Kukho ezinye izifo, iintlungu kunye nokungonwabi okuhambisana nazo kunzima kakhulu ukuphila nazo. Abantu abaninzi bahlushwa zizifo ezibangelwa kukuzikhusela komzimba, ingakumbi ezo zibangelwa ziingxaki ezithile kwinkqubo yomzimba yokuzikhusela. Ngoko ke namhlanje siza kuthetha ngenaliti ye-Adalimumab, iyeza eliphucukileyo elisetyenziselwa ukunyanga izifo ezininzi ezinjalo. Eli lisenokuba ulinikwe ngugqirha wakho phantsi kwegama elithi Humira.
Zeziphi izifo ezisetyenziselwa eli yeza?
I-Adalimumab ayiloyeza elinikwa ukunyanga isifo esinye. Inceda kakhulu ekulawuleni izifo ezibangelwa yinkqubo yomzimba yokuzikhusela ehlasela iiseli zayo eziphilileyo. Ngamafutshane, ilawula ukudumba okungeyomfuneko kunye nokudumba emzimbeni.
Nazi ezinye zeemeko eziphambili apho ugqirha wakho angakunika eli yeza:
- I-Rheumatoid Arthritis (RA): Le yimeko edla ngokuvela kubantu abadala kwaye ibangela ukudumba, ukuqina, kunye namalungu abuhlungu.
- I-Juvenile Idiopathic Arthritis (JIA): Imeko echaphazela abantwana abangaphezu kweminyaka emi-2 ubudala kwaye ibangela ukudumba kunye nentlungu yamalungu, kwaye inokuchaphazela ukukhula komntwana.
- Isifo sikaCrohn: Isifo esibangela ukudumba kwenkqubo yokugaya ukutya, ingakumbi amathumbu. Oku kubangela iimpawu ezifana nentlungu yesisu, ukudumba, kunye nokuncipha kobunzima.
- I-Ulcerative Colitis: Le yimeko ebangela ukudumba kunye nezilonda kumathumbu amakhulu nakwi-rectum.
- I-Ankylosing Spondylitis: Oku kuchaphazela kakhulu amalungu omqolo, nto leyo ebangela iintlungu nokuqina komqolo.
- I-Psoriatic Arthritis: Imeko apho isifo sesikhumba i-psoriasis sihamba nokuvuvukala kwamalungu.
- I-Hidradenitis Suppurativa: Imeko yesikhumba ebangela amathumba abuhlungu kunye namaqhubu afana ne-acne kwiindawo ezibilayo ezifana namakhwapha kunye nezihlunu.
- I-Uveitis : Yimeko ebangela ukudumba kwangaphakathi kweliso, okubangela ukuba libe bomvu kwaye libe neentlungu.
- I-Plaque Psoriasis: Isifo esiqhelekileyo solusu esibangela amabala abomvu, anamaxolo eluswini.
Eli yeza lisebenza njani emzimbeni?
Ukuze sikuqonde oku, masiqale siqonde kancinci malunga nokungasebenzi kakuhle kwenkqubo yomzimba yokuzikhusela. Khawuthelekelele ukuba ukhuselo lomzimba wethu (inkqubo yomzimba yokuzikhusela) luyaphambana kancinci luze luqale ukuhlasela iiseli zethu ezisempilweni kunye nezicubu endaweni yeentsholongwane zasemzini. Le yindlela ezikhula ngayo izifo ezininzi esithethe ngazo apha ngasentla.
Xa inkqubo yomzimba yokuzikhusela isebenza kakubi ngale ndlela, ngaphakathi emzimbeniIproteni ebizwa ngokuba yiTumor Necrosis Factor (TNF) iveliswa ngokugqithisileyo. Le proteni yeTNF yiyo ebangela iimpawu ezifana neentlungu, ukudumba, kunye nokudumba, kwaye yonakalisa iiseli ezisempilweni.
I-Adalimumab isebenza ngokulula kakhulu. Ifana nerokhethi eya ngqo kwindawo ekujoliswe kuyo. Xa eli yeza lingena emzimbeni, likhangela ezo protein ze-TNF eziveliswa ngokugqithisileyo kwaye lizicime. Ngokuchanekileyo, lithintela amandla ezo protein ze-TNF okonakalisa iiseli ezisempilweni. Emva koko intlungu, ukudumba, kunye nokudumba kulawulwa kancinci kancinci.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Oku kubaluleke kakhulu. Ngaphambi kokuba unike i-Adalimumab, ugqirha wakho kufuneka ayazi imbali yakho yempilo epheleleyo. Qiniseka ukuba uxelele ugqirha wakho ukuba unenye yezi meko zilandelayo:
- Ukuba unomhlaza okanye ukhe waba nawo ngaphambili.
- Ukuba unesifo seswekile.
- Ukuba ucwangciselwe utyando kungekudala.
- Ukuba unesifo sentliziyo.
- Ukuba unesifo seHepatitis B.
- Ukuba kukho ezinye iziphene kwinkqubo yomzimba yokuzikhusela.
- Ukuba okwangoku unentsholongwane emzimbeni wakho, umzekelo, isifo sephepha (TB) okanye olunye usulelo lwebhaktiriya, ifungus, okanye intsholongwane.
- Ukuba unesifo senkqubo yemithambo-luvo esifana ne-multiple sclerosis.
- Ukuba usandul’ ukufumana okanye uza kufumana isitofu sokugonya.
- Ukuba une-allergies kwi-adalimumab okanye kwirabha okanye kwi-latex.
- Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa.
Zithini iziphumo ebezingalindelekanga ezinokubakho zeyeza?
Njengalo naliphi na iyeza, i-Adalimumab inokubangela iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Eyona nto ibalulekileyo kukwazi ezi zinto kwaye uthathe amanyathelo ukuba kukho naziphi na iimpawu ezinzulu ezibonakala.
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko | |
|---|---|
| Isiphumo/impawu | Inkcazo |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi, ubunzima bokuphefumla. |
| Iimpawu zosulelo | Umkhuhlane, ukubanda, ukukhohlela, umphimbo obuhlungu, iintlungu xa uchama. |
| Iimpawu zokusilela kwentliziyo | Ubunzima bokuphefumla, ukubetha kwentliziyo ngokukhawuleza okanye ngokungangqalanga, ukunyuka kobunzima ngequbuliso, ukudumba kwamaqatha, iinyawo, izandla, ukudinwa kakhulu. |
| Iimpawu Zokulimala Kwesibindi | Umchamo otyheli okanye omdaka omnyama, ukutyheli kwamehlo okanye ulusu, ukungabi namdla wokutya, iintlungu kwicala eliphezulu lasekunene lesisu. |
| Iingxaki zenkqubo yemithambo-luvo | Ukutshintsha kombono, isiyezi, ukuba ndindisholo, intlungu okanye ukuphelelwa zimvakalelo kwimilenze, ubuthathaka bemisipha. |
| Ezinye iimpawu ezinzulu | Ukopha okanye ukukrweleka okungaqhelekanga, amaqhuma okanye ii-lymph nodes ezivuvukileyo entanyeni, emakhwapheni, emathunjini, amabala abomvu okanye amaqhuma eluswini. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga (kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka) | |
|---|---|
| Intloko ebuhlungu | Isicaphucaphu okanye ukuhlanza |
| Ububomvu, ukurhawuzelela, okanye intlungu apho kufakwe khona inaliti | Iimpawu ezifana nokubanda (i-snot, oku kufanele kube "yimpumlo egobhozayo okanye impumlo egobhozayo") - impumlo egobhozayo okanye impumlo egobhozayo |
Uyisebenzisa njani le naliti?
Eli yeza linikwa njengenaliti engaphantsi kwesikhumba. Ngokuqhelekileyo uya kufundiswa indlela yokulithatha esibhedlele okanye ekliniki. Kubaluleke kakhulu ukuthatha idosi echanekileyo ngosuku oluchanekileyo, njengoko ugqirha wakho ekuxelela. Ufanele uqhubeke nokulithatha iyeza de akuxelele ukuba uyeke.
Ungaze ulahle iinaliti neesirinji ezisetyenzisiweyo enkunkuma . Zifanele zibekwe kwisitya esibukhali. Ukuba awunayo, buza ugqirha wakho ukuba ungayifumana njani.
Eli yeza lisenokunciphisa kancinci amandla omzimba wakho okulwa nezifo (amandla okulwa nosulelo). Ke ngoko, umngcipheko wokufumana usulelo uphezulu. Ukuba ubonakalisa iimpawu ezifana nomkhuhlane okanye umkhuhlane, musa ukuzenza unyango kwaye utsalele umnxeba ugqirha wakho. Zama ukuhlala kude nabantu abagulayo.
Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?
Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba sele kuza kufuneka uyithathe idosi elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye. Kungcono ukuthetha nogqirha wakho malunga nento omawuyenze ukuba uphoswe yidosi.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, fowunela iZiko loLwazi lwePoisons kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko, okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Ungayigcina njani iyeza?
Kubaluleke kakhulu ukugcina oku ngokuchanekileyo.
- Efrijini: Gcina kubushushu obuphakathi kwe-2 kunye ne-8 degrees Celsius (ngaphakathi efrijini, hayi emnyango). Musa ukugcina efrijini. Musa ukusebenzisa iyeza ukuba liyabanda.
- Kwiqondo lobushushu begumbi: Ukuba kuyimfuneko, eli yeza lingagcinwa kwiqondo lobushushu begumbi ukuya kuthi ga kwiintsuku ezili-14. Nangona kunjalo, ukuba kunjalo, likhusele ekukhanyeni kwaye ulahle nayiphi na into eseleyo emva kweentsuku ezili-14.
- Lahla amayeza aphelelwe lixesha ngokukhuselekileyo kude nabantwana nezilwanyana zasekhaya.
Umyalezo Wokuya Ekhaya
- I-Adalimumab liyeza elinamandla elilawula izifo ezibangelwa ziingxaki zenkqubo yomzimba yokuzikhusela.
- Ngaphambi kokuba uqalise amayeza, xelela ugqirha wakho ngalo lonke ulwazi lwakho lwempilo kunye namanye amayeza owasebenzisayo.
- Kubalulekile ukufunda indlela yokunika inaliti ngokuchanekileyo.
- Xa usebenzisa iyeza, soloko ulumkele iimpawu zosulelo (umkhuhlane, ukukhwehlela) okanye ezinye iziphumo ebezingalindelekanga ezinzulu. Ukuba ubona nayiphi na kwezi, yazisa ugqirha wakho ngoko nangoko.
- Musa ukwabelana ngamayeza akho nabanye abantu nangasiphi na isizathu.
- Gcina iyeza ngokuchanekileyo, kubushushu obufanelekileyo.
- Ukuba unemibuzo malunga nale mithi, ungoyiki ukuyixoxa nogqirha wakho.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Ingaba isitofu sokugonya i-Adalimumab (i-Adalimumab / i-Humira) sisixhobo sokunyanga izifo zolusu?
Eli asiloyeza onokulithenga kwikhemesti! Eli liyeza elisebenza kakhulu, lanamhlanje (i-Biologic/TNF-blocker) elimiselwe sisibhedlele kwizifo ezihlasela umzimba ezifana ne-'Rheumatoid Arthritis' enzima, i-Psoriasis, kunye nesifo sikaCrohn!
💬 Olu gonyo (i-Adalimumab) lukuthintela njani ukudumba okukhulu kunye nokuvuvukala emzimbeni?
Le (Antibody) ihlasela ngokuthe ngqo iproteni eyingozi ebizwa ngokuba yi-'TNF-alpha' eveliswa yinkqubo yomzimba wethu yokuzikhusela. Le proteni yileyo itshabalalisa amalungu/amathumbu ethu kwaye ibangele ukudumba okukhulu. Xa le gonyo ingena emzimbeni, ifumana iproteni ye-'TNF-alpha' kwaye iyithintele/iyitshabalalise ngokupheleleyo. Emva koko amalungu amakhulu, amaqhuqhuva esikhumba, kunye neengxaki zesisu ziyanyangeka ngoko nangoko.
💬 Yintoni ingozi ebulalayo (iBlack Box Warning) kwabo bafaka olu gonyo (iHumira) oluxabisa izigidi zeerandi?
Oku kuyenza buthathaka yonke inkqubo yethu yomzimba yokuzikhusela, ngoko ke akukho mntu unokukusindisa 'kwizifo ezinzulu'! (Izifo Ezinzulu). Nokuba umkhuhlane oqhelekileyo ungaguquka ube yi-pneumonia enzima (TB) kwaye umguli angafa ngequbuliso. Kwakhona, kukho iingxelo kwihlabathi liphela zokuba abanye abantu baye bahlakulela 'umhlaza omtsha (iLymphoma/umhlaza)' emva kokufumana olu gonyo okwethutyana!
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