Xa ugqirha wakho ekuxelela ukuba unomhlaza webele, ngaba ulibonile igama elithi 'Taxane' likhankanywa kwisicwangciso sakho sonyango? Usenokuba woyika kancinci xa usiva eli gama. Kuqhelekile ukuba izinto zifike engqondweni xa usiva igama elithi 'chemotherapy' kunye neli gama. Kodwa ungakhathazeki. I-Taxane lunyango olusebenzayo kakhulu oluye lwasetyenziswa kunyango lomhlaza webele kangangeminyaka engaphezu kwama-40. Makhe sithethe ngayo ngendlela elula onokuyiqonda.
Zithini ezi rhafu? Zisebenza njani?
Ngamafutshane, i-taxanes luhlobo lwe-chemotherapy oluthintela iiseli zomhlaza ukuba zingahlukani, ziphindaphindeke, kwaye zisasazeke emzimbeni wonke.
Khawucinge nje, njengeeseli eziphilileyo emzimbeni wethu, iiseli zomhlaza ziyanda ngokwahlukana. Le nkqubo yokwahlukana kweeseli incediswa yinkqubo yeetyhubhu ezincinci (ii-microtubules) ngaphakathi kweeseli zazo. Udidi lweziyobisi lwe-taxane, okanye ngokuchanekileyo "ii-antimicrotubule agents", ziya ngqo kuloo nkqubo yeetyhubhu kwaye zijolise kuyo. La mayeza aphazamisa ukusebenza kwaloo nkqubo yeetyhubhu kwaye ayikhubaze. Emva koko iiseli zomhlaza azikwazi ukwahlukana, kwaye ekugqibeleni ezo seli ziyafa. Lo ngumgaqo osisiseko wolu nyango.
Olu nyango lusenokuba lolona lubalulekileyo kwisicwangciso sakho sonyango, ingakumbi ukuba unohlobo lomhlaza webele oluthi "(HER2-positive)".
Amayeza eTaxane (umzekelo, `(Docetaxel)` kunye `(Paclitaxel)`) asetyenziswa kuzo zombini ezi ntlobo:
1. Umhlaza webele okwinqanaba lokuqala: Eli yeza linikwa ngaphambi kotyando ukuze linciphe kwaye lenze ithumba libe lincinci. Linikwa nasemva kotyando ukuze kuthintelwe ukuba umhlaza ungabuyi.
2. Umhlaza webele osasazekayo: Olu nyango lukwasetyenziselwa ukulawula umhlaza osasazeke kwamanye amalungu omzimba.
Amayeza eTaxane anikwa njani?
Amayeza e-Taxane okwangoku anikwa ngemithambo yegazi (IV) , oko kuthetha ukuba anikwa njengesicombululo se-saline emthanjeni. Oku kwenziwa esibhedlele okanye kwikliniki yomhlaza.
Ngamanye amaxesha i-taxanes inikwa yodwa (i-monotherapy). Ngamanye amaxesha, inikwa kunye nezinye iziyobisi ze-chemotherapy ukuze unyango lusebenze ngakumbi. Umzekelo, inikwa kunye namayeza afana ne-Capecitabine, i-Carboplatin, kunye ne-Cyclophosphamide.
Iindaba ezimnandi zezokuba izazinzulu okwangoku zenza uphando ngendlela yokusebenzisa eli yeza njengepilisi, nto leyo enokunciphisa ukutyelela esibhedlele kwixesha elizayo.
Yintoni omele uyilindele xa ufumana unyango?
Xa ugqirha wakho egqibe ekubeni aqalise unyango lwe-taxane, uza kukwenzela inkqubo ethile yonyango. Oku kuquka ukuba kufuneka uye esibhedlele kangaphi kwaye kuza kuthatha ixesha elingakanani ukufumana amayeza.
- Inani lonyango: Oku kuyahluka kumntu nomntu. Kuxhomekeke kuhlobo lonyango olunikwayo (`(Docetaxel)` okanye `(Paclitaxel)`), idosi yonyango, kunye nendlela umzimba wakho osabela ngayo kulo.
- Umzekelo, `(Docetaxel)` idla ngokunikwa kanye kwiiveki ezi-3 . Idosi nganye ithatha malunga neyure.
- I-Paclitaxel inikwa rhoqo. Mhlawumbi kanye kwiiveki ezimbini . Ingathatha malunga neeyure ezimbini. Kukwakho neemeko apho idosi ephantsi inikwa kanye ngeveki kwabanye abantu.
- Idosi: Ubungakanani bamayeza owanikwayo buxhomekeke kwizinto ezahlukeneyo, kuquka uhlobo kunye nenqanaba lomhlaza wakho, ubunzima bakho kunye nobude bakho, kunye nezinye iziyobisi ozinikwayo.
- Ubude bonyango: Oku kuxhomekeke ekubeni unyango luphumelele kangakanani na kwaye nokuba uneziphumo ebezingalindelekanga ezibi na. Ngokwesiqhelo, kunikwa imijikelo emithathu ukuya kwemithandathu yonyango lomhlaza ongasasazekanga. Umhlaza osasazekileyo unokufuna unyango olude.
Kodwa khumbula, ukuba ufumana iziphumo ebezingalindelekanga ezibi kakhulu okanye awukwazi ukunyamezela amayeza, ugqirha wakho unokukutshintshela kolunye unyango.
Ngaba iTaxanes ibangela iziphumo ebezingalindelekanga?
Ewe. Ngelishwa, njengazo zonke iziyobisi ze-chemotherapy, i-taxanes inokubangela iziphumo ebezingalindelekanga. Oku kungenxa yokuba la mayeza awachaphazeli kuphela iiseli zomhlaza, kodwa neeseli eziphilileyo ezahlukana ngokukhawuleza. Nangona kunjalo, kwiimeko ezininzi, iziphumo ebezingalindelekanga ze-taxanes zincinci kwaye ziyanyamezeleka xa kuthelekiswa nezinye iziyobisi ze-chemotherapy.
Ezi ziphumo bezingalindelekanga zingahluka ukusuka kwezincinci ukuya kwezinzima ngokwaneleyo ukuba zifune ukulaliswa esibhedlele. Makhe sijonge ukuba zeziphi ezi ziphumo bezingalindelekanga.
| Iziphumo ebezingalindelekanga zonyango lwe-taxane | |
|---|---|
| Iziphumo ebezingalindelekanga eziqhelekileyo | |
| Ukudinwa | Usenokuziva udiniwe kakhulu amaxesha amaninzi. |
| Ukulahleka kweenwele | Iinwele ezisentloko, kunye nezinye iinwele zomzimba, zinokuwa. |
| Intlungu yemisipha kunye namalungu | Umzimba wakho usenokuziva ubuhlungu. Oogqirha bakubiza oku ngokuthi "i-myalgia". |
| Isicaphucaphu nokuhlanza | Ugqirha uza kukunika amayeza okulawula oku. |
| Intlungu kunye nokungakhululeki kwamalungu | Usenokuba nokurhawuzelelwa, ukutsha, okanye iintlungu ezintendeni zakho, ezinyaweni, nakwiiminwe. Oku kubizwa ngokuba yi-peripheral neuropathy. |
| Izilonda zomlomo | Amanxeba amancinci angenzeka ngaphakathi emlonyeni. |
| Umngcipheko okhulayo wosulelo | Ukuncipha kweeseli ezimhlophe zegazi (i-neutropenia) kunokukwenza ube sesichengeni sokufumana izifo. |
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko | |
| Urhudo oluqatha | Imeko yorhudo olungapheliyo. |
| Ubuthathaka obukhulu kwimilenze | Izandla ezibuthathaka kakhulu ukubamba into ethile okanye imilenze ebuthathaka kakhulu ukuba ingahamba. |
| Ifiva | Kungaba luphawu losulelo emzimbeni. |
| Utshintsho lombono | Umbono ofipheleyo okanye ukulahleka kombono. |
| Ukopha okungaqhelekanga | Ukopha okanye ukukrweleka emzimbeni wonke. |
Uninzi lwexesha, ezi ziphumo bezingalindelekanga ziyaphela emva kweeveki okanye iinyanga ezimbalwa emva kokuba unyango luyekisiwe. Nangona kunjalo, kukho iimeko apho i-neuropathy inzima kwaye ayipheli ngokupheleleyo kwabanye abantu.
Eyona nto ibalulekileyo kukuba ukuba ufumana naziphi na iimpawu ezingaqhelekanga, ungazityesheli kwaye wazise ugqirha wakho okanye umongikazi okunyangayo ngoko nangoko.
Lusebenza kangakanani olu nyango?
I-Taxane lunyango olusebenzayo kakhulu, yiyo loo nto isetyenzisiwe ixesha elide.
Kwisigaba sokuqala somhlaza:
Uphando lufumanise ukuba ukunika i-taxanes kubafazi abanomhlaza webele okwinqanaba lokuqala abenza utyando kwandisa amazinga abo okusinda kwaye kunciphisa umngcipheko wokuba umhlaza uphinde ubuye.
Ngomhlaza webele osasazekayo:
Kwimeko apho umhlaza usasazeke khona, unyango lwe-taxane alunakunyanga umhlaza, kodwa lunokunceda kakhulu ekulawuleni ukuqhubela phambili kwesi sifo kunye nokwandisa ixesha lokuphila.
Nangona olu nyango lusetyenziswa kakhulu kumhlaza we-`(HER2-positive)`, lungasetyenziselwa nomhlaza webele we-`(Triple-Negative Breast Cancer - TNBC)`, uhlobo lomhlaza olunzima kakhulu ukunyanga.
Ngaba kukho amaxesha apho unyango lweTaxane lungasebenzi?
Ewe, ngamanye amaxesha iyakwazi. Ayizizo zonke iintlobo zomhlaza ezisabela kwi-taxanes ngendlela efanayo. Ezinye iintlobo zomhlaza zisenokungaphenduli kweli yeza kwasekuqaleni. Ngamanye amaxesha, emva kokuba unyango lusebenze okwethutyana, umhlaza uyaqhela iyeza kwaye ube nokumelana nalo. Emva koko iyeza liyayeka ukusebenza.
Le meko ixhaphake kakhulu kwimidlaza "emithathu-engenayo". Izazinzulu azikayazi ukuba kutheni oku kusenzeka.
Ngeli xesha, ugqirha wakho unokutshintsha indibaniselwano yamayeza okanye akutshintshele kwindlela yonyango eyahlukileyo ngokupheleleyo.
Umyalezo Wokuya Ekhaya
- I-Taxane lunyango olusebenzayo kakhulu lwe-chemotherapy kumhlaza webele. Musa ukoyika oku.
- Olu nyango lunikezelwa ngomgca we-intravenous (IV). Kuya kufuneka uye esibhedlele ngeshedyuli ethile.
- Iziphumo ezinje ngokulahlekelwa ziinwele, ukudinwa, kunye neentlungu zomzimba zinokubakho. Uninzi lwazo ziyaphela xa unyango luyekisiwe.
- Ukuba ubonakalisa iimpawu ezinzima ezifana nomkhuhlane, urhudo oluqatha, okanye ubuthathaka obukhulu emalungeni akho, yazisa ugqirha wakho ngoko nangoko.
- Lilungelo lakho ukuxoxa ngokukhululekileyo ngayo nayiphi na imibuzo, uloyiko, okanye amathandabuzo onawo nogqirha wakho.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho