Ngaba wena okanye umntu osapho lwakho unesifo esingaqhelekanga semfuza esibizwa ngokuba yi-hATTR? Ngaba ugqirha wakho ukunike isitofu esibizwa ngokuba yi-Inotersen njengonyango lweengxaki zemithambo-luvo ezibangelwa yiso? Ngoko ke namhlanje siza kuthetha ngokucacileyo ngale mithi, indlela yokuyisebenzisa, kunye nezinto ekufuneka sizilumkele. Ekubeni eli liyeza elinzima kancinci, kubaluleke kakhulu ukuba siliqonde kakuhle.
Lithini eli yeza libizwa ngokuba yi-Inotersen?
Ngamafutshane, i-Inotersen liyeza elisetyenziselwa ukunyanga umonakalo wemithambo-luvo kwizigulana ezinemeko ethile yemfuza ebizwa ngokuba yi -hereditary transthyretin-mediated amyloidosis (hATTR) . Lithengiswa kakhulu phantsi kwegama lebrendi iTegsedi.
Ngoku masibone ukuba le meko ibizwa ngokuba yi-hATTR yintoni. Esi sisifo esingaqhelekanga esidluliselwa kwizizukulwana ngezizukulwana ngeejini. Ngenxa yotshintsho olungaqhelekanga kwiproteni ebizwa ngokuba yi-transthyretin, eveliswa kwisibindi somzimba wethu, le proteni iqokelelana kwaye igcinwe kwiindawo ezahlukeneyo zomzimba, ingakumbi kwinkqubo yemithambo-luvo. Ezi depositi (ii-amyloid deposits) zonakalisa imithambo-luvo kwaye zinokubangela ukungaziva malungu omzimba, iintlungu, ubuthathaka, ubunzima bokuhamba, kwaye zinokuchaphazela intliziyo kunye nezintso.
Ngoko ke into eyenziwa yi-Inotersen vaccine kukulawula ukuveliswa kweproteni engaqhelekanga nokunciphisa umonakalo ongakumbi kwimithambo-luvo. Oku akuyonyango lwesifo, kodwa kunceda kakhulu ekulawuleni ukuqhubela phambili kwesifo, oko kukuthi, ukuba mandundu kwesi sifo.
Khumbula, eli yeza lingasetyenziselwa nezinye iimeko zonyango njengoko kuyalelwe ngugqirha wakho. Ngoko ke hlala ulandela imiyalelo kagqirha wakho.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza
Ngaphambi kokuba uqale unyango nge-Inotersen, kubalulekile ukuxelela ugqirha wakho ngembali yakho epheleleyo yempilo. Qiniseka ukuba ubaxelela ngale nto ilandelayo:
- Isifo sezintso: Ukuba unesifo sezintso okanye wakha wanesifo sazo.
- Iingxaki zegazi: Ukuba unemeko enciphisa inani leeseli ezibomvu, iiseli ezimhlophe, okanye iiplatelets egazini lakho. Oku kubaluleke kakhulu kuba eli yeza linokuchaphazela inani leeplatelets zakho.
- Ii-Allergies: Ukuba ukhe waba ne-allergy kwi-Inotersen, naluphi na olunye unyango, ukutya, okanye idayi.
- Ukukhulelwa: Ukuba ukhulelwe, okanye unethemba lokukhulelwa kungekudala.
- Ukuncancisa: Ukuba ungumama oncancisa umntwana wakho.
Ngokusekelwe kolu lwazi, ugqirha wakho uya kugqiba ukuba eli yeza likulungele na kwaye zeziphi ezinye iindlela zokuzikhusela ekufuneka uzithathe ngexesha lonyango.
Ndingayisebenzisa njani le mithi?
Le yinaliti phantsi kwesikhumba. Idla ngokunikezelwa kube kanye ngeveki.
- Uqeqesho: Ugqirha wakho okanye umongikazi oqeqeshiweyo uza kukubonisa ngokucacileyo indlela yokulungiselela olu gonyo kunye nendlela yokuzitofa ekhaya. Ungakhathazeki, kulula kakhulu xa sele uqhele.
- Landela imiyalelo: Sela amayeza kanye njengoko kuyalelwe, ngamaxesha afanelekileyo, kwaye ungaze uthathe ngaphezu komlinganiselo omiselweyo.
- Ukulahla iinaliti: Ungaze ulahle iinaliti ezisetyenzisiweyo kunye neesirinji enkunkuma. Zifanele zibekwe kwisikhongozeli esikhethekileyo se-sharps. Ukuba awunayo, ungayifumana kugqirha wakho okanye esibhedlele.
- I-Overdose: Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, ungoyiki kwaye ngoko nangoko fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo, okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
- Ukuba uphoswe yidosi: Ukuba uphoswe yidosi, yithathe ngokukhawuleza ukuba uyakhumbula. Kodwa ukuba kungaphantsi kweentsuku ezimbini ngaphambi kokuba idosi yakho elandelayo ifike, yitsibe idosi oyiphosileyo. Thatha nje idosi elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini.
Iziphumo ebezingalindelekanga ezinokubakho xa uthatha iyeza
Njengayo nayiphi na iyeza, i-Inotersen inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zezi zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.
| Imiphumela | Iimpawu ekufuneka uziqaphele |
|---|---|
| Ukuba unale mpawu, yiya kugqirha wakho okanye kwi-ETU ngokukhawuleza. | |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi, ubunzima bokuphefumla. |
| Ukopha okungaqhelekanga | Indle emnyama okanye enegazi, umchamo obomvu okanye omdaka, ukuhlanza into efana nekofu egayiweyo, amabala abomvu eluswini, ukopha okungaqhelekanga kwiintsini, empumlweni, okanye emehlweni. |
| Iimpawu zestroke | Ukutshintsha kombono, ukudideka, ubunzima bokuthetha okanye ukuqonda, intloko ebuhlungu kakhulu, ukudinwa okanye ubuthathaka ngequbuliso ebusweni, engalweni okanye emlenzeni, ubunzima bokuhamba, isiyezi. |
| Iimpawu zomonakalo wezintso | Ubunzima bokuchama okanye utshintsho kubungakanani bomchamo ophumayo. |
| Iimpawu zomonakalo wesibindi | Umchamo otyheli okanye omdaka omnyama, ukutyheli kwamehlo okanye ulusu, ukuziva udiniwe, umkhuhlane, iintlungu kwicala eliphezulu lasekunene lesisu, isicaphucaphu. |
| Xelela ugqirha wakho ukuba ezi zinto ziyaqhubeka okanye ziyakukhathaza. | |
| Iziphumo ebezingalindelekanga eziqhelekileyo | Intloko ebuhlungu, iintlungu zamalungu, iintlungu zemisipha, isicaphucaphu, ukuhlanza, ukudinwa, ukuba bomvu, ukurhawuzelelwa, okanye intlungu kwindawo efakwe inaliti. |
Ezinye izinto ezinokusebenzisana nale mithi
Amanye amayeza owasebenzisayo anokuchaphazela ukusebenza kwawo okanye iziphumo ebezingalindelekanga. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo. Lumka ngakumbi ngala mayeza alandelayo:
- Izinto zokunciphisa igazi: Amayeza afana ne-warfarin, i-apixaban, i-clopidogrel, kunye ne-aspirin. Ukusela ezi kunye ne-Inotersen kunokunyusa umngcipheko wokopha.
- Iipilisi zokunciphisa iintlungu (ii-NSAID): Amayeza afana ne-ibuprofen kunye ne-naproxen. La mayeza anokuchaphazela nezintso kwaye anyuse umngcipheko wokopha.
- Amanye amayeza anokuchaphazela izintso aquka: amanye amayeza okubulala iintsholongwane kunye ne-diuretics (amayeza anyusa ukuphuma komchamo).
- IVithamini A: Amanqanaba akho eVithamini A anokwehla xa usebenzisa eli yeza. Ke ngoko, kubaluleke kakhulu ukufumana iVithamini A eyaneleyo.Thetha nogqirha wakho malunga nokutya kunye neevithamini ozityayo, kwaye uthabathe isongezelelo sevithamini A ukuba kuyimfuneko.
Olu luhlu lusenokungabandakanyi zonke iindlela ezinokwenzeka zokunxibelelana. Ngoko ke xelela ugqirha wakho ngawo onke amayeza, amayeza esintu, iivithamini, kunye nezongezo ozithathayo. Qiniseka ukuba uxelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi.
Umyalezo Wokuya Ekhaya
- I-Inotersen liyeza elisetyenziselwa ukunyanga umonakalo wemithambo-luvo obangelwa sisifo esithile semfuza esibizwa ngokuba yi-hATTR.
- Ngaphambi kokuba uqale unyango, xelela ugqirha wakho ngazo zonke iimeko zakho zempilo (ingakumbi eziphathelele izintso negazi) kunye nee-aleji.
- Funda indlela yokufaka inaliti ngokuchanekileyo. Lahla iinaliti kunye neesirinji ezisetyenzisiweyo ngokukhuselekileyo.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana naziphi na iziphumo ebezingalindelekanga, ezinje ngokopha okungaqhelekanga, iimpawu zestroke, okanye ukusabela okunamandla kokunganyamezelani komzimba.
- Eli yeza lelakho kuphela. Musa ukwabelana ngalo nabanye abantu nangasiphi na isizathu.
- Hlala unxibelelana rhoqo nogqirha wakho kwaye uye kwiimvavanyo ezicwangcisiweyo kunye namadinga okubonana.
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