Ngaba ukhe waqaphela kutshanje ukuba umntu omdala kusapho lwakho, mhlawumbi umama wakho, utata wakho, umakhulu okanye umakazi wakho, uyalibala izinto ezincinci? Izinto ezifana nokuba izitshixo zakho zikuphi, igama lomntu, umsebenzi obufanele uwenze... Kuqhelekile ukuba olu hlobo lokulibala lwenzeke njengoko sikhula. Kodwa ukuba le meko iya isiba mandundu kwaye inkumbulo yakho iba buthathaka kangangokuba awukwazi nokwenza imisebenzi yemihla ngemihla, inokuba luphawu lokuqala lwesifo esifana ne-Alzheimer's. Ngoko ke ingaba luncedo kangakanani ukuba bekukho indlela yokufumana oku kwangoko, ngokulula? Yiloo nto sithetha ngayo kweli nqaku namhlanje, kwaye isinika ithemba elikhulu.
Yintoni le vavanyo lwegazi litsha?
Uphando lwakutshanje lufumene uvavanyo olutsha lwegazi olunokubona iimpawu zesifo sika-Alzheimer. Okumangalisayo ngale nto kukuba olu vavanyo lwegazi lulula luchanekile njengovavanyo olusetyenziswayo ngoku, olubuhlungu nolunzima, i-spinal tap.
Ngamafutshane, olu vavanyo lwegazi lulinganisa amanqanaba eproteni ethile egazini lethu ebizwa ngokuba yi-p-tau217 . Abaphandi bafumanise ukuba ukuba umntu unezinga eliphezulu kakhulu leproteni ye-p-tau217 egazini lakhe, luphawu oluqinileyo lotshintsho kwezinye iiproteni ezimbini ezinxulumene ngqo nesifo se-Alzheimer: i-amyloid beta kunye ne-tau . Ezi ziiproteni eziphambili eziqokelelana engqondweni xa kusenzeka isifo se-Alzheimer.
Olu vavanyo lwegazi lutsha lubonise ukuchaneka okuya kuthi ga kwi-97% , nto leyo ethembekileyo kakhulu. Kwakhona, yi-20% kuphela yabantu abathathe inxaxheba kolu phononongo ababefuna iimvavanyo ezongezelelweyo ukuqinisekisa esi sifo.
Oku kwahluke njani kwiimvavanyo ezisetyenziswayo ngoku?
Iindlela ezilungileyo zangoku zokufumanisa ngokuchanekileyo isifo sika-Alzheimer ziyinkimbinkimbi kancinci. Makhe sijonge ukuba zeziphi kwaye zahluke njani kolu vavanyo lutsha lwegazi.
| Indlela yovavanyo | Inkcazo | Iingxaki kunye neengxaki |
|---|---|---|
| I-Spine Tap | Ukufaka inaliti ekhethekileyo kwintambo yomqolo nokususa inani elincinci lolwelo lwe-cerebrospinal, ulwelo olujikeleze ingqondo kunye nentambo yomqolo. | Kunokuba buhlungu, kukho umngcipheko othile, kwaye kufuneka ulaliswe esibhedlele, kwaye abantu abaninzi bayayoyika le nto. |
| Iskena sezilwanyana zasekhaya | Iskena esinobukrelekrele nesinobukrelekrele sithatha imifanekiso yeeproteni ze-amyloid kunye ne-tau engqondweni. | Ibiza kakhulu. Ezi zibonelelo azifumaneki kuzo zonke izibhedlele. Kunzima kwabo bahlala kude ukuzifumana. |
| Uvavanyo olutsha lwegazi lwe-p-tau217 | Ukuvavanya inqanaba leproteni ye-p-tau217 ngesampuli yegazi eqhelekileyo ethathwe kumthambo osengalweni. | Kulula kakhulu, akunangozi ingako, akubizi kakhulu xa kuthelekiswa nezinye iindlela, kwaye kungenziwa lula naphi na. |
Kuthiwa uvavanyo lwegazi olusetyenziswe kolu phononongo lunokufumaneka kumazwe angaphandle ngexabiso eliphakathi kwe-$200 ne-$500. Nangona le yimali eninzi eSri Lanka, eli xabiso liphantsi kakhulu xa lithelekiswa novavanyo olufana ne-PET scan, olubiza amakhulu amawaka eedola.
Sifumana myalezo mni ngokwenene kolu phando?
Olu phononongo, olupapashwe kwijenali yezonyango edumileyo kwihlabathi liphela iJAMA Neurology, lubonisa ukuba uvavanyo lwegazi lwe-p-tau217 lunokusebenza njengesixhobo sokuqala sokuhlola iingxaki zenkumbulo .
Cinga ngale ndlela. Xa umntu ekrokrela ukuba usenokuba neengxaki zokukhumbula, angaqala ngolu vavanyo lwegazi lulula. Kuphela xa lunika umqondiso wokuba uneempawu apho anokuthi aqhubeke novavanyo olubiza kakhulu nolunzima ngakumbi. Oku kunokongela izigulane kunye noogqirha ixesha elininzi kunye nemali.
Into ebalulekileyo kukuba ukuba isifo sifunyenwe kwangethuba ngale ndlela, unyango olutsha olujolise kwiproteni ye-amyloid engqondweni lunokuqaliswa kwangethuba. Okukhona unyango luqalwa kwangethuba nasiphi na isifo, kokukhona iziphumo zingcono.
Ukulibala ngokubanzi kunye nesifo sika-Alzheimer
Isifo sika-Alzheimer lolona hlobo luqhelekileyo lwe-dementia, okanye ukwehla kwengqondo. Kuqhelekile ukuba kubekho utshintsho oluncinci kwinkumbulo nasekucingeni njengoko sikhula. Nangona kunjalo, ukuba olu tshintsho luba lukhulu ngokwaneleyo ukwenza kube nzima ukwenza imisebenzi yemihla ngemihla, lunokuba luphawu lwe-dementia.
Umzekelo, yinto enye ukulibala apho uzibeka khona izitshixo zakho uze uzikhumbule kwakhona emva kwexesha elithile. Nangona kunjalo, ukuba uyalibala ngokupheleleyo ukuba yintoni isitshixo kwaye sisetyenziselwa ntoni, yimeko enzima leyo. Kulapho ke kufuneka sifune ingcebiso kugqirha.
Ngoko ke singalwenza olu vavanyo lwegazi ngoku?
Lo ngumbuzo obaluleke kakhulu. Nangona olu vavanyo sele lufumaneka kwamanye amazwe, lusekwinqanaba lokuqala. Abaphandi ngokwabo bathi kufuneka uphando olongezelelekileyo ukuqinisekisa indlela ezi ziphumo ezisebenza ngayo kuluntu ngokubanzi, oko kukuthi, abantu abangenazo iimpawu.
Olu vavanyo aluqhelekanga kangako eSri Lanka. Kodwa lunyuse amathemba amakhulu kwicandelo lezonyango kwihlabathi liphela. Kwixesha elizayo, kuza kufika imini apho nathi siya kukwazi ukwenza uvavanyo olulula nolungabizi kakhulu.
Eyona nto ibalulekileyo kukuba, ukuba wena okanye umntu kusapho lwakho unamathandabuzo okanye iingxaki malunga nokukhumbula, musa ukwenza izigqibo zakho ngokusekelwe koko ukufundileyo kwi-intanethi. Qiniseka ukuba ubona ugqirha wosapho lwakho (ugqirha) uze uthethe ngale nto. Uza kukunika isikhokelo esichanekileyo malunga novavanyo olufunekayo kunye namanyathelo omawuwathathe, kuxhomekeke kwiimpawu zakho.
Umyalezo Wokuya Ekhaya
- Uphando oluphumelelayo luyaqhubeka kuvavanyo olutsha nolulula lwegazi olunokuba nethemba lokufunyaniswa kwesifo se-Alzheimer kwangethuba.
- Olu vavanyo lulinganisa iproteni ebizwa ngokuba yi-p-tau217 egazini, kwaye lufunyenwe luchanekile njengovavanyo olubizayo nolunzima olusetyenziswayo ngoku.
- Oku kungabaluleka kakhulu kwixesha elizayo njengovavanyo lokuhlola ukuze kufunyanwe isifo kwangethuba.
- Ukuba wena okanye umntu osondeleyo kuwe unengxaki enkulu yokukhumbula, eyona nto ilungileyo nekuphela kwayo onokuyenza kukufuna ingcebiso kugqirha ofanelekileyo ngoko nangoko.
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