Masifunde ngeepilisi zeSirolimus. Ngaba nawe unikwe eli yeza?

Ngaba ugqirha ukunike ipilisi ebizwa ngokuba yi-'Sirolimus' okanye umntu omaziyo? Ukuba kunjalo, kubaluleke kakhulu ukwazi ukuba le yeza lithini kanye kanye. Ngenxa yokuba eli liyeza alifani neyeza lomkhuhlane okanye umkhuhlane, liyeza elifuna ukusetyenziswa ngononophelo olukhethekileyo, kwaye linemiphumo emibi kunye neengozi. Ngoko masithethe ngale nto ngokweenkcukacha ezithe vetshe, akunjalo?

Lithini eli yeza libizwa ngokuba yi-`Sirolimus`?

Ngamafutshane, iSirolimus liyeza elinciphisa ukusebenza kwenkqubo yomzimba wakho yokuzikhusela. Khawuthelekelele, xa umntu efumana utyando olutsha lwezitho ezifana nezintso okanye isibindi, inkqubo yomzimba yokuzikhusela izama ukulilahla eli lungu litsha. Libona ngathi lutshaba lufikile. Kulapho ke amayeza afana neSirolimus aluncedo khona. Oko kukuthi, isetyenziswa kakhulu ukuthintela umzimba ukuba ungalimkeli ilungu elitsha elisandula ukufakelwa.

Ikwasetyenziselwa ukunyanga isifo semiphunga esingaqhelekanga esibizwa ngokuba yi-lymphangioleiomyomatosis (LAM). Ifumaneka kakhulu phantsi kwegama lebrendi iRapamune. Nangona kunjalo, ngamanye amaxesha ugqirha wakho unokukunika eli yeza ngezinye izizathu. Ngoko ke ukuba unemibuzo, kungcono ukubuza ugqirha wakho okanye ikhemisti.

Yintoni omele uyixelele iqela lakho lezonyango ngaphambi kokuba usebenzise eli yeza?

Eli linqaku elibaluleke kakhulu. Ngaphambi kokuba uqale ukusebenzisa iSirolimus, kufuneka uxelele ugqirha wakho ngemeko yakho yempilo ngokupheleleyo. Oku kungenxa yokuba ezinye iimeko zisenokungahambelani neli yeza, okanye unokufuna ukulinika ingqalelo ekhethekileyo.

Ukuba unazo ezi zinto, ngokuqinisekileyo yitsho:

• Ukuba unesifo seswekile (iDiabetes Mellitus) .
• Ukuba unembali yesifo sentliziyo okanye ukungasebenzi kakuhle kwentliziyo .
• Ukuba unezinga eliphezulu le-cholesterol okanye i-triglycerides egazini lakho.
• Ukuba okwangoku unentsholongwane (efana nomkhuhlane, umkhuhlane, okanye usulelo lomchamo).
• Ukuba unesifo sesibindi .
• Ukuba ukhe waba ne -allergy ngaphambili okanye impendulo engaqhelekanga kwi-sirolimus, faka amanye amayeza, ukutya, iidayi, okanye izithinteli.
• Ukuba ukhulelwe okanye uzama ukukhulelwa .
• Ukuba ungumama oncancisayo .

Kuphela ngokuthetha ezi zinto ngokukhululekileyo apho ugqirha anokukwazi ukukunyanga ngeyona ndlela ifanelekileyo.

Ulisebenzisa njani kanye kanye eli yeza?

Kubaluleke kakhulu ukulandela imiyalelo echanekileyo yokusebenzisa eli yeza.

• Le pilisi kufuneka ithathwe neglasi yamanzi.
• Musa ukuphula, ukutyumza, okanye ukuhlafuna ipilisi. Yiginye yonke.
• Sebenzisa amayeza kanye njengoko kuyalelwe kwileyibhile kagqirha.
• Ukuba usela eli yeza kunye nokutya, lisele kunye nokutya yonke imihla. Oko kukuthi, musa ukutshintsha phakathi kokulisela ngaphambi kokutya ngosuku olunye nasemva kokutya ngosuku olulandelayo. Lisele ngendlela efanayo.
• Ungaze uthathe eli yeza kunye nejusi yegrapefruit. Ijusi yegrapefruit ingayichaphazela indlela eli yeza elisebenza ngayo.
• Ukuba usebenzisa neli yeza elithi `cyclosporine`, kufuneka ulisebenzise eli yeza elithi `Sirolimus` ubuncinci kwiiyure ezi-4 emva kokuba usebenzise `cyclosporine`.
• Zama ukusela amayeza akho ngexesha elifanayo yonke imihla, ngexesha elifanayo yonke imihla . Kulapho ke uya kuzuza khona kakhulu amayeza.
• Musa ukuthatha amayeza angaphezu kwalawo ugqirha akuxelele wona, okanye uyeke ukuwathatha ngaphambi kwexesha. Musa ukuyeka ukuwathatha ngaphandle kwengcebiso kagqirha.

Ukuba unika abantwana eli yeza:

Eli yeza linokunikwa abantwana abaneminyaka eli-13 ubudala kwezinye iimeko ezikhethiweyo. Nangona kunjalo, kufuneka kulandelwe amanyathelo akhethekileyo okuzikhusela. Ke ngoko, ukuba unika umntwana wakho eli yeza, thetha ngalo ngononophelo nogqirha wezingane uze ufumane ingcebiso.

Xa ufumana eli yeza kwikhemesti, uza kufumana i -'MedGuide' (iSikhokelo seMithi) . Uza kuyifumana kunye nomyalelo ngamnye kwaye ngalo lonke ixesha ufumana uhlaziyo. Soloko ufunda imiyalelo ngononophelo. Iqulethe ulwazi oluninzi olubalulekileyo.

Umthamo ogqithisileyo:

Ukuba ucinga ukuba usele eli yeza kakhulu, fowunela iziko lolawulo lwetyhefu okanye igumbi likaxakeka esibhedlele ngoko nangoko .

Kubalulekile: Eli yeza lelakho kuphela. Ungaze wabelane nabanye ngamayeza akho, nokuba baneempawu ezifanayo nezakho.

Wenza ntoni ukuba uphoswe yintlanganiso yamayeza?

Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba sele kusondele ixesha lomthamo wakho olandelayo, yeka umthamo ophoswe yidosi uze uthathe umthamo wakho olandelayo njengoko bekucwangcisiwe. Ungaze uthathe iidosi ezimbini ngaxeshanye. Kwakhona, ukuba uphoswe yidosi okanye uhlanza emva kokusela amayeza, fowunela ugqirha wakho okanye ingcali yezempilo ukuze akunike iingcebiso.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

Oku kukwayinto ekufuneka uyilumkele kakhulu. I-Sirolimus liyeza elinokusebenzisana namanye amayeza, ukutya, kunye nezongezo. Olu nxibelelwano lunokutshintsha indlela esebenza ngayo i-Sirolimus, lonyuse iziphumo ebezingalindelekanga, okanye lutshintshe indlela esebenza ngayo amanye amayeza owasebenzisayo.

Ungaze uthathe iSirolimus namayeza alandelayo:

• Ezinye iintlobo zee-antibiotics: ezifana ne-clarithromycin, i-erythromycin, kunye ne-telithromycin.
• Ijusi yegrapefruit (nditshilo ngaphambili, ibaluleke kakhulu!)
• Amayeza osulelo lwefungus: anje nge-`itraconazole`, `ketoconazole`, `posaconazole`, `voriconazole`.
• `I-Mifepristone (i-mifepristone), RU-486`
• `rifabutin`, `rifampin`

Eli yeza linokunxibelelana namayeza alandelayo:

• `I-Boceprevir`
• `Bromocriptine`
• `ICarbamazepine`
• I- Cimetidine
• `I-Cisapride`
• `I-Clotrimazole`
• `I-Cyclosporine` (ukongeza kwixesha elikhankanyiweyo, kunokubakho ezinye iindlela zokunxibelelana)
• `UDanazol`
• `IDiltiazem`
• `I-Fluconazole`
• `Indinavir`
• 'I-Metoclopramide'
• `I-Nicardipine`
• `I-Phenobarbital`
• `Phenytoin`
• `I-Rifapentine`
• `I-Ritonavir (i-ritonavir)`
• `I-St. John's wort` (le yimifuno)
• `Telaprevir`
• `I-Troleandomycin`
• Isitofu
• `I-Verapamil`

Olu luhlu alubandakanyi zonke iindlela onokuthi usebenzise ngayo amayeza. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owathathayo (abhalwe ngugqirha, athengiswa ngaphandle kwemvume kagqirha, amayeza esintu, iivithamini, izongezo zokutya), ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi. Ezinye izinto zinokuchaphazela amayeza akho.

Yintoni endifanele ndiyilumkele xa ndisebenzisa eli yeza?

Ugqirha wakho uza kujonga impilo yakho rhoqo ngelixa usela iSirolimus.

• Kubalulekile ukubona ugqirha wakho rhoqo kwaye wenze uvavanyo lwegazi . Oku kuya kunceda ugqirha wakho aqonde indlela amayeza akuchaphazela ngayo kwaye nokuba idosi ikulungele na.
• Eli yeza lisenokunyusa amanqanaba akho e-cholesterol okanye amafutha emzimbeni. Ukuba oku kuyenzeka, kunokufuneka uthathe unyango olwahlukileyo ngenxa yoko.
• Ukuba ufumana umkhuhlane okanye olunye usulelo ngelixa usebenzisa eli yeza, xelela ugqirha wakho ngoko nangoko. Musa ukuzinyanga. Eli yeza linokunciphisa amandla omzimba wakho okulwa nosulelo.
• Eli yeza lisenokunyusa amanqanaba eswekile egazini lakho. Ukuba unesifo seswekile, buza ugqirha wakho ukuba ufuna ukwenza naluphi na utshintsho kwindlela otya ngayo okanye amayeza akho.
• Eli yeza linokunyusa kancinci umngcipheko wakho wokuba neentlobo ezithile zomhlaza. Thetha nogqirha wakho ngale nto. Musa ukoyika, kodwa kubalulekile ukuba uqaphele.
• Ngenxa yale mithiUlusu lwakho lusenokuba buthathaka ngakumbi elangeni. Ngoko ke, kuphephe ukuchatshazelwa lilanga kangangoko unako. Ukuba uphuma phandle, nxiba impahla egquma ulusu lwakho, sebenzisa i-sunscreen, kwaye uphephe izibane zelanga okanye ii-dawn booths.
• Abafazi abakwiminyaka yokuzala kufuneka basebenzise uhlobo olusebenzayo kakhulu lokulawula ukuzala ngaphambi kokuba baqale eli yeza, ngelixa belisebenzisa, kwaye kangangeeveki ezili-12 emva kokuyeka ukusebenzisa eli yeza.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengayo nayiphi na iyeza, iSirolimus inokubangela ezinye iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo, kodwa kulungile ukuzazi.

Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha okanye kwingcali yezempilo ngoko nangoko:

• Iimpendulo ze-allergy: ukurhawuzelela kwesikhumba, ukurhawuzelela okanye ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi.
• Ubunzima bokuphefumla.
• Ukugodola, umkhuhlane, umphimbo obuhlungu. (Ezi zisenokuba ziimpawu zosulelo)
• Umchamo onombala omnyama.
• Ukubetha kwentliziyo okukhawulezayo nokungaqhelekanga.
• Ukuziva unesizungu okanye unesizungu.
• Igazi elonyukayo.
• Ukubonakala kwamabala abomvu amancinci eluswini.
• Iimpawu zeswekile ephezulu egazini: Ukuziva unxaniwe okanye ulambile ngaphezu kwesiqhelo, kufuneka uchame rhoqo. Usenokudinwa kakhulu okanye ubone izinto ezingaqondakaliyo.
• Ukudumba, ukugcinwa kwamanzi emzimbeni.
• Ubunzima bokuchama.
• Ukopha okanye ukukrweleka okungaqhelekanga.
• Ukuziva ubuthathaka obungaqhelekanga.

Iziphumo ebezingalindelekanga ezihlala zingadingi nyango, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza:

• Intlungu yomzimba, iintlungu.
• I-acne.
• Urhudo (intlungu yesisu).
• Isicaphucaphu, ukuhlanza.
• Ukungakhululeki esiswini.
• Ungcangcazelo.
• Ukungalali.

Olu luhlu lusenokungabandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, funa ingcebiso kagqirha. Ungaxela iziphumo ebezingalindelekanga kwi-FDA ku-1-800-FDA-1088.

Ndingawagcina phi amayeza am?

• Yigcine kude nabantwana. Oku kubaluleke kakhulu.
• Gcina kubushushu begumbi (20 ukuya kuma-25 degrees Celsius / 68 ukuya kuma-77 degrees Fahrenheit). Khusela kubushushu obugqithisileyo okanye kubanda.
• Lahla amayeza aphelelwe lixesha. Musa ukugcina amayeza angasetyenziswanga emva kokuba ephelelwe lixesha.

Umyalezo Wokugqibela Wokuya Ekhaya

Kulungile, ngoko ke sithethe kakhulu ngeSirolimus, akunjalo? Khumbula, eyona nto ibalulekileyo kukusebenzisa eli yeza kanye njengoko ugqirha wakho ekuyalele.

Kufuphi:

* Sela amayeza kanye njengoko ugqirha wakho ekuxelela, ngexesha elifanelekileyo, ngomlinganiselo ofanelekileyo.

* Nika ugqirha wakho inkcazo epheleleyo ngemeko yakho yempilo kunye nawo onke amanye amayeza kunye nezongezo ozithathayo.

* Musa ukulisebenzisa eli yeza kunye nejusi yeediliya.

* Qaphela iziphumo ebezingalindelekanga, kwaye ukuba ubona nantoni na engaqhelekanga, xelela ugqirha wakho ngoko nangoko.

* Funda i-'MedGuide' oyinikiweyo ngononophelo.

* Musa ukunika abanye amayeza akho.

Ukusebenzisa eli yeza kunokubonakala kunzima kancinci. Kodwa ungakhathazeki. Ukuba unemibuzo okanye iinkxalabo, buza ugqirha wakho okanye ikhemisti. Bakulungele ukukunceda. Impilo-ntle yakho yeyona nto ibalulekileyo kubo!

I - Sirolimus, i-Sirolimus, inkqubo yomzimba yokuzikhusela, ukufakelwa amalungu omzimba, i-LAM, i-Rapamune, iziphumo ebezingalindelekanga zamayeza, ukusebenzisana kwamayeza