Kua kōrerotia e tō tākuta ki a koe tētahi momo rongoā e kiia nei ko ngā SERM, ko ngā SERD rānei, hei rongoā i te mate pukupuku o te ū? Kaua e manukanuka, tera pea he ahua uaua ēnei ingoa. I tēnei rā, ka kōrero māmā tātou mō te aha rātou, me pēhea te mahi, me ngā mea e tika ana kia mōhio koe mō rātou. He momo rongoā tino nui ēnei e rua hei āwhina i a tātou ki te whawhai ki te mate pukupuku o te ū .
He aha ngā SERM? Me pēhea tā rātou mahi?
He whakarāpopototanga noa iho, ko ngā SERM (Selective Estrogen Receptor Modulators) he momo rongoā e aukati ana i te tipu o ngā pūtau matepukupuku ū. Heoi, ka mahi anake rātou ki tētahi momo matepukupuku motuhake. Koinei te momo matepukupuku e mōhiotia ana ko te Estrogen Receptor-Positive . E 75% noa iho o ngā matepukupuku ū e kitea ana i tō tātou whenua nō tēnei momo.
Whakaarohia, he iti noa ngā "pūnahi" kei runga i te mata o ēnei pūtau matepukupuku. I roto i te rongoā, ka kiia ēnei he kaiwhakawhiwhi . Ina piri te homoni estrogen i roto i tō tātou tinana ki ēnei pūnahi, ka whiwhi te pūtau matepukupuku i tētahi tohu kia "wehewehe, kia nui ake te tipu."
Koinei te mahi a ngā SERM :
Ka haere rātou ka aukati i aua pūihi, arā, ngā kaiwhakawhiwhi. Kātahi ka kore he wāhi e haere mai ai te homoni estrogen ki te piri atu ki a ia anō. Nā te mea kāore e whiwhi i te tohu, ka mutu te tipu o ngā pūtau matepukupuku, ka whakahaeretia rānei te nuinga.
Ko te mea nui, he take tōna e kiia ai he 'whiriwhiri'. Ahakoa ka āraihia e ēnei rongoā te mahi a te estrogen i roto i ngā ū, ka taea e rātou te mahi pai o te homoni i ētahi atu wāhanga o te tinana, pērā i ngā wheua me te kōpū. Koinei te mea e motuhake ai rātou.
Ngā momo SERM me ō rātou whakamahinga
He maha ngā momo matua o ngā SERM kua whakaaetia mō te mate pukupuku o te ū .
| Ingoa o te rongoā | Ngā whakamahinga matua |
|---|---|
| Tamoxifen |
|
| Toremifene | |
| Raloxifene |
Nā, he aha ngā SERD?
Ko ngā SERD (Selective Estrogen Receptor Downregulators) he momo rongoā he kaha ake te mahi i ngā SERM. Pērā i ngā SERM, ka āraihia hoki e rātou ngā kaiwhakawhiwhi estrogen. Engari hei tāpiritanga, ka whakaitihia e ngā SERD te maha o ngā kaiwhakawhiwhi (downregulate) ā, ka whakarerekētia hoki te mahi a ngā kaiwhakawhiwhi e toe ana, ka iti ake te whai huatanga.
E rua ngā momo SERD kua whakaaetia i tēnei wā:
- Fulvestrant
- Elacestant
Ko te nuinga o ēnei ka hoatuhia mō ngā mate pukupuku ū kua pāngia e te mate pukupuku homoni, me ngā mate pukupuku HER2-kino . Ko te tikanga o te HER2-kino kāore he pūmua e kiia nei ko te HER2 i runga i te mata o ngā pūtau mate pukupuku hei āwhina i a rātou ki te tipu.
Me pēhea te whakamahi i tēnei rongoā?
- SERM: Ko te nuinga o ēnei he pire . Ka kī atu tō tākuta kia tangohia e koe te 20mg ki te 40mg ia rā. Mena kei te tango koe i ēnei rongoā hei ārai i te hokinga mai o te mate pukupuku, me haere tonu te tango i aua rongoā mō ngā tau e 5 ki te 10.
- Ngā SERD: Hei tauira, ka puta mai a Fulvestrant hei werohanga.Tuarua. Ka tukuna ēnei werohanga e rua ki roto i te uaua o te papa. E toru ngā wā ka tukuna i te marama tuatahi o te maimoatanga, ā, kotahi i te marama i muri iho.
I roto i ēhea āhuatanga ka hoatu ngā SERM me ngā SERD?
He maha ngā āhuatanga ka tohua ai ēnei maimoatanga e tō tākuta.
| Whai wāhitanga | Whakamārama |
|---|---|
| I mua i te pokanga (Whakaora Neoadjuvant) | Mena he nui tō puku, ka taea te hoatu i tēnei rongoā i mua i te pokanga hei whakaiti, hei whakangawari hoki i te tango. |
| I muri i te pokanga (Whakaora Āwhina) | Ka hoatu tēnei maimoatanga hei whakangaro i ngā pūtau matepukupuku iti e toe ana i muri i te pokanga, hei ārai hoki i te hokinga mai o te matepukupuku. |
| Mō te Matepukupuku Wāhanga Mutunga | Mena kua horapa te mate pukupuku ki ētahi atu wāhanga o te tinana i waho o te ū, ka taea e ēnei rongoā te āwhina ki te whakahaere, ki te whakaroa rānei i tōna tipu. |
| Mō te Ārai | Ahakoa kāore anō kia pāngia koe e te mate pukupuku ū, ki te mea he nui ake tō tūponotanga ki te pangia e te mate nā ngā āhuatanga pēnei i te ira, ka tohua pea ngā SERM hei whakaiti i taua tūponotanga. |
He aha ngā pānga taha me ngā mōrearea o ēnei maimoatanga?
Pērā i ngā rongoā katoa, ka pāngia pea ēnei e ngā pānga taha. Engari kāore e pāngia te katoa. He mea nui kia mōhio ki ngā pānga taha ka pā mai.
Ngā pānga taha o ngā SERM
He rite tonu ngā pānga taha e kitea pinepinetia ana ki ērā e pāngia ana i te wā o te menopause.
- Ngā mura wera
- Te maroke o te tara, te rere o te toto, te toto iti rānei
- Te werawera o te pō
- Whakapairuaki
- Ngā huringa wairua
Ngā pānga taha onge engari he kino:
- He iti noa te pikinga o te mōrearea o te mate pukupuku kōpū
- Ngā toto totoka i roto i ngā waewae (Deep Vein Thrombosis, DVT rānei) ngā toto totoka rānei i roto i ngā pukahukahu (Pulmonary Embolism)
- Ngā katarata
- Te angiangi o ngā wheua i roto i ngā wāhine i mua i te menopause
Ngā pānga taha o ngā SERD
- Mamae rangitahi i te wāhi i werohia ai
- Whakapairuaki
- Mamae wheua, uaua, hononga rānei
- Ānini
- Te uaua
- Ngā mura wera
He mea tino nui: Ka taea e ngā SERD te whakaiti i te maha o ngā pereti toto, e āwhina ana i te toto kia totoka. Ka taea e tēnei te whakanui ake i te mōrearea o te toto. Waihoki, kāore ēnei rongoā e tūtohutia ana i te wā e hapu ana, i te wā rānei e ngana ana koe kia hapu . He mea nui kia whakamahia he momo ārai whānau kore-hormonal i te wā e tango ana i ēnei rongoā, ā, mō te iti rawa i te tau i muri i te whakamutu i te maimoatanga.
Ki te tūtohu tō tākuta i tēnei maimoatanga, kōrero ki a ia. Kaua e wehi ki te pātai i ngā pātai pēnei i te, "He aha ngā painga ka puta mai i tēnei rongoā?", "He aha ngā pānga taha ka taea e au te tumanako?", me te "Kia pēhea te roa me tango e au tēnei rongoā?"
Karere Tangohia ki te Kāinga
- He tino whai hua ngā SERM me ngā SERD mō te mate pukupuku ū e whai estrogen receptor-positive ana. Ka ārai rātou i te mahi a te homoni estrogen, he mea nui mō te tipu o ngā pūtau matepukupuku.
- Ehara i te mea he pai ēnei rongoā katoa mō te katoa. Ko tō tākuta anake ka taea te whakatau i te maimoatanga pai rawa atu māu i runga i te momo mate pukupuku, tō tau, me tō hauora.
- Tērā pea ka puta ngā pānga taha, engari ko te nuinga ka taea te whakahaere. Kōrero ki tō tākuta mō ngā mamae katoa e pā ana ki a koe, ahakoa te iti.
- He mea tino nui kia kaua e hapu i te wā e tango ana i tēnei rongoā. Me kōrero ki tō tākuta mō ngā tikanga ārai whānau e tika ana.
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