Ngaba unesifo seswekile sohlobo lwesibini? Okanye unengxaki yentliziyo okanye yemithambo yegazi? Ukuba kunjalo, ugqirha wakho usenokuba ukunike iyeza elibizwa ngokuba yi-Empagliflozin, ekwaziwa ngokuba yi-Jardiance. Eli yeza linikwa nabantu abangenaso isifo seswekile kodwa abaneengxaki ezithile zokungasebenzi kakuhle kwentliziyo. Ngoko ke, ekubeni eli liyeza elinikwa abantu abaninzi ngoku, masithethe ngalo ngokweenkcukacha namhlanje, ngokungathi sithetha nomhlobo.
Isebenza njani le chiza i-Empagliflozin (Jardiance)?
Oku kusenokuvakala ngathi kungokwesayensi kancinci, kodwa kulula kakhulu. Eli yeza likwiqela lamayeza abizwa ngokuba yi-SGLT2 inhibitors. Igama elipheleleyo yi-Sodium-glucose co-transporter 2 inhibitor.
Kulungile, ngoku ngamazwi alula, nantsi into eyenzekayo:
Izintso zethu zineproteni ebizwa ngokuba yi-SGLT2. Umsebenzi wazo kukuphinda zifunxe iswekile (iglucose) egazini zibuyele emzimbeni. I-Empagliflozin ithintela le proteni ebizwa ngokuba yi-SGLT2. Emva koko , izintso aziphindi zifunxe iswekile egqithisileyo egazini zibuyele emzimbeni, kodwa endaweni yoko ziyikhuphele emchameni. Kufana nesihluzo esisusa izinto ezingafunekiyo. Ngale ndlela, inqanaba leswekile egqithisileyo emzimbeni liyalawulwa.
Eli yeza likwanciphisa ukufunxwa kwakhona kwe-sodium (ityuwa) kwizintso iye emzimbeni. Oku kunciphisa umthwalo womsebenzi entliziyweni. Yiyo loo nto eli yeza likwaluncedo kakhulu kubantu abanesifo sentliziyo.
Yintoni omele uyilindele xa usebenzisa eli yeza?
I-Empagliflozin yipilisi oyithatha kube kanye ngemini. Kungcono ukunamathela kwixesha elifanayo yonke imihla. Oogqirha badla ngokukuxelela ukuba uyithathe kusasa. Ungayithatha nokuba utya okanye awutyanga.
Eli yeza liza ngamandla amabini: i-10 milligrams (10 mg) kunye ne-25 milligrams (25 mg). Ugqirha wakho angakuqala ngedosi ephantsi aze anyuse idosi ukuba kuyimfuneko.
Yintoni omawuyenze ukuba ulibele? Ukuba ulibele ukusela ipilisi, yisele kwangoko wakuba ukhumbule. Kodwa ukuba sele kuza kufuneka ipilisi yakho elandelayo, musa ukuyisela zombini ipilisi ongazange uyisele kunye nelandelayo ngaxeshanye. Yitsibe ipilisi ongazange uyisele uze uthathe ipilisi elandelayo ngexesha elicwangcisiweyo.
Ngamanye amaxesha ugqirha wakho uza kukunika eli yeza kunye nelinye iyeza leswekile. Umzekelo, ungalifumana kunye ne-metformin (ebizwa ngokuba yiSynjardy) okanye ne-linagliptin (ebizwa ngokuba yiGlyxambi) njengepilisi enye.
Ukuze ufumane okuninzi kweli yeza, kubalulekile ukutya ukutya okunempilo kunye nokuzilolonga rhoqo , njengoko kucetyisiwe ngugqirha wakho. Ungalibali ukusela amanzi amaninzi imini yonke.
Ngelixa usela eli yeza, ugqirha wakho uya kwenza uvavanyo lwegazi ngamanye amaxesha ukujonga ukuba izintso zakho zisebenza kakuhle kangakanani na. Uya kukuxelela nokuba ujonge amanqanaba eswekile yakho yegazi rhoqo. Kungathatha ukuya kuthi ga kwiinyanga ezi-6 ukuba isiphumo esipheleleyo seli yeza sibonakale.
Zithini iziphumo ebezingalindelekanga zoku?
Njengalo naliphi na iyeza, eli linokuba nemiphumo emibi emincinci. Kodwa ungakhathazeki, uninzi lwayo alubi nzulu. Makhe sijonge ukuba zeziphi ezi miphumo emibi.
| Imiphumela | Inkcazo kunye nento omawuyenze |
|---|---|
| Iziphumo Eziqhelekileyo Ezingalindelekanga | |
| Usulelo lweMvubelo kwiNdawo yeSini | Ixhaphake kakhulu kwabasetyhini, kodwa inokubakho nasemadodeni. Iimpawu ziquka ukurhawuzelela, iintlungu, ukudumba, ukuba bomvu, kunye nokuphuma kolwelo. Kukho unyango lwale ngxaki, ngoko ke bonana nogqirha ukuba unale mpawu. |
| Usulelo lwendlela yomchamo (UTIs) | Iimpawu ezinje ngokutsha, iintlungu, ukuchama rhoqo, umchamo onamafu, okanye igazi zinokubakho. Iintlungu zesisu nazo zinokubakho. Xelela ugqirha wakho ngezi zinto kuba nazo zifuna unyango. |
| Ezinye iziphumo ebezingalindelekanga ezincinci | Usenokuba nezinto ezinje ngokoma okukhulu, ukuchama rhoqo, isicaphucaphu, iintlungu zamalungu, kunye nosulelo lomphimbo. Ezi zinto zihlala ziphela ngokuhamba kwexesha njengoko umzimba wakho uqhelana namayeza. Ukuba ziyaqhubeka, xelela ugqirha wakho. |
| Iziphumo Ezimbi Ezifuna Ingqwalasela Ekhawulezileyo | |
| Usulelo olukhulu lomchamo | Umkhuhlane, ukubanda, iintlungu eziqatha esiswini okanye emqolo. Ezi zisenokuba ziimpawu zosulelo oluchaphazela izintso. Funa ingcebiso kagqirha ngoko nangoko. |
| Uxinzelelo lwegazi oluphantsi | Ukuba nesiyezi, ukuba nentloko ekhaphukhaphu, ingakumbi xa umi ngenyawo. |
| Iswekile yegazi ephantsi | Iimpawu ezinje ngokubila, ukungcangcazela, ukunyuka kwesantya sentliziyo, indlala, kunye nokudideka zinokubakho, ingakumbi xa zithathwa kunye namanye amayeza eswekile. |
| Isifo sokubola kwesikhumba sikaFournier | Olu lusulelo olungaqhelekanga nolunzima kwindawo yesini. Iimpawu ziquka iintlungu eziqatha kwindawo, ukudumba, umkhuhlane, kunye nokudinwa kakhulu. Olu lungxamiseko, yiya kwiSebe lezeMpilo eziNgxamisekileyo lesibhedlele (ETU) ngokukhawuleza. |
| I-ketoacidosis yesifo seswekile | Imeko embi kakhulu ebangelwa kukunyuka kweswekile egazini. Iimpawu ziquka ukoma kakhulu, ukuchama rhoqo, iintlungu zesisu, isicaphucaphu, ukuziva ubuthathaka, kunye nevumba leziqhamo emlonyeni. Oku kukwangxamiseko, yiya kwi-ETU ngokukhawuleza. |
| Iimpendulo ze-Allergic | Ukuqhambuka kwesikhumba, ukudumba kobuso, imilebe, okanye umphimbo, ubunzima bokuginya okanye ukuphefumla. Oku nako kungxamiseko, funa uncedo lwezonyango ngokukhawuleza. |
Izilumkiso kunye namanyathelo okhuseleko ekufuneka uwaqaphele ngaphambi kokuba uyisebenzise
Ngaphambi kokuba uqalise eli yeza, kubaluleke kakhulu ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka amayeza ezinye izifo, iivithamini, izongezo, kunye namayeza emveli). I-Empagliflozin inokunxibelelana namayeza alandelayo ngokukodwa:
- Amanye amayeza eswekile
- Amayeza oxinzelelo lwegazi afana ne-ACE inhibitors kunye ne-Angiotensin receptor blockers (ARBs)
- I-Diuretics okanye "iipilisi zamanzi"
- Izithomalalisi zentlungu ezifana ne-aspirin, i-ibuprofen, kunye ne-naproxen
Ugqirha wakho unokufuna ukutshintsha idosi yamanye amayeza owasebenzisayo okanye alumke ngakumbi ngemiphumo emibi.
Ukuba uneempawu ze-ketoacidosis, ugqirha wakho angakucela ukuba ujonge igazi lakho ukuba alinazo na ii-ketones. Kukho izixhobo ezikhethekileyo okanye imicu yovavanyo lomchamo yoku.
Ungalibali ukusela amanzi amaninzi , kuba eli yeza linokubangela ukuphelelwa ngamanzi emzimbeni.
Xelela ugqirha wakho ukuba usela utywala, kwaye ukuba une-yeast infections okanye i-urinary tract infections rhoqo.
Ngubani ongafanele athathe eli yeza?
I-Empagliflozin ayifanelekanga kuye wonke umntu. Kukho iimeko apho eli yeza lingafanele lisetyenziswe:
- Ukuba unyangwa nge-kidney dialysis.
- Ukuba ungumama oncancisayo (amayeza angadluliselwa kumntwana ngobisi lwebele).
- Ukuba ukhulelwe okanye uceba ukukhulelwa (njengoko kunokwenzakalisa umntwana, thetha nogqirha wakho ngale nto).
- Ukuba une-allergy kwi-empagliflozin okanye nakweyiphi na izithako zayo.
Kwakhona, eli yeza alivumelekanga kubantu abanesifo seswekile sohlobo loku-1, kuba linokunyusa umngcipheko wabo we-Ketoacidosis.
Isebenza kangakanani i-Empagliflozin (Jardiance)?
Ukusebenza kakuhle kwale chiza kuye kwabhalwa kakuhle kwiimvavanyo zeklinikhi. Kwisifundo seenyanga ezi-6 kubantu abadala abanesifo seswekile sohlobo lwesibini, i-Empagliflozin:
- Amanqanaba eswekile egazini lokuzila ukutya ngokubanzi ehle malunga ne-19-25.
- Ixabiso le-A1c, elibonisa amanqanaba aphakathi eswekile egazini kwiinyanga ezi-2-3 ezidlulileyo, lehle nge-0.7% - 0.8%.
Ukongeza, abanye abantu baye bancipha ubunzima bomzimba . Abo bathathe idosi ye-10mg ngosuku bancipha malunga ne-2.5% yobunzima bomzimba wabo (umzekelo, malunga ne-2.25 kg kumntu onobunzima obuyi-90 kg). Abo bathathe idosi ye-25mg bancipha malunga ne-2.8% yobunzima bomzimba wabo (umzekelo, malunga ne-2.5 kg kumntu onobunzima obuyi-90 kg).
Kukwakho nokwehla okuncinci koxinzelelo lwegazi lwe-systolic kwabo bathathe eli yeza.
Umyalezo Wokuya Ekhaya
- I-Empagliflozin (Jardiance) liyeza elisetyenziselwa ukunyanga isifo seswekile kunye nezifo ezithile zentliziyo. Lisebenza ngokunceda izintso zisuse iswekile egqithisileyo emzimbeni ngomchamo.
- Sela eli yeza kanye njengoko ugqirha wakho ekuyalele, ngexesha elifanayo yonke imihla. Ukuba uphoswe yidosi, musa ukuthatha iidosi ezimbini ngexesha elinye kwixesha elizayo.
- Usulelo lomchamo kunye nosulelo lwemvubelo yesini luqhelekile kweli yeza. Xelela ugqirha wakho ukuba ufumana naziphi na kwezi mpawu.
- Sela amanzi amaninzi imini yonke kuba eli yeza linokubangela ukuphelelwa ngamanzi emzimbeni.
- Kubalulekile ukwazisa ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo.
- Ukuba ubonakalisa iimpawu ezinzulu ezifana nokusabela okunamandla kwe-allergy, ubunzima bokuphefumla, i-Fournier's gangrene, okanye i-ketoacidosis , yiya kwicandelo likaxakeka lesibhedlele (ETU) ngokukhawuleza.
- Ungaze uyeke ukuthatha eli yeza ngaphandle kwengcebiso kagqirha.
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