Take-Home Thuchah hnuhnung ber

A awlsam zawngin sawi ila, histiocytosis tih hi thisen lama harsatna awm lo, tissue-a thisen var chi khat histiocytes tam lutuk avanga lo awm, tih hming a ni. Chûng zînga ṭhenkhat chu a awlsam hle thei a, natna lan chhuahna a awm lo thei a, ṭhenkhat erawh chu a nasat lutuk thei a, nunna atana hlauhawm tak a ni thei bawk .

Histiocytosis vei zawng zawng hian an tissue-ah histiocytes a tam lutuk a, chu chuan inflammation (swelling) a thlen thin. Mahse, natna lan chhuah dan, enkawl dan leh a chhuah dan chu a inang lo thei hle a, histiocytosis chi khat nei mite zingah pawh a inang lo thei hle .

I doctor hi i diagnosis leh a chhehvel thil danglam bikte hrethiam thei tur mi tha ber a ni. Chuvangin, i diagnosis leh treatment plan kimchang taka hriatthiam theih nan zawhna zawh hi hlau ngai suh. I rilru a thil awm zawng zawng chu i doctor nen sawiho rawh.

` Histiocytosis, Thisen var, Histiocytes, Immune system, LCH, ECD, RDD, A lan chhuah dan, Enkawl dan