Thisen a lo awm thin leukemia rare tak chungchang hi i zir dawn teh ang? (Lymphocytic Leukemia lian tak - LGL) tih a ni.

Thisenah hian leukemia chi mak tak, mahse a awm lo hle tih i hre tawh em? I thianpa pakhatin a nei tih i hre tawh mai thei. A nih loh leh i hre mai mai a, i ngaihtuah mai mai pawh a ni thei. Vawiin hian chutiang leukemia hmuh tur awm lo, mahse pawimawh tak pakhat chungchang kan sawi dawn a ni. A hming chu Large Granular Lymphocytic Leukemia (LGL) tih a ni. A hming hi a sei deuhin a lang thei a, mahse a awlsam zawngin han sawi ila.

LGL hian eng nge a awmzia tak?

A awlsam zawngin LGL hi leukemia chi khat a ni a, taksaah zawi zawiin a lo thang lian a, chronic (rei tak a daih tihna a ni). Kan thisena thisen var chi khat bik a nghawng a ni. Heng cell te hi lymphocyte kan ti a . Lymphocytes hi kan taksa hriselna atana pawimawh tak a ni tih i hria em. Kan sipaiah sipai ang mai an ni. Kan taksaa lut virus ang chi hrik dotu an ni a, natna laka min vengtu antibodies siamtute an ni.

Chuvangin, LGL-ah chuan thil thleng chu heng lymphocyte cell an tih te, a bik takin Cytotoxic T cells emaw Natural Killer cells (NK cells) an tih cell chi hnih te hi eng emaw chhan vangin a danglamin an inthlak danglam a, thunun theih lohvin an inthen darh a, an pung chho tan ta a ni. Heng cell pangngai lo te hi LGL cell an ti a.

He dinhmun, LGL tia koh hi a tlangpuiin a lo thang zawi zawi hle. Chuvang chuan chronic leukemia an ti a ni. Kum 60 chunglam ah a tam ber a, Doctor ten LGL an enkawl thei. Mahse a chang chuan chu natna chu a lo let leh thei a, hun rei tak chhung hriselna lama harsatna a ni thei bawk.

LGL hi chi hnih a awm a, chungte chu:

He LGL condition hi chi hnih lian ber a ni tih hmuhchhuah a ni. Anni chu:

1. T-cell lian tak, granular lymphocytic leukemia (T-LGL) 1. A rilru a hah lutuk chuan a rilru a buai em em a.

2. NK cell-a lymphoproliferative disorder (CLPD-NK) natna awm reng (chronic lymphoproliferative disorder ) .

Heng pahnihah hian a hmaa kan sawi tawh ang khan thil thleng chu T cell emaw NK cell emaw chu a pangngai lo ta a ni.

He dinhmun hian engtin nge kan taksa a nghawng?

He natna LGL an tih hian kan taksaah eng ang nghawng nge a neih tih i ngaihtuah mai thei. Awle, hei hi Chronic Lymphocytic Leukemia chi khat a nih avangin, chu LGL cell pangngai lo chu ruhroah a kal a, chutah chuan thisen cell pangngai siam chhuahna a tibuai a ni. Thlai tha lo rawn lut a, thlai tha tak a luah ang mai a ni.

Hei hian harsatna lian tak pahnih a thlen thei a ni:

• Neutropenia : Hei hi kan taksaa granulocyte awm zat tlahniam tihna a ni.Thisen var (granulocytes) (thisen var chi khat awm tam ber) tlahniam. Heng cell te hi an tlem chuan kan taksain natna, a nih loh leh immunity a do theihna chu a tlahniam a ni. Hei hian hri kai fo theihna a tipung a ni.
• Anemia : Hei hi i hre tawh mai thei. Anemia chu taksain thisen sen hrisel mamawh zat a hloh hian a ni. Hetiang dinhmun hi a awm thei a, a chhan chu LGL cells hian thisen sen siam chhuahna a nghawng bawk. Anemia a lo awm chuan i chau a, i chau hle bawk.

He natna hi tuin nge vei tam ber?

LGL hi a takah chuan natna hmuh tur awm lo tak a ni. Khawvel hmun hrang hrang i en chuan he natna hi mi maktaduai khatah pakhat velin an report a ni. Chumi awmzia chu Sri Lanka ang ramah chuan heng damlote hi an tlem hle mai thei tihna a ni. A tam zawkah chuan he natna hi hmuhchhuah a nih hian damlote chu kum 60 vel an ni.

Eng nge a lan chhuah dan? Hei hi engtin nge kan hriatthiam ang?

Hetah hian a mak deuh chu kan rawn tarlang e. LGL vei thenkhat chu kum tam tak chhung chu symptom nei lovin an kal thei . Zirchianna pakhatah chuan LGL vei zinga hmun thuma ṭhena hmun khat vel chuan an natna lan chhuah tirh khan symptom an nei lo tih hmuhchhuah a ni. Chhan dang avanga thisen test-naah thisen sen (red blood cells) emaw, thisen var neutrophils an tih tlem emaw a nih chuan an nei tih an hrechhuak chauh a ni.

Mahse, natna lan chhuahna nei miten an hriat theih tur chhinchhiahna tlanglawn thenkhat a awm a:

• Chauhna leh chau lutuk : Hei hi LGL chhinchhiahna langsar ber a ni. A tam zawkah chuan hei hi a chunga kan sawi tak thisen tlakchham vang a ni.
• Khawsik fo leh natna hrik kai leh thin : Bacterial infection hian khawsik a thlen thei. Hei hi immune system chak lo vang a ni.
• Splenomegaly: Hei hi kan taksa peng pakhat, spleen tihpunna a ni. Hei hi infection leh thisen tlakchhamna chi thenkhat vang a ni thei.

Heng symptoms te hi i neih mai mai hian LGL i nei tihna a ni lo tih hre reng ang che. Hengte hi natna dang tam tak chhinchhiahna a ni thei bawk. Chuvangin hetiang thil hi i tawng a nih chuan a tha ber chu Doctor hmuh a, thurawn lak hi a ni.

LGL nena inzawm condition dang a awm em?

Ni e, LGL vei tam tak chuan autoimmune natna dang an nei tih hmuhchhuah a ni . Chu chu kan taksa ngeia immune system-in kan cell hrisel tak takte a beih theihna dinhmun a ni. Chung zingah chuan Rheumatoid arthritis hi a tam ber a ni.

Chu bakah, LGL nen hian condition dang engemaw zat a inzawm thei bawk:

• Anemia : Hemi chungchang hi kan sawi tawh a. Mi thenkhat chu thisen tlakchhamna nasa tak an nei a, an thisen sen (red blood cell level) vawng reng turin thisen pek an ngai thin. Mi thenkhat LGL neiAnemia chi khat hemolytic anemia an tih pawh a lo awm thei bawk. Hetiang a nih chuan red blood cell siam chhuah tihtlem ai chuan red blood cell awmsa te chu tihchhiat a ni.
• Lymphocytosis : Hei hi thisen chhunga thisen var (white blood cells lymphocytes) an tih punna a ni. Hetianga lymphocyte pung hi lymphocytic leukemias, lymphomas, emaw virus infection nei te zingah hmuh tur a awm tlangpui.

LGL awm chhan dik tak chu eng nge ni?

Hei hi doctor-te pawhin an la hriatthiam kim loh thil a ni. LGL awm chhan dik tak erawh hriat a la ni lo. Mahse, he leukemia natna leh kan taksa hriselna (immune system) hnathawh dan, autoimmune natna leh cancer chi dangte hi inzawmna a awm niin an ngai.

• LGL vei zinga 30% vel chuan autoimmune natna dang, rheumatoid arthritis te an nei a ni.
• 25% atanga 30% dang chuan lymphoma chi dang emaw cancer chi dang emaw an nei thei bawk.
• Tin, LGL vei tam tak chuan an genes-ah inthlak danglamna an nei bawk. A bik takin, STAT3 leh STAT5B tih gene pahnih ah hian mutations a awm a. Heng gene pahnih hian cell immunity leh cell inthen leh pun danah hmun pawimawh tak an chang a ni.

He natna hi Doctor ten engtin nge an hriat chian?

Doctor-te chuan LGL an hriat theih nan thisen test leh genetic analysis an hmang ber a ni. Test tih fo thin thenkhat chu hetiang hi a ni:

• Complete blood count (CBC) with differential : Hei hian i thisena cell chi hrang hrang a chhiar vek a, a bik takin thisen var chi hrang hrang i neih zat chu a chhiar vek a ni.
• Peripheral blood smear : Hei hi microscope hmanga thisen sample en a, thisen chhunga LGL cell awm zat chhiar a ni.
• Flow cytometry : Hei hi laboratory test a ni a, cell awm dan an zirchiang thin. He test hi leukemia chi hrang hrang hriatchhuah leh thliar hrangna atan hman a ni fo thin.
• Immunophenotyping : Hei hi thisen emaw tissue sample lak a, cell chunglama marker bik awm leh awm loh enfiah a ni. Heng marker te hmang hian natna chi hrang hrang hriat theih a ni.
• T-cell receptor (TCR) gene rearrangement analysis : Hei hian thisen emaw ruhro emaw sample a la a, T-cells hnathawh dan control tu genes-a harsatna awm apiang a zawng chhuak thin.
• Genetic testing : A hmaa kan sawi tawh STAT3 leh STAT5B gene-a mutation awm leh awm loh pawh i test thei bawk.

Heng test bakah hian immunodeficiencyTest dang, ruhro enfiahna ang chite chu natna dang, immunodeficiency, rheumatoid arthritis, myelodysplasia , leh myeloid mutations te tihbo nan tih theih a ni. Immunoglobulin level leh monoclonal protein level te pawh enfiah theih a ni bawk.

LGL hi engtin nge enkawl a nih?

T-LGL emaw CLPD-NK leukemia emaw i nei ang u, mahse symptoms i nei lo . Chutiang a nih chuan i doctor chuan "watchful waiting" tih strategy a rawn rawt thei ang. Hei hian i hriselna enfiah chhunzawm zel a huam a ni. A tlangpuiin, thla engemaw zat danah thisen test i nei thin a, symptoms a awm em tih i enfiah thin.

Symptom nei tan chuan immunosuppressive therapy leh steroid te pek theih a ni. Doctor-te chuan enkawlna pakhat hnu pakhatin an tan thei a, a nih loh leh enkawlna hniam tak an tan thei bawk. LGL hi natna awm lo tak a nih avangin mi tam zawk chuan he natna lama mithiam doctor an zawng thin.

He natna vei hi kan ti tlem thei lo em ni?

Vanduaithlak takin, ni lo, kan ti thei lo. Doctor-te chuan eng nge a chhan chiah an la hre lo. Chuvangin, a ven dan tur sawi a har khawp mai. Mahse, autoimmune natna nei te chu he natna hi an vei theihna chance a sang zawk tih hmuhchhuah a ni. Chuvangin, heng autoimmune natna zinga pakhat i neih chuan LGL hi i ngaihtuah tur em tih doctor zawt la, a tha ang.

LGL hi natna hlauhawm tak a ni em?

A tam zawkah chuan LGL hi natna rei tak a ni a, thihna rapthlak tak a ni lo . T-LGL leukemia leh CLPD-LGL leukemia vei zinga 75% vel chu an hmuhchhuah hnuah kum nga chhung an dam thei a ni. Mahse, heng leukemia chi hrang hrang vei zinga 10% vel chu natna khirh tak tak avanga thi an ni a, chu chu leukemia complication anga lo awm thei a ni. Chuvang chuan hri kai laka inven a pawimawh hle.

Engtin nge ka in enkawl ang? Engtin nge he dinhmun hi ka nunpui ang?

LGL i neih chuan symptoms i nei lo mai thei. Mahse, i hriselna zawng zawng enkawl a pawimawh a, chutah chuan checkup neih reng pawh a pawimawh. Symptom i nei emaw nei lo emaw pawh ni se, heng rawtnate hian a pui thei ang:

• Ei leh in hrisel ei : Sa thau lo, sangha, thei, thlai, leh buh chi hrang hrang ei tam rawh.
• Exercise neih fo : Exercise tha tak leh i duh zawng thlang rawh.
• Mut that : Chawlh hahdam tawk hi a pawimawh hle.
• Stress hi enkawl rawh.: I hlim theihna tur thil ti la, ngaihtuahna seng la, yoga ti rawh.
• I immune system humhim : I doctor hnenah vaccine pek dan leh hri kai venna atana i tih theih dangte zawt rawh. Savun hmanga kut sil leh mipui tamna hmun atanga hla taka awm ang chi thil awlsam tak tak pawh hian a pui thei a ni.

Hetiang dinhmun nen hian nun pangngaia nun theih a ni em?

A tlangpuiin, LGL enkawl mekte chu nun pangngaiin an hmang fo thin . Condition nei lo mi angin an dam rei thei. Mahse, LGL vei thenkhat chuan an nunphung tichhe thei thisen natna khirh tak tak an nei tawh mai thei tih hriat reng a pawimawh.

Engtikah nge Doctor ka hmuh ang?

I dinhmun a chhe zual mai thei tih hriat theihna symptom i neih chuan doctor i pan ngei ngei tur a ni. Symptoms neia enkawl i nih tawh chuan i taksaa inthlak danglamna i hmuh apiang (entir nan, symptoms a zual zel) te pawh i doctor hnenah i hrilh tur a ni.

Doctor hnena zawh tur pawimawhte chu engte nge ni?

LGL hi chutiang natna hlauhawm tak a nih avangin zawhna tam tak neih chu thil pangngai a ni. LGL chungchang i hriat belh theih kan beisei zawhna thenkhat chu hetiang hi a ni:

• Eng chi LGL nge ka neih?
• Hei hi eng enkawlna nge ni?
• Enkawlna pakhat aia tam ka mamawh dawn em?
• Tunah chuan ka dam tha hle mai. Symptoms ka nei dawn em?
• Natna dang ka nei bawk. LGL hian a ti na zual ang em?

Hetiang zawhna zawh hi hlau ngai suh. I doctor chu pui turin a awm reng a ni. Engkim hi i hriatthiam theih ang anga sawifiah turin an inpeih reng a ni.

A tawp berah chuan thil hriat reng tur

Large granular lymphocytic leukemia (LGL) hi thisen cancer hmuh tur awm lo tak a ni a, i thisen varte a nghawng a ni. Hetiang natna hi i nei a nih pawhin i taksaah LGL symptom ni thei tur danglamna i hmu lo mai thei. A châng chuan, kum tam tak chhûng chu symptoms a lang lo thei bawk.

Doctor ten he natna hi an tidam kim thei lo. Mahse, a natna lan chhuah dan control thei tur enkawlna a awm. Natna tihdam theih loh i nei tih i hriat hian mangang leh hlauhna i neih hi thil pangngai a ni . Chutianga i rilru put hmang chu i doctor-te chuan an hrethiam ang.

Tuna i hriselna enkawl tura i tih theih turte, leh natna lan chhuahna a lo awm a nih chuan eng nge i beisei tur tih te chu lawm takin an hrilhfiah ang che. Nakin lawka i beisei tur hriat hian LGL nena nunpui turin inrintawkna leh chakna nasa tak a pe ang che. Chuvangin, zawhna i neih zawng zawng chu i doctor nen sawiho rawh. In hriattirna dawng rawh. Chu chu hetiang hun lai hian i tih theih ṭha ber a ni.

`LGL leukemia, thisen cancer, thisen var, lymphocyte, neutropenia, thisen tlakchhamna, immune system