Cholesterol tihhniamna damdawi chi thar ber (PCSK9 Inhibitors) i zir dawn em ni?

I doctor chuan i cholesterol level a sang tih a hrilh che em? Chutiang a nih chuan statin ei tan i ni tawh mai thei. Chu chu enkawlna line hmasa ber a ni tlangpui. Mahse, a chang chuan chu damdawi chauh chu a tawk lo. A nih loh leh mi thenkhat chuan damdawi ei avanga side effects te chu an tuar thei lo. Chuvangin tunah chuan doctor-te chuan damdawi class thar, ‘game-changer’ ni thei tur an sawi ta a ni. Chungte chu PCSK9 Inhibitors an ti a. Vawiin hian thumal awlsam takin an chungchang hi han sawi ila.

A awlsam zawngin, heng PCSK9 Inhibitor te hi engte nge ni?

Hengte hi damdawi chi thar, kan thisena cholesterol ‘tha lo’, a nih loh leh LDL cholesterol , chu nasa takin a tihziaawm thei a ni. Tunah hian khawvelah hian damdawi chi hnih pawmpui tawh chi hnih a awm a. Chungte chu `alirocumab (Praluent)` leh `evolocumab (Repatha)` te an ni.

Research atanga a lan dan chuan heng damdawi, PCSK9 inhibitor tia koh te hi mak tak maiin an thawk tha hle a ni. A châng chuan heart attack leh stroke pawh an veng thei a ni . Heng damdawi te hi a mah chauhin ei theih a ni a, statin damdawi i ei tawh nen pawh ei dun theih a ni bawk. Mahse thil pakhat hriat reng tur chu cholesterol damdawi dang aiin an man a to zawk hle .

Awle, tunah chuan he damdawi hian taksa chhungah engtin nge hna a thawh tih i en ang u.

Hei hi hrethiam tur chuan thawnthu tlem han ngaihtuah ila. Kan taksaa cholesterol control tu organ ber chu thin (liver) a ni.

Mahse, kan taksain a siam chhuah protein dang PCSK9 tih a awm bawk. A hna chu chutiang "thianfai" tha tak takte chu zawn chhuah leh tihchhiat hi a ni. Tichuan, cholesterol paih chhuak tur an awm loh avangin thisenah a pungkhawm a, thisen kalna kawng bangah a awm ta a ni.

Hei hi kan speaker, PCSK9 inhibitor damdawi hian a rawn pui a ni. He damdawi hian a tih chu chu PCSK9 protein tha lo chu a man a, hnathawh a titawp a ni. Naupang nalh tak chu man a, chair-a dah ang mai a ni. Tichuan kan "thianfai" te hian engmah daltu awm lovin an hna an thawk thei tawh ang. A rah chhuah chu? Thisen a LDL cholesterol level hi a tlahniam chak hle.

Engtin nge hengte hi ‘statins’ nen an danglam?

Statins leh PCSK9 inhibitors te hi cholesterol tihhniamtu damdawi chi hnih a ni a, mahse kawng hrang hrang pahnihin hna an thawk thung. He table hian hei hi a hriatthiam theih nan a pui ang che.

Chuti a nih chuan tuin nge he damdawi hi ei duh?

Hei hi zawhna pawimawh tak a ni a, a chhan chu cholesterol sang nei zawng zawng hian he damdawi hi an mamawh vek lo. I doctor chuan statin hmangin i cholesterol control a tum hmasa ang. Mahse i doctor chuan a hnuaia thil thlengah hian PCSK9 inhibitor hi a ngaihtuah thei ang:

• Genetic high cholesterol conditions: Mi thenkhat chuan genetic condition ``Familial Hypercholesterolemia'' an nei a, heng mite hian an taksain cholesterol a control danah chhiatna an nei a. Statin dose sang ber pawh nise, heng mite tan hian LDL cholesterol chu hrisel level-a tihhniam a harsa hle .
• Heart attack emaw stroke emaw vei theihna sang tak nei tan: Lung natna i nei tawh a, i cholesterol level pawh statin ang damdawi hmanga control tha tawk lo a nih chuan i doctor chuan he damdawi hi a ngaihtuah mai thei.
• ‘Statins’ tuar thei lo tan: Statin ei thin zinga 10%-20% vel chuan side effects an nei a, chu chu tuar theih loh taksa ruh natna, chak lohna, leh taksa na te hi a ni Chutiang mite tan chuan hei hi duhthlan tur tha tak a ni mai thei.

Doctor hian engtikah nge he damdawi hi a pek?

Doctor chuan he damdawi hi vawi khatah a pe vek ngai lovang. A kalphung tur a awm.

1. Pakhatnaah chuan i nunphung thlak rawh: Doctor chuan exercise tha tak leh ei tur hrisel, oil, sugar, leh flour tlem te ei tur a ti hmasa ber a ni .

2. A dawtah chuan ‘Statin’: Nunphung thlak danglam a tawk lo a nih chuan statin in tan a ni. Cholesterol a tlakhniam loh chuan a dose chu a tipung zauh zauh thin.

3. A hnuhnung ber atan: Statin dose sang ber pawhin i cholesterol control loh chuan, a side effects na tak a nih chuan i doctor chuan PCSK9 inhibitor a ngaihtuah thei ang. He thutlukna hi thinlung natna i vei theihna tur test, coronary calcium score ang chi tih hmanga siam a ni thei.

He damdawi hi engtin nge hman a nih a, a side effects te chu engte nge ni?

Subcutaneous injection angin a lo thleng a , kar hnih emaw kar li danah vun hnuaiah i pe thin . I pum vun, i kekawr chunglam, i kut chunglam vun-ah i hmu thei. I doctor emaw, nurse trained emaw chuan a pek dan tur dik tak a kawhhmuh ang che. A tlangpuiin a hrehawm lo va, a awlsam bawk.

Side effect chungchang sawi dawn chuan a tam ber chu a tenau deuh a ni.

• Hnunglam na
• Khawsik ang chi natna (itchy throat, mucus production) .
• Injection na hmuna sen, hliam emaw, natna tlem emaw a awm

A tawp berah chuan heng damdawi man chungchangah hian damdawi pangngai ang an ni lo va, a man pawh a to hle . Chuvangin he enkawlna hi mi zawng zawng tan a man tlawm lo mai thei. Hemi chungchangah hian i doctor nen zalen taka inbiakna neih a tha ber a, i mamawh leh mamawh loh te, i tan a tha em tih te, i cost options te chu eng nge ni tih sawiho a tha ber.