Usenokuba ukhe wabona umntu kusapho lwakho, mhlawumbi utata okanye umalume wakho, ethatha amayeza esifo sentliziyo, uxinzelelo lwegazi oluphezulu, okanye ukungasebenzi kakuhle kwe-erectile. Ngokufanayo, oogqirha banika amayeza ahlukeneyo ezifo zesikhumba, izifo zokuphefumla ezifana ne-asthma, njl. Ubusazi na ukuba kukho udidi olubaluleke kakhulu lwamayeza asetyenziselwa ukunyanga uninzi lwezi meko? Olu didi lwamayeza, oluyi-Phosphodiesterase Inhibitors, yinto esiza kuthetha ngayo kweli nqaku namhlanje, ngokulula nangendlela ehloniphekileyo.
Ngamafutshane, ziintoni ezi Phosphodiesterase Inhibitors?
Oku kusenokuvakala ngathi ligama elintsonkothileyo, kodwa eneneni kulula kakhulu. La luhlobo lwamayeza anceda ekuphumleni nasekukhuliseni imithambo yegazi emizimbeni yethu, okwenza kube lula ukujikeleza kwegazi. Xa ukuhamba kwegazi kuphucukile, uxinzelelo lwegazi nalo luyalawulwa. Yiyo loo nto la mayeza esetyenziselwa ukunyanga iimeko ezahlukeneyo, ukusuka kwiingxaki zolusu, amalungu, intliziyo, kunye nemiphunga ukuya kukungasebenzi kakuhle ngokwesondo.
Eli yeza lisebenza njani emzimbeni?
Imizimba yethu inohlobo lwe-enzyme ebizwa ngokuba yi -Phosphodiesterases (PDEs) . Ngamafutshane, ii-enzymes zifana nabancedisi abancinci abakhawulezisa iinkqubo zeekhemikhali emizimbeni yethu. Kukho iintlobo ezahlukeneyo zezi enzymes ze-PDE. Zibalwa kwaye zahlulwe. Ingcali kukuba uhlobo ngalunye lwe-enzyme ye-PDE lufumaneka kwiindawo ezithile emzimbeni.
| Uhlobo lwe-enzyme ye-PDE | Ihlala ifumaneka kwaye iyasebenza |
|---|---|
| I-PDE-3 | Ezi zifumaneka ngakumbi entliziyweni yakho nakwinkqubo yokujikeleza kwegazi . Zikwabandakanyeka ekujiyeni kwegazi. |
| I-PDE-4 | Ezi zifumaneka emiphungeni . Zibangela ukuba izihlunu ezikwindlela yomoya ziqine kwaye zinciphe. |
| I-PDE-5 | Ezi zifumaneka emaphashini nakwilungu lobudoda lamadoda. |
Ii-Phosphodiesterase Inhibitors (PDE Inhibitors) zisebenza ngokuthintela umsebenzi wee-enzymes ze-PDE ezikhankanyiweyo. Kufana nokuvala ucango. Ezinye ii-PDE Inhibitors zijolise kuhlobo olunye kuphela lwe-enzyme (ekhethayo), ngelixa ezinye zinokuchaphazela ii-enzymes ze-PDE ngokubanzi (ezingakhethiyo).
Zeziphi iimeko eziphambili ezinyangwa ngale mithi?
La mayeza avunyiwe ukunyanga izifo ezahlukeneyo ezingaphezu kweshumi elinesibini. Makhe sijonge ezinye zezona ntlobo ziphambili.
Izifo zentliziyo kunye nenkqubo yokujikeleza kwegazi
- Ukungasebenzi kakuhle kwentliziyo: Xa intliziyo iba buthathaka kwaye ingakwazi ukupompa igazi emzimbeni njengoko kufuneka.
- Uxinzelelo lwegazi oluphezulu kwimiphunga: Uxinzelelo oluphezulu kwimithambo yegazi emiphungeni.
- Ukuncipha kokuhamba kwegazi ukuya kwimilenze (Isifo semithambo yegazi ejikeleze imilenze - i-PAD): Ukungabikho kwegazi elaneleyo, ingakumbi emilenzeni.
- Ukuthintela ukuqhekeka kwegazi emva kotyando: Ukuqhekeka kwegazi emva kotyando kunokukhokelela kwiimeko eziyingozi ezifana nestroke, ukuhlaselwa yintliziyo, kunye ne-pulmonary embolism. Zithintele.
- I-Thrombocythemia: Ukuveliswa kweeplatelets ngokugqithisileyo, okunceda ukujiya kwegazi.
Izifo zokudumba kolusu kunye namalungu
- I-Eczema (i-Atopic dermatitis): Ukudumba, ukurhawuzelelwa kolusu.
- I-Psoriasis: Imeko yokuvuvukala kwesikhumba ebangelwa yinkqubo yomzimba yokuzikhusela esebenza kakhulu.
- I-Psoriatic arthritis: Ukudumba kwamalungu okwenzeka kwi-psoriasis.
Izifo ezinxulumene nenkqubo yokuzala yamadoda
- I-Benign prostatic hyperplasia: Ukudumba kwe-prostate gland ngenxa yezizathu ezingezizo zomhlaza.
- Ukungasebenzi kakuhle kwe-Erectile: Ubunzima bokufumana i-erection.
Izifo zenkqubo yokuphefumla
- Isifo semiphunga esingapheliyo (i-COPD): Iqela lezifo ezibangela ubunzima bokuphefumla.
- I-apnea yeentsana ezisandul’ ukuzalwa: Ubunzima bokuphefumla obuvela kwiintsana ezisandul’ ukuzalwa ngaphambi kwexesha , ingakumbi ezo zizelwe ngaphambi kweeveki ezisi-7.
Zithini iingenelo zale yeza?
Kukho iingenelo ezininzi zokusebenzisa la mayeza.
- Iifom ezilula: Ezi ziza ngohlobo lweepilisi zomlomo, iikhrimu ezifakwa emzimbeni, kunye neenaliti ze-IV. Amanye amayeza kufuneka athathwe yonke imihla, ngelixa amanye anokuthatyathwa kuphela xa kufuneka.
- Unyango olujoliswe kulo:Njengoko besitshilo ngaphambili, ekubeni unyango lunokujoliswa kuhlobo oluthile lwe-enzyme ye-PDE kuphela, iziphumo ebezingalindelekanga zinokuncitshiswa kakhulu.
- Iingenelo ezininzi zeyeza elinye: Ngamanye amaxesha izifo ezimbini ezenzeka kunye zinokunyangwa ngeyeza elinye. Umzekelo, umntu one-prostate ekhulisiweyo kunye nokungasebenzi kakuhle kwe-erectile unokunikwa i-PDE-5 inhibitor tadalafil . Ngokufanayo, i-Apremilast isetyenziselwa ukunyanga i-psoriasis kunye ne-psoriatic arthritis.
Masiqaphele nemiphumo emibi kunye neengozi.
Njengayo nayiphi na imithi, ezi zinokubangela iziphumo ebezingalindelekanga. Ezi ziphumo bezingalindelekanga zixhomekeke kakhulu kuhlobo lwe-PDE inhibitor oyithathayo.
Kubaluleke kakhulu: Ukuba uthatha i-PDE-5 inhibitor (umz. iSildenafil, iTadalafil) kwaye uneentlungu esifubeni zingadlulanga iiyure ezingama-24, kwaye uthatha ithebhulethi ye -nitroglycerin engaphantsi kolwimi, yiya kwigumbi likaxakeka lesibhedlele (ETU) ngoko nangoko. Ukudibana kwala mayeza mabini kunokubangela uxinzelelo lwegazi oluphantsi ngendlela eyingozi.
Ngezantsi kukho ezinye zeziphumo ebezingalindelekanga ezinxulumene neendidi eziphambili zamayeza.
| Udidi lweziyobisi | Iziphumo ebezingalindelekanga ezincinci neziphakathi | Iziphumo ebezingalindelekanga ezibalulekileyo/eziyingozi |
|---|---|---|
| Izithinteli ze-PDE-3 (Kunikelwe entliziyweni) | Intloko ebuhlungu, ubuthathaka, ukudumba, isisu esibuhlungu (isicaphucaphu, ukuhlanza), urhudo. | Ukungalingani kwesantya sentliziyo (i-arrhythmia), iintlungu zesifuba, ukopha okungaqhelekanga, iiplatelets ezisezantsi zegazi. |
| Izithinteli ze-PDE-4 (Inikwa izifo zokuphefumla/zolusu) | Ukunciphisa umzimba, isicaphucaphu, urhudo, intloko ebuhlungu, ukungalali, ukudumba apho kusetyenziswe khona ikhrimu. | Ukwanda koxinzelelo, iingcinga zokuzibulala, iimpendulo zoxinzelelo (ukurhawuzelela okukhulu, ukudumba). |
| Izithinteli ze-PDE-5 (Kunikwe ngenxa yobuthathaka besondo) | Intloko ebuhlungu, ukurhawuzelela, isisu esibuhlungu, impumlo exineneyo, iintlungu zemisipha, isiyezi. | I-Priapism: Ukuqina okubuhlungu okuhlala iiyure ezingaphezu kwe-4 ngaphandle kokukhuthazwa ngokwesondo. Yiya kwi-ETU ngoko nangoko. Utshintsho ekuboneni, ukuncipha okanye ukulahlekelwa kukuva. |
| Izithinteli zePDE ezingakhethiyo (umz. iCaffeine, iTheophylline) | Ukungazoli, ukungalali, ukungcangcazela, isisu esibuhlungu, iintloko ezibuhlungu. | Ukubetha kwentliziyo ngokukhawuleza, ukubetha kwentliziyo okungahambelaniyo, ukuxhuzula. |
Kunini apho ungafanele ulisebenzise eli yeza?
Eli yeza linokuba yingozi kwabanye abantu. Ukuba unenye yezi meko zilandelayo, ngokuqinisekileyo kufuneka uthethe nogqirha wakho ngaphambi kokuba ulisebenzise eli yeza.
- Ngayo nayiphi na inhibitor ye-PDE: Ukuba ukhe waba ne-allergy enzima (hypersensitivity) kuyo nayiphi na iyeza okanye into ethile ngaphambili.
- I-Cilostazol (PDE-3): Ayikhuthazwa le nto ukuba uneengxaki zentliziyo.
- Izithinteli ze-PDE-5: Kufuneka uziphephe ukuzisebenzisa ezi zinto ukuba unesifo sentliziyo esibi, usandul’ ukuba nesifo sentliziyo okanye isifo sohlangothi, okanye une-angina engazinzile.
- Ukuba uthatha ii-nitrate , ukuthatha ii-PDE-5 inhibitors kunokubangela ukuba uxinzelelo lwakho lwegazi lwehle kakhulu.
- Ezinye izithinteli ze-PDE (umz. iCilostazol) azifanelekanga ukuba unesifo sokopha.
Sebenzisa ngexesha lokukhulelwa
Ukuba ukhulelwe okanye uceba ukukhulelwa, kunokuba bubulumko ukuphepha ukusebenzisa iintlobo ezithile ze-PDE inhibitors. Nxibelelana nogqirha wakho ngale nto.
Ufanele uye nini kugqirha ngoko nangoko?
Kungcono ukuxelela ugqirha wakho ukuba ufumana naziphi na iimpawu ezingaqhelekanga ngelixa usebenzisa eli yeza. Nangona kunjalo, ukuba kukho naziphi na kwezi zilandelayo, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngaphandle kokulibazisa.
- Iimpawu zokuhlaselwa yintliziyo:Izinto ezifana neentlungu zesifuba, ukuqina, ubunzima bokuphefumla, ukubila, isiyezi, isicaphucaphu.
- I-Priapism: Ukuqina okubuhlungu okuhlala ixesha elingaphezulu kweeyure ezi-4 ngaphandle kokukhuthazwa ngokwesondo. Le yimeko efuna unyango olukhawulezileyo.
- Ukulahlekelwa/ukuncipha kokubona okanye ukuva ngequbuliso: Ezi zinto kufuneka zinyangwe ngaphambi kokuba kwenzeke umonakalo ongunaphakade.
La mayeza abaluleke kakhulu, asindisa ubomi kwaye aphucula umgangatho wobomi. Kodwa kufuneka athathwe kuphela ngokwengcebiso kagqirha kwaye ngokwemilinganiselo emiselweyo.
Umyalezo Wokuya Ekhaya
- Ii-phosphodiesterase inhibitors ziluhlobo olunamandla lwamayeza anyanga iimeko ezahlukeneyo, kubandakanya isifo sentliziyo, ukungasebenzi kakuhle ngokwesondo, izifo zolusu, kunye nezifo zokuphefumla.
- Soloko usela la mayeza kuphela xa ucetyiswe ngugqirha . Kuphephe ukucela abahlobo okanye ukucela ikhemesti ukuba uwasebenzise wedwa.
- Yazisa ugqirha wakho malunga neminye imithi oyithathayo kunye nezinye izifo onazo.
- Ukuba ufumana iziphumo ebezingalindelekanga ezibi kakhulu ezifana neentlungu zesifuba, i-priapism ehlala iiyure ezingaphezu kwe-4, okanye ukubona ngequbuliso okanye ukulahleka kokuva, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngoko nangoko.
- Ungaze wabelane ngamayeza akho nomnye umntu. Iyeza elifanelekileyo kumntu omnye linokuba yingozi kakhulu komnye umntu.
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