Xa ugqirha enika umntu onesifo somhlaza amayeza amatsha, kuyinto eqhelekileyo ukuba novalo kwaye ube nomdla. "Kuza kwenzeka ntoni ngale nto?", "Ndingayisebenzisa njani le nto?", "Ngaba kukho iziphumo ebezingalindelekanga?" Mhlawumbi unemibuzo emininzi engqondweni yakho. Yiyo loo nto silapha ukuze sithethe ngamayeza owanikiweyo, iCrizotinib, ngendlela elula neqondakala lula. Khawuthelekelele oku ngokungathi umhlobo okanye ilungu losapho likuxelela ngalo.
Kalula nje, yintoni iCrizotinib?
I-Crizotinib liyeza elithile elisetyenziselwa ukunyanga iintlobo ezithile zomhlaza. Kwilizwe lethu, eli yeza lisetyenziswa kakhulu phantsi kwegama lebrendi i-XALKORI . Eli liyeza elisebenza njengerokhethi ehlasela ithagethi yalo.
Cinga ngeeseli zomhlaza njengezityalo ezimbi ezikhula ngokungalawulekiyo. Kukho iproteni ekhethekileyo enceda ezi zityalo zimbi zikhule kwaye zisasazeke. Ifana nombhobho onika amanzi kweso sityalo sibi. Eli yeza libizwa ngokuba yiCrizotinib livimba loo mbhobho, loo proteni ikhethekileyo. Emva koko amandla eeseli zomhlaza okukhula nokusasazeka emzimbeni wonke ayancitshiswa, okanye ayeki ngokupheleleyo. Le yindlela eli yeza elinceda ngayo ukulawula umhlaza.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale eli yeza
I-Crizotinib liyeza elinamandla kakhulu, ngoko ke kubalulekile ukuba ugqirha wakho abe nomfanekiso opheleleyo wempilo yakho ngaphambi kokuba aqale olu nyango. Musa ukufihla nantoni na, nokuba zeziphi iinkcukacha ezincinci. Lonke ulwazi olubelana ngalo luya kunceda ugqirha wakho akunyange ngokukhuselekileyo.
Ukhuseleko lwakho luza kuqala, ngoko ke qiniseka ukuba uxoxa ngolu lwazi ngokucacileyo nogqirha wakho.
Jonga le theyibhile ingezantsi. Ukuba kukho naziphi na kwezi zinto ezikukhathazayo, qiniseka ukuba uyazikhankanya.
| Uhlobo lolwazi | Yintoni omawuyixelele ugqirha wakho |
|---|---|
| Iimeko zonyango zangoku |
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| Ii-aleji | Ukuba une-allergy kwiCrizotinib okanye naliphi na elinye iyeza, ukutya, okanye izithinteli. |
| Ukukhulelwa kunye nokuncancisa |
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Indlela yokusebenzisa amayeza ngokuchanekileyo?
Ukuze ufumane okuninzi kweli yeza, kubaluleke kakhulu ukulisebenzisa ngokuchanekileyo.
- Ginya kuphela: Eli yeza liza likwimo yekhaphu. Musa ukuliqhekeza, ukulityumza, okanye ukulihlafuna. Ginya liphelele ngeglasi yamanzi.
- Ngexesha: Ziqhelise ukusela amayeza akho ngexesha elifanayo yonke imihla. Thatha idosi echanekileyo, kanye njengoko ugqirha wakho ekuxelele.
- Nokuba utye okanye utye ngaphandle kokutya: Eli yeza lingasetyenziswa ngaphambi okanye emva kokutya. Nangona kunjalo, abanye abantu banokuba nokuphazamiseka kancinci kwesisu okanye isicaphucaphu xa belisebenzisa ngaphandle kokutya. Ukuba oku kuyenzeka, thatha eli yeza kunye nokutya.
- Musa ukuyisebenzisa nejusi yegrapefruit: Oku kubaluleke kakhulu. Kuphephe ukuyisebenzisa le mithi kunye nejusi yegrapefruit okanye yegrapefruit. Oku kungenxa yokuba izithako ezikwijusi yegrapefruit zinokutshintsha indlela amayeza afunxwa ngayo ngumzimba kwaye zonyuse iziphumo ebezingalindelekanga.
- Ukuba uyahlanza: Ukuba uyahlanza emva kokusela iyeza, musa ukuthatha elinye idosi. Yitsibe loo xesha uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo.
- Ukuba uphoswe yidosi:
- Ukuba kudlule iiyure ezi-6 ngaphambi kokuba uthathe idosi elandelayo, thatha idosi oyiphosileyo ngokukhawuleza xa ukhumbula.
- Nangona kunjalo, ukuba kungaphantsi kweeyure ezi-6 ngaphambi kokuba uthathe idosi elandelayo, yitsibe idosi oyiphosileyo. Thatha idosi elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye.
- Musa ukuyeka ukusebenzisa amayeza: Nokuba ufumana iziphumo ebezingalindelekanga okanye ngenxa yesinye isizathu, musa ukuyeka ukuwasebenzisa amayeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
Ukugqithisa
Ukuba unesikrokro sokuba ngempazamo uthathe amayeza amaninzi kunokuba ucinga, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane ngoko nangoko. Okanye utsalele umnxeba iZiko loLwazi lweeTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso.
Ezinye izinto ezinokusebenzisana nale mithi (Intsebenziswano)
Amanye amayeza owasebenzisayo anokusebenzisana neCrizotinib aze abangele iziphumo ezingafunekiyo. Ngoko ke, kubalulekile ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (amayeza ezinye izifo, iivithamini, izongezo zesondlo, amayeza aseSinhala, amayeza e-Ayurvedic).
Lumka ngakumbi kuba iCrizotinib inokusebenzisana namayeza alandelayo.
| Amachiza angafanele athathwe neCrizotinib | |
|---|---|
| Amanye amayeza osulelo lwefungus | Umzekelo: Ketoconazole, Itraconazole, Fluconazole, Posaconazole |
| Amanye amayeza athile | Amayeza afana neDronedarone, iPimozide, iThioridazine, iSaquinavir, iFlibanserin, iLevoketoconazole, iLomitapide, iLonafarnib, iPacritinib. |
| Ezinye iziyobisi kunye nezinto ezinokubangela iingxabano | |
| Ijusi yeGrapefruit | Oku kungayitshintsha indlela elisebenza ngayo iyeza. |
| Amayeza okunciphisa izinga lentliziyo | Umzekelo: iDigoxin, iMetoprolol, iPropranolol, iDiltiazem, iClonidine |
| Amanye amayeza achaphazela isigqi sentliziyo | Buza ugqirha wakho ngale nto. |
Izinto ekufuneka uzilumkele xa usebenzisa iyeza
Kubaluleke kakhulu ukunyamekela umzimba wakho kulo lonke unyango lwakho.
Ukuhlolwa rhoqo kwezonyango
Ugqirha wakho uza kukujonga rhoqo aze acwangcise uvavanyo lwegazi. Qiniseka ukuba uya rhoqo kwezi mvavanyo. Ezi mvavanyo ziza kunceda ugqirha wakho abone indlela amayeza achaphazela ngayo umzimba wakho kunye nendlela esebenza ngayo isibindi sakho.
Lumka amehlo akho.
Abanye abantu abasebenzisa eli yeza banokutshintsha umbono wabo. Umzekelo, ukubona izinto zingabonakali, ukubona izinto ezijikeleze izibane, kunye nokuziva ngathi izibane ziyavela zize zinyamalale ngequbuliso. Ukuba ufumana naluphi na olu tshintsho embonweni wakho, xelela ugqirha wakho ngoko nangoko.
Zikhusele kwiintsholongwane
Amayeza omhlaza afana neCrizotinib anokwenza buthathaka kancinci amajoni omzimba wakho, nto leyo ethetha ukuba usengozini enkulu yokugula, ingakumbi usulelo.
- Ukuba ubonakalisa iimpawu ezinje ngomkhuhlane, ukubanda, umphimbo obuhlungu, okanye ukukhwehlela , musa ukuzinyanga. Fowunela ugqirha wakho ngoko nangoko.
- Ziphephe iindawo ezinabantu abaninzi kunye neendawo apho abantu abanezifo bafumaneka khona kangangoko.
- Hlamba izandla zakho rhoqo ngesepha.
- Xa unomkhuhlane, musa ukuthatha amayeza afana ne -Aspirin, i-Ibuprofen, okanye i-Panadol (Acetaminophen) ngaphandle kokubonisana nogqirha wakho ukuze awunciphise. La mayeza anokunciphisa umkhuhlane aze athintele umzimba ekufumaneni usulelo.
Zikhusele elangeni.
Ulusu lwakho lusenokuba buthathaka ngakumbi elangeni ngelixa usela eli yeza.
- Kuphephe ukuphuma elangeni kangangoko unako.
- Ukuba uphuma phandle, nxiba impahla egquma umzimba wakho kakuhle kwaye unxibe umnqwazi.
- Buza ugqirha wakho uze usebenzise i-sunscreen elungileyo.
Ukukhulelwa, ukuncancisa kunye nokuzala
Le ngongoma ibaluleke kakhulu.
- Ngexesha lokukhulelwa: Kufuneka uphephe ukukhulelwa ngokupheleleyo ngelixa usebenzisa eli yeza okanye iintsuku ezingama-45 emva kokuyeka unyango. Eli yeza linokubangela iziphene ezinkulu zokuzalwa komntwana ongekazalwa. Kufuneka wenze uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango ukuqinisekisa ukuba awukhulelwanga.
- Kwabesilisa: Ukuba uthatha iCrizotinib kwaye iqabane lakho lisenokukwazi ukuzala abantwana, qiniseka ukuba usebenzisa ikhondom ngexesha lokwabelana ngesondo ngexesha lonyango kwaye emva kweentsuku ezingama-90 emva kokuyeka unyango.
- Ukuncancisa: Kuphephe ukuncancisa umntwana wakho ngexesha lonyango nangeentsuku ezingama-45 emva kokuyeka unyango.
- Ukuchuma:Eli yeza linokuchaphazela ukuzala (amandla okuzala abantwana) kubafazi nakumadoda. Ukuba uneenkxalabo malunga noku, thetha nogqirha wakho ngayo ngaphambi kokuba uqalise unyango.
Iziphumo ebezingalindelekanga ezinokubakho ngenxa yale yeza
Njengalo naliphi na iyeza, iCrizotinib inokubangela iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Ezinye zincinci. Kodwa kukho izinto ekufuneka uzazi kwangoko.
| Iziphumo ebezingalindelekanga ekufuneka uzixele kugqirha wakho ngoko nangoko | |
|---|---|
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Utshintsho kwisantya sentliziyo | Ukuziva ngathi intliziyo yakho ibetha ngokukhawuleza okanye ngokungacwangciswanga, isiyezi, ukuquleka, iintlungu zesifuba, kunye nobunzima bokuphefumla. |
| Ukwehla kwesantya sentliziyo | Ukuba nesiyezi, ukuquleka, ukudideka, ubunzima bokuphefumla, kunye nokuziva udiniwe ngendlela engaqhelekanga. |
| Iimpawu zomonakalo wesibindi | Intlungu kwinxalenye ephezulu ngasekunene yesisu, ukuphelelwa ngumdla wokutya, isicaphucaphu, indle ekhanyayo, umchamo otyheli okanye omdaka omnyama, ukutyheli kolusu okanye amehlo, ukudinwa okungaqhelekanga. |
| Iingxaki ezinxulumene nemiphunga | Ukukhohlela okomileyo okungachazekiyo, ubunzima bokuphefumla, ukuphefumla okufutshane. |
| Iimpawu zosulelo | Umkhuhlane, ukubanda, ukukhohlela, umphimbo obuhlungu, amanxeba angapholiyo, iintlungu xa uchama. |
| Ezinye iimpawu ezinzulu | Utshintsho lombono, izilonda zomlomo okanye zomqala, urhudo oluqatha okanye oluqhubekayo, ukuva ukukhanya. |
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza | |
| Iziphumo ebezingalindelekanga eziqhelekileyo |
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Umyalezo Wokuya Ekhaya
- I-Crizotinib lunyango lomhlaza olujoliswe kulo. Kufuneka luthathwe kanye njengoko ugqirha wakho ekuxelele.
- Xelela ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo (kuquka amayeza athengiswa ngaphandle kwemvume kagqirha). Musa ukulisebenzisa eli yeza kunye nejusi yegrapefruit.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinzulu ezifana notshintsho embonweni, ubunzima bokuphefumla, utshintsho kwisantya sentliziyo, okanye umkhuhlane , yazisa ugqirha wakho ngoko nangoko.
- Musa ukuyeka ukuthatha amayeza okanye ukutshintsha idosi ngaphandle kwengcebiso kagqirha wakho.
- Kuphephe ukukhulelwa ngokupheleleyo ngelixa usebenzisa eli yeza kwaye ixesha elimiselweyo. Thetha nogqirha wakho malunga neendlela zokulawula ukukhulelwa ezikhuselekileyo.
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