Kodi kusamba kumakhudza bwanji chithandizo chanu cha khansa ya m'mawere?

Ndikumvetsa momwe zimakhalira zovuta komanso zoopsa mukapezeka ndi khansa ya m'mawere. Kumbali imodzi, pali nkhawa yokhudza matendawa, ndipo kumbali ina, madokotala akamanena mawu monga ``(Chemotherapy)`` ndi hormone therapy , maganizo anu amasokonezeka kwambiri, sichoncho? "Kodi inenso ndilandira chemotherapy? Kodi tsitsi langa lidzagwa? Kodi zidzavuta thupi langa?" Muyenera kuti muli ndi mafunso ambiri m'maganizo mwanu. Koma musadandaule. Lero, tikambirana momwe zaka zanu komanso ngati mwadutsa nthawi yosiya kusamba kapena ayi zidzakhalire zofunika podziwa chithandizo chomwe mukupatsidwa.

Kale, pafupifupi aliyense ankapatsidwa mankhwala a chemotherapy akangodziwa kuti khansa ya m'mawere yafalikira ku ma lymph nodes. Zinali ngati kugwira nyundo ndikupangitsa chilichonse kuoneka ngati msomali. Koma tsopano mankhwala apita patsogolo kwambiri. Tsopano tikudziwa kuti si khansa yonse ya m'mawere yomwe ndi yofanana, ndipo si odwala onse omwe angayankhe chithandizo chomwecho. Nthawi zina zotsatira zoyipa za mankhwala a chemotherapy zimatha kuposa zabwino zake. Chifukwa chake tsopano madokotala akuda nkhawa kwambiri osati ndi kukula kwa chotupa ndi gawo la khansa, komanso ndi momwe khansayo imakhalira.

N’chifukwa chiyani kusamba ndikofunikira pa nkhaniyi?

Kaya mwakhala mukusiya kusamba kapena ayi, nthawi imene kusamba kwanu kwa mwezi kumasiya, ndi yofunika kwambiri pa chithandizo cha khansa ya m'mawere. Pali zifukwa zingapo zomwe zimapangitsa izi.

Mwachidule, khansa ya m'mawere mwa amayi achichepere omwe asanakwane nthawi yosiya kusamba imakhala yoopsa kwambiri kuposa khansa mwa amayi omwe apitirira nthawi yosiya kusamba .

Kuphatikiza apo, imasankhanso mtundu wa chithandizo chomwe mudzalandire. Mwachitsanzo, ngati muli ndi khansa yodalira mahomoni, mtundu wa chithandizo cha mahomoni chomwe mungalandire chidzasiyana malinga ndi momwe mulili pa nthawi ya kusamba.

• Pambuyo pa kusamba: Mungapatsidwe mankhwala monga Arimidex, omwe amaletsa thupi kupanga mahomoni otchedwa estrogen.
• Ngati muli ndi nthawi yopuma: Mazira anu a mazira akupangabe estrogen, kotero mankhwala monga Arimidex sangakhale othandiza kwambiri. Choncho dokotala wanu nthawi zambiri amalemba mankhwala otchedwa Tamoxifen. Izi zimagwira ntchito poletsa uthenga womwe estrogen imatumiza ku maselo a khansa.

Biology ya Khansa: Ma Hormone Receptors ndi HER2

Chabwino, tsopano tiyeni tifufuze mozama pang'ono. Tikasiya kuganizira ngati chithandizo cha mahomoni chili choyenera kwa inu, funso lalikulu lotsatira ndi lakuti ngati mukufunikira chemotherapy kapena ayi.

Chisankho ichi nthawi zambiri chimadalira mitundu ya ma receptor pamwamba pa maselo anu a khansa . Ganizirani ma receptor awa ngati 'ma antenna' pa maselo a khansa. Ma antenna awa amatenga 'zizindikiro' zomwe khansa ikufunika kuti ikule. Pali mitundu iwiri ikuluikulu ya ma receptor omwe timayang'ana.

1. Ma Receptor a Hormone (HR): Ma Receptor omwe amakhudzidwa ndi mahomoni a estrogen ndi progesterone.

2. Cholandirira cha HER2: Ichi ndi puloteni ina yomwe imathandiza maselo a khansa kukula.

Onani tebulo ili m'munsimu kuti mudziwe momwe khansa imagawidwira m'magulu ndi momwe chithandizo chimadziwikira kutengera kuphatikiza kwa izi.

Kodi mayeso a Oncotype Dx ndi chiyani?

Ngati khansa yanu ili ndi HR-positive, HER2-negative, ndiye kuti, mtundu woyamba patebulo pamwambapa, funso lakuti "Kodi ndikufunika chemo?" ndilovuta kwambiri kuyankha. Ndi m'mikhalidwe ngati iyi pomwe madokotala amagwiritsa ntchito mayeso a genomic monga `Oncotype Dx` .

Kuyesaku kumafufuza majini 21 mu chitsanzo chaching'ono cha khansa yanu. Kutengera izi, kumakupatsani zigoli zosonyeza ngati khansa yanu ili ndi chiopsezo chochepa, chapakati, kapena chachikulu choti ibwererenso mtsogolo.

• Kutsika kwa zigoli: Nthawi zambiri mumatha kuchira popanda mankhwala a chemotherapy .
• Ngati zotsatira zake zili zapamwamba: Chemotherapy ndiyo yoyenera kwambiri.

Koma anthu ambiri amapeza zigoli zapakati . Pamenepo ndi pomwe vuto limayambanso.

Mayankho ochokera ku kafukufuku watsopano

Mwamwayi, maphunziro awiri akuluakulu aposachedwa, TAILORx ndi RxPONDER, apereka mayankho abwino kwambiri pa funso loti achite chiyani ndi akazi olemera kwambiri. Maphunziro awa atsimikiziranso kufunika kwa kusamba.

• Kuyesa kwa TAILORx (kwa anthu omwe khansa yawo sinafalikire ku ma lymph nodes):
• Kafukufukuyu akuwonetsa momveka bwino kuti akazi omwe asiya kusamba omwe ali ndi zigoli zochepa za Oncotype Dx sapeza phindu lina lililonse kuchokera ku chemotherapy. Chithandizo cha mahomoni chokha ndi chokwanira kwa iwo.
• Kafukufuku wa RxPONDER (kwa anthu omwe ali ndi khansa yomwe yafalikira ku ma lymph nodes):
• Izi zikusonyezanso chimodzimodzi. Azimayi ambiri omwe asiya kusamba , ngakhale khansa yawo itafalikira ku ma lymph nodes, sapindula kwambiri ndi mankhwala a chemotherapy.
• Komabe, nkhaniyi ndi yosiyana kwambiri kwa akazi omwe sanakwanitse kusamba, makamaka omwe ali ndi zaka zosakwana 50. Pamene mankhwala a chemotherapy awonjezeredwa ku mankhwala a mahomoni kwa iwo, mphamvu yoletsa khansa kuti isabwererenso imawonjezeka kwambiri .

Mwachidule, ngati ndinu mtsikana amene ali ndi nthawi yopuma, mankhwala a chemotherapy angakhale chida champhamvu chomwe chingapulumutse moyo wanu. Koma ngati mwafika nthawi yopuma, mutha kupeza zotsatira zabwino pogwiritsa ntchito mankhwala a mahomoni popanda kukumana ndi zotsatirapo zake.

Chisankho chomaliza ndi zinthu zoti muganizire

Ndi zonsezi, mwina mukumvetsa momwe zimakhalira zovuta kupanga zisankho izi nokha. Ndicho chifukwa chake ndikofunikira kwambiri kukambirana momasuka za zonsezi ndi dokotala wanu.

Ngati muli ndi nthawi yopuma, makamaka muzaka za m'ma 40, pali china chomwe muyenera kukumbukira. Mankhwala a chemotherapy angayambitse kusamba kwanu kutha kwamuyaya ndikuyambitsa kusamba msanga. Kwa omwe ali aang'ono, kusamba kwanu kungasiye kwakanthawi kenako nkuyambanso. Koma ngati mukuyembekeza kukhala ndi ana mtsogolo, onetsetsani kuti mwalankhula ndi dokotala wanu za kusunga chonde musanayambe chithandizo.

Pamapeto pake, inu ndi dokotala wanu mudzasankha chithandizo chomwe chili chabwino kwa inu. Pakukambirana kumeneku, mtundu wa khansa yanu, gawo lanu, kuchuluka kwa Oncotype Dx, komanso ngati mwafika nthawi yopuma ndi nkhani zofunika kukambirana.