"Doctor, he cholesterol damdawi ka ei tan atang hian hun rei tak a liam tawh a. Ka ei leh in pawh ka control tha hle. Mahse ka cholesterol level erawh a la tlahniam lo..." Nang pawhin hetiang thil hi i hre ve em? Nge i chhungkuaa tu emaw hian he harsatna hi a nei em? Dik tak chuan cholesterol control hi mi thenkhat tan chuan harsatna lian tak a ni. Mi tam takin ‘statin’ type drugs atang hian result tha tak hmu mahse, thenkhat chuan an hmu lo. Chuvangin, chutiang mite tanpui nan damdawi thar Leqvio tih chu an rawn chhuak ta a ni. Hemi chungchang hi vawiin hian chipchiar tak leh awlsam takin i sawi dawn nia.
He cholesterol sang (Hyperlipidemia) hi eng nge ni?
A awlsam zawngin, Hyperlipidemia chu i thisenah thau chi hrang hrang (lipid kan ti) tam lutuk hi a ni. Kan taksaah thau tlem kan mamawh vek a. Hna pawimawh tam tak an thawk a ni. Mahse an san lutuk chuan harsatna a intan thin. Hun kal zelah heng thau level te hi a sang a nih chuan natna khirh tak tak, heart disease, stroke, leh heart attack te vei theihna a sang hle.
Thau chi hrang hrang pahnih chungchang kan sawi fo thin.
| Thau chi hrang hrang | A awlsam zawngin... |
|---|---|
| LDL (Low-Density Lipoprotein) tih hi a tha hle | Hei hi "bad cholesterol" kan tih chu a ni a, a chhan chu thisen kalna kawng bangah a awm a, zawi zawiin a tikhawlo a, thinlung natna a thlen thin. |
| HDL (High-Density Lipoprotein) a ni a, a tha lo hle | Hei hi "good cholesterol" an ti a, a chhan chu bad cholesterol (LDL) chu liver-ah a phurh a, taksa atanga paih chhuah a pui a ni. |
Hei bakah hian thau chi dang triglycerides an tih pawh a awm bawk. An neih tam lutuk hi a tha lo.
Cholesterol sang hi engte nge ni?
A tam zawkah chuan hei hi kan nunphung, ei leh in leh natna thenkhat inzawmkhawm vang a ni.
- Chaw leh In: Sa sen, sausage, bacon, leh eitur hriak (fried rice, khuthu, paratha) te hian saturated fat a pai tam hle. Hengte ei fo hian cholesterol a tisang a ni.
- Nunphung: 1.1.Meizial zuk, zu in tam lutuk, stress, leh exercise neih loh ang chi thilte hian cholesterol tihpunna kawngah nghawng lian tak a nei a ni.
- Damdawi lam thil dang: Diabetes, liver emaw kidney lama harsatna, hypothyroidism, leh sleep apnea te pawh hian cholesterol sang a thlen thei bawk.
Enkawlna tum ber chu thisena heng thau "tha lo" awm zat tihtlem hi a ni. Hei hian thil pawi tak tak, heart attack leh stroke te a tihziaawm thei a ni.
Engtin nge damdawi Leqvio hian hna a thawh?
Statins hi cholesterol damdawi ber a ni. Mahse, mi thenkhat chuan heng damdawi ei leh ei leh in hrisel zawm chung pawhin an duh angin an cholesterol level an hmu lo. "Primary hyperlipidemia" tih hming pu genetic condition nei te chuan damdawi pakhat aia tam an mamawh thei.
Leqvio hi damdawi thar, heng mite tanpui tura lo kal a ni. A chhunga active ingredient chu Inclisiran a ni. Damdawi chi khat `small interfering RNA (siRNA)` an tih zingah a tel a ni.
A awlsam zawngin sawi ila, he damdawi hian thisen atanga "bad cholesterol" (LDL) a lakluh theihna a tipung a ni. A bik takin, liver-in LDL particle a hriat theih nan a pui a ni. Liver hian heng LDL particle te hi a absorb hnuah a hmang emaw, taksa atangin a paih chhuak emaw a ni. Hei hian thisenah LDL level nasa takin a tihhniam a ni.
Hei hi statin damdawi hnathawh dan aiin a danglam bik hle.
Cholesterol nei tu pawhin Leqvio hi an hmang thei ang em?
Ni lo, hei hi mi zawng zawng tan damdawi a ni lo. Leqvio hi diet hmang tawh leh statin dose sang ber ei tawh, mahse cholesterol level sang tak nei tan chuan phalsak a ni
He damdawi hi a tha hle mai thei a, a bik takin `Heterozygous Familial Hypercholesterolemia (HeFH)` tih hming pu genetic condition nei tan chuan a tha hle. Hei hi i tan a tha em tih chu i doctor chauhvin a rel thei ang.
Engtin nge he vaccine hi ka lak theih ang?
Leqvio hi pill a ni lo va, shot a ni . Subcutaneous injection a ni. In lamah i pe thei lo. Damdawi in emaw clinic emaw-a healthcare professional (doctor emaw nurse emaw)-in a pek thin a ni.
Vaccine pek dan tur chu hetiang hi a ni:
1. Vaccine hmasa ber: Vaccine vawi khat pek hmasak i ni ang.
2. Vaccine pek vawi hnihna:Vaccine pahnihna hi a hmasa ber atanga thla 3 hnuah pek thin a ni.
3. Chumi hnuah: Chumi hnuah chuan thla 6 danah injection vawi khat i lak a ngai a ni .
He vaccine hi a kekawrte, pum chhungah emaw, kut chunglam hnung lamah emaw inject theih a ni. Vaccine hi a hun taka lak a pawimawh hle a, appointment engmah tih loh a pawimawh hle.
Leqvio hlawhtlinna chungchang hi eng nge i hriat?
Leqvio hi engtiang chiahin nge a hlawk leh him tih hriat nan zirchianna lian pathum neih a ni tawh bawk. Heng zirchiannate hi thla 18 chhunga neih a ni.
- Zirna pahnih: He zirchiannaah hian statin hmang chung pawha cholesterol level tihhniam thei lo thinlung natna vei te an tel a ni.
- Zirna dang ah chuan telte chu ‘HeFH` tih hming pu genetic cholesterol condition nei te an ni.
Heng zirchiannaah hian group pakhat chu Leqvio vaccine pek an ni a, group dang chu placebo vaccine pek an ni a, chu chuan nghawng a nei lo. Results chu a chiang hle mai.
| Pawl | Thla 18 hnuah cholesterol "bad" (LDL) level a inthlak danglam thin |
|---|---|
| Leqvio dawngtu te chuan | A vaiin 40% - 51% in a tlahniam tawh a ni. |
| Placebo (damdawi lem) dawng tawhte chuan . | A pung zat chu 1% - 8% a ni. |
Heng result atang hian Leqvio hi damdawi a ni a, statin-in a control loh LDL cholesterol level nasa takin a tihhniam thei a ni. Cholesterol level hi thla 3 hmasa berah a tlahniam tan tlangpui.
He damdawi hian heart attack leh stroke hlauhawmna a ti tlem em?
Hei hi zawhna pawimawh tak a ni. Statin damdawi hian LDL cholesterol a tihniam bakah heart attack leh stroke hlauhawmna a tihziaawm tih hmuhchhuah a ni. Mahse Leqvio hi damdawi a ni a, a hnathawh dan a danglam hle.
Tuna zirchianna atanga a lan dan chuan Leqvio hian LDL cholesterol nasa takin a tihniam thei a ni. Mahse, heng zirchiannate hi hun rei lote chhung, thla 18 vel zet an nei a ni. Chuvangin, chu hun chhung chu damdawi hian heart attack leh stroke hlauhawmna a tihziaawm tak tak em tih hriat nan a tawk lo.
Mahse, hetiang zat LDL cholesterol tlahniam hian nakin lawkah he hlauhawmna hi a tlahniam thei tih a tilang. Hei hi finfiah turin hun rei tak chhunga zirchianna tam zawk neih mek a ni.
Side effects leh engtin nge kan enkawl ang?
Damdawi dang ang bawkin Leqvio hian side effect tenau te a thlen thei a ni. A tam ber chu injection site a reaction te hi a ni .
- Injection na hmuna sen (redness) a awm
- Itching a ni
- Na
Hemi avang hian vaccine petu healthcare professional chuan ni zung kang, vun rawng nei, hri kai awmna hmunah vaccine hi a pe dawn lo. A hmaa injection i lo neih tawh a, na zawk i neih chuan doctor emaw nurse emaw hnenah hrilh rawh. Chumi hnuah chuan site dang an thlang thei ta a ni.
Heng bakah hian side effect dang pawh a awm thei bawk. Symptom danglam tak tak i neih chuan doctor nen inbia nghal rawh.
Tunah hian Leqvio leh damdawi dang inzawmna hi report a la awm lo. Mahse, i damdawi ei zawng zawng, vitamin leh herbal product i ei zawng zawng chu doctor hnenah hrilh vek a pawimawh.
Take-Home Thuchah a ni
- Leqvio hi cholesterol control nana vaccine thar a ni.
- Hei hi statin damdawi leh ei leh in hmanga control theih loh cholesterol level sang tak nei tan a tha hle.
- Hei hi healthcare professional-in thla 6 danah (dose hmasa pahnih hnuah) vaccine a pek thin a ni.
- Zirna hrang hrangah chuan hei hian LDL cholesterol level "tha lo" tihhniamna kawngah a thawk tha hle tih hmuhchhuah a ni.
- He damdawi hi i tan a tha em tih chu i doctor chauhin a rel thei a, chuvangin hemi chungchang hi i doctor nen inbia ang che.
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