Ukudakumba akulula njengoko kubonakala. Ukuphila nako kudla ngokuba ngumceli mngeni. Kuthatha abanye abantu ixesha ukufumana unyango olufanelekileyo kubo. Ngamanye amaxesha, iyeza elinye lisenokungabaniki ncedo lupheleleyo. Kukho isizathu soko. Masiqonde oku kwasekuqaleni.
Kutheni kukho ukudakumba? Inganceda njani iyeza elifana neRexulti?
Ngamafutshane, kwiMajor Depression Disorder (MDD), amanqanaba eekhemikhali ezithile engqondweni yethu ayancipha. Ezi sizibiza ngokuba zii-neurotransmitters. Usenokuba ukhe weva nge-serotonin kunye ne-dopamine . Ezi zezona zithunywa zekhemikhali ziphambili ezilawula izinto ezifana nendlela esicinga ngayo, esiceba ngayo, esiziva sonwabile ngayo, esinikela ngayo ingqalelo, kunye nendlela esilala ngayo. Ngoko ke xa ezi zinto zinciphile, iimpawu zokudakumba ziyavela.
Amayeza okudakumba adla ngokunikwa ukunceda ukubuyisela la manqanaba eekhemikhali. Kodwa ngamanye amaxesha, nangona la mayeza enokunciphisa iimpawu, anokushiya iimpawu ezinzima kakhulu ukuba zingasebenzi kubomi bemihla ngemihla. Abanye abantu basabela kancinci kunyango. Oku kubizwa ngokuba kukudandatheka okunganyangekiyo kunyango.
Kulapho oogqirha bongeza elinye iyeza kunyango olusetyenziswayo ngoku. Oku kubizwa ngokuba lunyango oluncedisayo . Oko kukuthi, iyeza elinikwa "ukunceda" unyango olusetyenziswa ngoku, "ukuphucula" ukusebenza kwalo.
I-Rexulti (i-brexpiprazole) yenye yemithi encedisayo. Ezi zikwiklasi yamayeza abizwa ngokuba zii-antipsychotics zesizukulwana sesibini. La mayeza amatsha aneziphumo ebezingalindelekanga ezimbalwa, njengokungcangcazela, ukuqina kwemisipha, kunye nokutyeba, kunamayeza amadala. I-Rexulti isebenza ngokulawula iikhemikhali zobuchopho ngendlela eyahlukileyo, inciphisa iimpawu ngelixa ikwanciphisa umngcipheko weziphumo ebezingalindelekanga.
Isebenza njani iRexulti emzimbeni?
I-Rexulti isebenza kakhulu ngokunyusa amanqanaba e-dopamine kunye ne-serotonin engqondweni. Ngokukodwa, eli yeza libopha kwii-receptors ezithile engqondweni kwaye linceda ukukhulula i-dopamine ebambekileyo. Ikwavuselela isenzo se-serotonin, enokunceda ukuphucula imeko yeemvakalelo kunye nokunciphisa iimpawu zokudakumba.
Ndingayisebenzisa njani le yeza?
I-Rexulti yipilisi oyithathayo kube kanye ngemini. Ingathathwa nokutya okanye ngaphandle kokutya. Idla ngokuqala ngedosi ephantsi kakhulu, malunga nesiqingatha se-milligram (0.5mg). Ugqirha wakho uya kunyusa idosi kancinci ngokusekwe kwindlela umzimba wakho osabela ngayo, amanye amayeza owasebenzisayo, kunye nendlela izintso okanye isibindi sakho esisebenza ngayo. Idosi ephezulu yokudakumba yi-3 milligrams (3mg) ngosuku.
Eyona nto ibalulekileyo kukulandela imiyalelo kagqirha wakho ngokuchanekileyo. Ukusela amayeza akho ngexesha elifanelekileyo yonke imihla yindlela ekuphela kwayo yokulinganisela ikhemistri yengqondo yakho, ukulawula iimpawu zakho, nokusebenza kakuhle.
Khumbula, eli yeza alikuphilisi ngoko nangoko. Kungathatha iiveki ezininzi ukuba uphawule utshintsho kwiimpawu zakho. Ke ngoko, ukusebenzisa eli yeza rhoqo yeyona nto ibalulekileyo ukuze uphumelele.
Zithini izifundo malunga nempumelelo yale chiza?
Kuye kwenziwa izifundo ezibini eziphambili ukuze kufunyaniswe ukuba iRexulti iyasebenza kwaye ikhuselekile kangakanani na kwingxaki yokudakumba. Kwezi zifundo, elinye iqela labantu lanikwa iRexulti kwaye elinye iqela lanikwa i-placebo. Oku kwenze abaphandi bakwazi ukulinganisa iziphumo zokwenyani zeyeza.
Ngokweziphumo zezi zifundo, emva kweeveki ezi-6, uninzi lwabantu abathathe iRexulti ukongeza kumayeza abo aqhelekileyo okudakumba babeneempawu zokudakumba eziphakathi ukuya kwezincinci.
Le theyibhile ingezantsi ibonisa nje iziphumo. Okukhona amanqaku esezantsi, kokukhona iimpawu zisiba mandundu.
| Iqela | Inqanaba lokudakumba ekuqaleni (amanqaku aphakathi) | Inqanaba lokudakumba emva kweeveki ezi-6 (amanqaku aphakathi) | Umahluko kumanqaku (uphuculo) |
|---|---|---|---|
| Isifundo 1: I-Placebo (ipilisi yobuxoki) | 27.3 | 22.1 | -5.2 |
| Isifundo 1: I-Rexulti 2 mg | 26.9 | 18.5 | -8.4 |
| Isifundo 2: I-Placebo (ipilisi yobuxoki) | 26.5 | 20.2 | -6.3 |
| Isifundo sesi-2: I-Rexulti 1 mg | 26.5 | 18.9 | -7.6 |
| Isifundo sesi-2: I-Rexulti 3 mg | 26.5 | 18.2 | -8.3 |
Njengoko unokubona kwezi zifundo, abo bathathe iRexulti babe notshintsho olukhulu kwiimpawu zabo. Ezi zifundo zikwaqinisekisile ukuba amandla abo okusebenza kubomi bemihla ngemihla, nosapho, kuluntu, nasemsebenzini/esikolweni, aphucukile.
Ndingazi njani ukuba iyeza liyasebenza?
Kwiiveki okanye iinyanga ezimbalwa, uza kuqala ukuqaphela ukuphucuka okukhulu kwiimpawu zakho. Usapho lwakho kunye nabahlobo bakho nabo baya kubona umahluko kuwe.
- Ukuphucula imo yengqondo
- Amandla okanye inkuthazo engakumbi
- Ubuthongo obungcono
- Ndinomdla kwimisebenzi obukade uyonwabela.
- Ukunciphisa ixhala okanye ixhala
- Ukwanda komnqweno wokutya
- Ukugxila okungcono
Olu tshintsho alwenzeki ngobusuku obunye. Lwenzeka kancinci kancinci. Ke ngoko, kubalulekile ukugcina umkhondo wotshintsho kwiimpawu zakho. Ixesha olidingayo ukuthatha unyango liyahluka kumntu nomntu. Abanye abantu bayalufuna ixesha elifutshane, ngelixa abanye belufuna ixesha elide.
Eyona nto ibalulekileyo kukuba ungayeki ukuthatha amayeza akho ngaphandle kokuthetha nogqirha wakho kuba ucinga ukuba iimpawu zakho ziya zisiba ngcono. Ukuba wenza njalo, iimpawu zakho zingaphinda zibe mandundu. Ukuba awuziva ungcono emva kweenyanga ezimbalwa, xelela ugqirha wakho ngaloo nto.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Iziphumo ebezingalindelekanga zeRexulti zixhaphakile kukwanda kobunzima, ukozela, isiyezi, iimpawu ezifana nomkhuhlane, kunye nokungakwazi ukuhlala phantsi. Ezi azenzeki kuwo wonke umntu, kodwa zihlala zincipha ngokuhamba kwexesha.
| Imiphumela | Oko unokukwenza |
|---|---|
| Ukwanda kobunzima, ukwanda kwe-cholesterol/iswekile | Ziqhelise indlela yokuphila enempilo. Zilolonge, yongeza imifuno, iziqhamo, kunye nenyama engenamafutha ekutyeni kwakho. Nciphisa ioyile, ityuwa, kunye neswekile. Ugqirha wakho uza kujonga rhoqo ubunzima bakho, uxinzelelo lwegazi, i-cholesterol, kunye namanqanaba eswekile. |
| Ukozela okanye isiyezi | Ukuba uziva ulele, thatha iyeza ngaphambi kokuba ulale ebusuku. Sukuma kancinci uhleli okanye ulele. Kuphephe ukuqhuba imoto ude wazi ukuba iyeza likuchaphazela njani. |
| Ukungazoli (Akathisia) | Oku kubhekisa kwimvakalelo yokungakwazi ukuhlala kwindawo enye nokuzulazula nje. Ukuzilolonga okulula njengokuhamba nokuzolula kunokunceda. Zolisa ingqondo yakho ngezinto ezifana nokuzilolonga ukuphefumla kunye nokucamngca. Nciphisa izinto ezifana nekofu, iti, kunye ne-cola, kuba zinokunyusa olu vakalelo. |
| Ukunganyamezelani nobushushu | Eli yeza linokunciphisa amandla omzimba okuzipholisa. Kuphephe ubushushu obugqithisileyo kunye nokuphelelwa ngamanzi emzimbeni. Nxiba impahla ekhaphukhaphu kwaye usele amanzi amaninzi. |
| Ukuphazamiseka kwesisu, ukuqhinwa, umlomo owomileyo | Sela iyeza kunye nokutya. Ukuba umlomo wakho uyoma, sela amanzi amancinci rhoqo, ufunxe ii-ice cubes, okanye uhlafune itshungama engenaswekile. Ukuba unesiphene sokuqunjelwa, sela amanzi amaninzi kwaye utye ukutya okunefayibha eninzi (ingqolowa, iimbotyi, iziqhamo). |
Ezi zezona zinto zixhaphakileyo ezinokwenzeka. Ukuba naziphi na kwezi ntlungu ziyaqhubeka okanye ziba mandundu, qiniseka ukuba uxelele ugqirha wakho.
Ngaba kukho iingxaki ngamanye amayeza? (Ukusebenzisana kwamayeza)
Ewe. Amanye amayeza anokunyusa okanye anciphise ukusebenza kweRexulti, okanye anyuse umngcipheko weziphumo ebezingalindelekanga, xa esetyenziswa neRexulti. Umzekelo, amanye amayeza okulwa nentsholongwane (umz., i-ketoconazole), amanye amayeza okulwa nentsholongwane (umz., i-clarithromycin), amanye amayeza okulwa noxinzelelo (umz., i-fluoxetine, i-paroxetine), kwanejusi yegrapefruit anokutshintsha iziphumo zeRexulti.
Kungoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho malunga nawo onke amayeza, iivithamini, kunye neemveliso zezityalo ozisebenzisayo, ukuze akwazi ukulungisa umthamo weRexulti ukuze ulungele wena.
Zeziphi iimvavanyo ekufuneka zenziwe ngexesha lonyango?
Ugqirha wakho uza kwenza uvavanyo oluthile ukuze ajonge impilo yakho ngaphambi kokuba uqale ukuthatha amayeza kwaye ngelixa uwasebenzisa.
- Ubunzima bakho, ubude, kunye nobubanzi besinqe sakho.
- Ubalo lwegazi olupheleleyo (CBC).
- Uvavanyo lwe-cholesterol yegazi kunye neswekile yokuzila ukutya (Uvavanyo lwe-lipids yokuzila ukutya kunye neswekile yegazi).
- Ifuthe legazi.
- Uvavanyo lwe-AIMS lokujonga iintshukumo ezingaqhelekanga (umz., iintshukumo zamalungu ezingafunekiyo).
Olu vavanyo lolona hlobo lokwazi ngqo ukuba iyeza liza kuyichaphazela njani umzimba wakho.
Umyalezo Wokuya Ekhaya
- I-Rexulti liyeza "elongezelelweyo" elinikwayo ukongeza kumayeza asele esetyenziswa ukudakumba, ukuphucula ukusebenza kwawo.
- Oku kusebenza ngokulinganisela iikhemikhali ezikwingqondo ezinxulumene nolonwabo kunye nochulumanco.
- Thatha amayeza rhoqo, ngokwemilinganiselo emiselweyo, njengoko ugqirha wakho ekuyalele.
- Nokuba iimpawu zakho ziyaphucuka, kuphephe ukuyeka amayeza ngaphandle kokubonisana nogqirha wakho.
- Qaphela iziphumo ebezingalindelekanga ezifana nokutyeba, ukozela, kunye nokungaphumli. Ukuba ziyakukhathaza, thetha nogqirha wakho.
- Kubalulekile ukwazisa ugqirha wakho ngazo zonke ezinye iindlela zonyango, iivithamini, kunye namayeza esintu owasebenzisayo.
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