Kunzima ukuchaza ngamazwi indlela ovakalelwa ngayo xa ufumanisa ukuba wena okanye umntu omthandayo unomhlaza. Kuqhelekile ukuba uzive usoyika kwaye unomdla xa ugqirha wakho ekuxelela ngonyango olutsha, olufana ne-PRRT, eligama elingaziwayo. Kodwa ungakhathazeki. Nangona eli linqaku elinzima, namhlanje siza kuthetha ngokuba yintoni i-PRRT, yintoni eyenzayo, kunye neenzuzo kunye neengxaki zayo, ngendlela elula kakhulu onokuyiqonda.
Ithetha ukuthini i-PRRT nje?
Ngamafutshane, i-PRRT lunyango oluphambili kakhulu olujolise, lufune, kwaye lutshabalalise iiseli zomhlaza, njenge- 'missile ekhokelwayo' . Isetyenziselwa ngokukodwa ukunyanga uhlobo lomhlaza olubizwa ngokuba yi-'Neuroendocrine Tumors (NETs).'
Eyona nto ikhethekileyo kolu nyango kukuba izinto ezisebenzisa i-radioactive (i-radioactivity) ezikhutshwa yiyo ziya ngqo kwiiseli zomhlaza zize zizitshabalalise. Ke ngoko, umonakalo kwiiseli ezisempilweni uncinci kakhulu kunonyango oluqhelekileyo lwe-radiation.
Olu nyango lusebenza njani ngaphakathi emzimbeni?
Ukuze siqonde oku, masisebenzise umzekelo olula. Khawucinge ukuba iiseli zakho zomhlaza ziyiminyango ene-'keyholes' ezininzi ezikhethekileyo ('ii-receptors'). Ucango ngalunye lungena kuphela isitshixo esinesimo esithile.
Eli yeza, elibizwa ngokuba yiPRRT, lenziwa ngokudibanisa izinto ezimbini:
1. Isitshixo: Le yiproteni. Esi sitshixo sinokungena kuphela 'kwisihluthulelo' seeseli zomhlaza. Asingeni kwiiseli eziphilileyo.
2. Umkhweli weRadioactive: Esi sitshixo sinesithako esincinci kakhulu seradioactive (`radionuclide`) esiqhotyoshelwe kuso.
Ngoko ke, xa unika umzimba wakho eli yeza, eli 'sitshixo' lihamba emzimbeni wonke, lifumane 'imingxuma' kwiiseli zomhlaza, lize lizinamathele kuzo. Emva koko, 'umkhweli we-radioactive' kwisitshixo ungena ngaphakathi kwiseli yomhlaza, wonakalisa i-DNA yaloo seli, kwaye utshabalalise iseli ngaphakathi.
Le ndlela ivumela ukutshatyalaliswa okukhethiweyo kweeseli zomhlaza kuphela, ngaphandle kokubangela umonakalo omkhulu kwiiseli ezisempilweni. Le yeyona nzuzo inkulu yolu nyango.
Iyeza le-PRRT elisetyenziswa kakhulu namhlanje yi-`lutetium Lu 177 dotatate (LUTATHERA®)`.
Ngubani ocetyiswa unyango lwe-PRRT?
Olu nyango alufanelekanga kubo bonke abaguli abanomhlaza. Okwangoku, lucetyiswa kakhulu kumhlaza obizwa ngokuba yi-'gastroenteropancreatic NETs', ongumhlaza womgudu wokugaya ukutya (amathumbu, isisu, i-rectum) kunye ne-pancreas. Kukho iimeko ezininzi apho olu nyango lunokufaneleka kuwe.
| Imeko | Ingcaciso |
|---|---|
| Ayifanelekanga utyando | Ukuba umhlaza usasazeke kwiindawo ezininzi zomzimba, utyando lodwa alunakunyanga ngokupheleleyo. Abantu abaninzi abane-NETs basenokuba sele bewusasaze umhlaza xa befunyaniswa ukuba bane-HIV. |
| Ezinye iindlela zonyango aziphumelelanga | Kwimeko apho utyando lungenakwenzeka, izinto ezifana nonyango lweehomoni ziyanikwa. Kodwa ngamanye amaxesha, olo nyango lubangela ukuba iiseli zomhlaza ziqhubeke zikhula ngendlela engalawulekiyo. Kwabo bantu, i-PRRT lukhetho olufanelekileyo. |
| Iiseli zomhlaza zine "keyhole" | Le yeyona nto ibalulekileyo. Ukuze iyeza le-PRRT lifikelele 'kwisitshixo' kwaye lidibane, kufuneka kubekho 'ii-keyholes' ezibizwa ngokuba yi-somatostatin receptors kumphezulu weeseli zomhlaza. Ugqirha wakho uza kwenza iskeni ekhethekileyo, efana ne -octreotide scan okanye i -PET scan , ukuze abone ukuba iiseli zakho zomhlaza zinazo na ezi. |
Kwenzeka ntoni ngaphambi nangexesha lonyango?
Ngaphambi konyango
Ukuba usebenzisa amanye amayeza e-NETs (ingakumbi ii-somatostatin analogues), ugqirha wakho uya kukucebisa ukuba uyeke ukuwasebenzisa kwiiveki ezimbalwa ngaphambi kwe-PRRT. Ugqirha wakho uya kwenza uvavanyo lwegazi malunga neveki ngaphambi konyango lwakho ukujonga ukusebenza kwezintso zakho kunye nokubalwa kweeseli zegazi ukuqinisekisa ukuba umzimba wakho ukwimeko elungileyo yokufumana unyango.
Ngomhla wonyango
Olu nyango ludla ngokwenziwa rhoqo emva kweenyanga ezimbini kangangeeseshoni ezi-4 kwixesha leenyanga ezi-8. Le yinkqubo yokulaliswa ngaphandle kwesibhedlele, ngaphandle kokuhlala esibhedlele. Lonke olu nyango luthatha malunga neeyure ezi-5-6.
- Okokuqala, ityhubhu encinci (i-cannula) ifakwa kumthambo osengalweni yakho kwaye kwenziwa umgca wetyuwa.
- Malunga neyure ngaphambi kokuba unyango luqale, kunikwa amayeza okuthintela isicaphucaphu nokuhlanza.
- Emva koko, uza kunikwa isisombululo setyuwa esinee-amino acids ukukhusela izintso zakho malunga neeyure ezi-4. Oku kubaluleke kakhulu.
- Malunga nemizuzu engama-30 emva kokuba ii-amino acids ziqalile ukunikwa, iyeza le-PRRT linikwa umzimba nge-saline kangangemizuzu engama-30-45.
- Nje ukuba yonke ityuwa inikwe, ityhubhu engalweni iyasuswa.
Ngosuku olulandelayo emva konyango, uza kuphinda uhlolwe ukuze ujonge ukuba iyeza elinomhlaza liye phi emzimbeni wakho, ingakumbi apho kukho izimila zomhlaza.
Zithini iziphumo ebezingalindelekanga kunye neengozi?
Njengakwezinye iindlela zonyango, kusenokubakho iziphumo ebezingalindelekanga.
Iziphumo ebezingalindelekanga eziqhelekileyo:
Iziphumo ebezingalindelekanga eziqhelekileyo kukuba sisicaphucaphu nokuhlanza , kodwa ezi zinokulawulwa kakhulu ngonyango lwangethuba.
Ezinye iingxaki ezinokubakho:
- Nasiphi na isiphumo ekusebenzeni kwezintso okanye kwesibindi.
- Ukuncipha kwenani leeseli zegazi (iiseli ezimhlophe zegazi, iiseli ezibomvu zegazi, iiplatelets). Oku kunokubangela ubunzima bokuphefumla, ukwanda kokuchaphazeleka zizifo, kunye nomngcipheko ophezulu wokopha okanye ukukrweleka.
- Kunqabile kakhulu ukuba kubekho umngcipheko omncinci wokufumana eminye imidlaza yegazi efana ne-myelodysplastic syndrome okanye i-leukemia.
Ugqirha wakho uza kujonga amanqanaba egazi lakho rhoqo kulo lonke unyango lwakho. Ukuba kukho naziphi na iingxaki, banokugqiba ekubeni batshintshe idosi okanye bayeke unyango lwakho.
Imeko enzima kakhulu efuna ingqalelo ekhawulezileyo!
Ingxaki yeCarcinoid yimeko engaqhelekanga kodwa enokuba yingozi ebomini enokwenzeka ngexesha lonyango. Ibangelwa kukukhululwa ngequbuliso kweehomoni ezininzi ezivela kwiiseli zomhlaza ziye egazini. Iimpawu zinokubonakala kwiiyure zokuqala ezingama-48 zokufumana unyango.
Ukuba unayo nayiphi na kwezi mpawu, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) elikufutshane ngoko nangoko okanye utsalele umnxeba ku-1990:
* Ubunzima bokuphefumla
* Ububomvu bobuso okanye intamo, ukuziva ushushu okanye utshisa emzimbeni (Ukuhlanjwa ngamanzi)
* Ukwehla ngequbuliso koxinzelelo lwegazi (ukuziva unesizungu)
* Ukubetha kwentliziyo
* Urhudo oluqatha
Ubomi bemihla ngemihla emva konyango
Uninzi lwabantu luyanyamezela olu nyango kakuhle kwaye luyaphola ngokukhawuleza.
Ukhuseleko kunye ne-radioactivity:
Olu nyango lusebenzisa imitha encinci kakhulu. Le mitha iza kudluliselwa emzimbeni wakho kumchamo wakho nakwindle yakho kwiintsuku ezimbalwa ezizayo. Ngeli xesha, ugqirha wakho uza kukunika imiyalelo yokuthintela abanye ekubeni bachaphazeleke yimitha.
- Kubaluleke kakhulu ukuhlala kude nabasetyhini abakhulelweyo nabantwana abancinci kangangeentsuku ezimbalwa.
- Hlamba izandla zakho kakuhle ngesepha emva kokusebenzisa indlu yangasese.
Ukuhamba:
Kunokubakho inani elincinci kakhulu lemitha emzimbeni wakho ukuya kuthi ga kwiinyanga ezi-3 emva konyango lwakho. Oku kunokubangela ukuba izixhobo zokubona imitha zisebenze kwizikhululo zeenqwelo-moya okanye kwimida. Ngoko ke, hlala ugcina ikhadi elikhethekileyo olifumana esibhedlele kunye neenkcukacha zakho zonyango. Oku kubaluleke kakhulu ukuze uphephe naziphi na iingxaki xa uhamba.
Umyalezo Wokuya Ekhaya
- I-PRRT lunyango oluphambili oluhambisa imitha ejoliswe ngokukodwa kwiiseli zomhlaza. Isetyenziswa ngokukodwa kwi-Neuroendocrine Tumors (NETs).
- Nangona olu nyango lungelulo oluphilisa umhlaza ngokupheleleyo, lunceda ekunciphiseni okanye ekumiseni ukukhula kweethumba, lulawule iimpawu, kwaye luphucule umgangatho wobomi ngokwandisa ixesha lokusinda.
- Kangangeentsuku ezimbalwa emva konyango, landela imiyalelo enikiweyo yokukhusela abanye kwimitha yelanga (ingakumbi ukuhlala kude nabantwana abancinci kunye nabasetyhini abakhulelweyo).
- Qaphela iimpawu zesifo somhlaza (ubunzima bokuphefumla, ukuphefumla nzima, urhudo oluqatha, ukunyuka kwesantya sentliziyo). Ukuba ufumana naziphi na kwezi mpawu, yiya kwi -ETU yesibhedlele ngokukhawuleza.
- Musa ukuthandabuza ukuthetha nogqirha wakho malunga nemiphumo emibi okanye iingxaki onokuhlangabezana nazo.
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