Ngaba wena okanye umntu osapho lwakho une -cystic fibrosis? Ukuba kunjalo, ugqirha wakho usenokuba ukunike ipilisi edibanisa amayeza amabini abizwa ngokuba yiTezacaftor kunye neIvacaftor. Ungayifumana le pilisi phantsi kwegama leSymdeko. Eli liyeza elikhethekileyo. Ke namhlanje, masithethe ngendlela elula neyobuhlobo malunga nokuba eli yeza lenza ntoni na, indlela yokulisebenzisa kanye kanye, zeziphi izinto ekufuneka uzilumkele, kunye neziphumo ebezingalindelekanga ezinokubangela.
Kwenzeka ntoni ngokwenene ngale mithi?
Ngamafutshane, i-cystic fibrosis sisifo esibangelwa sisiphene semfuza esilawula ulungelelwaniso lwetyuwa namanzi emizimbeni yethu. Ngenxa yoko, ukukhupha amanzi, ingakumbi emiphungeni nakwinkqubo yokugaya ukutya, njenge-mucus, kuba nkulu kakhulu kwaye kunamathela. Enyanisweni, kufana neglue. Le mucus ityebileyo yenza kube nzima ukuphefumla emiphungeni, kwaye inokukhokelela kwiintsholongwane ezixhaphakileyo .
Cinga ngayo njengeengcango ezincinci kwiiseli zomzimba wethu, apho ityuwa namanzi zingena ziphuma khona kwiiseli. Kwi-cystic fibrosis, ezi ngcango azisebenzi kakuhle.
Kulapho la mayeza mabini, iTezacaftor kunye neIvacaftor, angena khona. Oko kwenziwa ngala mayeza kukuba aya kula masango angasebenzi kakuhle (iiproteni) aze awancede asebenze kakuhle . Xa intshukumo yetyuwa namanzi ibuyiselwa ngale ndlela, i-mucus etyebileyo iyanyibilika kancinci kancinci kwaye isuswe lula emiphungeni. Emva koko ukuphefumla kuba lula, kwaye iimpawu zilawulwa kakhulu.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uthathe amayeza
Ngaphambi kokuba uqale ukusebenzisa eli yeza, kubaluleke kakhulu ukuxelela ugqirha wakho ngemeko yakho yempilo epheleleyo. Kuba kukho ezinye iimeko ezifuna unonophelo olukhethekileyo xa usebenzisa eli yeza. Qiniseka ukuba ubaxelela ngezi zinto ngokukodwa.
- Ukuba unesifo sezintso .
- Ukuba unesifo sesibindi , oku kubaluleke kakhulu, kuba eli yeza lisuswa emzimbeni ngesibindi .
- Ukuba une-allergies kwiTezacaftor, i-Ivacaftor, okanye naliphi na elinye iyeza, ukutya, okanye idayi .
- Ukuba ukhulelwe okanye uzama ukukhulelwaAmagama.
- Ukuba ungumama oncancisayo .
Ngokusekelwe kolu lwazi, ugqirha uya kugqiba ukuba eli yeza lifanelekile kuwe okanye akunjalo, okanye ukuba kufuneka kutshintshwe idosi.
Iyeza lifanele lisetyenziswe ngendlela eyiyo.
Ukuze ufumane okuninzi kweli yeza, kubaluleke kakhulu ukulisebenzisa ngokuchanekileyo.
- Yithathe nokutya: Le pilisi kufuneka ithathwe kunye nokutya okunamafutha . Umzekelo, amaqanda, ibhotolo yamandongomane , itshizi, ubisi, iyogathi, okanye isidlo esineoyile encinci yekhokhonathi. Le yeyona ndlela ilungileyo yokufunxa iyeza.
- Yithathe ngexesha elinye: Zama ukusela amayeza akho ngexesha elifanayo yonke imihla kangangoko unako. Shiya malunga neeyure ezili-12 phakathi kweedosi zasekuseni nezangokuhlwa.
- Ginya ithebhulethi yonke: Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna. Ginya ithebhulethi yonke ngeglasi yamanzi . Ngenxa yokuba ezi pilisi zenzelwe ukunyibilika kancinci emzimbeni, ukuziqhekeza kunokutshintsha indlela elisebenza ngayo iyeza.
- Ijusi yeGrapefruit: Enye into ebaluleke kakhulu kukuba ungaze uyithathe le yeza kunye nejusi yegrapefruit. Ingachaphazela kakhulu ukusebenza kweyeza. Kwakhona, yeka ukutya igrapefruit.
- Musa ukuyeka: Musa ukuyeka ukuthatha amayeza akho de ugqirha wakho akuxelele ukuba wenjenjalo. Qhubeka uwathatha nokuba uzive ungcono.
Kuthekani ukuba ngempazamo ndithathe amayeza amaninzi kakhulu?
Khawucinge ukuba ngempazamo usele iipilisi ezininzi kakhulu. Ukuba oku kuyenzeka , yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane ngaphandle kokulibazisa. Okanye utsalele umnxeba iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso.
Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?
Khawuthelekelele ukuba ulibele ukusela amayeza akho ngo-8 kusasa. Ukuba uyakhumbula malunga nentsimbi ye-12 emini, oko kuthetha ukuba kusele iiyure ezingaphezu kwezi-6 ngaphambi kokuba uthathe idosi elandelayo, thatha idosi oyiphosileyo kwangoko nje ukuba uyakhumbula. Kodwa ukuba kusele iiyure ezingaphantsi kwezi-6 ngaphambi kokuba uthathe idosi elandelayo, yeka idosi oyiphosileyo uze uthathe idosi elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye.
Amanye amayeza anokusebenza kunye nale mayeza
Eli yeza lisenokusebenzisana namanye amayeza. Ngoko ke, kubalulekile ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka iivithamini, amayeza esintu, kunye nezongezo).
| Uhlobo lweyeza | Imizekelo |
|---|---|
| Kuphephe ukuthatha eli yeza kunye nezi zinto ngokupheleleyo | |
| Amayeza athile okuxhuzula | I-Carbamazepine, iPhenobarbital, iPhenytoin |
| Amayeza athile esifo sephepha | I-Rifampin, i-Rifabutin |
| Isongezelelo sezityalo | I-St. John's Wort |
| Isiselo | Ijusi yegrapefruit |
| Yazisa ugqirha wakho xa kunokwenzeka ukuba kubekho unxibelelwano phakathi kwezi zinto. | |
| Amayeza athile okubulala iintsholongwane | IClarithromycin, i-Erythromycin |
| Izinto ezilwa nokungunda | I-Fluconazole, i-Itraconazole, iKetoconazole |
| Izinto ezithintela amasosha omzimba | I-Cyclosporine, iSirolimus, iTacrolimus |
| Iyeza lesifo sentliziyo | I-Digoxin |
Olu luhlu aluphelelanga, ngoko xelela ugqirha wakho ngayo yonke into oyisebenzisayo.
Izinto ekufuneka uzilumkele xa usebenzisa amayeza
Ugqirha wakho uza kukujonga rhoqo ngelixa usebenzisa eli yeza.
- Ukuhlolwa rhoqo: Ugqirha wakho uza kukuxelela ukuba uze ekliniki ngeentsuku ezicwangcisiweyo. Musa ukuziphosa. Oku kubalulekile ukuze ubone ukuba iimpawu zakho ziyaphucuka okanye aziphucuki.
- Uvavanyo lwegazi: Ugqirha wakho usenokuyalela uvavanyo lwegazi olumbalwa ngelixa usebenzisa eli yeza. Baza kujonga ii-enzymes zesibindi sakho, ingakumbi ii-enzymes zesibindi sakho. Oku kuqhelekile, ngoko ungakhathazeki. Kukuqinisekisa ukuba iyeza liyasebenza kuwe kwaye alichaphazeli isibindi sakho.
- Uvavanyo lwamehlo: Ungacelwa ukuba uhlolwe amehlo ngaphambi kokuba uqale amayeza kwaye ngelixa uwasebenzisa. Ukuba ubona naluphi na utshintsho ekuboneni kwakho (njengokubona okufipheleyo, ukubona imigca ejikeleze izibane) , xelela ugqirha wakho ngoko nangoko.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengalo naliphi na iyeza, eli linokubangela iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo. Kodwa kubalulekile ukuba uzazi.
| Uhlobo lwesiphumo esibi | Iimpawu |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala, ubunzima bokuphefumla. |
| Iimpawu zokulimala kwesibindi | Intlungu esiswini esingaphezulu ngasekunene, ukuphelelwa ngumdla wokutya, isicaphucaphu, indle ekhanyayo, umchamo otyheli okanye omdaka, ukutyheli kwamehlo okanye ulusu, kunye nokuziva udiniwe ngendlela engaqhelekanga. |
| Utshintsho kumbono | Umbono ofipheleyo, ukubona izangqa ezijikeleze izibane, ukulahlekelwa ngumbono. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Intloko ebuhlungu | Intloko ebuhlungu ngokubanzi. |
| Isiyezi | Isiyezi . |
| Isicaphucaphu | Ukuziva ngathi uza kuhlanza (Isicaphucaphu). |
| Intlungu yeSinus | Ukuziva intlungu okanye ukuxinana ebusweni okanye ebunzini. |
Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga ezingakhankanywanga kolu luhlu, nceda wazise ugqirha wakho ngazo.
Ungayigcina njani amayeza ngokukhuselekileyo?
- Gcina kude nabantwana: Soloko ugcine amayeza kude nabantwana nezilwanyana zasekhaya, kwindawo etshixiweyo.
- Ubushushu obufanelekileyo: Gcina kubushushu begumbi (phakathi kwama-20 nama-25 degrees Celsius). Khusela kubushushu obugqithisileyo kunye nokufuma.
- Amayeza Aphelelwe Lixesha: Musa ukusebenzisa amayeza aphelelwe lixesha. Walahle ngokufanelekileyo.
- Ukulahlwa: Musa ukulahla amayeza angasetyenziswanga kwindlu yangasese okanye ngqo enkunkuma. Buza ugqirha wakho ngendlela echanekileyo yokuwalahla.
Umyalezo Wokuya Ekhaya
- Tezacaftor; Soloko usela iyeza elibizwa ngokuba yi-Ivacaftor kunye nokutya okunamafutha. Oku kunceda ukuba iyeza lifunxwe ngcono ngumzimba.
- Musa ukusela ijusi yegrapefruit okanye igrapefruit ngokupheleleyo ngelixa usebenzisa eli yeza.
- Qiniseka ukuba wazisa ugqirha wakho ngazo zonke ezinye iindlela zonyango, iivithamini, kunye namayeza esintu owasebenzisayo.
- Ukuba uphoswe yidosi, thatha idosi ephoswe yiyo kuphela ukuba kudlule iiyure ezi-6 ngaphambi kwedosi yakho elandelayo. Kungenjalo, yiyeke. Ungaze uthathe iidosi ezimbini ngaxeshanye.
- Ukuba ufumana isiphumo esibi kakhulu, njengokutshintsha kombono, ukutyheli kolusu okanye amehlo, qhagamshelana nogqirha wakho ngoko nangoko.
- Eli nqaku lenzelwe ulwazi ngokubanzi kuphela. Hlala ulandela icebiso likagqirha wakho.
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