Ngaba wena okanye umntu omaziyo unesifo se-sickle cell? Ngoko ke mhlawumbi uqhelene neengxaki ze-sickle cell ezibuhlungu ezihlala zihamba nesi sifo. Mhlawumbi uyazi ngamava akho ukuba kunzima kangakanani ukwenza imisebenzi yemihla ngemihla ngenxa yale ntlungu inganyamezelekiyo. Ngoko ke, namhlanje sithetha ngeyeza elitsha elinokunceda ukunciphisa ukuphindaphindeka kwale meko ibuhlungu. Elo liyeza lokugonya elibizwa ngokuba yiCrizanlizumab.
Luhlobo luni lonyango olu?
Ngamafutshane, iCrizanlizumab liyeza elikwiqela lamayeza abizwa ngokuba yi-'selectin blockers'. Kulungile, ngaba oko kuvakala kuyinkimbinkimbi? Masiyihlalutye ngolu hlobo.
Cinga ngemithambo yegazi yethu njengendlela ehamba ngayo igazi. Kwisifo se-sickle cell, iiseli ezibomvu zegazi ziyatshintsha imilo (njengesickle), zinamathelane, zihlangane, kwaye zenze ingxinano yezithuthi kule 'ndlela'. Xa ukuhamba kwegazi kuvaliwe ngale ndlela, loo ntlungu imbi iyenzeka.
Iproteni ebizwa ngokuba yi-selectin ikwanceda ezi seli zinamathele kunye. Ukuchaneka, le proteni isebenza njengeglu kwaye inceda iiseli zinamathele kunye. I-Crizanlizumab ivimba i-selectin, esebenza njengeglue. Emva koko, iiseli zinamathelana kancinci, kwaye ukuthintelwa kokuhamba kwegazi kuyancitshiswa. Ngenxa yoko, ukuphindaphindeka kwezo 'ngxaki ze-sickle cell' ezibuhlungu kunokuncipha kakhulu.
Eli yeza libonakala kakhulu kwimarike phantsi kwegama elithi ADAKVEO .
Ndimele ndimxelele ntoni ugqirha ngaphambi kokuba ndithathe eli yeza?
Ngaphambi kokuba uqale ukusebenzisa eli yeza, kukho izinto ezimbalwa ekufuneka uzixelele ugqirha wakho. Kubaluleke kakhulu kukhuseleko lwakho ukuba unyaniseke ngezi zinto.
- Ngaba unayo i-allergy kwiCrizanlizumab, naluphi na olunye unyango, ukutya, okanye idayi?
- Ngaba ukhulelwe, okanye unethemba lokukhulelwa kungekudala ?
- Ingaba ungumama oncancisayo ?
Ngokusekelwe kolu lwazi, kuya kuba lula kugqirha ukugqiba ukuba eli yeza lifanelekile kuwe okanye akunjalo.
Ulisebenzisa njani eli yeza?
Eli asiloyeza onokulisela ekhaya. Eli liyeza elifakwa emthanjeni. Oku kuthetha ukuba eli yeza lifakwa emthanjeni wakho ngebhotile, efana netyuwa, kangangemizuzu engama-30. Le nkqubo yonke yenziwa esibhedlele okanye eklinikhi phantsi kweliso elipheleleyo lengcali yezempilo.
Kwezinye iimeko ezithile, ugqirha anganika eli yeza kubantwana abancinci abangaphezu kweminyaka eli-16 ubudala. Nangona kunjalo, kufuneka kuthathwe ingqalelo ekhethekileyo, ngoko ke ukuba unika umntwana wakho eli yeza, thetha nogqirha wakho wezingane ukuze ufumane iinkcukacha.
Khumbula, ukuba unesikrokro sokuba usele kakhulu eli yeza, fowunela iZiko loLwazi lweeTyhefu zeSizwe kwiSibhedlele sikaZwelonke eColombo ngoko nangoko, okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Eli yeza limiselwe wena wedwa. Ungaze wabelane ngalo nabanye abantu. Linokubeka ubomi babo emngciphekweni.
Wenza ntoni ukuba uphoswe yidosi yeyeza?
Kubaluleke kakhulu ukusela eli yeza ngemihla emiselweyo nangamaxesha amiselweyo. Ngoko ke ungaphoswa zii-aphoyintimenti zakho. Ukuba awukwazi ukuya kwi-aphoyintimenti yakho emiselweyo, fowunela ugqirha wakho ngoko nangoko umxelele. Uza kukuxelela into omawuyenze emva koko.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengalo naliphi na iyeza, iCrizanlizumab inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zezi zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.
| Uhlobo lwesiphumo esibi | Inkcazo kunye neempawu |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha okanye esibhedlele ngoko nangoko | |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela okanye ukudumba kobuso, imilebe okanye ulwimi. |
| Iimpendulo zokungenisa | Umkhuhlane, ukubanda, isicaphucaphu okanye ukuhlanza, ukudinwa kakhulu, isiyezi, ukubila, ubunzima bokuphefumla, okanye isandi 'setshizi' esiphuma esifubeni. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Iintlungu zomzimba | Intlungu yomqolo, iintlungu zamalungu, iintlungu zesisu |
| Okunye | Urhudo |
Kubalulekile: Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, thetha nogqirha wakho ngazo.
Ngaba kukho ezinye izinto ezinokusebenzisana nale mithi?
Eli yeza alikafunyaniswa ukuba lisebenzisana kakhulu namanye amayeza , kodwa oko akuthethi ukuba aliyi kubangela naziphi na iingxaki.
Ngoko ke, ukuze ukhuseleke, nika ugqirha wakho ingxelo epheleleyo nenyanisekileyo ngayo yonke imithi oyisebenzisayo (kuquka amayeza ezinye izifo, iivithamini, amayeza esintu, izongezo zokutya, njl.njl.), nokuba uyatshaya, okanye usela utywala.
Umyalezo Wokuya Ekhaya
- I-Crizanlizumab yinaliti efakwa emthanjeni enciphisa ukuphindaphindeka kweengxaki ezibuhlungu ezibangelwa sisifo se-sickle cell.
- Eli yeza linikwa esibhedlele okanye ekliniki, phantsi kweliso likagqirha.
- Ngaphambi kokuba usebenzise amayeza, xelela ugqirha wakho ngazo zonke izinto ezikubangela ukuba ungabi namdla, ukukhulelwa, kunye nawo onke amanye amayeza owasebenzisayo.
- Ungaphoswa ziintlanganiso zakho. Ukuba awukwazi ukuya, yazisa ugqirha wakho kwangaphambili.
- Ukuba ufumana iimpembelelo ze-allergy (ukudumba kwesikhumba, amaqhuqhuva) okanye ezinye iimpembelelo eziqatha (umkhuhlane, ubunzima bokuphefumla) ngexesha okanye emva kokusebenzisa iyeza, funa ingcebiso kagqirha ngoko nangoko.
- Musa ukoyika ukuthetha ngokukhululekileyo nogqirha wakho ngazo naziphi na iingxaki onokuba nazo.
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