Ngamanye amaxesha xa ugqirha ekuxelela ukuba wenze uvavanyo lwegazi, awukwazi ukuqonda ukuba lithetha ukuthini okanye lifuna ntoni, akunjalo? Uvavanyo lwe-ANCA lelinye lamagama angaqhelekanga. Kodwa akukho sizathu sokoyika okanye sokukhathazeka kuba nje usiva eli gama. Namhlanje, siza kuthetha ngento eliyifunayo, isizathu sokuba lenziwe, kunye nokuba iziphumo zithetha ukuthini ngendlela elula kakhulu onokuyiqonda.
Kalula nje, yintoni olu vavanyo lwe-ANCA?
Uvavanyo lwe-ANCA luvavanyo oluthatha isampuli yegazi lakho. Lujonga ikakhulu ukuba kukho into ebizwa ngokuba yi -antineutrophil cytoplasmic antibodies ( i-ANCA ngamafutshane) egazini lakho.
Ngoku usenokuba uyazibuza ukuba lithini elo gama. Masilichaze ngokulula size siliqonde.
Khawuthelekelele ukuba imizimba yethu ifana nelizwe. Kukho umkhosi okhusela eli lizwe. Loo mkhosi sisixokelelwano sethu sokuzikhusela . Uhlobo olukhethekileyo lwejoni kulo mkhosi lubizwa ngokuba zii-neutrophils . Umsebenzi wabo kukulwa neentshaba ezifana neentsholongwane kunye neebhaktheriya ezingena emizimbeni yethu zize zisikhusele kwizifo.
Kodwa ngamanye amaxesha inkqubo yethu yomzimba yokuzikhusela iyaphazama. Ukuzikhusela kwethu kuqala ukuhlasela iiseli zethu ezilungileyo. Le yindlela esiyibiza ngayo ii-autoantibodies , iiproteni eziveliswa yimizimba yethu.
I-ANCA yenye yezo antibodies ezizi-autoantibodies. Le ANCA iyenza kukuhlasela iiseli ezimhlophe zegazi ezibizwa ngokuba zii-neutrophils ezisikhuselayo. Ngoko ke uvavanyo lwe-ANCA lulinganisa ukuba kukho ii-autoantibodies egazini lakho ezisebenza ngokuchasene nemizimba yethu, kwaye ukuba kunjalo, zingaphi kuzo ezikhoyo.
Kutheni ugqirha angakuxelela ukuba wenze olu vavanyo lwe-ANCA?
Ugqirha udla ngokuyalela olu vavanyo ukuba urhanela ukuba kukho imeko ebizwa ngokuba yi -vasculitis .
Ngamafutshane, i-vasculitis kukudumba kwemithambo yegazi (imithambo yegazi) emzimbeni wethu. Kanye njengokuba umbhobho wamanzi uvuvukala, kuba nzima ukuba amanzi adlule kuwo. Xa imithambo yegazi ivuvukala, ukuhamba kwegazi kuyavaleka kwaye amalungu ahlukeneyo emzimbeni wethu anokonakala. Esi sisifo esibangelwa kukuzikhusela komzimba, oko kuthetha ukuba sibangelwa ngumsebenzi wenkqubo yethu yokuzikhusela komzimba.
Kukho iintlobo ezininzi eziphambili ze-vasculitis ezinxulumene ne-autoantibodies ezibizwa ngokuba yi-ANCA. Ukuba unayo nayiphi na kwezi mpawu, olu vavanyo lunokukunceda ukuqinisekisa oko.
| Iintlobo zeVasculitis ezinxulumene ne-ANCA | Igama langaphambili |
|---|---|
| I-Granulomatosis ene-polyangiitis | I-Wegener's granulomatosis |
| I-Microscopic polyangiitis | - |
| I-granulomatosis ye-Eosinophilic ene-polyangiitis | Isifo seChurg-Strauss |
Ukudumba kwemithambo yegazi kunokuphazamisa ukuhanjiswa kwegazi kumalungu abalulekileyo afana nentliziyo, imiphunga, kunye nezintso. Ngoko ke, kubaluleke kakhulu ukufumanisa nokunyanga ezi meko kwangethuba.
Ngaba kukho iintlobo ze-ANCA?
Ewe, kukho iintlobo ezimbini eziphambili ze-ANCA. Ezi zinokukhankanywa kwingxelo yakho yovavanyo.
1. i-canca: Oku kuhlasela iproteni ebizwa ngokuba yi-proteinase 3 (PR3) .
2. i-pANCA: Oku kuhlasela iproteni ebizwa ngokuba yi -myeloperoxidase (MPO) .
Ukwazi ukuba loluphi uhlobo kwezi zimbini onalo emzimbeni wakho kuya kunceda ugqirha wakho ukuba afumanise ukuba loluphi uhlobo lwe-vasculitis onalo.
Indlela yokwenza uvavanyo nokulungiselela
Le yinkqubo elula kakhulu. Akunyanzelekanga ukuba wenze nantoni na ekhethekileyo ukulungiselela oku. Nangona kunjalo, ngamanye amaxesha ugqirha wakho uya kuyalela ezinye iimvavanyo zegazi ezininzi kunye nolu vavanyo. Kwimeko ezinjalo, unokucelwa ukuba uzile ukutya iiyure ezisi-8 ukuya kwezili-12, ngaphandle kokutya namanzi kuphela. Ugqirha wakho uya kukunika imiyalelo ethile malunga noku.
Kwenzeka ntoni ngexesha lovavanyo?
Oku kufana nje nokufumana uvavanyo lwegazi. Kugqitywa kwimizuzu embalwa.
- Umongikazi okanye ugqirha uza kukhetha umthambo ofanelekileyo engalweni yakho kufutshane nengqiniba yakho ukuze atsale igazi.
- Loo ndawo icocwa ngesibulali-ntsholongwane.
- Emva koko kufakwa inaliti encinci emthanjeni kwaye inani legazi elifunekayo liqokelelwa kwityhubhu. Usenokuziva urhawuzelelwa kancinci xa kufakwa inaliti, kodwa oko kuyenzeka okwexeshana.
- Nje ukuba igazi litsalwe, inaliti iyasuswa, kubekwe umqhaphu phezu kwendawo leyo kuze kufakwe uxinzelelo. Emva koko kufakwa iplasta encinci kwindawo leyo.
Kwenzeka ntoni emva kovavanyo?
Emva kokutsalwa kwegazi, ungenza imisebenzi yakho yesiqhelo. Kodwa ugqirha uza kukuxelela ukuba ugcine iplasta iiyure ezimbalwa. Usenokukuxelela nokuba ungawusebenzisi umzimba onzima ngaloo mini.
Ukutsalwa kwegazi lakho kukhuselekile kakhulu. Uninzi lwexesha, indawo apho inaliti ifakwe khona inokuba luhlaza okwesibhakabhaka kancinci, nto leyo edla ngokuziphelela emva kosuku olunye okanye ezimbini. Amaxesha amaninzi, umthambo unokudumba kancinci. Ukuba oku kuyenzeka, ungafumana isiqabu ngokuwufaka emanzini afudumeleyo.
Kuthatha ixesha elingakanani ukuba ingxelo ifike? Zithini iziphumo?
Ngenxa yokuba uvavanyo lwe-ANCA luvavanyo olukhethekileyo, kungathatha iintsuku ezimbalwa okanye iveki ukufumana iziphumo. Nje ukuba ingxelo ifike, ugqirha wakho uza kukuchazela ukuba kuthetha ukuthini kuwe.
- Ukuba isiphumo sibi:
Oku kuthetha ukuba awunazo ii-autoantibodies ze-ANCA egazini lakho. Oko kuthetha ukuba akunakwenzeka ukuba ube ne-ANCA-associated autoimmune vasculitis. Ezi ziindaba ezimnandi.
- Ukuba isiphumo silungile:
Oku kuthetha ukuba une-autoantibodies ebizwa ngokuba yi-ANCA egazini lakho. Oku kuthetha ukuba usenokuba nesifo se-autoimmune vasculitis.
Kodwa eyona nto ibalulekileyo ekufuneka uyikhumbule apha kukuba ukuba uvavanyo lwe-ANCA lune-positive akuqinisekisi ngokupheleleyo ukuba une-vasculitis.
Ukuze enze uxilongo oluchanekileyo, ugqirha uya kuthathela ingqalelo ezinye izinto ezininzi:
- Zithini iimpawu zakho?
- Yintoni efunyenweyo ngexesha lovavanyo lomzimba?
- Zithini iziphumo zezinye iimvavanyo zegazi nomchamo?
- Ngamanye amaxesha, unokucelwa ukuba wenze i-biopsy, equka ukuthatha iqhekeza elincinci lesicwili kwilungu elichaphazelekayo uze ulihlolisise.
Ngoko ke, ungoyiki ukucinga ngengxelo yodwa. Umntu ofanelekileyo onokuyiqonda le ngxelo ngugqirha wakho. Nguye oza kudibanisa yonke into aze afikelele kwisigqibo esichanekileyo ngemeko yakho.
Umyalezo Wokuya Ekhaya
- Uvavanyo lwe-ANCA luvavanyo lwegazi olukhethekileyo oluchonga izifo ezithile ezibangelwa yinkqubo yethu yokuzikhusela komzimba, ezifana ne-vasculitis.
- Olu luvavanyo olulula nolukhuselekileyo, njengovavanyo lwegazi oluqhelekileyo. Akufuneki lungiselelo lukhethekileyo.
- Ungakhathazeki ukuba iziphumo zovavanyo 'zilungile'. Lona lodwa alunakukwazi ukumisela ukuba unesifo na.
- Thetha ngokukhululekileyo nogqirha wakho malunga nengxelo yakho, intsingiselo yayo, kunye nento omawuyenze emva koko. Uza kukuchazela yonke into.
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