Ngatidzidzei nezveFSH (Follicle-Stimulating Hormone) nenzira iri nyore. Inoitei kumuviri wako?

Wakambonzwa nezveHormone Inokurudzira Follicle here, kana kuti FSH muchidimbu? Ungangoona zita iri seresainzi. Zvisinei, ihomoni inokosha zvikuru pakukura kwepabonde kwemuviri wedu uye kugona kubereka vana. Inoshanda semutumwa mudiki mumuviri wedu. Ngatitaurei nezvazvo zvakadzama, handiti?

Chii chinonzi FSH?

Zvakanaka, saka ngationei kuti FSH chii chaizvo. FSH, iyo inomiririra Follicle-Stimulating Hormone, ikemikari yakakosha inogadzirwa negland diki riri pasi peuropi hwako, inonzi pituitary gland , uye inoburitswa mumuviri. Iri ihormone . Mahormone akafanana nevatumwa mumiviri yedu. Anofamba nemuropa uye anoudza nhengo dzedu, tsandanyama, nedzimwe nyama zvekuita uye nguva yekuzviita.

Zvino, paunonzwa izwi rekuti 'follicle-stimulating', vamwe vanhu vangafunga kuti ichi chinhu chine chekuita nebvudzi. Nekuti izwi rekuti follicle rinoshandiswawo nebvudzi. Asi kutaura chokwadi, iyi FSH hormone haikanganisi zvakananga mafollicle ebvudzi rako kana kukura kwebvudzi. Kukura kwebvudzi kunokanganiswa neboka rakasiyana remahormone anonzi androgens . FSH inowana zita rayo kubva mumasagi madiki ari mumaovari evasikana, kureva masagi ane mvura ane mazai, atinodaidza kuti ovarian follicles , nekuti iyi hormone inokanganisa iwo. Zvichitaurwa zviri nyore, FSH ihormone inokosha inobva mugland repituitary rinobatsira mukukura kwedu pabonde nekugadzira vana. Inokanganisa maovari muvasikana nematesticles muvakomana.

Chii chinoitika neFSH?

Homoni iyi inoshamisa inonzi FSH inoita mabasa akawanda akakosha mumiviri yedu pamazera akasiyana uye nenzira dzakasiyana. Ngatitarisei rimwe nerimwe rawo zvakasiyana.

Matambudziko api eFSH kumwana ari mudumbu

Waizviziva here kuti iyi hormone yeFSH inotanga kushanda tisati tazvarwa? Kana amai vaine mwana mudumbu, panguva yechipiri neyechitatu yekuzvitakura (kureva, kubva pamavhiki gumi nematatu kusvika pamavhiki makumi maviri nematanhatu, uye kubva pamavhiki makumi maviri nemanomwe kusvika pakupera kwekuzvitakura), pituitary gland yemwana inoburitsa FSH neimwe hormone inokosha , Luteinizing Hormone (LH) . Mahomoni aya anosvika pakati pekuzvitakura. Ndipo panokura follicle yekutanga yemwana (kana ari musikana) kana machubhu anogadzira mbeu ( seminiferous tubules - kana ari mukomana). Fungidzira, mahomoni aya anotanga kushanda mumiviri yedu kubva pazera diki kudaro.

Basa reFSH panguva yekuyaruka

Munguva yehudiki, huwandu hweFSH hunowanzova hwakaderera. Asi mwana paanosvika pakuyaruka (kazhinji ari pakati pemakore gumi nemana), chikamu cheuropi chinonzi hypothalamus chinoburitsa hormone inonzi gonadotropin-releasing hormone (GnRH) . GnRH inokurudzira kugadzirwa kweFSH neLH. Apa ndipo panotanga kukura pabonde uye kuchinja kwekukura.

• Muvakomana , FSH neLH zvinoshanda pamwe chete kukurudzira machende avo kuti agadzire hormone inonzi testosterone . Iyi testosterone ndiyo inokonzera shanduko mumuviri wevakomana panguva yekuyaruka (senge bvudzi rechiso, bvudzi repachipfuva, uye izwi rinodzika) uye inokonzerawo kugadzirwa kwembeu.
• Muvasikana , FSH neLH zvinoshanda pamwe chete kukurudzira mazai avo kuti agadzire hormone inonzi estrogen . Iyi estrogen ndiyo inokonzera zviratidzo zvekuyaruka, zvakaita sekukura kwemazamu uye kutanga kwemwedzi.

FSH inokosha sei kuvakadzi vari kumwedzi?

Kuvakadzi vanoenda kumwedzi pamwedzi, basa guru reFSH nderekubatsira kudzora kutenderera kwemwedzi. Zvikuru sei, FSH inokurudzira follicles dziri mumaovari kuti dzikure uye dzigadzirire mazai eovulation . Sezvo follicles idzi dzichikura, dzinotanga kuburitsa mahormone eestrogen uye, kusvika pamwero wakati , progesterone muropa.

Kubuda kwezai (ovulation) inguva yekuenda kumwedzi. Mumwedzi wemazuva makumi maviri nemasere, izvi zvinoitika pazuva rechi14. Zvichitaurwa zviri nyore, zai (ovum) rinobuda muchibereko.

Mwedzi wega wega, pakati pemazuva 6 ne14 ekuenda kumwedzi, FSH inokurudzira kukura kwema follicles akati wandei mu ovary imwe chete. Zvisinei, pakati pemazuva 10 ne14, follicle imwe chete iyi inokura inokura kuita zai rakakwana. Panosvika zuva regumi nemana rekuenda kumwedzi, kuwedzera kamwe kamwe kwehomoni yeLH kunoita kuti follicle iyi yakakura ibude uye ibudise zai (izvi zvinonzi ovulation ).

Mushure mekuvhurwa kwembeu, follicle yakaputika inova corpus luteum (gland renguva pfupi rinogadzira mahormone). Izvi zvinoburitsa progesterone yakawanda. Progesterone inomisa kuburitswa kweFSH uye inobatsira kugadzirira mukati mechibereko kuti chikwanise kubata pamuviri.

Zai rinoburitswa rinofamba kwemazuva angangoita mashanu richipfuura nemuchubhu yeFallopian kuenda kuchibereko. Kana rikabudirira kusangana nembeu panguva iyi, pamuviri unoitika. Kana kusangana nembeu kukasaitika, corpus luteum inoputsika pakupera kwekuenda kumwedzi. Zvadaro, zai remudumbu rinotanga kuputsika.Kugadzirwa kweprogesterone kunoderera, huwandu hweFSH hunotanga kukwira zvakare, uye kutenderera kunotevera kwekuenda kumwedzi kunotanga - zvinoreva kuti unenge wava nemwedzi.

Zvinoitwa neFSH kuvarume

Muvarume, FSH inonyanya kukurudzira kugadzirwa kwembeu . LH inosimudzira kugadzirwa kwe testosterone mumachende, uye FSH inoshanda ne testosterone kuti irambe ichikura.

Kugadzirwa kweFSH kunodzorwa sei?

Zvino ungangove uchishamisika kuti FSH iyi inodzorwa sei nemazvo. Izvi zvinoitwa nehurongwa hwakaoma kunzwisisa, asi hunoshanda zvinoshamisa. Tinohudaidza kuti Hypothalamic-Pituitary-Gonadal axis . Zvakafanana necall centre. Kufona kunobva kune imwe nzvimbo, nzvimbo inotevera inopindura, uye zvichienderana nemhinduro iyoyo, kufona kwakasiyana kunobva pakutanga. Kana chimwe chezvikamu zvehurongwa uhwu muuropi (hypothalamus), pituitary gland, kana sex glands (ovari kana gonads) zvisiri kushanda zvakanaka, huwandu hwemahormone huri muhurongwa uhwu hunogona kunge husina kujairika.

Kutanga, chikamu cheuropi hwako chinonzi hypothalamus chinoburitsa gonadotropin-releasing hormone (GnRH) . GnRH iyi inokurudzira pituitary gland kuti iburitse FSH neLH (zvose zvinonziwo gonadotropins). Hypothalamus inoburitsa GnRH zvishoma, zvinonzi pulses . Kana pulses idzi dzikasauya kazhinji, FSH yakawanda inogadzirwa, uye kana dzikauya kakawanda, LH yakawanda inogadzirwa. Hazvishamisi here izvozvo?

Zvadaro, FSH neLH zvinobuda zvinofamba nemuropa zvobatana nemareceptor akakosha ari mumachende kana maovari. Ndizvo zvinoita kuti FSH neLH zvishande pamwe chete kudzora mashandiro emachende nemaovari.

Mukupindura, mahormone anoburitswa kubva mumatestes kana maovari anodzora huwandu hweGnRH hunogadzirwa nehypothalamus. Kutenderera uku kunoenderera mberi. Zvisinei, huwandu hwakasiyana hwemamwe mahormone muhurongwa uhwu hunokanganisa kuburitswa kwemamwe mahormone zvakasiyana.

Semuenzaniso, hormone yevakadzi inonzi estrogen ine mhedzisiro yakati wandei pakuburitswa kweFSH. Kugara uchisangana neestrogen kwenguva refu kunoderedza kuburitswa kweFSH. Zvisinei, kana huwandu hweestrogen hukakwira sezvavanowanzoita nguva dzose ovulation isati yatanga, zvinokurudzira pituitary gland kuti iwedzere huwandu hwegonadotropin (FSH neLH). Progesterone inoderedza kuwanda kwekuburitswa kweGnRH kubva muhypothalamus, asi inowedzera kupindura kwegonadotropins kuGnRH.

Inhibin B, inoburitswa mumasero ari mumachende evarumeHomoni inonzi FSH inomira kugadzirwa sechikamu cheiyi feedback loop.

Saka, zvakare, kana paine kukanganiswa kana dambudziko muketani iyi yekuburitswa kwemahormone, zvichakonzera kudzikira kwemahormone epabonde. Izvi zvinokanganisa kukura kwepabonde kwevana uye zvinokanganisawo kushanda zvakanaka kwematende kana maovari muvanhu vakuru.

Mazinga eFSH akajairika anofanira kunge akaita sei?

Mazinga eFSH akajairika anosiyana zvichienderana nezera rako uye bonde rako (kureva kuti uri mukadzi kana murume). Chimwe chinhu chekurangarira ndechekuti aya marudzi eFSH akajairika anogona kusiyana zvishoma kubva kune rimwe rabhoritari kuenda kune rimwe. Saka, gara uchitarisa huwandu hwakajairika hwerabhoritari pamushumo wako wekuongororwa kweropa . Kana uine mibvunzo nezvemhedzisiro yako, iva nechokwadi chekubvunza chiremba wako.

Mazinga eFSH akajairika muvarume

Mazinga eFSH akajairika muvarume ndeaya anotevera (mayuniti: mIU/mL - milli-International Units pa milliliter):

• Usati wasvika pazera rekuyaruka: 0 kusvika 5.0 mIU/mL.
• Munguva yekuyaruka: 0.3 kusvika 10.0 mIU/mL.
• Munhu mukuru: 1.5 kusvika 12.4 mIU/mL.

Mazinga eFSH akajairika muvakadzi

Mwero weFSH wakajairika muvakadzi ndewekuti (yuniti: mIU/mL ):

• Usati wasvika pazera rekuyaruka: 0 kusvika 4.0 mIU/mL.
• Munguva yekuyaruka: 0.3 kusvika 10.0 mIU/mL.
• Mushure mekuyaruka (usati wasvika pakuguma kuenda kumwedzi): 4.7 kusvika 21.5 mIU/mL.
• Mushure mekuguma kuenda kumwedzi : 25.8 kusvika 134.8 mIU/mL.

Unotarisa sei huwandu hweFSH hwemunhu ari kuedza kubata pamuviri?

Kana uchitarisa huwandu hweFSH hwekubereka, nguva yekuongororwa kwakakosha zvikuru . Huwandu hweFSH hunochinja mukati menguva yako yekuenda kumwedzi. Pakuongororwa kwehunhu hwekubereka, kuongororwa kweropa reFSH kunowanzoitwa paZuva rechitatu remwedzi wako ( Zuva rekutanga ndiro zuva raunotanga kuenda kumwedzi).

Imwe ongororo yakaratidza kuti vakadzi vane mazinga eFSH ari pasi pe15 mIU/mL pazuva rechitatu rekuenda kwavo kumwedzi vaive nemukana wekubata pamuviri kuburikidza neIVF (In Vitro Fertilization) kupfuura avo vane mazinga eFSH ari pakati pe15 mIU/mL ne24.9 mIU/mL. Vakadzi vane mazinga eFSH ari pamusoro pe25 mIU/mL vaive nemazinga akaderera ekubata pamuviri mushure mekuedza kweIVF.

Asi yeuka, kune zvimwe zvinhu zvakawanda zvinokanganisa kugona kwako kuva nevana - huwandu hwako hweFSH handihwo hwega hunosarudza . Kana uine mibvunzo nezvekukwanisa kwako kuva nevana kana nezvekuva nepamuviri, bvunza chiremba wako kana nyanzvi yekubereka .

Chii chingaitika kana huwandu hweFSH hukawedzera?

Kazhinji, kana huwandu hweFSH hwakakwira kupfuura hwakajairika zvinoreva kuti pane dambudziko mumazai kana mumachende (ndiko kuti, magonads).Zvinoreva kuti pane dambudziko.

Fungidzira, kana gonads dzako dzisingakwanise kugadzira estrogen yakakwana, testosterone, uye/kana inhibin, feedback loop kubva ku pituitary gland kuti igadzire FSH inokanganiswa. Zvadaro, huwandu hweFSH neLH hunowedzera. Chirwere ichi chinonzi hypergonadotropic-hypogonadism kana primary hypogonadism . Izvi zvine chekuita nePrimary Ovarian Insufficiency (POI) kana testicular failure .

Kusagona kwemunhu mukuru kunogona kuitika kana kuwanikwa nekuda kwezvimwe zvirwere.

Mhando dzekutanga dze hypogonadism dzekuzvarwa nadzo ndedzinotevera:

• Klinefelter syndrome muvarume.
• Turner syndrome muvakadzi.
• Chirwere chekusanzwa kweAndrogen .
• Kushomeka kwema enzyme (izvi hazviwanzoitiki).

Zvinotevera zvinogona kukonzera kutanga kwe hypogonadism yekutanga:

• Zvinhu zvine chepfu kumasero emudumbu, semuenzaniso kurapwa nemwaranzi kana chemotherapy .
• Kukuvara kana kukuvara kwemazai kana machende.
• Kuderera kwemahormone epabonde nekukura.
• Zvimwe zvirwere zve autoimmune .
• Utachiona hwakaita semapundu .

Kashoma, matambudziko ane pituitary gland yemukadzi anogona kukonzera FSH yakakwira. Izvi zvinogona kukanganisa feedback loop yakajairika uye dzimwe nguva zvinotungamira kuchirwere chinonzi ovarian hyperstimulation syndrome . Izvi zvinogona kukonzera kuti maovari azvimbe uye kukonzera mvura ine njodzi mudumbu.

Mazinga eFSH anowedzera zvechisikigo sezvo vakadzi vava kusvika uye panguva yekuguma kuenda kumwedzi . Izvi zvakajairika.

Muvana, kana huwandu hweFSH neLH hwakakwira kupfuura zvinotarisirwa pazera ravo - pamwe nekuonekwa kwekutanga kwehunhu hwepabonde - chiratidzo chekuyaruka kwepakutanga . Izvi zvinonyanya kuitika kuvasikana. Kuyaruka kwepamberi penguva kunotsanangurwa sekuyaruka kunoitika vasati vasvitsa makore mapfumbamwe kuvasikana uye gumi kuvakomana.

Chii chingaitika kana huwandu hweFSH hukadzikira?

Kuderera kweFSH pane zvakajairika kunowanzo kukonzera kukura kusina kukwana panguva yekuyaruka. Kuvanhu vakuru, mashandiro emazai kana machende anokanganiswa, izvo zvinogona kukonzera kusabereka .) mamiriro ezvinhu. Chirwere ichi chinonzi hypogonadotropic-hypogonadism . Chinowanzo kukonzerwa nematambudziko negland rako repituitary kana hypothalamus.

Matambudziko epituitary gland anogona sei kukonzera FSH yakaderera

Hypopituitarism chirwere chisingawanzoitiki apo pituitary gland yako inoburitsa mahormone mashoma, akawanda, kana ese. Saka, hypopituitarism inogona kukonzera kudzikira kwemazinga eFSH.

Kunyangwe zvisingawanzoitiki, zvirwere zvakawanda nezvikonzero zvinogona kukonzera hypopituitarism. Kazhinji, zvikonzero zvikuru zvitatu izvi zvinogona kukonzera hypopituitarism:

• Pane chiri kumanikidza pituitary gland yako kana hypothalamus.
• Kukuvadzwa kwegland repituitary kana hypothalamus.
• Une chirwere chisingawanzoitiki chinogona kukonzera hypopituitarism.

Chimwe chikonzero chinowanzoita kuti chirwere chepituitary chisashande zvakanaka igomarara repituitary . Iri igomarara risina njodzi rinokura mugomarara repituitary. Kana gomarara iri rakakura zvakakwana kana kuti richiramba richikura, rinogona kumanikidza gomarara repituitary kana kudzivirira kufamba kweropa kwaro.

Matambudziko e hypothalamic anogona sei kukonzera FSH yakaderera

Kallmann syndrome chirwere chinogara nhaka. Muchirwere ichi, hypothalamus yako haibudisi gonadotropin-releasing hormone (GnRH) yakakwana. Kana pasina GnRH yakakwana, huwandu hweFSH hunoderera, uye huwandu hwemahormone epabonde hunodererawo. Kana ikasarapwa, munhu ane Kallmann syndrome haazosviki pazera rekuyaruka uye haazokwanisi kubereka vana.

Ndezvipi zviratidzo zvekusagadzikana kweFSH level?

Kana huwandu hweFSH muvana husina kunaka uye huchikonzera kutanga kwekuyaruka, huwandu hweFSH, hungave hwakakwira kana hwakaderera, hunowanzo ratidza chirwere chinonzi hypogonadism . Hypogonadism inguva apo gonads, kungave matesticles kana maovari, dzinogadzira mahormone mashoma kana kuti hadzina kana kumboburitsa zvachose.

Kana huwandu hweFSH hwakaderera nekuda kwedambudziko rehypothalamus yako kana pituitary gland, zvinotungamira zvakananga ku hypogonadism. Zvisinei, huwandu hweFSH hwakakwira kupfuura hwakajairika hunogona kuva chiratidzo kana mhedzisiro ye hypogonadism inokonzerwa nedambudziko re gonads yako.

Izvi zvinodaro nekuti kana magonad ari kugadzira mahormone mashoma epabonde (kazhinji nekuda kwekukuvadzwa), pituitary gland yako inoedza kuakurudzira kuti agadzire mahormone akawanda epabonde. Ndokusaka ichiburitsa FSH yakawanda. Panguva ino, FSH inowanzo shaya simba, nekuti pane chimwe chinhu chisina kunaka pamatishu emagonad anogadzira mahormone epabonde.

Zviratidzo zve hypogonadism zvinosiyana zvichienderana nezera rako uye kuti uri murume here kana mukadzi.

Zviratidzo zve hypogonadism muvana vacheche zvinogona kusanganisira:

• Kuva nenhengo diki isina kujairika ( micropenis ).
• Machende asina kudzika ( Cryptorchidism ).

Zviratidzo zve hypogonadism muvana zvinogona kusanganisira:

• Mazamu evasikana haakure panguva yekuyaruka.
• Kusavapo kana kunonoka kuenda kumwedzi ( amenorrhea ).
• Machende evakomana haasi kukura.
• Kusakurumidza kukura kwemwana panguva yekuyaruka.

Zviratidzo zve hypogonadism muvarume:

• Kuderera kwechido chepabonde.
• Kuneta .
• Kusabereka , kazhinji kunokonzerwa nekushaikwa kwembeu ( Azoospermia ).
• Kusashanda zvakanaka kwenhengo dzesikarudzi .
• Kuwedzera kwezamu ( gynecomastia ).
• Kuderera kwesimba remhasuru.
• Kurasikirwa nebvudzi rechiso kana remuviri.

Zviratidzo zve hypogonadism muvakadzi:

• Kuderera kwechido chepabonde.
• Kuneta.
• Kusabereka, kazhinji kunokonzerwa nematambudziko ekubuda kwechibereko.
• Kupisa kunopisa .
• Kuenda kumwedzi kusingaenderane nenguva kana kuti kurega kuenda kumwedzi zvachose.
• Kudonha kwebvudzi panzvimbo yakavanzika.

Nzira yekuongorora mazinga eFSH?

Chiremba anogona kuongorora huwandu hweFSH yako nekuongororwa ropa . Izvi zvinosanganisira kutora ropa kubva mutsinga iri muruoko rwako uchishandisa tsono. Zviri nyore kwazvo.

Vanachiremba vanogona kuraira kuongororwa kweropa reFSH nekuda kwezvikonzero zvakasiyana-siyana. Vanogonawo kuraira kuongororwa kweropa remahormone panguva imwe chete, kungave kuongorora kana kubvisa zvimwe zvirwere. Semuenzaniso:

• Luteinizing hormone (LH).
• Testosterone.
• Estradiol uye/kana progesterone.

Kazhinji, bvunzo idzi dzinobatsira nezvinhu zvakaita se:

• Tsvaga chikonzero chekusaita vana.
• Ongorora zvirwere zvine chekuita nekusashanda zvakanaka kwemazai kana machende.
• Batsirai pakuongorora zvirwere zviri mugland repituitary kana hypothalamus zvinogona kukanganisa kugadzirwa kweFSH.

Kuti zvive zvakananga, kuvakadzi, kuongororwa kweropa reFSH kunogona kuratidza ruzivo runotevera:

• Tsvagai nguva yekuenda kumwedzi isina kurongeka .
• Fanotaura kana vava pedyo nekuguma kwemwedzi kana kuti vatotanga kuenda kumwedzi.

Kuvarume, kuongororwa kweropa reFSH kunogona kubatsira kuona chikonzero chekuderera kwehuwandu hwembeu.

Vanachiremba vanoshandisa bvunzo dzeropa dzeFSH neLH kuti vaone kana vana vari kunonoka kuyaruka kana kuti vari kutanga kuyaruka .

Unofanira kutaura nachiremba rini nezveFSH?

Kana uchinzwa sekuti une zviratidzo zvekusagona kuita chimwe chinhu, iva nechokwadi chekuona chiremba wako .

Kana mwana wako achiita seari kuyaruka nekukurumidza kana kunonoka kupfuura zvaitarisirwa, enda kuna chiremba wake. Vanogona kuita bvunzo dzeropa kuti vaone kana paine chisina kumira zvakanaka pamazinga ake eFSH.

Kana uchinetseka nekubata pamuviri, taura nachiremba wako kana nyanzvi yezvekubereka. Kunyange zvazvo paine zvikonzero zvakawanda zvekusabereka, huwandu hweFSH yako hunogona kunge huri chimwe chazvo.

Muchidimbu

Zvakanaka, saka chinhu chakakosha chaunofanira kuyeuka kubva pane zvatataura ndechekuti follicle-stimulating hormone (FSH) ihormone inokosha ine simba guru pakukura kwedu pabonde uye kubereka . Sezvo FSH iri chikamu chehurongwa hwakaoma hunoshanda pamwe chete nemamwe mahormone akawanda nemagland, hazvishamisi kuti mazinga eFSH ave asina kujairika.

Kana iwe kana mwana wako muine zviratidzo zvine chekuita nekukura pabonde kana kubereka, ndapota onai chiremba wenyu mokurukura nezvazvo. Varipo kuti vakubatsirei. Musamboedza kuva mega, kuchenjera kutsvaga mazano echiremba nguva dzose.

Homoni inokurudzira follicle, FSH, mahormone, pituitary gland, hutano hwekubereka, kuyaruka, kutenderera kwemwedzi, kusabereka, hypogonadism, LH, GnRH