Fungidzira kuti chikamu chimwe chete chemuviri wako, semuenzaniso ruoko, gumbo, kana imwe nzvimbo yeganda, chinokura nekukurumidza kupfuura zvimwe. Ichi chirwere chisingawanzoitika icho vamwe vanhu vanozvarwa nacho. Mukurapa, tinodana boka iri rezvirwere kuti PIK3CA-Related Overgrowth Spectrum, kana kuti PROS muchidimbu. Ichi chinhu chinokonzera matambudziko akawanda kumunhu anochiona, pamwe nemunhu anosangana nacho. Nhasi, muchinyorwa chino, tichataura nezve PROS iyi uye nezve Vijoice, mushonga wekutanga wakatenderwa kunyanya chirwere ichi.
Chii chaizvo chinonzi PROS?
Zvichitaurwa zviri nyore, PROS chirwere chemajini. Tose tine majini mumiviri yedu anodzora kukura, kupatsanurwa, uye kufa kwemasero. `PIK3CA` ijini rimwe rinokosha kudaro. Funga nezvejini iri se'switch' inodzora kukura kwemasero edu.
Zvisinei, mumunhu ane PROS, pane chikanganiso, kana kuti mutation, mujini re'PIK3CA'. Izvi zvinoita kuti 'switch' irambe iri panzvimbo 'pa'. Zvadaro puroteni iri kutaurwa nezvayo inotanga kushanda nekukurumidza uye zvakanyanya. Nekuda kweizvozvo, dzimwe nhengo dzemuviri, semuenzaniso ganda, mitsipa yeropa , mapfupa , nehuropi, zvinotanga kukura zvisingadzoreki.
Chinhu chakakosha ndechekuti PROS haikanganisi nhengo dzese dzemuviri. Inogona kusiyana kubva kune imwe nhengo yemuviri kuenda kune imwe, uye kubva kumunhu kuenda kune mumwe. Saka, zviratidzo zvacho zvakasiyana-siyanawo.
Kusvika pari zvino, pakanga pasina mushonga wakakwana weZVINHU ZVAKANYANYA KUSHANDISWA. Kurapa kwainyanya kutarisa pakugadzirisa zviratidzo. Semuenzaniso, mishonga yekurwadziwa, kuvaviwa, uye pfari, uye kuvhiyiwa kubvisa mabundu asina kujairika. Zvisinei, pakanga paine mukana wekuti mabundu iwayo akure zvakare mushure mekuvhiyiwa.
Mushonga weVijoice (alpelisib) unoshanda sei?
Apa ndipo panopinda mushonga weVijoice. Vijoice ndiwo mushonga wekutanga kurwisa chikonzero chePROS, kunyanya kushanda kunokonzerwa nekuchinja kwemajini.
Chinhu chinoshanda chiri muizvi ialpelisib . Mushonga uyu unoshandiswa pakurapa mamwe marudzi egomarara remazamu . Chikonzero chacho ndechekuti,Masero egomarara anokura nekuda kwekushanda zvakanyanya kwenzira yePIK3, sezvinoitwa muPROS.
Saka zvinoitwa naVijoice kuvhara nzira yePIK3, iyo inoshanda se'switch' yakabatirira panzvimbo 'ye'. Izvi zvinononotsa kukura kwemasero kusingawanzoitiki, zvinoderedza saizi yenyama dziri kukura, uye zvinodzora zviratidzo.
Ndezvipi zvakanakira mushonga uyu?
Ongororo dzakaitwa pamushonga uyu (EPIK-P1 neEPIK-P3) dzakaratidza mabhenefiti akakosha kuvarwere.
| Kubatsirwa | Tsananguro iri nyore |
|---|---|
| Kukura kudiki (maronda) | Zvakaonekwa kuti vanhu vazhinji vakatora mushonga uyu vakaderedza huwandu hwemabundu ane mafuta (lipomas) uye tsinga dzeropa ne20% kana kupfuura. |
| Kuderedzwa kwekudiwa kwekuvhiyiwa | Vana vanosvika 70% ne90% yevanhu vakuru vanotora Vijoice havana kumboda kuvhiyiwa. |
| Kurerutsira zviratidzo | Varwere vakataura nezvekudzikira kukuru kwezviratidzo zvakaita sekurwadziwa, kuvaviwa, uye kuneta. |
| Kuita kuti mabasa ezuva nezuva ave nyore | Varwere vanosvika 81% vakapinda muongororo iyi vakataura kuti kugona kwavo kuita mabasa ezuva nezuva uye hupenyu hwavo hwakanga hwavandudzika zvichienzaniswa nepavasati vapiwa mushonga uyu. |
Zvakakosha: Mhedzisiro iyi ingasave yakafanana kune wese munhu. Taura nachiremba wako nezvekuti mushonga uyu wakakunakira here uye kuti ndeapi mabhenefiti nenjodzi.Zviri nani kutaura navo mosarudza.
Ndezvipi zvinonyanya kukonzera migumisiro yakaipa uye nzira yekuzvigadzirisa nayo?
Kufanana nemishonga chero ipi zvayo, Vijoice inogona kukonzera migumisiro yakaipa . Zvisinei, yakawanda yacho haina kunyanya kuipa kana kuti iri pakati nepakati uye inogona kudzorwa.
| Mhedzisiro yedivi | Maitiro ekutarisira uye zvekutarisira |
|---|---|
| Manyoka | Inwa mvura yakawanda yakaita semvura nejusi. Kana ukaona zviratidzo zvakaita semanyoka akanyanya, kurwadziwa mudumbu, kana ropa kana mamina mutsvina yako, taurira chiremba wako nekukasika . |
| Kushaya mvura mumuviri | Manyoka anogona kukonzera kupera mvura mumuviri. Chenjerera zviratidzo zvakaita sedzungu rakanyanya, kuneta, uye kudzikira kweweti. Izvi zvinogona kukanganisa itsvo dzako, saka udza chiremba wako nekukasika. |
| Maronda emuromo (Stomatitis) | Maronda emuromo nekurwadziwa zvinogona kuitika. Dzivisa mishonga yekugeza muromo ine doro. Shamba muromo wako nemvura ine munyu inodziya. Rega kudya chikafu chine mafuta akawanda. |
| Kuwedzera kweshuga muropa (Hyperglycemia) | Chiremba wako achaongorora huwandu hweshuga muropa rako usati watanga kutora mushonga uyu uye panguva yekurapwa kwako. Udza chiremba wako kana uine zviratidzo zvakaita senyota yakawandisa, kuita weti kakawanda, kana kuneta. Vanhu vane chirwere cheshuga vanofanira kungwarira zvikuru nezveizvi. |
| Kuonda kwebvudzi (Alopecia) | Kupera kwebvudzi kana kutetepa kunogona kuitika panguva yekurapwa. Shandisa shampoos dzisina kusimba. Taura nachiremba wako nezveizvi. |
Panogona kuva nematambudziko nemimwe mishonga here?
Ehe. Vijoice inogona kushanda pamwe chete nemimwe mishonga. Zvichitaurwa zviri nyore, mimwe mishonga inogona kuderedza kushanda kweVijoice. Vijoice inogonawo kuchinja kushanda kwemimwe mishonga.
Semuenzaniso, mishonga yakaita secarbamazepine yekurapa pfari, rifampin yekurapa TB, uye mishonga yemishonga yakaita seSt. John's wort inogona kukanganisa izvi.
Saka, usati watanga mushonga uyu, zvakakosha kuudza chiremba wako nezvemishonga yese yauri kutora (kusanganisira mavhitamini, mishonga yemiti, uye mishonga inoderedza marwadzo) kuitira kuti agone kugadzirisa chero chinhu chinodiwa.
Mharidzo Yekuenda Nayo Kumba
- ZVINHU ZVAKANAKA chirwere chisingawanzoitiki apo nhengo dzemuviri dzinokura zvisina kujairika nekuda kwekuchinja kwemajini kunonzi `PIK3CA`.
- Vijoice (alpelisib) ndiwo mushonga wekutanga wakabvumidzwa kurwisa chirwere ichi.
- Izvi zvinogona kubatsira kuderedza kukura kusingawanzoitiki, kuderedza kudiwa kwekuvhiyiwa, uye kuvandudza hupenyu.
- Migumisiro yakadai semanyoka, shuga yakawanda muropa, uye maronda mumuromo inogona kuitika, uye zvakakosha zvikuru kuzvigadzirisa uye kuzivisa chiremba.
- Zvakakosha kuzivisa chiremba wako nezvemimwe mishonga yese yauri kutora. Usambofa watanga kana kurega kutora chero mushonga usina kupiwa mazano nachiremba.
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