Asinalo ingqalelo ingako kwezinye zenguqu ezincinci ezenzeka emizimbeni yethu, akunjalo? Kodwa ngamanye amaxesha ezo nguqu zincinci, umzekelo, into efana notshintsho kwindlela umchamo wakho obonakala ngayo, zinokuba luphawu lwengxaki enkulu yempilo kunokuba ucinga. Namhlanje siza kuthetha ngesifo sezintso esingaqhelekanga, kodwa esichaphazela kakhulu. Oku kubizwa ngokuba yiComplement 3 Glomerulopathy, okanye i-C3G ngamafutshane.
Kalula nje, yintoni i-C3G?
Cinga ngezintso zakho njengesihluzo esikhulu esicoca igazi emzimbeni wakho. Ngaphakathi kwesi sihluzo kukho izakhiwo ezintle kakhulu, ezifana ne-mesh ezibizwa ngokuba yi-glomeruli. Ezi zezona zihluza inkunkuma egazini zize ziyikhuphe njengomchamo.
Sonke sinenkqubo yomzimba yokuzikhusela emizimbeni yethu. Ifana nomkhosi wokhuselo olwa neentsholongwane ezingena emizimbeni yethu. Amandla akhethekileyo kulo mkhosi yinto esiyibiza ngokuba yinkqubo yokuncedisa. Ngokwesiqhelo, la mandla ayasinceda, kodwa emzimbeni womntu onesifo se-C3G, umsebenzi wale nkqubo yokuncedisa uyaphazamiseka. Ngamafutshane, lo mkhosi wokhuselo unempazamo, kwaye uqala ukuhlasela isihluzo esithambileyo kwizintso zethu.
Olu hlaselo lonakalisa i-filter mesh, kwaye izinto ezifana neeproteni kunye neeseli ezibomvu zegazi ezimele ukuba zisegazini ziqala ukuqokelelana kumchamo. Ekuhambeni kwexesha, lo monakalo uyanda kwaye ukusebenza kwezintso kuyehla kancinci kancinci, ekugqibeleni kukhokelela ekungasebenzini kwezintso kunye nesidingo se-dialysis.
Zithini iimpawu zesi sifo?
Ayinguye wonke umntu onesifo se-C3G oza kuba neempawu ezifanayo. Abanye abantu banokuba neempawu ezininzi kwezi, ngelixa abanye banokuba nenye okanye ezimbini kuphela.
| Uphawu | Ithetha ukuba... |
|---|---|
| Utshintsho kwimbonakalo yomchamo | Ukuba umchamo wakho ubonakala unamafu, ufana negwebu, okanye umnyama ngombala (obomvu, opinki, okanye omdaka), oku kungenxa yokuba iiproteni kunye neeseli zegazi zikhona kumchamo. |
| Ukudumba komzimba | Kunokubakho ukudumba, ingakumbi emilenzeni, emaqatheni, ezandleni, okanye kufutshane namehlo. Oku kwenzeka xa umzimba ungenaproteni ininzi. |
| Intlungu yamalungu | Iintlungu zamalungu zinokwenzeka ngenxa yokungasebenzi kakuhle kwenkqubo yomzimba yokuzikhusela. |
| Igazi elonyukayo | Xa izintso zonakele, oku kuchaphazela nolawulo loxinzelelo lwegazi. |
| Ukudinwa rhoqo | Xa izintso zingasebenzi kakuhle, inkunkuma iyaqokelelana emzimbeni, nto leyo ebangela ukuba uzive udiniwe kwaye ubuthathaka rhoqo. |
| Usulelo oluqhelekileyo | Ukungasebenzi kakuhle kwenkqubo yokuncedisana kunokunciphisa amandla omzimba okulwa neentsholongwane. |
| Iingxaki zamehlo | Abanye abantu banokuba neengxaki zokubona. |
Masifunde ngesiyobisi esitsha esibizwa ngokuba yiFabhalta (Iptacopan)
Njengonyango lwesifo se-C3G, oogqirha badla ngokunika amayeza alawula uxinzelelo lwegazi kwaye anciphise ukuphuma kweeproteni kumchamo (ezifana ne-ACE inhibitors, ii-ARB). Bakwanika amayeza e-cholesterol ephezulu. Ngamanye amaxesha, kusetyenziswa amayeza alawula ukusebenza kwenkqubo yomzimba yokuzikhusela (i-glucocorticoids, i-mycophenolate mofetil).
Nangona kunjalo, iFabhalta yahlukile kuba yeyona iyeza lokuqala elivunyiweyo lokunciphisa ukuphuma kweeproteni kumchamo kubantu abadala abanesifo se-C3G.
Lisebenza njani eli yeza?
Uyakhumbula loo nkqubo yokuzikhusela edidekileyo emzimbeni wethu (inkqubo encedisayo) endikhankanyileyo ngaphambili? Iyeza iFabhalta lithintela umsebenzi weprotheyini ekhethekileyo kuloo mkhosi ebizwa ngokuba yiFactor B. Ngokuchanekileyo, lithomalalisa umkhosi odidekileyo ohlasela izintso zawo. Oku kunciphisa umonakalo kwizintso kwaye kulawula iproteinuria.
Ndingayisebenzisa njani le mithi?
I-Fabhalta yikhaphu oyithatha ngomlomo. Ingathathwa kabini ngemini, nokuba kutyiwe okanye akutyiwa. Eyona nto ibalulekileyo kukuginya ikhaphu yonke. Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna. Ukuba uphoswe yidosi, yithathe kwangoko xa ukhumbula uze uthathe ezinye iidosi njengesiqhelo.
Izifundo malunga nokusebenza kakuhle kweFabhalta zibonise ukuba abantu abasebenzisa eli yeza baye banciphisa ukukhutshwa kweproteni kumchamo wabo malunga ne-35% kwiinyanga ezi-6. Ikwancede ekugcineni okanye ukuphucula ukusebenza kwezintso.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Njengayo nayiphi na iyeza, iFabhalta inokuba nemiphumo emibi. Ezona miphumo zixhaphakileyo ziimpawu zomkhuhlane, ezifana nokuvala impumlo, impumlo egobhozayo, ukukhohlela, ukuthimla, kunye nomphimbo obuhlungu.
Nangona kunjalo, kukho into enye ebalulekileyo ekufuneka siyilumkele kakhulu ngeli yeza. Oko kukuthi, ngenxa yokuba eli yeza lilawula inxalenye yenkqubo yokuncedisa, kukho umngcipheko wosulelo olunzima olubangelwa ziintlobo ezithile zeebhaktheriya (iStreptococcus pneumoniae, iNeisseria meningitidis, iHaemophilus influenzae type B). Ezi sulelo zinokuba yingozi nakubomi.
Ngoko ke, kufuneka uhlale unolwazi ngazo zonke izitofu ezifunekayo (ingakumbi izitofu ze-meningitis kunye ne-pneumonia) ubuncinane iiveki ezimbini ngaphambi kokuba uqale eli yeza. Ugqirha wakho uza kukunika iingcebiso ngalo mba.
| Ukuba unale mpawu, bonana nogqirha ngokukhawuleza! | |
|---|---|
| Umkhuhlane (nokuba ubanda okanye awunawo), iintlungu zesifuba, ukukhohlela, ubunzima bokuphefumla, ukubetha kwentliziyo ngokukhawuleza. | |
| Iintlungu zomzimba kunye neempawu ezifana nomkhuhlane. | |
| Ulusu oluxineneyo. | |
| Intloko ebuhlungu engapheliyo, umkhuhlane, isicaphucaphu, ukuhlanza, ukuqina kwentamo okanye umqolo. | |
| Ukuziva udiniwe ngaphezu kwesiqhelo, udidekile, kunye notshintsho embonweni. | |
Khumbula, ezi azizo zonke iziphumo ebezingalindelekanga. Thetha nogqirha wakho malunga nazo naziphi na iimpawu ezikukhathazayo.
Uvavanyo kunye nezinye izinto ezifunekayo ngexesha lonyango
- Uvavanyo lwegazi: Ngelixa usela eli yeza, ugqirha wakho uza kwenza uvavanyo lwegazi rhoqo ukujonga indlela umzimba wakho osabela ngayo kwiyeza. I-Fabhalta inokunyusa amanqanaba akho e-cholesterol kunye ne-triglyceride, ngoko kuya kufuneka ukuba ezi zihlolwe rhoqo.
- Ukusebenzisana namanye amayeza: Amanye amayeza owasebenzisayo anokuchaphazela indlela esebenza ngayo iFabhalta. Ngoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka iivithamini kunye namayeza esintu. Emva koko unokugqiba ngonyango olulungele wena.
- Inkqubo yoKhuseleko oluKhethekileyo: Ngenxa yomngcipheko wokosuleleka kakhulu ngeli yeza, linikwa phantsi kwenkqubo yokhuseleko oluKhethekileyo (inkqubo ye-REMS). Ugqirha wakho uza kukuxelela ngalo aze akunike ikhadi lokhuseleko. Kubalulekile ukugcina ikhadi nawe kulo lonke unyango lwakho kwaye kangangeeveki ezimbini emva kokuyeka iyeza.
Umyalezo Wokuya Ekhaya
- I-C3G sisifo esingaqhelekanga kodwa esibi kakhulu esonakalisa izintso ngenxa yokungasebenzi kakuhle kwenkqubo yomzimba yokuzikhusela.
- I-Fabhalta (Iptacopan) lunyango olutsha, olujoliswe ngqo oluvunyiweyo ukunciphisa ukukhutshwa kweeproteni kumchamo wezigulane ezine-C3G.
- Kukho umngcipheko wosulelo olukhulu xa usebenzisa eli yeza. Kungoko ke, kubalulekile ukufumana ugonyo olufunekayo ngaphambi kokuba uqale unyango.
- Yazisa ugqirha wakho ngoko nangoko ngazo naziphi na iimpawu okanye iziphumo ebezingalindelekanga ezingaqhelekanga. Qaphela ngakumbi iimpawu zosulelo, ezinje ngomkhuhlane kunye nentloko ebuhlungu kakhulu.
- Akufuneki uqale, uyeke, okanye utshintshe umthamo wamayeza akho ngaphandle kwengcebiso kagqirha wakho.
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