Ngaba ugqirha wakho ukunike iyeza elibizwa ngokuba yi-Avapritinib? Mhlawumbi unemibuzo emininzi engqondweni yakho, efana nokuba lisetyenziselwa luphi uhlobo lwesifo, amanyathelo okhuseleko ekufuneka uwathathe ngelixa ulisebenzisa, kunye nokuba kukho naziphi na iziphumo ebezingalindelekanga. Ungakhathazeki. Namhlanje, siza kuthetha ngale yeza ngendlela elula kakhulu onokuyiqonda.
Luhlobo luni lonyango i-Avapritinib?
Ngamafutshane, i-Avapritinib liyeza eliphucukileyo kakhulu elijolise kwiiproteni ezithile kwiiseli zomhlaza kwaye lithintele ukukhula kwezo seli zomhlaza. Sibiza oku ngokuthi "unyango olujoliswe kulo." Njengomdubuli we-sniper, eli yeza likhangela kwaye lilawula ukukhula kweeseli zomhlaza ngelixa ligcina iiseli ezisempilweni kangangoko kunokwenzeka.
Eli yeza lisetyenziswa kakhulu ukunyanga iimeko ezimbini:
1. I-Systemic Mastocytosis: Le yimeko ebangelwa kukukhula okungaqhelekanga kohlobo lweseli olubizwa ngokuba yi-'mast cells' emzimbeni.
2. IiGIST (IiTumors zeSisu): Olu luhlobo olukhethekileyo lomhlaza oluvela kwinkqubo yethu yokugaya ukutya (amathumbu).
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba uqale ukuthatha i-Avapritinib, kubaluleke kakhulu ukuba uxelele ugqirha wakho ngokucacileyo ngale nto ilandelayo:
- Ukuba ukhe wopha ingqondo okanye wahlaselwa sistroke ngaphambili.
- Ukuba uyazi ukuba uneendonga zemithambo yegazi ezivuvukileyo okanye ezibuthathaka.
- Ukuba amanqanaba eeplatelet zakho egazini aphantsi .
- Ukuba une -allergies kwi-avapritinib okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukuba ukhulelwe , okanye uzama ukukhulelwa kungekudala.
- Ukuba ungumama oncancisayo .
Ngokusekelwe kolu lwazi, ugqirha wakho uya kugqiba ukuba eli yeza lifanelekile na kuwe okanye kufuneka linikwe ngononophelo olukhethekileyo.
Ndingayisebenzisa njani kanye kanye le yeza?
Ukuze ufumane unyango olungcono kakhulu, kubaluleke kakhulu ukulusebenzisa ngokuchanekileyo.
- Le iza ngendlela yepilisi. Ipilisi mayiginywe yonke ngeglasi yamanzi. Ungaze uyihlafune, uyityumze, okanye uyiqhekeze ipilisi.
- Eli yeza lifanele lithathwe ungenanto esiswini. Oko kuthetha ukuba, lifanele lithathwe ubuncinane iyure enye ngaphambi okanye iiyure ezimbini emva kwesidlo sakusasa. Musa ukulisebenzisa kunye nokutya.
- Ungaze uthathe eli yeza kunye nejusi yegrapefruit, kuba ijusi yegrapefruit ingayichaphazela indlela eli yeza elisebenza ngayo.
- Thatha amayeza yonke imihla, ngexesha elimiselweyo nangamaxesha athile amiselweyo.
- Musa ukuyeka ukuthatha amayeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.
Kuthekani ukuba ngempazamo usela kakhulu?
Ukuba ucinga ukuba uthathe ngaphezu kwedosi ecetyiswayo, ungoyiki kwaye ngoko nangoko fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo . Okanye yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?
Ukuba ulibele ukuthatha idosi, yithathe kwangoko xa ukhumbula. Nangona kunjalo, ukuba kungaphantsi kweeyure ezisi-8 ngaphambi kokuba uthathe idosi elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi elandelayo ngexesha elicwangcisiweyo. Musa ukuthatha iidosi ezimbini ngaxeshanye nangasiphi na isizathu.
Ngaba kukho unxibelelwano phakathi kwezinye amayeza?
Ewe, i-Avapritinib inokunxibelelana namanye amayeza, iimveliso zezityalo, kunye nokutya okuthathayo. Ngoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo.
Nazi ezinye zezinto ezinokusebenzisana ne-Avapritinib.
| Uhlobo lwamayeza/lokutya | Imizekelo |
|---|---|
| Amanye amayeza okubulala iintsholongwane | i-clarithromycin, i-erythromycin |
| Amayeza osulelo lwefungus | i-fluconazole, i-itraconazole, i-ketoconazole |
| Amanye amayeza okubulala iintsholongwane anikwa i-HIV okanye i-Hepatitis | Buza ugqirha. |
| Amanye amayeza okunyanga isifo sokuwa (ukugula ngengqondo) | i-carbamazepine, i-phenobarbital, i-phenytoin |
| Amanye amayeza | i-cyclosporine, i-diltiazem, i-verapamil, i-rifampin |
| Iimveliso zezityalo | I-St. John's Wort |
| Ukutya | Ijusi yegrapefruit |
Olu luhlu aluphelelanga, ngoko qiniseka ukuba uxelela ugqirha wakho malunga nawo onke amayeza, iivithamini, amayeza emifuno, kunye nezongezo ozithathayo.
Izinto ekufuneka uzikhumbule xa usebenzisa amayeza
- Yiya kuvavanyo lwezonyango rhoqo: Kungathatha ixesha ukuba iziphumo zale mayeza zibonakale. Ngoko ke, yiya kwiikliniki ngemihla emiselweyo njengoko ugqirha ecebisile kwaye ujonge imeko yakho.
- Lumka amazinyo neentsini zakho: Eli yeza linokunyusa umngcipheko wakho wokopha. Ngoko ke lumka xa uhlamba amazinyo akho kwaye ufaka i-floss. Ukuba ufumana naluphi na unyango lwamazinyo (njengokukhupha amazinyo), qiniseka ukuba uxelele ugqirha wakho wamazinyo ukuba usela eli yeza.
- Ukozela kunye nesiyezi: Usenokuziva ulele okanye unesizungu. Ngoko ke, kuphephe ukuqhuba okanye ukusebenzisa oomatshini de wazi kakuhle indlela eli yeza elikuchaphazela ngayo. Musa ukuphakama kwindawo ohleli kuyo ngequbuliso.
- Ukukhulelwa nabantwana: Le yingxaki ebaluleke kakhulu.
- Abafazi: Musa ukukhulelwa ngelixa usebenzisa eli yeza kwaye kangangeeveki ezi-6 emva kokuyeka ukusebenzisa eli yeza.
- Amadoda: Musa ukuzama ukuba nguyise womntwana ngelixa usebenzisa eli yeza okanye iiveki ezi-6 emva kokuyeka ukusebenzisa eli yeza.
- Eli cebiso linikwa kuba kukho ithuba lokuba umntwana ongekazalwa angenzakaliswe kakhulu.
- Ukuncancisa: Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye emva kweeveki ezimbini uyekile.
- Ukuzala: Eli yeza lisenokuchaphazela amandla akho okufumana abantwana. Ukuba uneengxaki malunga noku, thetha nogqirha wakho ngokukhululekileyo.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengalo naliphi na iyeza, i-Avapritinib inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zezi zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.
| Imiphumela | Inkcazo |
|---|---|
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi. |
| Iimpawu zestroke | Ukutshintsha kombono, ukudideka, ubunzima bokuthetha okanye ukuqonda, intloko ebuhlungu kakhulu, ukudinwa okanye ubuthathaka ngequbuliso bobuso, ingalo okanye umlenze, ubunzima bokuhamba, isiyezi. |
| Utshintsho lwengqondo | Utshintsho olukhawulezileyo kwimo yengqondo, ukubona okanye ukuva izinto ezingekhoyo (imibono). |
| Ukopha okungaqhelekanga okanye ukukrweleka | Ukudumba kwesikhumba okungachazwanga, ukopha kweentsini. |
| Ukuhlanza | Ukuhlanza okuphindaphindiweyo. |
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza | |
| Iingxaki zenkqubo yokugaya ukutya | Ukuqhinwa, urhudo, iintlungu zesisu, isicaphucaphu. |
| Ezinye iingxaki eziqhelekileyo | Ukuphelelwa ngumdla wokutya, ukudinwa kakhulu, ukudumba kwezandla, iinyawo, namaqatha. |
Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga ezingakhankanywanga kolu luhlu, nceda wazise ugqirha wakho ngazo.
Ugcina kwaye ulahla njani amayeza?
- Gcina amayeza kude nabantwana kunye nezilwanyana zasekhaya .
- Gcina kubushushu begumbi (phakathi kwama-20-25 degrees Celsius).
- Musa ukusebenzisa amayeza aphelelwe lixesha.
- Buza ugqirha wakho ngeyona ndlela ilungileyo yokulahla amayeza aphelelwe lixesha okanye angafunekiyo. Ukuba kukhuselekile ukuwalahla enkunkuma, susa iipilisi kwisikhongozeli, uzixube nento efana namagqabi eti asetyenzisiweyo, i-coffee ground, okanye umhlaba, uze uzifake kwingxowa evalwe kakuhle uze ulahle.
Umyalezo Wokuya Ekhaya
- I-Avapritinib liyeza elikhethekileyo neliphucukileyo elijolise kwiiseli zomhlaza.
- Soloko usela eli yeza ungenanto esiswini . Ungaze ulisebenzise nejusi yegrapefruit.
- Kubalulekile ukwazisa ugqirha wakho malunga nazo zonke ezinye iziyobisi kunye nezongezelelo ozithathayo.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana iziphumo ebezingalindelekanga ezibi ezifana neempawu zestroke (ukuba ndindisholo ebusweni/engalweni, ubunzima bokuthetha), okanye ukopha okungaqhelekanga.
- Kuphephe ukukhulelwa (kwabasetyhini namadoda) ngelixa usebenzisa amayeza kwaye kangangexesha elithile emva kokuyeka.
- Musa ukuyeka ukuthatha amayeza akho okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho. Landela imiyalelo yakhe rhoqo.
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