Ukuqala unyango lomhlaza kuwe okanye kumntu omthandayo kunokuba lixesha elinzima nelididayo. Usenokuba nemibuzo malunga namayeza ugqirha wakho akunika wona, amagama awo, kunye nemiphumo emibi. Ngoko ke namhlanje siza kuthetha ngelinye lamayeza omhlaza akhethekileyo, iSelpercatinib . Usenokuba uyazi ngegama leRetevmo. Makhe sithethe ngeli yeza, into eliyenzayo, kunye nento ekufuneka uyiqaphele ngendlela elula neqondakala lula.
Kwenzeka ntoni ngokwenene ngale mithi?
Ngamafutshane, iSelpercatinib ayifani nechemotherapy yendabuko. Isebenza "njengonyango olujoliswe kuyo." Iiproteni ezithile emizimbeni yethu zithumela imiqondiso kwiiseli zomhlaza ukuze "zikhule ngakumbi, zisasazeke ngokukhawuleza." Cinga ngayo njengotshintsho olwenza iiseli zomhlaza zikhule. Into eyenziwa yiSelpercatinib kukuvala iproteni ethumela imiqondiso engalunganga . Kufana nokucima olo tshintsho. Emva koko ukukhula nokusasazeka kweeseli zomhlaza emzimbeni wonke kulawulwa.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba uqale olu nyango, ugqirha wakho kufuneka abe nomfanekiso opheleleyo wempilo yakho. Qiniseka ukuba ubaxelela ngayo nayiphi na kwezi meko zilandelayo, ingakumbi ukuba unayo:
| Ngaba unale meko? | Kutheni isaziso sibalulekile? |
|---|---|
| Iingxaki zokopha | Eli yeza linokunyusa umngcipheko wokopha. |
| Ukuba usandula ukwenziwa okanye ucwangciselwe utyando kwixesha elizayo | Iyeza linokulibazisa ukuphola kwenxeba. |
| Igazi elonyukayo | Eli yeza linokunyusa uxinzelelo lwegazi ngakumbi. |
| Ukubetha kwentliziyo okungaqhelekanga | Utshintsho kwisantya sentliziyo lunokwenzeka. |
| Izifo zesibindi okanye zemiphunga | Umsebenzi wezi zitho unokuchaphazeleka. |
| Ukunganyamezelani kwamanye amayeza, ukutya, okanye idayi | Kubalulekile ukwazi ukuba une-allergy na kwiyeza okanye nakweyiphi na izithako zalo. |
| Ukukhulelwa okanye ukuzama ukukhulelwa | Eli yeza linokubangela ingozi enkulu kumntwana ongekazalwa. |
| Ukuncancisa | Eli yeza linokudluliselwa kumntwana ngobisi lwebele. |
Ndingayisebenzisa njani le yeza?
Le yikhaphu oyisela ngomlomo. Kubaluleke kakhulu ukuyithatha ngexesha elifanayo yonke imihla , kanye njengoko ugqirha wakho ekuyalele.
- Ginya ikhaphu yonke ngamanzi . Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna ikhaphu.
- Ungayithatha le nto nokuba utya okanye ungakhange uyitye. Nangona kunjalo, ukuba uziva isisu sibuhlungu kancinci, kungcono ukuyithatha xa usitya.
- Qhubeka nonyango de ugqirha wakho akuxelele ukuba uyeke.
- Kubaluleke kakhulu: Musa ukusela ijusi yegrapefruit ngokupheleleyo ngelixa usebenzisa eli yeza.
Kuthekani ukuba ndiphoswa lidosi leyeza?
Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba sele kudlule iiyure ezili-18 emva kwedosi yakho elandelayo (oko kuthetha ukuba kusele iiyure ezingaphantsi kwezi-6 ngaphambi kwedosi yakho elandelayo), yeka idosi ongayithathanga uze uthathe idosi yakho elandelayo ngexesha eliqhelekileyo. Ungaze uthathe iidosi ezimbini ngaxeshanye ukuze ubuyisele idosi ongayithathanga.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe amayeza amaninzi kunokuba ucinga, ungoyiki. Yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) elikufutshane nawe ngoko nangoko. Okanye, fowunela iZiko loLwazi lweeTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso.
Ezinye izinto ezinokusebenzisana nale mithi
Amanye amayeza anokusebenzisana neSelpercatinib, nto leyo etshintsha ukusebenza kwayo okanye enyusa iziphumo ebezingalindelekanga.
Isilumkiso: Ukuba usela naliphi na kula mayeza alandelayo, musa ukusebenzisa iSelpercatinib. Thetha nogqirha wakho ngale nto.
* I-Cisapride
* I-Dronedarone
* I-Ketoconazole
* I-Levoketoconazole
* I-Pimozide
* I-Thioridazine
Ukongeza, amanye amayeza, iimveliso zezityalo, kunye nokutya kunokuchaphazela eli yeza. Ngoko ke, kubalulekile ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka iivithamini, amayeza ezityalo, kunye nezongezo).
- Amanye amayeza oxinzelelo lwegazi oluphezulu (i-diltiazem okanye i-verapamil)
- Amanye amayeza e-antiviral e-HIV okanye i-Hepatitis
- Amayeza osulelo lwefungus (itraconazole, posaconazole)
- Ijusi yegrapefruit
- Amanye amayeza atshintsha izinga lentliziyo
- I-Repaglinide yesifo seswekile
- I-Rifampin yesifo sephepha
- Iimveliso zezityalo ezifana neSt. John's Wort
- Amayeza anciphisa i-asidi yesisu (afana ne-cimetidine, i-famotidine, i-ranitidine, i-lansoprazole, i-omeprazole)
Izinto ekufuneka uzilumkele ngakumbi xa usebenzisa amayeza
- Ukuziva ungaphilanga: Kuqhelekile ukuziva ungaphilanga okanye ungaphilanga ngelixa usebenzisa eli yeza. Oku kungenxa yokuba eli yeza lichaphazela zombini iiseli zomhlaza kunye neeseli eziphilileyo ukuya kwinqanaba elithile. Nangona kunjalo, musa ukuyeka unyango de ugqirha wakho akuxelele ukuba wenze njalo. Xelela ugqirha wakho ngazo naziphi na iziphumo ebezingalindelekanga ozifumanayo.
- Utyando: Ukuba uza kwenziwa utyando (nokuba yinto encinci njengokukhutshwa kwezinyo), xelela ugqirha wakho. Eli yeza linokulibazisa ukuphola kwenxeba. Ke ngoko, kuya kufuneka uyeke ukuthatha iyeza ubuncinane kwiintsuku ezisi-7 ngaphambi kotyando kwaye uqale kwakhona kwiiveki ezi-2 emva kotyando, xa inxeba selipholile ngokupheleleyo.
- Ukukhulelwa nokuncancisa: Kwabasetyhini: Kuphephe ukukhulelwa ngelixa usebenzisa eli yeza kwaye iveki enye emva kokuyeka ukusebenzisa eli yeza. Yingakho kubalulekile ukusebenzisa uhlobo oluthembekileyo lokulawula ukukhulelwa. Kufuneka wenze uvavanyo lokukhulelwa ngaphambi kokuba uqale eli yeza ukuqinisekisa ukuba awukhulelwanga. Kwakhona, kuphephe ukuncancisa ngeli xesha kwaye iveki enye emva kokuyeka ukusebenzisa eli yeza. Kwabesilisa: Sebenzisa ikhondom rhoqo ukuba ulala nomfazi onokukhulelwa ngelixa usebenzisa eli yeza kwaye iveki enye emva kokuyeka ukusebenzisa eli yeza. Ukuba iqabane lakho liyakhulelwa, kunokuba yingozi kumntwana osesibelekweni.
- Ukuzala: Eli yeza lisenokuchaphazela amandla akho okufumana abantwana. Thetha nogqirha wakho ukuba uneengxaki malunga noku.
- Ifuthe legazi:Soloko ujonga uxinzelelo lwegazi lwakho njengoko ugqirha wakho ekuxelela. Yazi ukuba kufuneka lube yintoni kwaye kufuneka ubize ugqirha wakho nini.
Zeziphi iziphumo ebezingalindelekanga endinokuzifumana?
Njengalo naliphi na iyeza, iSelpercatinib inokubangela iziphumo ebezingalindelekanga. Ezinye zinzima, ngelixa ezinye zixhaphakile.
| Imiphumela | Inkcazo |
|---|---|
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Ukopha okungaqhelekanga | Indle emnyama okanye enegazi, ukuhlanza igazi elifana nekofu egayiweyo, umchamo omdaka/obomvu, amabala abomvu/amfusa eluswini. |
| Ubunzima bokuphefumla | Ukukhohlela okomileyo, ubunzima bokuphefumla. |
| Utshintsho kwisantya sentliziyo | Ukubetha kwentliziyo, isiyezi, iintlungu zesifuba. |
| Ukulimala kwesibindi | Intlungu kwicala eliphezulu lasekunene lesisu, ukuphelelwa ngumdla wokutya, ukutyheli kolusu okanye amehlo, indle enombala okhanyayo, umchamo otyheli/omdaka omnyama. |
| I-Hypothyroidism | Ukudinwa okungaqhelekanga, ukungakwazi ukunyamezela ingqele, ukuqhina, ukulahleka kweenwele, ulusu olomileyo, ukutyeba. |
| Isifo seTumor Lysis (TLS) | Ukugabha, urhudo, ukuncipha komchamo, ukuxhuzula kwemisipha, iintlungu zamalungu, ukudideka. |
| Xelela ugqirha wakho ukuba iyaqhubeka okanye iyakukhathaza. | |
| Ukuqhinwa, urhudo, umlomo owomileyo, isicaphucaphu, ukurhawuzelela kolusu, ukudumba kwamaqatha, iinyawo nezandla. | |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana into engaqhelekanga, thetha nogqirha wakho ngayo.
Umyalezo Wokuya Ekhaya
- I-Selpercatinib liyeza elijolise kwaye lingasebenzi iproteni ethile ebandakanyeka ekukhuleni kweeseli zomhlaza.
- Sela amayeza ngexesha elifanayo yonke imihla njengoko ugqirha wakho ekuyalele. Ungaze uwasebenzise nejusi yegrapefruit.
- Xelela ugqirha wakho ngazo zonke ezinye iziyobisi (kuquka iivithamini kunye neemveliso zezityalo) ozisebenzisayo.
- Eli yeza alifanelekanga ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa. Kubalulekile ukuba abafazi namadoda basebenzise ucwangciso lokuzala olufanelekileyo ngexesha lonyango nakwiveki enye emva koko.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinje ngobunzima bokuphefumla, ukopha kakhulu, okanye iimpawu ezibi kakhulu ze-allergy, funa ingcebiso kagqirha ngoko nangoko.
- Musa ukoyika ukuthetha nogqirha wakho ngayo nayiphi na imibuzo okanye iinkxalabo onokuba nazo. Khumbula ukuba awuwedwa.
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